Big Bang Baryogenesis

An overview of baryogenesis in the early Universe is presented. The standard big bang model including big bang nucleosynthesis and inflation is breifly reviewed. Three basic models for baryogenesis will be developed: The ``standard" out-of-equilibrium decay model; the decay of scalar consensates along flat directions in supersymmetric models; and lepto-baryogenesis, which is the conversion of a lepton asymmetry into a baryon asymmetry via non-perturbative electroweak interactions.Comment: 36 pages, LaTeX, UMN-TH-1249, Lectures given at the 33rd International Winter School on Nuclear and Particle Physics, ``Matter Under Extreme Conditions", Feb. 27 - March 5 1994, Schladming Austri

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of SARS-CoV-2 genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three available genomic nomenclature systems for SARS-CoV-2 to all sequence data from the WHO European Region available during the COVID-19 pandemic until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation. We provide a comparison of the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.Peer reviewe

Information and economics in Fisher’s design of experiments

In 1951 R. A. Fisher described what had been achieved in the 20th century so far: "we have learnt (i) To conserve in its statistical reduction the scientific information latent in any body of observations. (ii) To conduct experimental and observational inquiries so as to maximise the information obtained for a given expenditure." This paper asks what Fisher meant and, in particular, how he saw his work on experimental design as contributing to the objective of maximizing information for a given expenditure. The material examined ranges from detailed work on issues like "the information lost in measurement of error" to polemics against decision theory.<br/