Coeducational ideas In physical education teachers: Pshycometric properties of a scale

Ante la falta de cuestionarios o escalas que evaluaran los diferentes aspectos coeducativos que caracterizan al profesorado de Educación Física y la necesidad de conocer cuál es la concepción que tienen sobre este modelo, se desprende el objetivo de este trabajo, como el de evaluar las propiedades psicométricas mediante un instrumento que hemos denominado Escala sobre el pensamiento coeducativo del profesorado de EF para valorar las opiniones respecto a la coeducación y la metodología que se utiliza en sus clases. La muestra estuvo compuesta por 213 profesores, 133 hombres y 43 mujeres. La escala fue aplicada mediante papel, envío de correo electrónico y plataforma moddle. El análisis de los datos muestra unos resultados adecuados en cuanto a estructura factorial, consistencia interna y tipos de validez. Se concluye que esta Escala representa un instrumento válido y fiable para analizar las características coeducativas del profesoradoBecause of the absence of questionnaires or scales which will assess different coeducative aspects that are characteristics of PE teacher and need to know which is the conception that they have about this model, it is deduced the aim of this work as that which evaluate the psychometric properties through a tool called the Scale of coeducational ideas in physical education teachers to value the opinions about coeducation and the methodology used in their classes. The sample was composed by 213 teachers, 133 men and 43 women. The questionnaire was applied by means of paper, electronic mail shipment and platform moddle. The data analysis shows appropriate results in terms of factor structure, internal consistency and validity types. We conclude that the escale represents a valid and reliable instrument to analyze the coeducative characteristics of the teacher

Arylisoquinoline-derived organoboron dyes with a triaryl skeleton show dual fluorescence

[EN] Four new dyes that derive from borylated arylisoquinolines were prepared, containing a third aryl residue (naphthyl, 4-methoxynaphthyl, pyrenyl or anthryl) that is linked via an additional stereogenic axis. The triaryl cores were synthesized by Suzuki couplings and then transformed into boronic acid esters by employing an Ir(I)-catalyzed reaction. The chromophores show dual emission behavior, where the long-wavelength emission band can reach maxima close to 600 nm in polar solvents. The fluorescence quantum yields of the dyes are generally in the range of 0.2¿0.4, reaching in some cases values as high as 0.5¿0.6. Laserflash photolysis provided evidence for the existence of excited triplet states. The dyes form fluoroboronate complexes with fluoride anions, leading to the observation of the quenching of the long-wavelength emission band and ratiometric response by the build-up of a hypsochromically shifted emission signal.Funding by the Spanish Ministry of Economy, Industry, and Competitiveness (CTQ2014-54729-C2-1-P for U.P., CTQ2013-48164-C2-1-P and CTQ2013-48164-C2-2-P for A.R., Ramon y Cajal contracts RYC-2013-12585 for A.R. and RYC-2015-17737 for I.V.), the Spanish Ministry of Science, Innovation, and Universities (CTQ2017-89832-P for U.P., CTQ2016-78875-P for M.C.J., and CTQ2017-89416-R for I.V.), the European Research and Development Fund, and the Andalusian Government (2012/FQM-2140 for U.P., 2009/FQM-4537 and 2012/FQM-1078 for A.R) is gratefully acknowledged.Pais, VF.; Neumann, T.; Vayá Pérez, I.; Jiménez Molero, MC.; Ros, A.; Pischel, U. (2019). Arylisoquinoline-derived organoboron dyes with a triaryl skeleton show dual fluorescence. Beilstein Journal of Organic Chemistry. 15:2612-2622. https://doi.org/10.3762/BJOC.15.254S2612262215Frath, D., Massue, J., Ulrich, G., & Ziessel, R. (2014). Lumineszierende Materialien: Fixierung von π-konjugierten und heterocyclischen Liganden mit Bor(III). Angewandte Chemie, 126(9), 2322-2342. doi:10.1002/ange.201305554Ji, L., Griesbeck, S., & Marder, T. B. (2017). Recent developments in and perspectives on three-coordinate boron materials: a bright future. Chemical Science, 8(2), 846-863. doi:10.1039/c6sc04245gVanga, M., Lalancette, R. A., & Jäkle, F. (2019). Controlling the Optoelectronic Properties of Pyrene by Regioselective Lewis Base‐Directed Electrophilic Aromatic Borylation. Chemistry – A European Journal, 25(43), 10133-10140. doi:10.1002/chem.201901231Alcaide, M. M., Santos, F. M. F., Pais, V. F., Carvalho, J. I., Collado, D., Pérez-Inestrosa, E., … Pischel, U. (2017). Electronic and Functional Scope of Boronic Acid Derived Salicylidenehydrazone (BASHY) Complexes as Fluorescent Dyes. The Journal of Organic Chemistry, 82(14), 7151-7158. doi:10.1021/acs.joc.7b00601Bozdemir, O. A., Guliyev, R., Buyukcakir, O., Selcuk, S., Kolemen, S., Gulseren, G., … Akkaya, E. U. (2010). Selective Manipulation of ICT and PET Processes in Styryl-Bodipy Derivatives: Applications in Molecular Logic and Fluorescence Sensing of Metal Ions. Journal of the American Chemical Society, 132(23), 8029-8036. doi:10.1021/ja1008163Niu, L.-Y., Guan, Y.-S., Chen, Y.-Z., Wu, L.-Z., Tung, C.-H., & Yang, Q.-Z. (2012). BODIPY-Based Ratiometric Fluorescent Sensor for Highly Selective Detection of Glutathione over Cysteine and Homocysteine. Journal of the American Chemical Society, 134(46), 18928-18931. doi:10.1021/ja309079fZheng, Q., Xu, G., & Prasad, P. N. (2008). Conformationally Restricted Dipyrromethene Boron Difluoride (BODIPY) Dyes: Highly Fluorescent, Multicolored Probes for Cellular Imaging. Chemistry - A European Journal, 14(19), 5812-5819. doi:10.1002/chem.200800309Han, J., Loudet, A., Barhoumi, R., Burghardt, R. C., & Burgess, K. (2009). A Ratiometric pH Reporter For Imaging Protein-dye Conjugates In Living Cells. Journal of the American Chemical Society, 131(5), 1642-1643. doi:10.1021/ja8073374Kolemen, S., Işık, M., Kim, G. M., Kim, D., Geng, H., Buyuktemiz, M., … Akkaya, E. U. (2015). Intracellular Modulation of Excited-State Dynamics in a Chromophore Dyad: Differential Enhancement of Photocytotoxicity Targeting Cancer Cells. Angewandte Chemie, 127(18), 5430-5434. doi:10.1002/ange.201411962Bachollet, S. P. J. T., Volz, D., Fiser, B., Münch, S., Rönicke, F., Carrillo, J., … Harrity, J. P. A. (2016). A Modular Class of Fluorescent Difluoroboranes: Synthesis, Structure, Optical Properties, Theoretical Calculations and Applications for Biological Imaging. Chemistry - A European Journal, 22(35), 12430-12438. doi:10.1002/chem.201601915Frath, D., Didier, P., Mély, Y., Massue, J., & Ulrich, G. (2017). Vectorization and Intracellular Distribution of a Two-Photon-Absorbing, Near-Infrared-Emitting π-Extended Boranil Dye. ChemPhotoChem, 1(4), 109-112. doi:10.1002/cptc.201700012Melaimi, M., & Gabbaï, F. P. (2005). A Heteronuclear Bidentate Lewis Acid as a Phosphorescent Fluoride Sensor. Journal of the American Chemical Society, 127(27), 9680-9681. doi:10.1021/ja053058sHudnall, T. W., Kim, Y.-M., Bebbington, M. W. P., Bourissou, D., & Gabbaï, F. P. (2008). Fluoride Ion Chelation By a Bidentate Phosphonium/Borane Lewis Acid. Journal of the American Chemical Society, 130(33), 10890-10891. doi:10.1021/ja804492yWade, C. R., Broomsgrove, A. E. J., Aldridge, S., & Gabbaï, F. P. (2010). Fluoride Ion Complexation and Sensing Using Organoboron Compounds. Chemical Reviews, 110(7), 3958-3984. doi:10.1021/cr900401aBai, D.-R., Liu, X.-Y., & Wang, S. (2007). Charge-Transfer Emission Involving Three-Coordinate Organoboron: V-Shape versus U-Shape and Impact of the Spacer on Dual Emission and Fluorescent Sensing. Chemistry - A European Journal, 13(20), 5713-5723. doi:10.1002/chem.200700364Proń, A., Zhou, G., Norouzi-Arasi, H., Baumgarten, M., & Müllen, K. (2009). Controlling the Charge Transfer in Phenylene-Bridged Borylene−Amine π-Conjugated Systems. Organic Letters, 11(16), 3550-3553. doi:10.1021/ol9012487Pan, H., Fu, G.-L., Zhao, Y.-H., & Zhao, C.-H. (2011). Through-Space Charge-Transfer Emitting Biphenyls Containing a Boryl and an Amino Group at theo,o′-Positions. Organic Letters, 13(18), 4830-4833. doi:10.1021/ol201909rBonn, A. G., & Wenger, O. S. (2015). Charge Transfer Emission in Oligotriarylamine–Triarylborane Compounds. The Journal of Organic Chemistry, 80(8), 4097-4107. doi:10.1021/acs.joc.5b00416Pais, V. F., Lineros, M., López-Rodríguez, R., El-Sheshtawy, H. S., Fernández, R., Lassaletta, J. M., … Pischel, U. (2013). Preparation and pH-Switching of Fluorescent Borylated Arylisoquinolines for Multilevel Molecular Logic. The Journal of Organic Chemistry, 78(16), 7949-7961. doi:10.1021/jo401147tPais, V. F., Lassaletta, J. M., Fernández, R., El-Sheshtawy, H. S., Ros, A., & Pischel, U. (2014). Organic Fluorescent Thermometers Based on Borylated Arylisoquinoline Dyes. Chemistry - A European Journal, 20(25), 7638-7645. doi:10.1002/chem.201402027Domínguez, Z., López-Rodríguez, R., Álvarez, E., Abbate, S., Longhi, G., Pischel, U., & Ros, A. (2018). Azabora[5]helicene Charge-Transfer Dyes Show Efficient and Spectrally Variable Circularly Polarized Luminescence. Chemistry - A European Journal, 24(48), 12660-12668. doi:10.1002/chem.201801908Zhu, L., Shabbir, S. H., Gray, M., Lynch, V. M., Sorey, S., & Anslyn, E. V. (2006). A Structural Investigation of the N−B Interaction in ano-(N,N-Dialkylaminomethyl)arylboronate System. Journal of the American Chemical Society, 128(4), 1222-1232. doi:10.1021/ja055817cBoscá, F., Cuquerella, M. C., Pais, V. F., Ros, A., & Pischel, U. (2017). Excited-State Pathways of Four-Coordinate N,C-Chelate Organoboron Dyes. ChemPhotoChem, 2(1), 34-41. doi:10.1002/cptc.201700176Hara, M., Tojo, S., Kawai, K., & Majima, T. (2004). Formation and decay of pyrene radical cation and pyrene dimer radical cation in the absence and presence of cyclodextrins during resonant two-photon ionization of pyrene and sodium 1-pyrene sulfonate. Phys. Chem. Chem. Phys., 6(13), 3215-3220. doi:10.1039/b403409kMelhuish, W. H. (1960). A STANDARD FLUORESCENCE SPECTRUM FOR CALIBRATING SPECTRO-FLUOROPHOTOMETERS. The Journal of Physical Chemistry, 64(6), 762-764. doi:10.1021/j100835a014Melhuish, W. H. (1961). QUANTUM EFFICIENCIES OF FLUORESCENCE OF ORGANIC SUBSTANCES: EFFECT OF SOLVENT AND CONCENTRATION OF THE FLUORESCENT SOLUTE1. The Journal of Physical Chemistry, 65(2), 229-235. doi:10.1021/j100820a00

The NRF2 transcription factor plays a dual role in colorectal cancer : A systematic review

Background: Colorectal cancer is one of the most common cancers worldwide, and is influenced by the interplay of various factors, including a very strong genetic component. For instance, incorrect mitochondrial biogenesis is correlated with increased risk of developing colorectal cancer. Thus, it is important to understand the consequences of changes in both the expression and the correct function of the transcription factors that regulate mitochondrial biogenesis, namely NRF2. Objectives: The main objective of this paper is to characterise the relationship between NRF2 and colorectal cancer by compiling data from an exhaustive literature search. Methods: Information was obtained by defining specific search terms and searching in several databases. After a strict selection procedure, data were tabulated and the relationships between articles were assessed by measuring heterogeneity and by constructing conceptual maps. Results and discussion: We found a general consensus in the literature that the presence of oxidizing agents as well as the inhibition of the NRF2 repressor Keap1 maintain NRF2 expression at basal levels. This predominantly exerts a cytoprotective effect on cells and decreases risk of colorectal cancer. However, if NRF2 is inhibited, protection against external agents disappears and risk of colorectal cancer increases. Interestingly, colorectal cancer risk is also increased when NRF2 becomes overexpressed. In this case, the increased risk arises from NRF2-induced inflammation and resistance to chemotherapy. Conclusion: The proper basal function of NRF2 and Keap1 are essential for preventing oncogenic processes in the colon. Consequently, any disruption to the expression of these genes can promote the genesis and progression of colon cancer

Métodos não farmacológicos de controlo da dor no trabalho de parto: revisão narrativa de literatura

O parto é um momento único e marcante na vida de uma mulher, sendo muitas vezes associado a dor, mitos e medos. O objetivo desta revisão narrativa de literatura é perceber quais os métodos não farmacológicos que existem e são mais usuais para controlar a dor no trabalho de parto. Foi realizada pesquisa nas bases de dados Pubmed e Scielo. Após definidos os Palavras-chave e os critérios de inclusão, foram selecionados sete artigos que constituem a amostra final desta revisão. Conclui-se que a utilização de métodos não farmacológicos promove o alívio da dor no trabalho de parto e também uma maior sensação de controlo por parte da mulher

Blink: Fast Connectivity Recovery Entirely in the Data Plane

We present Blink, a data-driven system that leverages TCPinduced signals to detect failures directly in the data plane. The key intuition behind Blink is that a TCP flow exhibits a predictable behavior upon disruption: retransmitting the same packet over and over, at epochs exponentially spaced in time. When compounded over multiple flows, this behavior creates a strong and characteristic failure signal. Blink efficiently analyzes TCP flows to: (i) select which ones to track; (ii) reliably and quickly detect major traffic disruptions; and (iii) recover connectivity—all this, completely in the data plane. We present an implementation of Blink in P4 together with an extensive evaluation on real and synthetic traffic traces. Our results indicate that Blink: (i) achieves sub-second rerouting for large fractions of Internet traffic; and (ii) prevents unnecessary traffic shifts even in the presence of noise. We further show the feasibility of Blink by running it on an actual Tofino switch

Advances in geobotany and new tools in biogeographic and bioclimatic maps: Sierra de Guadarrama National Park

20 páginas, 14 tablas, 3 mapas

Educación para la salud: implementación del programa "Sportfruits" en escolares de Granada

Eating habits are in decline and weight problems are increasing in Primary Education. This study aims to establish the levels of body mass index, the degree of adherence to the Mediterranean diet and self-concept in a sample of schoolchildren, determining the possible physical-health and psychosocial differences after the implementation of the "SportFruits" intervention program. The design is descriptive, preexperimental with pretest and posttest, longitudinal cut, for a sample of 79 schoolchildren aged 6 to 8 years old (M=7.1 and D.T.=0.638). Instruments such as the bioimpedance scale, the KIDMED test and the Autoconcept Form 5 test (AF5) were used. The results did not show statistically significant associations, although they show the need to improve diet, reeducating eating habits and promoting physical activity for psychosocial improvements and reducing the problems of obesity and overweight, through intervention programs.Los hábitos alimentarios se encuentran en decadencia y los problemas de peso van en aumento en Educación Primaria. Este estudio persigue establecer los niveles de índices de masa corporal, el grado de adherencia a la dieta mediterránea y el autoconcepto en una muestra de escolares, determinando las posibles diferencias físico-saludables y psicosociales tras la realización del programa de intervención “SportFruits”. El diseño esdescriptivo, preexperimental con pretest y posttest, de corte longitudinal, para una muestra de 79 escolares con edades de 6 a 8 años (M=7,1 y D.T.=0.638). Se utilizaron instrumentos como la báscula de bioimpedancia, el test KIDMED y el test de Autoconcepto Forma 5 (AF5). Los resultados no mostraron asociaciones estadísticamente significativas, aunque si evidencian la necesidad de mejorar la dieta, reeducando los hábitos alimentarios y promover la actividad física para mejoras psicosociales y reducir los problemas de obesidad y sobrepeso, a través de programas de intervención.

Four-dimensional distribution of the 2010 Eyjafjallajökull volcanic cloud over Europe observed by EARLINET

© Author(s) 2013. This work is distributed under the Creative Commons Attribution 3.0 License.The eruption of the Icelandic volcano Eyjafjallaj ökull in April-May 2010 represents a "natural experiment" to study the impact of volcanic emissions on a continental scale. For the first time, quantitative data about the presence, altitude, and layering of the volcanic cloud, in conjunction with optical information, are available for most parts of Europe derived from the observations by the European Aerosol Research Lidar NETwork (EARLINET). Based on multi-wavelength Raman lidar systems, EARLINET is the only instrument worldwide that is able to provide dense time series of high-quality optical data to be used for aerosol typing and for the retrieval of particle microphysical properties as a function of altitude. In this work we show the four-dimensional (4-D) distribution of the Eyjafjallajökull volcanic cloud in the troposphere over Europe as observed by EARLINET during the entire volcanic event (15 April-26 May 2010). All optical properties directly measured (backscatter, extinction, and particle linear depolarization ratio) are stored in the EARLINET database available at www.earlinet.org. A specific relational database providing the volcanic mask over Europe, realized ad hoc for this specific event, has been developed and is available on request at www.earlinet.org. During the first days after the eruption, volcanic particles were detected over Central Europe within a wide range of altitudes, from the upper troposphere down to the local planetary boundary layer (PBL). After 19 April 2010, volcanic particles were detected over southern and south-eastern Europe. During the first half of May (5-15 May), material emitted by the Eyjafjallajökull volcano was detected over Spain and Portugal and then over the Mediterranean and the Balkans. The last observations of the event were recorded until 25 May in Central Europe and in the Eastern Mediterranean area. The 4-D distribution of volcanic aerosol layering and optical properties on European scale reported here provides an unprecedented data set for evaluating satellite data and aerosol dispersion models for this kind of volcanic events.Peer reviewe

Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1

Protein-based therapeutics feature large interacting surfaces. Protein folding endows structural stability to localised surface epitopes, imparting high affinity and target specificity upon interactions with binding partners. However, short synthetic peptides with sequences corresponding to such protein epitopes are unstructured in water and promiscuously bind to proteins with low affinity and specificity. Here we combine structural stability and target specificity of proteins, with low cost and rapid synthesis of small molecules, towards meeting the significant challenge of binding coiled coil proteins in transcriptional regulation. By iteratively truncating a Jun-based peptide from 37 to 22 residues, strategically incorporating i-->i+4 helix-inducing constraints, and positioning unnatural amino acids, we have produced short, water-stable, alpha-helical peptides that bind cFos. A three-dimensional NMR-derived structure for one peptide (24) confirmed a highly stable alpha-helix which was resistant to proteolytic degradation in serum. These short structured peptides are entropically pre-organized for binding with high affinity and specificity to cFos, a key component of the oncogenic transcriptional regulator Activator Protein-1 (AP-1). They competitively antagonized the cJun–cFos coiled-coil interaction. Truncating a Jun-based peptide from 37 to 22 residues decreased the binding enthalpy for cJun by ~9 kcal/mol, but this was compensated by increased conformational entropy (TDS ≤ 7.5 kcal/mol). This study demonstrates that rational design of short peptides constrained by alpha-helical cyclic pentapeptide modules is able to retain parental high helicity, as well as high affinity and specificity for cFos. These are important steps towards small antagonists of the cJun-cFos interaction that mediates gene transcription in cancer and inflammatory diseases