The sense of smell, its signalling pathways, and the dichotomy of cilia and microvilli in olfactory sensory cells

Smell is often regarded as an ancillary perception in primates, who seem so dominated by their sense of vision. In this paper, we will portray some aspects of the significance of olfaction to human life and speculate on what evolutionary factors contribute to keeping it alive. We then outline the functional architecture of olfactory sensory neurons and their signal transduction pathways, which are the primary detectors that render olfactory perception possible. Throughout the phylogenetic tree, olfactory neurons, at their apical tip, are either decorated with cilia or with microvilli. The significance of this dichotomy is unknown. It is generally assumed that mammalian olfactory neurons are of the ciliary type only. The existance of so-called olfactory microvillar cells in mammals, however, is well documented, but their nature remains unclear and their function orphaned. This paper discusses the possibility, that in the main olfactory epithelium of mammals ciliated and microvillar sensory cells exist concurrently. We review evidence related to this hypothesis and ask, what function olfactory microvillar cells might have and what signalling mechanisms they use

Jet reconstruction and performance using particle flow with the ATLAS Detector

This paper describes the implementation and performance of a particle flow algorithm applied to 20.2 fb -1-1 of ATLAS data from 8 TeV proton–proton collisions in Run 1 of the LHC. The algorithm removes calorimeter energy deposits due to charged hadrons from consideration during jet reconstruction, instead using measurements of their momenta from the inner tracker. This improves the accuracy of the charged-hadron measurement, while retaining the calorimeter measurements of neutral-particle energies. The paper places emphasis on how this is achieved, while minimising double-counting of charged-hadron signals between the inner tracker and calorimeter. The performance of particle flow jets, formed from the ensemble of signals from the calorimeter and the inner tracker, is compared to that of jets reconstructed from calorimeter energy deposits alone, demonstrating improvements in resolution and pile-up stability