Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation

Background. Acne is a dermatosis that involves an altered sebum pattern. Objectives. (1) To evaluate if a treatment based on antibiotics (lymecycline) can alter fatty acids contents of the sebum of patients with acne; (2) to evaluate if oral supplementation of fatty acids can interfere with fatty acids contents of the sebum of patients with acne; (3) to evaluate if there is any interaction in fatty acids contents of the sebum of patients with acne when they use both antibiotics and oral supplementation of fatty acids. Methods. Forty-five male volunteers with inflammatory acne vulgaris were treated with 300 mg of lymecycline per day, with 540 mg of γ-linolenic acid, 1,200 mg of linoleic acid, and 510 mg of oleic acid per day, or with both regimens for 90 days. Every 30 days, a sample of sebum from the forehead was collected for fatty acids’ chromatographic analysis. Results. Twelve fatty acids studied exhibited some kind of pattern changes during the study: C12:0, C14:0, C15:0, C16:1, C18:0, C18:1n9c+C18:1n9t, C18:2n6t, C18:3n6, C18:3n3, C20:1, C22:0, and C24:0. Conclusions. The daily administration of lymecycline and/or specific fatty acids may slightly influence some fatty acids levels present in the sebum of patients with inflammatory acne vulgaris

O gerenciamento de uma Liga Acadêmica no contexto do distanciamento social: um relato de experiência.

Este estudo relata a experiência da Liga Acadêmica em Gênero, Sexualidade e Saúde (LAGS) acerca das modificações sofridas na estruturação das atividades exercidas pela liga em meio à pandemia causada pela Covid-19. Trata-se de uma descrição feita pelos componentes da LAGS sobre a reorganização do funcionamento da Liga no atual contexto. Nessa perspectiva, fala-se sobre o impacto da utilização das plataformas digitais por seus organizadores e público na realização de eventos e na produção de conteúdo a ser disponibilizado nas redes sociais. Foram observadas, também, mudanças nas atividades relacionadas à pesquisa, ensino e extensão; e maior demanda da atividade nas redes. Assim foram criados meios estratégicos para que não houvesse uma sobrecarga dos membros ligados a essas funções

Evidências científicas sobre o tratamento cirúrgico da queratose actínica / Scientific evidence on the surgical treatment of actinic keratosis

As queratoses actínicas são máculas, pápulas ou placas queratósicas ou escamosas resultantes da proliferação intraepidérmica de queratinócitos atípicos em resposta à exposição prolongada à radiação ultravioleta. As queratoses actínicas são uma preocupação porque a maioria dos CECs cutâneos que surgem de queratoses actínicas pré-existentes, e as queratoses actínicas que irão progredir para o CEC não podem ser distinguidas de queratoses actínicas que se resolverão espontaneamente ou persistirão, devido a esses fatores, a maioria dos estudos recomedam tratar rotineiramente as queratoses actínicas.  As opções de tratamento para queratose actínica  incluem terapias destrutivas direcionadas à lesão (por exemplo, cirurgia, crioterapia, dermoabrasão) e terapias direcionadas ao campo com medicamentos tópicos como fluorouracil, imiquimod e  mebutato de ingenol, ou terapia fotodinâmica. As terapias de campo são indicadas para o tratamento de áreas com múltiplas queratoses actínicas, lesões subclínicas que não são detectadas por inspeção visual ou palpação e cancerização de campo

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London