Seasonal H2O and CO2 Ice Cycles at the Mars Phoenix Landing Site: 1. Prelanding CRISM and HiRISE Observations

The condensation, evolution, and sublimation of seasonal water and carbon dioxide ices were characterized at the Mars Phoenix landing site from Martian northern midsummer to midspring (Ls ∼ 142° – Ls ∼ 60°) for the year prior to the Phoenix landing on 25 May 2008. Ice relative abundances and grain sizes were estimated using data from the Compact Reconnaissance Imaging Spectrometer for Mars and High Resolution Imaging Science Experiment aboard Mars Reconnaissance Orbiter and a nonlinear mixing model. Water ice first appeared at the Phoenix landing site during the afternoon in late summer (Ls ∼ 167°) as an optically thin layer on top of soil. CO2 ice appeared after the fall equinox. By late winter (Ls ∼ 344°), the site was covered by relatively pure CO2 ice (∼30 cm thick), with a small amount of ∼100 μm diameter water ice and soil. As spring progressed, CO2 ice grain sizes gradually decreased, a change interpreted to result from granulation during sublimation losses. The combined effect of CO2 sublimation and decreasing H2O ice grain sizes allowed H2O ice to dominate spectra during the spring and significantly brightened the surface. CO2 ice disappeared by early spring (Ls ∼ 34°) and H2O ice by midspring (Ls ∼ 59°). Spring defrosting was not uniform and occurred more rapidly over the centers of polygons and geomorphic units with relatively higher thermal inertia values

Seasonal H2O and CO2 Ice Cycles at the Mars Phoenix Landing Site: 1. Prelanding CRISM and HiRISE Observations

The condensation, evolution, and sublimation of seasonal water and carbon dioxide ices were characterized at the Mars Phoenix landing site from Martian northern midsummer to midspring (Ls ∼ 142° – Ls ∼ 60°) for the year prior to the Phoenix landing on 25 May 2008. Ice relative abundances and grain sizes were estimated using data from the Compact Reconnaissance Imaging Spectrometer for Mars and High Resolution Imaging Science Experiment aboard Mars Reconnaissance Orbiter and a nonlinear mixing model. Water ice first appeared at the Phoenix landing site during the afternoon in late summer (Ls ∼ 167°) as an optically thin layer on top of soil. CO2 ice appeared after the fall equinox. By late winter (Ls ∼ 344°), the site was covered by relatively pure CO2 ice (∼30 cm thick), with a small amount of ∼100 μm diameter water ice and soil. As spring progressed, CO2 ice grain sizes gradually decreased, a change interpreted to result from granulation during sublimation losses. The combined effect of CO2 sublimation and decreasing H2O ice grain sizes allowed H2O ice to dominate spectra during the spring and significantly brightened the surface. CO2 ice disappeared by early spring (Ls ∼ 34°) and H2O ice by midspring (Ls ∼ 59°). Spring defrosting was not uniform and occurred more rapidly over the centers of polygons and geomorphic units with relatively higher thermal inertia values

Skunk River Review Fall 2004, vol 16

https://openspace.dmacc.edu/skunkriver/1012/thumbnail.jp

Marsh macrophyte responses to inundation anticipate impacts of sea-level rise and indicate ongoing drowning of North Carolina marshes

In situ persistence of coastal marsh habitat as sea level rises depends on whether macrophytes induce compensatory accretion of the marsh surface. Experimental planters in two North Carolina marshes served to expose two dominant macrophyte species to six different elevations spanning 0.75 m (inundation durations 0.4–99 %). Spartina alterniflora and Juncus roemerianus exhibited similar responses—with production in planters suggesting initial increases and then demonstrating subsequent steep declines with increasing inundation, conforming to a segment of the ecophysiological parabola. Projecting inundation levels experienced by macrophytes in the planters onto adjacent marsh platforms revealed that neither species occupied elevations associated with increasing production. Declining macrophyte production with rising seas reduces both bioaccumulation of roots below-ground and baffle-induced sedimentation above-ground. By occupying only descending portions of the parabola, macrophytes in central North Carolina marshes are responding to rising water levels by progressive declines in production, ultimately leading to marsh drowning

Seasonal melting and the formation of sedimentary rocks on Mars, with predictions for the Gale Crater mound

A model for the formation and distribution of sedimentary rocks on Mars is proposed. The rate-limiting step is supply of liquid water from seasonal melting of snow or ice. The model is run for a O(10^2) mbar pure CO2 atmosphere, dusty snow, and solar luminosity reduced by 23%. For these conditions snow only melts near the equator, and only when obliquity >40 degrees, eccentricity >0.12, and perihelion occurs near equinox. These requirements for melting are satisfied by 0.01-20% of the probability distribution of Mars' past spin-orbit parameters. Total melt production is sufficient to account for aqueous alteration of the sedimentary rocks. The pattern of seasonal snowmelt is integrated over all spin-orbit parameters and compared to the observed distribution of sedimentary rocks. The global distribution of snowmelt has maxima in Valles Marineris, Meridiani Planum and Gale Crater. These correspond to maxima in the sedimentary-rock distribution. Higher pressures and especially higher temperatures lead to melting over a broader range of spin-orbit parameters. The pattern of sedimentary rocks on Mars is most consistent with a Mars paleoclimate that only rarely produced enough meltwater to precipitate aqueous cements and indurate sediment. The results suggest intermittency of snowmelt and long globally-dry intervals, unfavorable for past life on Mars. This model makes testable predictions for the Mars Science Laboratory rover at Gale Crater. Gale Crater is predicted to be a hemispheric maximum for snowmelt on Mars.Comment: Submitted to Icarus. Minor changes from submitted versio

l-Arginine deprivation impairs Leishmania major-specific T-cell responses

The amino acid l-arginine plays a crucial role in the regulation of immune responses. We have recently shown that uncontrolled replication of Leishmania parasites at the site of pathology correlates with high levels of arginase activity in nonhealing leishmaniasis and that this elevated arginase activity causes local depletion of l-arginine. To further our understanding of the impact of l-arginine deprivation in experimental leishmaniasis, here we characterize in detail the effects of l-arginine deprivation on antigen-specific T cells and MΦ. The results of our study show that decrease of l-arginine levels in the extracellular milieu affects the biological activities of Leishmania major-specific T cells, both at the level of the magnitude and the quality of their responses. L. major-specific CD4+ T cells rendered hyporesponsive by l-arginine deprivation can be partially rescued by addition of exogenous l-arginine to produce IL-4 and IL-10, but not to produce IFN-γ. Furthermore, our results show that l-arginine deprivation also greatly impacts parasite growth in activated macrophages. In summary, our results suggest that l-arginine levels affect both Th cell responses and parasite replication

Enhanced Leishmania braziliensis Infection Following Pre-Exposure to Sandfly Saliva

Parasites of the genus Leishmania cause a variety of diseases known as leishmaniasis, that are transmitted by bites of female sand flies that, during blood-feeding, inject humans with parasites and saliva. It was shown that, in mice, immunity to sand-fly saliva is able to protect against the development of leishmaniasis. We have investigated, in the present study, whether this finding extends the sand fly species Lutzomyia intermedia, which is responsible for transmission of Leishmania braziliensis, a parasite species able to cause destructive skin lesions that can be fatal if left untreated. We observed that mice injected with sand fly saliva develop a specific immune response against salivary proteins. Most importantly, however, this immune response was unable to protect mice against a challenge infection with L. braziliensis, indicating that exposure to this sand fly saliva is harmful to the host. Indeed, subjects with cutaneous leishmaniasis have a higher immune response against L. intermedia saliva. These findings indicate that the anti-saliva immune response to sand fly saliva plays an important role in the outcome of leishmaniasis caused by L. braziliensis, in both mice and humans, and emphasize possible hurdles in the development of vaccines based on sand fly saliva

Protection against Mycobacterium ulcerans Lesion Development by Exposure to Aquatic Insect Saliva

BACKGROUND: Buruli ulcer is a severe human skin disease caused by Mycobacterium ulcerans. This disease is primarily diagnosed in West Africa with increasing incidence. Antimycobacterial drug therapy is relatively effective during the preulcerative stage of the disease, but surgical excision of lesions with skin grafting is often the ultimate treatment. The mode of transmission of this Mycobacterium species remains a matter of debate, and relevant interventions to prevent this disease lack (i) the proper understanding of the M. ulcerans life history traits in its natural aquatic ecosystem and (ii) immune signatures that could be correlates of protection. We previously set up a laboratory ecosystem with predatory aquatic insects of the family Naucoridae and laboratory mice and showed that (i) M. ulcerans-carrying aquatic insects can transmit the mycobacterium through bites and (ii) that their salivary glands are the only tissues hosting replicative M. ulcerans. Further investigation in natural settings revealed that 5%–10% of these aquatic insects captured in endemic areas have M. ulcerans–loaded salivary glands. In search of novel epidemiological features we noticed that individuals working close to aquatic environments inhabited by insect predators were less prone to developing Buruli ulcers than their relatives. Thus we set out to investigate whether those individuals might display any immune signatures of exposure to M. ulcerans-free insect predator bites, and whether those could correlate with protection. METHODS AND FINDINGS: We took a two-pronged approach in this study, first investigating whether the insect bites are protective in a mouse model, and subsequently looking for possibly protective immune signatures in humans. We found that, in contrast to control BALB/c mice, BALB/c mice exposed to Naucoris aquatic insect bites or sensitized to Naucoris salivary gland homogenates (SGHs) displayed no lesion at the site of inoculation of M. ulcerans coated with Naucoris SGH components. Then using human serum samples collected in a Buruli ulcer–endemic area (in the Republic of Benin, West Africa), we assayed sera collected from either ulcer-free individuals or patients with Buruli ulcers for the titre of IgGs that bind to insect predator SGH, focusing on those molecules otherwise shown to be retained by M. ulcerans colonies. IgG titres were lower in the Buruli ulcer patient group than in the ulcer-free group. CONCLUSIONS: These data will help structure future investigations in Buruli ulcer–endemic areas, providing a rationale for research into human immune signatures of exposure to predatory aquatic insects, with special attention to those insect saliva molecules that bind to M. ulcerans