Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Aeroallergen immunotherapy associated with reduced risk of severe COVID-19 in 1095 allergic patients

Introduction: Allergen immunotherapy (AIT) brings along changes in the immune system, restoring dendritic cell function, reducing T2 inflammation and augmenting the regulatory cell activation. Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, interferes with the immune system causing immune suppression during the first phase and over-activation in more advanced disease. We decided to explore the interaction of both in a real-world observational trial. Methods: We registered COVID-19 outcomes in patients with allergic disorders in Latin America, treated with and without AIT. The registry was conducted during the first 1.3 years of the pandemic, with most of the data collected before COVID-19 vaccination was concluded in most countries. Data collection was anonymous via a web-based instrument. Ten countries participated. Results: 630/1095 (57.6%) of the included patients received AIT. Compared to patients without AIT, those treated with AIT had a reduced risk ratio (RR) for COVID-19 lower respiratory symptoms (RR 0.78, 95% CI: 0.6703–0.9024; p = 0.001662) and need for oxygen therapy (RR 0.65, 95% CI: 0.4217–0.9992; p = 0.048). In adherent patients on maintenance sublingual immunotherapy/subcutaneous immunotherapy (SLIT/SCIT) the RR reduction was larger [RR = 0.6136 (95% CI 0.4623–0.8143; p < 0.001) and RR: 0.3495 (95% CI 0.1822–0.6701; p < 0.005), respectively]. SLIT was slightly more effective (NS). We excluded age, comorbidities, level of health care attendance, and type of allergic disorder as confounders, although asthma was related to a higher frequency of severe disease. When analyzing patients with allergic asthma (n = 503) the RR reduction favoring AIT was more pronounced with 30% for lower respiratory symptoms or worse (RR 0.6914, 95% CI 0.5264 to 0.9081, p = 0.0087) and 51% for need of oxygen therapy or worse (RR 0.4868, 95% CI 0.2829–0.8376, p = 0.0082). Among severe allergic patients treated with biologics (n = 24) only 2/24 needed oxygen therapy. There were no critical cases among them. Conclusion: In our registry AIT was associated with reduced COVID-19 severity

Multiplicity dependence of light (anti-)nuclei production in p–Pb collisions at sNN=5.02 TeV

The measurement of the deuteron and anti-deuteron production in the rapidity range −1 < y < 0 as a function of transverse momentum and event multiplicity in p–Pb collisions at √sNN = 5.02 TeV is presented. (Anti-)deuterons are identified via their specific energy loss dE/dx and via their time-of- flight. Their production in p–Pb collisions is compared to pp and Pb–Pb collisions and is discussed within the context of thermal and coalescence models. The ratio of integrated yields of deuterons to protons (d/p) shows a significant increase as a function of the charged-particle multiplicity of the event starting from values similar to those observed in pp collisions at low multiplicities and approaching those observed in Pb–Pb collisions at high multiplicities. The mean transverse particle momenta are extracted from the deuteron spectra and the values are similar to those obtained for p and particles. Thus, deuteron spectra do not follow mass ordering. This behaviour is in contrast to the trend observed for non-composite particles in p–Pb collisions. In addition, the production of the rare 3He and 3He nuclei has been studied. The spectrum corresponding to all non-single diffractive p-Pb collisions is obtained in the rapidity window −1 < y < 0 and the pT-integrated yield dN/dy is extracted. It is found that the yields of protons, deuterons, and 3He, normalised by the spin degeneracy factor, follow an exponential decrease with mass number

π0\pi ^{0} and η\eta meson production in proton-proton collisions at s=8\sqrt{s}=8 TeV

An invariant differential cross section measurement of inclusive $\pi ^{0}$ and $\eta$ meson production at mid-rapidity in pp collisions at $\sqrt{s}=8$  TeV was carried out by the ALICE experiment at the LHC. The spectra of $\pi ^{0}$ and $\eta$ mesons were measured in transverse momentum ranges of $0.33.5$   $\text{ GeV/c }$ . However, a deviation from this empirical scaling rule is observed for transverse momenta below $p_{ \text{ T }} <3.5$   $\text{ GeV/c }$ in the $\eta /\pi ^0$ ratio with a significance of $6.2\sigma$

Inclusive J/ψ\psi production in Xe–Xe collisions at sNN\sqrt{s_{\rm NN}} = 5.44 TeV

Inclusive J/$\psi$ production is studied in Xe-Xe interactions at a centre-of-mass energy per nucleon pair of $\sqrt{s_{\rm NN}}= 5.44$ TeV, using the ALICE detector at the CERN LHC. The J/$\psi$ meson is reconstructed via its decay into a muon pair, in the centre-of-mass rapidity interval $2.5<y<4$ and down to zero transverse momentum. In this Letter, the nuclear modification factors $R_{\rm AA}$ for inclusive J/$\psi$, measured in the centrality range 0-90% as well as in the centrality intervals 0-20% and 20-90% are presented. The $R_{\rm AA}$ values are compared to previously published results for Pb-Pb collisions at $\sqrt{s_{\rm NN}}= 5.02$ TeV and to the calculation of a transport model. A good agreement is found between Xe-Xe and Pb-Pb results as well as between data and the model

Anisotropic flow in Xe-Xe collisions at sNN=5.44\mathbf{\sqrt{s_{\rm{NN}}} = 5.44} TeV

The first measurements of anisotropic flow coefficients vn for mid-rapidity charged particles in Xe–Xe collisions at sNN=5.44 TeV are presented. Comparing these measurements to those from Pb–Pb collisions at sNN=5.02 TeV, v2 is found to be suppressed for mid-central collisions at the same centrality, and enhanced for central collisions. The values of v3 are generally larger in Xe–Xe than in Pb–Pb at a given centrality. These observations are consistent with expectations from hydrodynamic predictions. When both v2 and v3 are divided by their corresponding eccentricities for a variety of initial state models, they generally scale with transverse density when comparing Xe–Xe and Pb–Pb, with some deviations observed in central Xe–Xe and Pb–Pb collisions. These results assist in placing strong constraints on both the initial state geometry and medium response for relativistic heavy-ion collisions

Systematic studies of correlations between different order flow harmonics in Pb-Pb collisions at sNN\sqrt{s_{\rm NN}} = 2.76 TeV

The correlations between event-by-event fluctuations of anisotropic flow harmonic amplitudes have been measured in Pb-Pb collisions at sNN=2.76 TeV with the ALICE detector at the Large Hadron Collider. The results are reported in terms of multiparticle correlation observables dubbed symmetric cumulants. These observables are robust against biases originating from nonflow effects. The centrality dependence of correlations between the higher order harmonics (the quadrangular v4 and pentagonal v5 flow) and the lower order harmonics (the elliptic v2 and triangular v3 flow) is presented. The transverse momentum dependences of correlations between v3 and v2 and between v4 and v2 are also reported. The results are compared to calculations from viscous hydrodynamics and a multiphase transport (AMPT) model calculations. The comparisons to viscous hydrodynamic models demonstrate that the different order harmonic correlations respond differently to the initial conditions and the temperature dependence of the ratio of shear viscosity to entropy density (η/s). A small average value of η/s is favored independent of the specific choice of initial conditions in the models. The calculations with the AMPT initial conditions yield results closest to the measurements. Correlations among the magnitudes of v2, v3, and v4 show moderate pT dependence in midcentral collisions. This might be an indication of possible viscous corrections to the equilibrium distribution at hadronic freeze-out, which might help to understand the possible contribution of bulk viscosity in the hadronic phase of the system. Together with existing measurements of individual flow harmonics, the presented results provide further constraints on the initial conditions and the transport properties of the system produced in heavy-ion collisions

Azimuthally-differential pion femtoscopy relative to the third harmonic event plane in Pb-Pb collisions at sNN\mathbf{\sqrt{\textit{s}_{_{\rm NN}}}} = 2.76 TeV

International audienceAzimuthally-differential femtoscopic measurements, being sensitive to spatio-temporal characteristics of the source as well as to the collective velocity fields at freeze out, provide very important information on the nature and dynamics of the system evolution. While the HBT radii oscillations relative to the second harmonic event plane measured recently reflect mostly the spatial geometry of the source, model studies have shown that the HBT radii oscillations relative to the third harmonic event plane are predominantly defined by the velocity fields. In this Letter, we present the first results on azimuthally-differential pion femtoscopy relative to the third harmonic event plane as a function of the pion pair transverse momentum kT for different collision centralities in Pb–Pb collisions at sNN=2.76 TeV . We find that the Rside and Rout radii, which characterize the pion source size in the directions perpendicular and parallel to the pion transverse momentum, oscillate in phase relative to the third harmonic event plane, similar to the results from 3+1D hydrodynamical calculations. The observed radii oscillations unambiguously signal a collective expansion and anisotropy in the velocity fields. A comparison of the measured radii oscillations with the Blast-Wave model calculations indicate that the initial state triangularity is washed-out at freeze out

Transverse momentum spectra and nuclear modification factors of charged particles in Xe-Xe collisions at sNN\sqrt{s_{\rm NN}} = 5.44 TeV

International audienceTransverse momentum ( pT ) spectra of charged particles at mid-pseudorapidity in Xe–Xe collisions at sNN=5.44TeV measured with the ALICE apparatus at the Large Hadron Collider are reported. The kinematic range 0.1510 GeV/c . The centrality dependence of the ratio of the average transverse momentum 〈pT〉 in Xe–Xe collisions over Pb–Pb collision at s=5.02 TeV is compared to hydrodynamical model calculations

Prompt and non-prompt J/ψ\hbox {J}/\psi production and nuclear modification at mid-rapidity in p–Pb collisions at sNN=5.02\mathbf{\sqrt{{ s}_{\text {NN}}}= 5.02} TeV

A measurement of beauty hadron production at mid-rapidity in proton-lead collisions at a nucleon–nucleon centre-of-mass energy $\sqrt{s_\text {NN}}=5.02$ TeV is presented. The semi-inclusive decay channel of beauty hadrons into $\hbox {J}/\psi$ is considered, where the $\hbox {J}/\psi$ mesons are reconstructed in the dielectron decay channel at mid-rapidity down to transverse momenta of 1.3 GeV/c. The $\hbox {b}\bar{\hbox {b}}$ production cross section at mid-rapidity, $\hbox {d}\sigma _{\hbox {b}\bar{\hbox {b}}}/\hbox {d}y$ , and the total cross section extrapolated over full phase space, $\sigma _{\text {b}\bar{\text {b}}}$ , are obtained. This measurement is combined with results on inclusive $\hbox {J}/\psi$ production to determine the prompt $\hbox {J}/\psi$ cross sections. The results in p–Pb collisions are then scaled to expectations from pp collisions at the same centre-of-mass energy to derive the nuclear modification factor $R_{\text {pPb}}$ , and compared to models to study possible nuclear modifications of the production induced by cold nuclear matter effects. $R_{\text {pPb}}$ is found to be smaller than unity at low $p_{\mathrm{T}}$ for both $\hbox {J}/\psi$ coming from beauty hadron decays and prompt $\hbox {J}/\psi$