Do systemic collaboration and network governance matter? Living Labs beyond user-driven innovation

Despite the emergence and fast expansion of Living Lab (LL) around the world, little research has been conducted on the concept of LL from the perspective of both technological and social innovation and network governance. This paper critically reviews literature on the LL concept and other ‘innovation labs’ involving cross-border collaboration between private, public, and third sectors. Furthermore, we develop a framework outlining key analytical dimensions (context and aims, innovation types, stakeholders, partnership models, supporting, institutional environments, collaboration and network governance practices) and discuss findings from a study of an international sample of 120 LLs

Hacia una pedagogía de los valores en la Educación Superior

Se analiza el Proyecto Educativo como vía para desarrollar la educación en valores del estudiante de la Educación Superior en Cuba, lo cual puede generalizarse a otros contextos educativos. Se ofrecen las premisas y requerimientos para la concepción de un Proyecto Educativo científicamente fundamentado en las leyes y regularidades del proceso pedagógico En las bases psicopedagógicas para el diagnóstico se trata de precisar el lugar que ocupan los valores en la estructura de la personalidad y su relación con otras categorías psicológicas. Se concluye proponiendo que se tomen como base las esferas de actuación del estudiante universitario: las dimensiones curricular, sociopolítica y extensionista. El conteni-do esencial de las mismas se ha integrado en categorías que se podrán explorar mediante indicadores

Fatores associados à qualidade de vida relacionada à saúde de adultos com sequelas de AVC

OBJECTIVE: To assess health-related quality of life (HRQoL) among adults with stroke sequelae and to identify the factors that influenced the domains of HRQoL. METHOD: The subjects were adults with stroke who were admitted to a rehabilitation program between March and August 2008. They were investigated using the following instruments: Medical Outcomes 36-Item Short-Form Health Survey (SF-36), Functional Independence Measure (FIM) and Beck Depression Inventory (BDI). Sixty-four adults of mean age 58.8 years were evaluated. RESULTS: The individuals who had had their injuries for longer times and who were more independent and younger had better HRQoL regarding physical functioning. Social participation was associated with better HRQoL, and there was a difference between groups with and without depressive symptoms. CONCLUSION: HRQoL was compromised primarily with regard to functional characteristics. Moreover, the presence of depressive symptoms contributed towards a decline in HRQoL. Rehabilitation needs to focus on improving functionality and social participation, which may stimulate reductions in depressive symptoms and improvement of HRQoL

Quality Of Life Assessment In Children With Cerebral Palsy

Objectives: Evaluate the QoL of children with CP followed at Núcleo de Tratamento e Estimulação Precoce, in Fortaleza, Ceará, Brazil; identify the most affected domains of the Pediatric Quality of Life Inventory. Methods: This was a cross-sectional, of which target population consisted of parents of children with CP (N = 62). Data collection was carried out by applying the socioeconomic questionnaire and the Health-related Quality of Life tool – HRQoL-PedsQL version 4.0, module applied to parents. Data analysis was performed with SPSS statistical software, version 23.0. Results: The results after transformation of scores into a scale of 0 to 100 in PedsQL, the data showed statistical difference between QOL domains except for physical capacity and social aspect and in descending order of impairment, the domains were related to school activity, the emotional aspect, physical capacity and the social aspect. Conclusions: Given the above, to attain improvement in QoL indicators, it is reasonable to propose interdisciplinary intervention among healthcare professionals in order to develop improved strategies aiming to promote early integration of children with CP in schools, to obtain significant results

Crowdfunding para organizaciones del Tercer y Cuarto Sector

Máster en Dirección Empresarial desde la Innovación y la Internacionalización. Curso 2013/2014[ES] Las organizaciones sin ánimo de lucro así como las empresas de innovación social son muy necesarias en cualquier sociedad, puesto que juegan un papel esencial en la identificación y resolución de carencias socio-económicas, y se constituyen, junto con las administraciones públicas, en agentes vertebradores para la cohesión social y económica en un aspecto más práctico, y para el avance ético en un sentido más moral. La crisis financiera actual ha supuesto un varapalo para estas organizaciones que han visto recortadas drásticamente sus fuentes de financiación, mayoritariamente de origen público. En este contexto las tecnologías open source están ayudando a al desarrollo y supervivencia de organizaciones de pequeño tamaño y recursos limitados a través de diversas herramientas, como por ejemplo el Crowdfunding. Ahora bien, no hay que olvidar que más allá de la explosión de este fenómeno, el Crowdfunding necesita de cierta regulación y control para que pueda consolidarse como un instrumento importante de captación de fondos.[EU] Irabazi-asmorik gabeko erakundeak eta berrikuntza sozialeko enpresak baita ere oso beharrezkoak dira edozein gizartetan, giza beharrak identifikaziorako eta gabezia sozio-ekonomikoak asetzen dituztelako. Administrazio publikoekin batera, kohesio sozial eta ekonomikorako eragile bihurtzen dira zentzu praktiko batean, eta aurrerapen morala garatzen dute arlo etikoan. Gaurko krisi finantzarioak bere finantzaketa-iturriak drastikoki murriztu ditu, jatorri publikoak gehienak. Kontestu honetan open source teknologiak baliabide gutxiko eta tamaina txikiko erakundeak laguntzen ari dira bere garapen eta biziraupenerako tresna ezberdinak eskainiz, Crowdfunding adibidez. Ez da ahaztu behar, hori bai, Crowdfunding-a fenomeno iragankorra baino gehiago izan dadila, erregulazio eta kontrola behar duela diru-bilketako mekanismo garrantzitsu bat ezartzeko.[EN] Non-profit Organizations and also Social Innovation Enterprises are essential in any society because they play an important role in the identification and resolution of social and economic lacks, and they establish themselves, together with Public Institutions, as agents who provide social and economic cohesion in a practical sense, and contribute to the moral advance from an ethical point of view. The financial crisis hit drastically those organizations who has suffered cuts in their funding, especially publics funds. In the current context the open source technologies are helping to the development and survive of small sized organizations with little resources through several tools as Crowdfunding. Anyway, is important to remark that for the consolidation of crowdfunding as a fundraising tool, beyond a temporal phenomenon, is necessary some kind of regulation and control over it

Mutational spectrum of GNAL, THAP1 and TOR1A genes in isolated dystonia: study in a population from Spain and systematic literature review

[Objective] We aimed to investigate the prevalence of TOR1A, GNAL and THAP1 variants as the cause of dystonia in a cohort of Spanish patients with isolated dystonia and in the literature.[Methods] A population of 2028 subjects (including 1053 patients with different subtypes of isolated dystonia and 975 healthy controls) from southern and central Spain was included. The genes TOR1A, THAP1 and GNAL were screened using a combination of high-resolution melting analysis and direct DNA resequencing. In addition, an extensive literature search to identify original articles (published before 10 August 2020) reporting mutations in TOR1A, THAP1 or GNAL associated to dystonia was performed.[Results] Pathogenic or likely pathogenic variants in TOR1A, THAP1 and GNAL were identified in 0.48%, 0.57% and 0.29% of our patients, respectively. Five patients carried the variation p.Glu303del in TOR1A. A very rare variant in GNAL (p.Ser238Asn) was found as a putative risk factor for dystonia. In the literature, variations in TOR1A, THAP1 and GNAL accounted for about 6%, 1.8% and 1.1% of published dystonia patients, respectively.[Conclusions] There is a different genetic contribution to dystonia of these three genes in our patients (about 1.3% of patients) and in the literature (about 3.6% of patients), probably due the high proportion of adult-onset cases in our cohort. As regards age at onset, site of dystonia onset, and final distribution, in our population there is a clear differentiation between DYT-TOR1A and DYT-GNAL, with DYT-THAP1 likely to be an intermediate phenotype.This work was supported by the Carlos III Health Institute-European Regional Development Fund (ISCIII-FEDER) [PI14/01823, PI16/01575, PI18/01898, PI19/01576], the Andalusian Regional Ministry of Economics, Innovation, Science and Employment [CVI-02526, CTS-7685], the Andalusian Regional Ministry of Health and Welfare [PI-0741-2010, PI-0471-2013, PE-0210-2018, PI-0459-2018, PE-0186-2019], and the Alicia Koplowitz and Mutua Madrileña Foundations. Pilar Gómez-Garre was supported by the "Miguel Servet" program [MSII14/00018] (from ISCIII-FEDER) and “Nicolás Monardes” program [C-0048-2017] (from the Andalusian Regional Ministry of Health). Silvia Jesús was supported by the "Juan Rodés" program [B-0007-2019] and Daniel Macías-García by the “Río Hortega” program [CM18/00142] (both from ISCIII-FEDER). María Teresa Periñán was supported by the Spanish Ministry of Education [FPU16/05061]. Cristina Tejera was supported by VPPI-US from the University of Seville.Peer reviewe

Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.

Introduction: In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage. Materials and methods: Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0-20; B: NMSS = 21-40; C: NMSS = 41-70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results: A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p < 0.0001). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (p < 0.005; e.g., PDQ-39SI in 1D [n = 15] vs 2A [n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; p < 0.0001). Conclusion: The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the HΨ Patients with a lower H&Y stage may be more affected if they have a greater NMS burden

Amor, empatía y conductas prosociales: una reflexión interdisciplinaria

This book presents, through reflection, the relevance, timeliness and necessity of love, empathy and prosocial behaviors within the framework of the professional and disciplinary work of the authors. The reader will be able to find here what these professionals, academics and intellectuals think and feel about it. Let the reader know that it was not a simple writing project, maybe because of the invitation to think about oneself, maybe because of the presence of the concept of "love" in the academy, or maybe, because we are not so accustomed to putting in the first person the reflection turned from what we relate to day by day. May this text be the excuse to continue to reflect on the role of love, empathy and prosocial behavior in a world that sometimes shows great desolation. May these unknotted reflections allow us to understand and resignify, learn and continue.PublishedEste libro expone, por la vía de la reflexión, la pertinencia, actualidad y necesidad del amor, la empatía y las conductas prosociales en el marco del quehacer profesional y disciplinar de los autores. El lector podrá encontrar aquí lo que esos profesionales, académicos e intelectuales piensan y sienten al respecto. Sepa el lector que no fue un proyecto de escritura sencillo, quizá por la invitación a pensar sobre sí, quizá por la presencia del concepto “amor” en la academia, o quizá, simplemente, porque no estamos tan acostumbrados a poner en primera persona la reflexión devenida de aquello con lo que día a día nos relacionamos. Que sea este texto la excusa para continuar reflexionando sobre el papel del amor, la empatía y las conductas prosociales en un mundo que a veces muestra gran desolación. Que estas reflexiones des-anudadas permitan comprender y resignificar, aprender y continuar

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe