345 research outputs found

    Het Rotterdamse Toezichtmodel: boven op de hotspot

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    In Rotterdam is een Toezichtmodel ontwikkeld voor de aanpak van hotspots. Met dit model wordt een bijzonder slechte veiligheidsituatie door gezamenlijk toezicht en handhaving teruggebracht naar een acceptabel niveau. Ruth Prins, Peter Marks en Arie Sluis beschrijven in dit artikel de functie, toepassing, ervaringen en opbrengsten van het Toezichtmodel binnen het R otterdamse veiligheidsbelei

    Community policing in the Netherlands: A continuously changing constant

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    __Abstract__ 1977 was an important year for the Dutch police as it was then that a seminal strategy document called ‘A Changing Police was published that would set the course for the next three decades. The writers of the report felt that for the police to bridge the growing gap between them and the society they serve, they would have to be innovative, and think outside of their usual security paradigms. They found their solution in community policing and the strategy document laid out the framework for Community Policing (COP) in the Netherlands. This document was widely considered a milestone in the development of Dutch policing (see Cachet et al. 1998). However, by 2005, the Dutch Board of Chief Commissioners felt it necessary to publish a new strategy document to once again map out the future of Dutch Policing. After nearly three decades, the Dutch police was again in need of a shared philosophy that would serve as a foundation for their mandate. This new document was titled ‘The Police in Evolution’ (PIE) but it stayed true to the values of COP by once again focusing on the local community and stressing community policing. In this paper we explore the establishment and development of Dutch COP. We look at several distinct phases in the long term development of Dutch COP, and examine the factors that explain the shifts that have taken place in the way Dutch COP is carried out. We ask also about the prospects of Dutch COP in the future. The paper will consist of four sections. In the first Section, we examine the historical roots and the development of Dutch COP since its inception in 1977. In Section 2, we look at the current state of affairs for COP in the Netherlands. In the third section, we put forward several explanations for the significant shifts that have taken place over the course of the COP’s 30-year history. In the fourth section, we discuss the prospects for Dutch COP in the coming years. Section 5 presents our conclusions

    An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

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    For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

    Measurement of the Bs0J/ψKS0B_s^0\to J/\psi K_S^0 branching fraction

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    The Bs0J/ψKS0B_s^0\to J/\psi K_S^0 branching fraction is measured in a data sample corresponding to 0.41fb1fb^{-1} of integrated luminosity collected with the LHCb detector at the LHC. This channel is sensitive to the penguin contributions affecting the sin2β\beta measurement from B0J/ψKS0B^0\to J/\psi K_S^0 The time-integrated branching fraction is measured to be BF(Bs0J/ψKS0)=(1.83±0.28)×105BF(B_s^0\to J/\psi K_S^0)=(1.83\pm0.28)\times10^{-5}. This is the most precise measurement to date

    Measurement of the ratio of branching fractions BR(B0 -> K*0 gamma)/BR(Bs0 -> phi gamma) and the direct CP asymmetry in B0 -> K*0 gamma

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    The ratio of branching fractions of the radiative B decays B0 -> K*0 gamma and Bs0 phi gamma has been measured using an integrated luminosity of 1.0 fb-1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of sqrt(s)=7 TeV. The value obtained is BR(B0 -> K*0 gamma)/BR(Bs0 -> phi gamma) = 1.23 +/- 0.06(stat.) +/- 0.04(syst.) +/- 0.10(fs/fd), where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for BR(B0 -> K*0 gamma), the branching fraction BR(Bs0 -> phi gamma) is measured to be (3.5 +/- 0.4) x 10^{-5}. The direct CP asymmetry in B0 -> K*0 gamma decays has also been measured with the same data and found to be A(CP)(B0 -> K*0 gamma) = (0.8 +/- 1.7(stat.) +/- 0.9(syst.))%. Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations.Comment: 21 pages, 3 figues, 4 table

    First observation of the decay Bˉs0D0K0\bar{B}^0_s \to D^0 K^{*0} and a measurement of the ratio of branching fractions B(Bˉs0D0K0)B(Bˉ0D0ρ0)\frac{{\cal B}(\bar{B}^0_s \to D^0 K^{*0})}{{\cal B}(\bar{B}^0 \to D^0 \rho^0)}

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    The first observation of the decay Bˉs0D0K0\bar{B}^0_s \to D^0 K^{*0} using pppp data collected by the LHCb detector at a centre-of-mass energy of 7 TeV, corresponding to an integrated luminosity of 36 pb1^{-1}, is reported. A signal of 34.4±6.834.4 \pm 6.8 events is obtained and the absence of signal is rejected with a statistical significance of more than nine standard deviations. The Bˉs0D0K0\bar{B}^0_s \to D^0 K^{*0} branching fraction is measured relative to that of Bˉ0D0ρ0\bar{B}^0 \to D^0 \rho^0: B(Bˉs0D0K0)B(Bˉ0D0ρ0)=1.48±0.34±0.15±0.12\frac{{\cal B}(\bar{B}^0_s \to D^0 K^{*0})}{{\cal B}(\bar{B}^0 \to D^0 \rho^0)} = 1.48 \pm 0.34 \pm 0.15 \pm 0.12, where the first uncertainty is statistical, the second systematic and the third is due to the uncertainty on the ratio of the B0B^0 and Bs0B^0_s hadronisation fractions.Comment: 10 pages, 3 figures, submitted to Phys. Lett. B; ISSN 0370-269

    Mouse Chromosome 3

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46995/1/335_2004_Article_BF00648421.pd

    Understandings of cervical screening in sexual minority women: A Q-methodological study

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    Discursive perspectives argue that cervical screening carries social and moral meaning. Overlooked by research into the health needs of sexual minority women, previous literature that has examined uptake of cervical screening has instead targeted increasing attendance via information and service provision. In order to explore the diversity of meanings that British sexual minority women have about cervical screening, the Q-sorts of 34 sexual minority women were factor analysed by-person and rotated to simple structure using Varimax. The five factors are interpreted and discussed relative to competing discourses on information provision within cervical screening. The five accounts are labelled 'cervical screening is': an essential health check that women have the right to refuse; a woman's health entitlement; a vital test but degrading experience; a sensible thing to do; and an unnecessary imposition for some women. Critical approaches to informed choice are explored with attention to recent developments in cervical cancer prevention. Findings highlighting the need for affirmation of diversity within healthcare are considered in relation to existing criteria for UK national screening programmes

    Dense Stellar Populations: Initial Conditions

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    This chapter is based on four lectures given at the Cambridge N-body school "Cambody". The material covered includes the IMF, the 6D structure of dense clusters, residual gas expulsion and the initial binary population. It is aimed at those needing to initialise stellar populations for a variety of purposes (N-body experiments, stellar population synthesis).Comment: 85 pages. To appear in The Cambridge N-body Lectures, Sverre Aarseth, Christopher Tout, Rosemary Mardling (eds), Lecture Notes in Physics Series, Springer Verla

    Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.

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    Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy
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