62 research outputs found
Role of Chemerin in Cardiovascular Diseases
(1) Background: Obesity is closely connected to the pathophysiology of cardiovascular diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that disrupt cardiovascular homeostasis by activating inflammatory processes that recruit immune cells to the site of injury and reduce nitric oxide levels, resulting in increased blood pressure, endothelial cell migration, proliferation, and apoptosis. Adipose tissue produces adipokines, such as chemerin, that may alter immune responses, lipid metabolism, vascular homeostasis, and angiogenesis. (2) Methods: We performed PubMed and MEDLINE searches for articles with English abstracts published between 1997 (when the first report on chemerin identification was published) and 2022. The search retrieved original peer-reviewed articles analyzed in the context of the role of chemerin in CVDs, explicitly focusing on the most recent findings published in the past five years. (3) Results: This review summarizes up-to-date findings related to mechanisms of chemerin action, its role in the development and progression of CVDs, and novel strategies for developing chemerin-targeting therapeutic agents for treating CVDs. (4) Conclusions: Extensive evidence points to chemerin's role in vascular inflammation, angiogenesis, and blood pressure modulation, which opens up exciting perspectives for developing chemerin-targeting therapeutic agents for the treatment of CVDs
Biomasa iz poljoprivrede kao potencijani izvor alternativnih goriva pogonskih agregata
Liquid fossil fuels are the dominant fuel for the plant, as means of all forms of
transport, employment and agricultural machines and aggregates. In the coming period is
unrealistic to expect more intense and massive development, implementation,
construction of new engines that would be adapted to another type of fuel. All efforts
have been focused on finding such a fuel that could be adapted to existing engine
structures, and to simultaneously satisfy additional criteria related to ecology, as well as
reliability and privacy.
In this context, biofuel is given increasing attention, which can be produced from
renewable primary and secondary agricultural raw materials, with generally positive
effects of performance, reliability, emissions and thus protect the environment, as well as
other requirements that the current fossil fuel backgrounds meet.
As biofuels can be considered methanol, biometanol, bioethanol, biodiesel, natural
gas, hydrogen and others. Raw materials from agricultural biomass to produce
alternative fuels could be: sugar cane, sugar beet, corn sorghum, corn, wheat, rapeseed,
sunflower, potatoes, barley, olive, palm, sweet potato, monioka, Jerusalem artichokes
(topinambur) and others. Products and residues from forest mass: wood, pulp, paper,
black lug and others. Now it different kinds of waste such as municipal and secondary
waste, food wastes, wastes from production of cereals and food, etc.., With the current
use of fossil origin fuel from oil, coal, oil shale, natural gas and others.
The paper gives a brief review of possible fuel from biomass, which can be, with its
advantages and disadvantages, potential use as fuel internal combustion engines.TeÄna fosilna goriva su najdominantnija goriva za pogon, kako sredstava svih
vidova saobraÄaja, tako i poljoprivrednih radnih maÅ”ina i agregata. U narednom periodu
je nerealno oÄekivati intenzivniji i masovniji razvoj, u primeni, novih konstrukcija
motora koje bi bile prilagoÄene nekoj drugoj vrsti goriva. Svi napori su usredsreÄeni na
pronalaženju supstitucije goriva, koje bi bilo prilagoÄeno postojeÄim konstrukcijama
motora, a da istovremeno zadovolje i dodatne kriterijume vezane za obnovljivost,
ekologiju, pouzdanost koriÅ”Äenja i dr.
U tom kontekstu, biogorivima se posveÄuje sve veÄa pažnja, koja se mogu
proizvesti iz obnovljivih primarnih i sekundarnih poljoprivrednih sirovina, sa generalno
pozitivnim efektima performansi, pouzdanosti, emisije izduvnih gasova, a time i zaŔtite
životne sredine, kao i drugim zahtevima koje sadaŔnja goriva fosilnog porekla
ispunjavaju.
Kao biogoriva mogu se razmatrati metanol, biometanol, bioetanol, biodizel,
prirodni gas, vodonik i dr. Sirovine iz poljoprivredne biomase za proizvodnju
alternativnih goriva mogu biti: Å”eÄerna trska, Å”eÄerna repa, sirak Å”eÄerac, kukuruz,
pÅ”enica, uljana repica, suncokret, krompir, jeÄam, maslina, palma, batata, monioka,
jerusalemska artiÄoka (topinambur) i dr. Iz proizvoda i ostataka Å”umskih masa: drvo,
celuloza, papir, crni lug i dr. Zatim iz razliÄitih vidova otpada, kao Å”to su: komunalni i
sekundarni otpad, otpadi iz proizvodnje žitarica i hrane i dr., uz sadaŔnju primenu goriva
fosilnog porekla iz: nafte, uglja, uljnih Ŕkriljaca, prirodnog gasa i dr.
U radu je dat kraÄi prikaz moguÄih vrsta goriva iz biomase, koja se mogu, sa svojim
prednostima i manama, potencijalno koristiti kao pogonsko gorivo motora SUS
Editorial: Non-coding RNA in diabetes and cardiovascular diseases
Editorial on the Research Topic: [https://www.frontiersin.org/research-topics/33365/non-coding-rna-in-diabetes-and-cardiovascular-diseases
Uticaj potencijalnih vuÄnih karakteristika traktora Fendt u optimizaciji obrade zemljiÅ”ta
Trend development of agricultural tractors, follows agrotechnique and to the
general development of technique, that fundamental investigations find their full
application in the world manufacturing of tractors also.
This paper analyses the potential performance of a tractor Fendt production and their
impact on the optimization of agricultural conditions in the processing of agricultural
land in Serbia.
Fendt tractors manufacturing have all the characteristics of contemporary world of
tractors based on the basis of increasing engine power while keeping intact mass of the
tractor in the individual series.
Comprehensive analysis of Fendt tractors is made of several approaches, the three
series of tractors from 700, 800 and 900, and one of these results is shown in this paper.
Based on the analysis it can be concluded that the particular batch of tractors
complement each other in relation to the demands of agricultural technology and farm
size, which provide optimum conditions for processing various types of soil in
accordance with the requirements of modern production agriculture.
Such an approach to the analysis of potential impact on the optimization of
processing characteristics of the soil, allows potential buyers relief decision to buy the
tractor, depending on their requirements.Trend razvoja poljoprivrednih traktora prati agrotehniÄki i opÅ”ti razvoj tehnike,
tako da fundamentalna istraživanja nalaze punu primenu i u svetskoj proizvodnji
traktora.
U radu su analizirane potencijalne eksploatacione karakteristike traktora proizvodnje
Fendt i njihov uticaj na optimizaciju agrotehniÄkih uslova u obradi poljoprivrednog
zemljiŔta Srbije.
Traktori proizvodnje Fendt imaju sve karakteristike savremenih svetskih traktora
koje se zasnivaju na bazi poveÄanja snage motora uz zadržavanje nepromenjene mase
traktora u okviru pojedinih serija.
Sveobuhvatna analiza traktora Fendt je izvrŔena od viŔe raspoloživih modela, na tri
traktora iz serija 700, 800 i 900, a jedan deo tih rezultata, prikazan je u ovom radu.
Na osnovu izvrÅ”ene analize nameÄe se zakljuÄak, da se pojedine serije traktora
meÄusobno dopunjuju u odnosu na zahteve agrotehnike i veliÄinu poseda, Äime se
obezbeÄuju uslovi za optimalnu obradu razliÄitih tipova zemljiÅ”ta u skladu sa zahtevima
proizvodnje savremene poljoprivrede. Takav pristup analizi uticaja potencijalnih
karakteristika na optimizaciju obrade zemljiÅ”ta, omoguÄava potencijalnim kupcima
olakŔanje odluke o kupovini traktora u zavisnosti od njihovih zahteva
The antibacterial activity of date syrup polyphenols against S. aureus and E. coli
Plant-derived products such as date syrup have demonstrated antibacterial activity and can inhibit bacteria through numerous different mechanisms, which may be attributed to bioactive compounds including plant-derived phenolic molecules. Date syrup is rich in polyphenols and this study hypothesized that date syrup polyphenols demonstrate inherent antimicrobial activity, which cause oxidative damage. This investigation revealed that date syrup has a high content of total polyphenols (605 mg/100g), and is rich in tannins (357 mg/100g), flavonoids (40.5 mg/100g) and flavanols (31.7 mg/100g) that are known potent antioxidants. Furthermore, date syrup, and polyphenols extracted from date syrup, the most abundant bioactive constituent of date syrup are bacteriostatic to both Gram positive and Gram negative Escherichia coli and Staphylococcus aureus respectively. It has further been shown that the extracted polyphenols independently suppress the growth of bacteria at minimum inhibitory concentration (MIC) of 30 mg/mL and 20 mg/mL for E. coli and S. aureus, and have observed that date syrup behaves as a prooxidant by generating hydrogen peroxide that mediates bacterial growth inhibition as a result of oxidative stress. At sub-lethal MIC concentrations date syrup demonstrated antioxidative activity by reducing hydrogen peroxide, and at lethal concentrations date syrup demonstrated prooxidant activity that inhibited the growth of E. coli and S. aureus. The high sugar content naturally present in date syrup did not significantly contribute to this effect. These findings highlight that date syrupās antimicrobial activity is mediated through hydrogen peroxide generation in inducing oxidative stress in bacteria
Nitric oxide, thyroglobulin, and calcitonin: unraveling the nature of thyroid nodules
BackgroundThyroid nodules (TN) are localized morphological changes in the thyroid gland and can be benign or malignant.ObjectiveThe present study investigates the relationships between biochemical markers in serum (s) and their homologs in washout (w) after fine-needle aspiration biopsy (FNAB) of the TN of interest and their correlation with cytology specimen findings.MethodsWe investigated the relationships between serum biochemical markers nitric oxide (NO), thyroglobulin (TG), and calcitonin (CT), their homologs in washout after FNAB of the TN of interest, and cytology findings of biopsy samples classified according to the Bethesda system for thyroid cytopathology in this study, which included 86 subjects.ResultsWashout TG (TGw) level positively correlates with the cytology finding of the biopsy. A higher level of TGw correlates with higher categories of the Bethesda classification and indicates a higher malignant potential. The levels of serum NO (NOs), serum TG (TGs), serum CT (CTs), and washout CT (CTw) do not correlate with the cytology finding of the biopsy, and the higher levels of washout NO (NOw) correspond to the more suspicious ultrasound findings.ConclusionThe findings of our study suggest that TGw and NOw could be used as potential predictors of malignancy in TN
The genetic basis of the fitness costs of antimicrobial resistance : : a meta-analysis approach
Peer reviewedPublisher PD
Supercoiling in DNA and chromatin
Supercoiling is a fundamental property of DNA and chromatin. It is modulated by polymerase and topoisomerase activities and, through regulated constraint, by DNA/chromatin binding proteins. As a non-covalent and elusive topological modification, supercoiling has proved intractable to research despite being a crucial regulator of nuclear structure and function. Recent studies have improved our understanding of the formation, regulation and organisation of supercoiling domains in vivo, and reinforce the prospect that the propagation of supercoiling can influence local and global chromatin structure. However, to further our understanding the development of new experimental tools and models are required to better dissect the mechanics of this key topological regulator
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