Treatment of Chronic Hepatitis C in a Patient Affected by Systemic Sclerosis

The currently recommended treatment for patients infected with hepatitis C virus (HCV) is pegilated interferon α (IFN α) plus ribavirin. Despite the numerous benefits of this therapy, there is an increasing concern regarding his tolerance. Among the most common side effects, interferon may trigger the onset or exacerbation of autoimmune diseases. When chronic hepatitis C coexists with an autoimmune disorder, it is not clear whether using interferon is better than avoiding it. We evaluated the disease state of a 55-year old female affected by sistemic sclerosis (SSc), during and after therapy with IFNα pegilated plus ribavirin for chronic HCV infection. We were worried about the potential worsening of the autoimmune disease during the therapy, but we were confident that we would give our patient a short course of peginterferon and ribavirin. A mild, asymptomatic worsening of lung SSc was observed during IFN administration, without life threatening symptoms. After 24 months follow up we observed the maintenance of the virological response and a good control of the rheumatological disease. Thus, in liver disease at high risk of progression and concomitant SSc, the antiviral therapy with IFNα is a feasible approach

First report of Gonipterus scutellatus complex (Coleoptera Curculionidae) in Sicily (Italy).

During August 2015, the weevil Gonipterus scutellatus complex (Coleoptera Curculionidae), a pest of Eucalyptus spp., was found for the first time in Sicily. According to our surveys, Eucalyptus globulus was the only infested tree species

Estratégias de disposição do solo público: mercantilização e inflexões do neoliberalismo urbano na Cidade de Buenos Aires (2015-2018)

El presente artículo se enmarca en un estudio comparativo de los proyectos de concesión y privatización de suelo llevados adelante en la Ciudad de Buenos Aires desde 2015 a 2018. Nuestro objetivo es analizar las estrategias de disposición de tierra desplegadas por medio de la concesión y privatización en el ámbito de la Ciudad de Buenos Aires, reconstruyendo las racionalidades políticas que se articularon en torno a ellas y los dispositivos institucionales creados para viabilizarlas. Nuestro argumento central es que, inscriptos en discursos sobre la ‘ociosidad’ de los terrenos, se movilizan grandes superficies de suelo mediante la creación de dispositivos institucionales que profundizan la fragmentación presupuestaria y territorial, sustrayendo del ámbito legislativo sus atribuciones en la definición de usos del suelo. Intentamos abordar así las continuidades e inflexiones en el urbanismo neoliberal porteño. Adoptamos una estrategia metodológica basada en el análisis de documentos producidos por las autoridades.This article is part of a comparative study of land concession and privatization projects carried out in the City of Buenos Aires from 2015 to 2018. Our goal is to analyze the land disposal strategies deployed by authorities through the concession and privatization in the City of Buenos Aires, reconstructing the political rationalities that were articulated around them and the institutional devices created to make them viable. Our central argument is that, inscribed in discourses about the ‘idleness’ of the land, large areas were mobilized through the creation of institutional devices that deepen the budgetary and territorial fragmentation, subtracting from the legislative scope its attributions in the definition of land uses. In doing so, we address the continuities and inflections in Buenos Aires’ urban neoliberalism. We adopt a methodological strategy based on the analysis of documents produced by authorities.O presente artigo enquadra-se em um estudo comparativo dos projetos de concessão e privatização de solo levados a cabo na Cidade de Buenos Aires desde 2015 a 2018. O nosso objetivo é analisar as estratégias de disposição de terra desenvolvidas por meio da concessão e privatização no âmbito da Cidade de Buenos Aires, reconstruindo as racionalidades políticas que se articularam em torno a elas e os dispositivos institucionais criados para viabilizá-las. Nosso argumento central é que, inscritos em discursos sobre a ‘ociosidade’ dos terrenos, se mobilizam grandes superfícies de solo mediante a criação de dispositivos institucionais que aprofundam a fragmentação orçamentária e territorial, subtraindo do âmbito legislativo suas atribuições na definição de usos do solo. Tentamos abordar assim as continuidades e inflexões no urbanismo neoliberal portenho. Adotamos uma estratégia metodológica baseada na análise de documentos produzidos pelas autoridades.Fil: Socoloff, Ivana Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Estudios de América Latina y el Caribe; ArgentinaFil: Camji, Nicole. Universidad de Buenos Aires. Facultad de Ciencias Sociales; ArgentinaFil: Montagna, Federico. Universidad de Buenos Aires. Facultad de Ciencias Sociales; ArgentinaFil: Peralta, María Agustina. Universidad de Buenos Aires. Facultad de Ciencias Sociales; ArgentinaFil: Sahakian, Yamila Lara. Universidad de Buenos Aires. Facultad de Ciencias Sociales; Argentin

Developmental stages and gut microenvironments influence gut microbiota dynamics in the invasive beetle Popillia japonica Newman (Coleoptera: Scarabaeidae)

Popillia japonica Newman (Coleoptera: Scarabaeidae) is a highly polyphagous invasive beetle originating from Japan. This insect is highly resilient and able to rapidly adapt to new vegetation. Insect?associated microorganisms can play important roles in insect physiology, helping their hosts to adapt to changing conditions and potentially contributing to an insect's invasive potential. Such symbiotic bacteria can be part of a core microbiota that is stably transmitted throughout the host's life cycle or selectively recruited from the environment at each developmental stage. The aim of this study was to investigate the origin, stability and turnover of the bacterial communities associated with an invasive population of P. japonica from Italy. Our results demonstrate that soil microbes represent an important source of gut bacteria for P. japonica larvae, but as the insect develops, its gut microbiota richness and diversity decreased substantially, paralleled by changes in community composition. Notably, only 16.75% of the soil bacteria present in larvae are maintained until the adult stage. We further identified the micro?environments of different gut sections as an important factor shaping microbiota composition in this species, likely due to differences in pH, oxygen availability and redox potential. In addition, P. japonica also harboured a stable bacterial community across all developmental stages, consisting of taxa well known for the degradation of plant material, namely the families Ruminococcacae, Christensenellaceae and Lachnospiraceae. Interestingly, the family Christensenallaceae had so far been observed exclusively in humans. However, the Christensenellaceae operational taxonomic units found in P. japonica belong to different taxonomic clades within this family

High Risk of Secondary Infections Following Thrombotic Complications in Patients With COVID-19

Background. This study’s primary aim was to evaluate the impact of thrombotic complications on the development of secondary infections. The secondary aim was to compare the etiology of secondary infections in patients with and without thrombotic complications. Methods. This was a cohort study (NCT04318366) of coronavirus disease 2019 (COVID-19) patients hospitalized at IRCCS San Raffaele Hospital between February 25 and June 30, 2020. Incidence rates (IRs) were calculated by univariable Poisson regression as the number of cases per 1000 person-days of follow-up (PDFU) with 95% confidence intervals. The cumulative incidence functions of secondary infections according to thrombotic complications were compared with Gray’s method accounting for competing risk of death. A multivariable Fine-Gray model was applied to assess factors associated with risk of secondary infections. Results. Overall, 109/904 patients had 176 secondary infections (IR, 10.0; 95% CI, 8.8–11.5; per 1000-PDFU). The IRs of secondary infections among patients with or without thrombotic complications were 15.0 (95% CI, 10.7–21.0) and 9.3 (95% CI, 7.9–11.0) per 1000-PDFU, respectively (P = .017). At multivariable analysis, thrombotic complications were associated with the development of secondary infections (subdistribution hazard ratio, 1.788; 95% CI, 1.018–3.140; P = .043). The etiology of secondary infections was similar in patients with and without thrombotic complications. Conclusions. In patients with COVID-19, thrombotic complications were associated with a high risk of secondary infections

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10−8) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer.

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM -/- patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors