68 research outputs found
MSLED, Neutrino Oscillations and the Cosmological Constant
We explore the implications for neutrino masses and mixings within the
minimal version of the supersymmetric large-extra-dimensions scenario (MSLED).
This model was proposed in {\tt hep-ph/0404135} to extract the phenomenological
implications of the promising recent attempt (in {\tt hep-th/0304256}) to
address the cosmological constant problem. Remarkably, we find that the
simplest couplings between brane and bulk fermions within this approach can
lead to a phenomenologically-viable pattern of neutrino masses and mixings that
is also consistent with the supernova bounds which are usually the bane of
extra-dimensional neutrino models. Under certain circumstances the MSLED
scenario can lead to a lepton mixing (PMNS) matrix close to the so-called
bi-maximal or the tri-bimaximal forms (which are known to provide a good
description of the neutrino oscillation data). We discuss the implications of
MSLED models for neutrino phenomenology.Comment: 38 pages, 1 figure; Reposted with a few additional reference
eta-prime Meson Production in Nucleon-Nucleon Collisions Near The Threshold
The production of mesons in the reactions and at threshold-near energies is analyzed within a covariant effective
meson-nucleon theory. The description of cross section and angular
distributions of the available data in this kinematical region in the
channel is accomplished by including meson currents and nucleon currents with
the resonances , and . Predictions
for the channel are given. The di-electron production from subsequent
Dalitz decay is also
calculated and numerical results are presented for intermediate energy and
kinematics of possible experiments with HADES, CLAS and KEK-PS
The First Data Release of the Sloan Digital Sky Survey
The Sloan Digital Sky Survey has validated and made publicly available its
First Data Release. This consists of 2099 square degrees of five-band (u, g, r,
i, z) imaging data, 186,240 spectra of galaxies, quasars, stars and calibrating
blank sky patches selected over 1360 square degrees of this area, and tables of
measured parameters from these data. The imaging data go to a depth of r ~ 22.6
and are photometrically and astrometrically calibrated to 2% rms and 100
milli-arcsec rms per coordinate, respectively. The spectra cover the range
3800--9200 A, with a resolution of 1800--2100. Further characteristics of the
data are described, as are the data products themselves.Comment: Submitted to The Astronomical Journal. 16 pages. For associated
documentation, see http://www.sdss.org/dr
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at âs=0.9 and 2.36 TeV
Measurements of inclusive charged-hadron transverse-momentum and pseudorapidity distributions are presented for proton-proton collisions at root s = 0.9 and 2.36 TeV. The data were collected with the CMS detector during the LHC commissioning in December 2009. For non-single-diffractive interactions, the average charged-hadron transverse momentum is measured to be 0.46 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 0.9 TeV and 0.50 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 2.36 TeV, for pseudorapidities between -2.4 and +2.4. At these energies, the measured pseudorapidity densities in the central region, dN(ch)/d eta vertical bar(vertical bar eta vertical bar and pp collisions. The results at 2.36 TeV represent the highest-energy measurements at a particle collider to date
Tumor-associated Macrophages and Macrophage-Related Immune Checkpoint Expression in Sarcomas
Early trials for immune checkpoint inhibitors in sarcomas have delivered mixed results, and efforts to improve outcomes now look to combinatorial strategies with novel immunotherapeutics, including some that target macrophages. To enhance our understanding of the sarcoma immune landscape, we quantified and characterized tumor-associated macrophage infiltration and expression of the targetable macrophage-related immune checkpoint CD47/SIRPÎą across sarcoma types. We surveyed immunohistochemical expression of CD68, CD163, CD47, and SIRPÎą in tissue microarrays of 1242 sarcoma specimens (spanning 24 types). Non-translocation sarcomas, particularly undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma, had significantly higher counts of both CD68+ and CD163+ macrophages than translocation-associated sarcomas. Across nearly all sarcoma types, macrophages outnumbered tumor-infiltrating lymphocytes and CD163+ (M2-like) macrophages outnumbered CD68+ (M1-like) macrophages. These findings were supported by data from The Cancer Genome Atlas, which showed a correlation between increasing macrophage contributions to immune infiltration and several measures of DNA damage. CD47 expression was bimodal, with most cases showing either 0% or >90% tumor cell staining, and the highest CD47 scores were observed in chordoma, angiosarcoma, and pleomorphic liposarcoma. SIRPÎą scores correlated well with CD47 expression. Given the predominance of macrophage infiltrates over tumor-infiltrating lymphocytes, the bias toward M2-like (immunosuppressive) macrophage polarization, and the generally high scores for CD47 and SIRPÎą, macrophage-focused immunomodulatory agents, such as CD47 or IDO-1 inhibitors, may be particularly worthwhile to pursue in sarcoma patients, alone or in combination with lymphocyte-focused agents
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