Diagnosis of Rosai-Dorfman Disease in Elderly Female on Fine Needle Aspiration Cytology: A Case Report

Rosai-Dorfman disease (RDD) is a rare benign disorder of histiocytic proliferation that usually presents with bilateral cervical lymphadenopathy in children. We describe the case of a 50-year-old lady suffering from this disease who presented with generalized lymphadenopathy and a left sided chest wall lump. Fine needle aspiration cytology (FNAC) from all the lesions showed abundant benign histiocytes with lymphophagocytosis which was compatible with the diagnosis of RDD. This case is being reported for its rarity in presentation in an elderly female with both generalized nodal as well as extranodal manifestations

Phytochemical and Pharmacological Evaluation along with Antimicrobial Properties of Gynura Procumbens Leaves Extract

The accentuated growth inside the use of Gynura procumbens go away as suitable for eating leave and herbal medicinal drug to deal with sicknesses makes its miles essential to evaluate facts available on its antibacterial, antifungal, phytochemical screening and antioxidant activities. G. procumbens leaves methanol and ethyl acetate crude extract was prepared via the cold extraction approach. The methanolic G. procumbens extract became used to phytochemical assessments for plant secondary metabolites; carbohydrates, alkaloids, phenolic compounds, flavonoids, tannins, glycosides, steroids, proteins, acidic compounds and saponins using preferred processes techniques. Antibacterial activities of G. procumbens extracts was investigated by using agar well diffusion method and antifungal activities by using the disc-diffusion method. G. procumbens extracts antioxidant activity was assessed via DPPH assay to measure its free radical scavenging capability. Phytochemical screening revealed that presence of carbohydrate, alkaloids, flavonoids, glycosides, phenolic compounds and tannins but saponins, proteins, acidic compounds and steroids were not found. Antimicrobial investigation showed that only ethyl acetate extracts have the mild sensitivity to almost all the bacteria and fungi (except Escherichia coli), whereas methanol extracts did not demonstrate any antimicrobial property. The average zones of inhibition produced by ethyl acetate extracts were found to be 6-7 mm at a concentration of 400μg/disc. Antioxidant study showed that IC50 of ethyl acetate extract of G. procumbens leaves was 322.244 μg/ml whereas the IC50 of standard ascorbic acid was 41.683 μg/ml. From the present experiment it could be concluded that G. Procumbens is the source of alkaloids, flavonoids, tannins and it's has also antimicrobial, antioxidant properties. These findings imply that G. Procumbens leaves extracts is a good medicinal supply or herbal properties that may have high therapeutic value. [J Bangladesh Agril Univ 2022; 20(2.000): 141-149

Cryptic destruction of India’s native forests

India sustains some of the world's most imperiled forests. The Forest Survey of India recently announced that forest cover in India had expanded by nearly 5% over the past decade. This result, while technically accurate, is misleading. The Forest Survey estimates forest cover by using automated algorithms to analyze satellite imagery—an approach that fails to distinguish native forests from tree plantations, which are often monocultures of exotic species that have limited value for endangered biodiversity. Since the early 1990s, tree plantations have expanded in India at an estimated rate of roughly 15,400 km2/year. Subtracting plantations from total forest cover shows that native forests in India have declined by 1.5%–2.7% per year. The limited precision of our estimate highlights a paucity of data on native forest cover in India—a problem requiring urgent attention. Forest cutting for fuelwood has been the biggest driver of forest loss and thinning in India. Like India, many nations now rely on satellite imagery to discern changes in vegetation cover, and these frequently lump native, exotic, and degraded forest types. Without sufficiently high-resolution imagery and adequate safeguards, such approaches could paint a misleading picture of the fate of the world's native forests

Metastatic colorectal carcinoma with signet-ring cells: Clinical, histological and molecular description from an Association des Gastro-Entérologues Oncologues (AGEO) French multicenter retrospective cohort

International audienc

Geriatric analysis from PRODIGE 20 randomized phase II trial evaluating bevacizumab + chemotherapy versus chemotherapy alone in older patients with untreated metastatic colorectal cancer

IF 7.191 (2017)International audienceBackgroundOlder patients have frailty characteristics that impair the transposition of treatment results found in younger patients. Predictive factors are needed to help with treatment choices for older patients. The PRODIGE 20 study is a randomized phase II study that evaluated chemotherapy associated with bevacizumab (BEV) or not (CT) in patients aged 75 years or older.Patients and methodsPatients underwent a geriatric assessment at randomization and at each evaluation. The predictive value of geriatric and oncologic factors was determined for the primary composite end-point assessing safety and efficacy of treatment (BEV or CT) simultaneously and also progression-free survival (PFS) and overall survival (OS).Results102 patients were randomized (51 BEV and 51 CT; median age 80 years [range 75–91]). On multivariate analysis, baseline normal independent activity of daily living (IADL) score and no previous cardiovascular disease predicted the primary end-point. High (versus low) baseline Köhne score predicted short PFS and baseline Spitzer quality of life (QoL) score 2 LN levels above normal and high baseline Köhne score predicted short OS. Survival without deteriorated QoL and autonomy was similar with BEV and CT. On subgroup analyses, the benefit of bevacizumab seemed to be maintained in patients with baseline impaired IADL or nutritional status.ConclusionNormal IADL score was associated with a good efficacy and safety of both BEV and CT. Köhne criteria may be relevant prognostic factors in older patients. Adding bevacizumab to chemotherapy does not impair patient autonomy or QoL