High-angle wave instability and emergent shoreline shapes : 2. Wave climate analysis and comparisons to nature

Author Posting. © American Geophysical Union, 2006. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 111 (2006): F04012, doi:10.1029/2005JF000423.Recent research has revealed that the plan view evolution of a coast due to gradients in alongshore sediment transport is highly dependant upon the angles at which waves approach the shore, giving rise to an instability in shoreline shape that can generate different types of naturally occurring coastal landforms, including capes, flying spits, and alongshore sand waves. This instability merely requires that alongshore sediment flux is maximized for a given deepwater wave angle, a maximum that occurs between 35° and 50° for several common alongshore sediment transport formulae. Here we introduce metrics that sum over records of wave data to quantify the long-term stability of wave climates and to investigate how wave climates change along a coast. For Long Point, a flying spit on the north shore of Lake Erie, Canada, wave climate metrics suggest that unstable waves have shaped the spit and, furthermore, that smaller-scale alongshore sand waves occur along the spit at the same locations where the wave climate becomes unstable. A shoreline aligned along the trend of the Carolina Capes, United States, would be dominated by high-angle waves; numerical simulations driven by a comparable wave climate develop a similarly shaped cuspate coast. Local wave climates along these simulated capes and the Carolina Capes show similar trends: Shoreline reorientation and shadowing from neighboring capes causes most of the coast to experience locally stable wave climates despite regional instability.This research was funded by the Andrew W. Mellon Foundation and NSF grants DEB-05-07987 and EAR-04-44792

Cumulative versus transient shoreline change : dependencies on temporal and spatial scale

Author Posting. © American Geophysical Union, 2011. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 116 (2011): F02014, doi:10.1029/2010JF001835.Using shoreline change measurements of two oceanside reaches of the North Carolina Outer Banks, USA, we explore an existing premise that shoreline change on a sandy coast is a self-affine signal, wherein patterns of change are scale invariant. Wavelet analysis confirms that the mean variance (spectral power) of shoreline change can be approximated by a power law at alongshore scales from tens of meters up to ∼4–8 km. However, the possibility of a power law relationship does not necessarily reveal a unifying, scale-free, dominant process, and deviations from power law scaling at scales of kilometers to tens of kilometers may suggest further insights into shoreline change processes. Specifically, the maximum of the variance in shoreline change and the scale at which that maximum occurs both increase when shoreline change is measured over longer time scales. This suggests a temporal control on the magnitude of change possible at a given spatial scale and, by extension, that aggregation of shoreline change over time is an important component of large-scale shifts in shoreline position. We also find a consistent difference in variance magnitude between the two survey reaches at large spatial scales, which may be related to differences in oceanographic forcing conditions or may involve hydrodynamic interactions with nearshore geologic bathymetric structures. Overall, the findings suggest that shoreline change at small spatial scales (less than kilometers) does not represent a peak in the shoreline change signal and that change at larger spatial scales dominates the signal, emphasizing the need for studies that target long-term, large-scale shoreline change.Our thanks to the NSF (grant EAR‐04‐ 44792) for funding this researc

High-angle wave instability and emergent shoreline shapes : 1. Modeling of sand waves, flying spits, and capes

Author Posting. © American Geophysical Union, 2006. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 111 (2006): F04011, doi:10.1029/2005JF000422.Contrary to traditional findings, the deepwater angle of wave approach strongly affects plan view coastal evolution, giving rise to an antidiffusional “high wave angle” instability for sufficiently oblique deepwater waves (with angles between wave crests and the shoreline trend larger than the value that maximizes alongshore sediment transport, ∼45°). A one-contour-line numerical model shows that a predominance of high-angle waves can cause a shoreline to self-organize into regular, quasiperiodic shapes similar to those found along many natural coasts at scales ranging from kilometers to hundreds of kilometers. The numerical model has been updated from a previous version to include a formulation for the widening of an overly thin barrier by the process of barrier overwash, which is assumed to maintain a minimum barrier width. Systematic analysis shows that the wave climate determines the form of coastal response. For nearly symmetric wave climates (small net alongshore sediment transport), cuspate coasts develop that exhibit increasing relative cross-shore amplitude and pointier tips as the proportion of high-angle waves is increased. For asymmetrical wave climates, shoreline features migrate in the downdrift direction, either as subtle alongshore sand waves or as offshore-extending “flying spits,” depending on the proportion of high-angle waves. Numerical analyses further show that the rate that the alongshore scale of model features increases through merging follows a diffusional temporal scale over several orders of magnitude, a rate that is insensitive to the proportion of high-angle waves. The proportion of high-angle waves determines the offshore versus alongshore aspect ratio of self-organized shoreline undulations.This research was funded by the Andrew W. Mellon Foundation and NSF grants DEB-05-07987 and EAR-04-44792

Dietary reference values for vitamin K

Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derives dietary reference values (DRVs) for vitamin K. In this Opinion, the Panel considers vitamin K to comprise both phylloquinone and menaquinones. The Panel considers that none of the biomarkers of vitamin K intake or status is suitable by itself to derive DRVs for vitamin K. Several health outcomes possibly associated with vitamin K intake were also considered but data could not be used to establish DRVs. The Panel considers that average requirements and population reference intakes for vitamin K cannot be derived for adults, infants and children, and therefore sets adequate intakes (AIs). The Panel considers that available evidence on occurrence, absorption, function and content in the body or organs of menaquinones is insufficient, and, therefore, sets AIs for phylloquinone only. Having assessed additional evidence available since 1993 in particular related to biomarkers, intake data and the factorial approach, which all are associated with considerable uncertainties, the Panel maintains the reference value proposed by the Scientific Committee for Food (SCF) in 1993. An AI of 1 mu g phylloquinone/kg body weight per day is set for all age and sex population groups. Considering the respective reference body weights, AIs for phylloquinone are set at 70 mu g/day for all adults including pregnant and lactating women, at 10 mu g/day for infants aged 7-11 months, and between 12 mu g/day for children aged 1-3 years and 65 mu g/day for children aged 15-17 years. (C) 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority

Identification of eight novel proteasome variants in five unrelated cases of proteasome-associated autoinflammatory syndromes (PRAAS)

Mutations in genes coding for proteasome subunits and/or proteasome assembly helpers typically cause recurring autoinflammation referred to as chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures (CANDLE) or proteasome-associated autoinflammatory syndrome (PRAAS). Patients with CANDLE/PRAAS present with mostly chronically elevated type I interferon scores that emerge as a consequence of increased proteotoxic stress by mechanisms that are not fully understood. Here, we report on five unrelated patients with CANDLE/PRAAS carrying novel inherited proteasome missense and/or nonsense variants. Four patients were compound heterozygous for novel pathogenic variants in the known CANDLE/PRAAS associated genes, PSMB8 and PSMB10, whereas one patient showed additive loss-of-function mutations in PSMB8. Variants in two previously not associated proteasome genes, PSMA5 and PSMC5, were found in a patient who also carried the PSMB8 founder mutation, p.T75M. All newly identified mutations substantially impact the steady-state expression of the affected proteasome subunits and/or their incorporation into mature 26S proteasomes. Our observations expand the spectrum of PRAAS-associated genetic variants and improve a molecular diagnosis and genetic counseling of patients with sterile autoinflammation

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Vitamin K deficiency bleeding after NICE guidance and withdrawal of Konakion Neonatal: British Paediatric Surveillance Unit study, 2006-2008.

To survey vitamin K deficiency bleeding (VKDB) and document vitamin K (VK) prophylaxis practice, and compare with findings predating withdrawal of Konakion Neonatal and guidance from the National Institute of Health and Clinical Excellence (NICE), both occurring in 2006.This article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text from the publisher's site