Análisis y aplicabilidad en el mercado peruano de los métodos más usados y las nuevas metodologías en el cálculo de asentamientos de zapatas en arcillas

En el presente trabajo se explica los diferentes tipos de asentamientos generados en una zapata sobre arcilla y se resalta las peculiaridades e importancia de cada uno. A su vez, se describen los daños que pueden ejercer estos asentamientos a la estructura y se contextualiza las condiciones sobre las que la respuesta de la arcilla a esta carga de la cimentación es variada. Por ello, se presenta una variada cantidad de fórmulas usadas y propuestas para el cálculo de los asentamientos de zapatas en arcillas. Dichas formulas se detallan y describen identificando sus requerimientos y condiciones bajo las cuales fueron planteadas. Este punto es importante ya que saber los requerimientos que presenten, así como las condiciones bajo las que se diseñaron ayuda a elegir la correcta o más idónea al momento de requerir el cálculo de asentamientos de zapatas en zarcillas para algún proyecto. Dentro de los métodos evaluados se verán asentamientos inmediatos, por consolidación primaria y por consolidación secundaria. Sabiendo que estamos evaluando para arcillas se toma en mayor consideración el asentamiento por consolidación primaria. Como una de las principales conclusiones del trabajo se tiene que para elegir el mejor método de cálculo se debe tener en cuenta varios factores técnicos, así como económicos, a su vez se debe tener en cuenta el riesgo del diseño para decidir si los esfuerzos extras requeridos para usar métodos más modernos valdrán la pena para el proyecto. Mediante la masificación y difusión de los nuevos métodos se podrá elevar la calidad de los trabajos, así como generar que se sean económicamente factible su uso y registro de información más detallada

Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy

Background: Although genotyping allows family screening and influences risk-stratification in patients with nonischemic dilated cardiomyopathy (DCM) or isolated left ventricular systolic dysfunction (LVSD), its result is negative in a significant number of patients, limiting its widespread adoption. Objectives: This study sought to develop and externally validate a score that predicts the probability for a positive genetic test result (G+) in DCM/LVSD. Methods: Clinical, electrocardiogram, and echocardiographic variables were collected in 1,015 genotyped patients from Spain with DCM/LVSD. Multivariable logistic regression analysis was used to identify variables independently predicting G+, which were summed to create the Madrid Genotype Score. The external validation sample comprised 1,097 genotyped patients from the Maastricht and Trieste registries. Results: A G+ result was found in 377 (37%) and 289 (26%) patients from the derivation and validation cohorts, respectively. Independent predictors of a G+ result in the derivation cohort were: family history of DCM (OR: 2.29; 95% CI: 1.73-3.04; P < 0.001), low electrocardiogram voltage in peripheral leads (OR: 3.61; 95% CI: 2.38-5.49; P < 0.001), skeletal myopathy (OR: 3.42; 95% CI: 1.60-7.31; P = 0.001), absence of hypertension (OR: 2.28; 95% CI: 1.67-3.13; P < 0.001), and absence of left bundle branch block (OR: 3.58; 95% CI: 2.57-5.01; P < 0.001). A score containing these factors predicted a G+ result, ranging from 3% when all predictors were absent to 79% when ≥4 predictors were present. Internal validation provided a C-statistic of 0.74 (95% CI: 0.71-0.77) and a calibration slope of 0.94 (95% CI: 0.80-1.10). The C-statistic in the external validation cohort was 0.74 (95% CI: 0.71-0.78). Conclusions: The Madrid Genotype Score is an accurate tool to predict a G+ result in DCM/LVSD

Estimating the global conservation status of more than 15,000 Amazonian tree species

Estimates of extinction risk for Amazonian plant and animal species are rare and not often incorporated into land-use policy and conservation planning. We overlay spatial distribution models with historical and projected deforestation to show that at least 36% and up to 57% of all Amazonian tree species are likely to qualify as globally threatened under International Union for Conservation of Nature (IUCN) Red List criteria. If confirmed, these results would increase the number of threatened plant species on Earth by 22%. We show that the trends observed in Amazonia apply to trees throughout the tropics, and we predict thatmost of the world’s >40,000 tropical tree species now qualify as globally threatened. A gap analysis suggests that existing Amazonian protected areas and indigenous territories will protect viable populations of most threatened species if these areas suffer no further degradation, highlighting the key roles that protected areas, indigenous peoples, and improved governance can play in preventing large-scale extinctions in the tropics in this century

Consistent patterns of common species across tropical tree communities

Trees structure the Earth’s most biodiverse ecosystem, tropical forests. The vast number of tree species presents a formidable challenge to understanding these forests, including their response to environmental change, as very little is known about most tropical tree species. A focus on the common species may circumvent this challenge. Here we investigate abundance patterns of common tree species using inventory data on 1,003,805 trees with trunk diameters of at least 10 cm across 1,568 locations 1–6 in closed-canopy, structurally intact old-growth tropical forests in Africa, Amazonia and Southeast Asia. We estimate that 2.2%, 2.2% and 2.3% of species comprise 50% of the tropical trees in these regions, respectively. Extrapolating across all closed-canopy tropical forests, we estimate that just 1,053 species comprise half of Earth’s 800 billion tropical trees with trunk diameters of at least 10 cm. Despite differing biogeographic, climatic and anthropogenic histories 7, we find notably consistent patterns of common species and species abundance distributions across the continents. This suggests that fundamental mechanisms of tree community assembly may apply to all tropical forests. Resampling analyses show that the most common species are likely to belong to a manageable list of known species, enabling targeted efforts to understand their ecology. Although they do not detract from the importance of rare species, our results open new opportunities to understand the world’s most diverse forests, including modelling their response to environmental change, by focusing on the common species that constitute the majority of their trees

Importance of the Information Security Management System (ISMS) and its impact on internal control

Actualmente, las tecnologías de la información y comunicación (TIC) representan un apoyo fundamental en materia de progreso y sostenibilidad al interior de las empresas. Este recurso estratégico no solo aporta valor en la mejora de la prestación de servicios y ejecución de procesos internos, sino que actúa como una herramienta que, a través de un uso sistematizado, provee seguridad a la información que genera día a día una empresa. Un sistema de gestión de seguridad de la información (SGSI) representa un apoyo en la aplicación y ejecución de todos los procesos relacionados con la generación, almacenamiento y disposición de información. Siendo el aseguramiento de la oportunidad y confiabilidad de los registros de la información, uno de los propósitos del control interno, la importancia del optimo tratamiento de la información se verá reflejada en este análisis conceptual de los aspectos fundamentales y estándares internacionales relacionados tales como: La norma ISO/IEC 27001, El modelo COBIT y el modelo ITIL. Esto, con el propósito de identificar los lineamientos que logran un nivel de seguridad de la información aceptable, en donde las posibilidades de que se materialice alguna amenaza sean mínimas y así se preserve de la mejor manera la administración y control de la información de las organizaciones sin importar si su naturaleza es pública o privada.Currently, information and communication technologies (ICT) represent a fundamental support in terms of progress and sustainability within companies. This strategic resource not only adds value in improving the provision of services and execution of internal processes, but also acts as a tool that, through systematic use, provides security to the information generated by a company on a daily basis. An information security management system (SGSI) represents support in the application and execution of all processes related to the generation, storage and provision of information. Being the assurance of timeliness and reliability of information records, one of the purposes of internal control, the importance of optimal treatment of information will be reflected in this conceptual analysis of the fundamental aspects and related international standards such as: ISO/IEC 27001 standard, the COBIT model and the ITIL model. This, with the purpose of identifying the guidelines that achieve an acceptable level of information security, where the chances of any threat materializing are minimal and thus the administration and control of information of organizations is preserved in the best way. regardless of whether its nature is public or private.Especializació

Thrombus Development on a Transseptal Sheath in the Right Atrium Before Electrical Pulmonary Vein Isolation

We describe the case of a patient who developed a thrombus on the transseptal sheath in the right atrium before transseptal puncture for circumferential pulmonary vein isolation for paroxysmal atrial fibrillation treatment. The use of intracardiac echocardiography allowed to its identification and probably prevented the patient from suffering a serious thromboembolic complication

Construyendo juntos estrategias para la promoción de la salud de la escuela saludable en la Institución Nuestra Señora de Las Mercedes del municipio de Sardinata durante el segundo semestre del 2017 y segundo semestre del 2018

Proyecto de extensión que se realiza en el municipio de Sardinata con el objetivo de promover la salud escolar y prevenir o corregir conductas de riesgo de dicha población; interviniendo los determinantes en salud y los ejes transversales del PEI. se realiza una valoración que abarca la esfera biopsicosocial del escolar, involucrando comunidad, estudiantes, trabajadores de la escuela, docentes y padres de familia, comprometiéndolas a adoptar practicas saludables.PregradoEnfermero(a

Recycling of tires in the mining sector for the operation of an energy plant: a solution with reverse logistics

Anualmente se desecha una gran cantidad de llantas de las cuales un bajo porcentaje tiene una adecuada disposición final, el otro porcentaje son almacenadas en espacios no aptos, desechadas a los ríos y mares o incineradas, lo cual genera impactos y riesgos desde el ámbito económico, por el costo de oportunidad y sanciones por incumplimiento de normas ambientales, y desde el ámbito ambiental, enfermedades por la generación de insectos en el agua estancada dentro las llantas y pulmonares causadas por quema de llantas, y daños en la atmósfera y suelo producto de la descomposición de químicos. Este proyecto tiene como objetivo diseñar una cadena de logística inversa integrando los procesos de recolección de llantas residuales en el sector minero y transporte hacia una planta generadora de energía implementando un modelo matemático que permita establecer la ubicación de la planta, centro de acopio y distribución de la materia prima, para así darle solución a la problemática planteada. El alcance del proyecto es encontrar una solución viable y efectiva de distribución de materia prima de 4 minas ubicadas en Colombia, actualización de inventario de llantas de las minas, la relación entre demanda de la planta y cantidad de llantas enviadas en un periodo de tiempo, la ubicación de la planta y la red de logística de distribución teniendo en cuenta los costos de la red de transporte y el impacto financiero. Los resultados que son interés para el proyecto son los que están relacionados con la ubicación de la planta generadora de energía, la secuencia de uso del conjunto de máquinas trituradoras en la cual se cumplen las restricciones impuestas por la ley sobre la cantidad de llantas residuales que deben tener en inventario la empresas, la cantidad de toneladas a enviar de cada una de las plantas que apoya el cumplimiento de la ley mencionada y asegura el funcionamiento de la generadora de energía y los costos asociados con la operación.Annually a great number of tires are discarded of which a low percentage has a suitable final disposition, the other percentage is stored in spaces unfit, discarded to the rivers and seas or incinerated, which generates impacts and risks from the economic scope, the opportunity cost and sanctions for non-compliance environmental regulations, and from the environmental field, diseases caused by the generation of insects in the stagnant water inside the tires and lungs caused by tire burning, and damage to the atmosphere and soil caused by Decomposition of chemicals. This project aims to design a reverse logistics chain integrating the processes of waste tire collection in the mining sector and transportation to an energy generating plant by implementing a mathematical model that allows establishing the location of the plant, collection center and distribution of the raw material, in order to solve the problem. The scope of the project is to find a viable and effective raw material distribution solution for 4 mines located in Colombia, covering the collection and updating of inventory of accumulated tires in each of the mines, the relationship between plant demand and quantity of tire sent from the mines to the plant in a period of time, plant location and distribution logistics network taking into account transport network costs and financial impact. The results that are interest for the project are which have relation with the energy generator plant, the use’s sequence for the crusher machines, with which we find the fulfillment of the constraints imposed for the law about residual tire’s can quantities that the companies would have in their inventory, the quantities of tire’s tone to send from each one of the mines that supports the law previously mentioned and ensures the energy generator’s functioning and the operation’s cost

Attacking the SARS-CoV-2 Replication Machinery with the Pathogen Box’s Molecules

The world is currently facing a pandemic caused by the new 2019 coronavirus disease (COVID-19), caused by SARS-CoV-2. Among the fundamental processes of this virus are viral transcription and replication. They allow the synthesisof genetic material and the consequent multiplication of the virus to infect other cells or organisms. These are performed by a multi-subunit machinery of various nonstructural proteins (nsp); among which the RNA-dependent RNApolymerase (RdRp or nsp12) is the most important, and, at the same time, conserved among coronaviruses. The structure of this protein (PDB ID: 6M71) was used as a target in the application of computational strategies for drugsearch, like virtual screening and molecular docking. The region considered for virtual screening has three important amino acids for protein catalysis: T680 (located in Motif A), N691 and D623 (located in Motif B), where a grid box was located. In turn, applying the concept of drug repositioning isconsidered as a quick response in the treatment of sudden outbreaks of diseases. Here, we used the Pathogen Box, a database of chemical compounds analyzed for the treatment against malaria, which were filtered under the criteria of selecting those that do not present any violation of Lipinski\u27sRule of Five. At the same time, the Remdesivir, Beclabuvir and Sofosbuvir drug, previously used in in silico and clinical studies for inhibition of nsp12, were used as positive controls. The results showed a Top10 potential target inhibitors, with binding energy higher than those of the positive controls, of which TCMDC-134153 and TCMDC-135052, both with -7.53 kcal/mol, present interactions with the three important residues of the nsp12 catalytic site. These proposed ligands would be used for subsequent validation by molecular dynamics, where they can beconsidered as drugs for the development of effective treatments against this new pandemic