More than a Bumper Sticker: The Factors Influencing Information Systems Career Choices

Considering the ongoing concerns regarding enrollments in MIS programs, it is necessary for MIS educators to understand the underlying motivations that influence student choices of major, as well as how students view the field of MIS related to these factors. To address this problem, a series of focus group sessions were conducted on three distinct samples of students which examined the following questions: (1) What factors influence a business student’s selection of a field of study and/or career? (2) What factors encourage or deter a business student’s choice to enter the field of MIS? and (3) What strategies can an MIS department employ to increase awareness about MIS-related careers among business students? Results from these focus groups suggest that most students rated job scope as an important issue in their deciding on a major; however, students with little or no knowledge of MIS perceived this career path as narrowly focused (e.g., sitting at a computer and coding all day). Results also suggest that non-MIS majors held more negative perceptions of the characteristics associated with MIS professionals, whereas freshman and sophomore students declaring MIS as their future major held more positive perceptions than non-MIS majors, and junior and senior MIS majors held even more positive perceptions

Help or hinder: Bayesian models of social goal inference

Everyday social interactions are heavily influenced by our snap judgments about others’ goals. Even young infants can infer the goals of intentional agents from observing how they interact with objects and other agents in their environment: e.g., that one agent is ‘helping’ or ‘hindering’ another’s attempt to get up a hill or open a box. We propose a model for how people can infer these social goals from actions, based on inverse planning in multiagent Markov decision problems (MDPs). The model infers the goal most likely to be driving an agent’s behavior by assuming the agent acts approximately rationally given environmental constraints and its model of other agents present. We also present behavioral evidence in support of this model over a simpler, perceptual cue-based alternative.United States. Army Research Office (ARO MURI grant W911NF-08-1-0242)United States. Air Force Office of Scientific Research (MURI grant FA9550-07-1-0075)National Science Foundation (U.S.) (Graduate Research Fellowship)James S. McDonnell Foundation (Collaborative Interdisciplinary Grant on Causal Reasoning

Cumulative disadvantage, employment–marriage, and health inequalities among American and British mothers

This paper illuminates processes of cumulative disadvantage and the generation of health inequalities among mothers. It asks whether adverse circumstances early in the life course cumulate as health-harming biographical patterns across the prime working and family caregiving years. It also explores whether broader institutional contexts may moderate the cumulative effects of micro-level processes. An analysis of data from the British National Child Development Study and the US National Longitudinal Survey of Youth reveals several expected social inequalities in health. In addition, the study uncovers new evidence of cumulative disadvantage: Adversities in early life selected women into long-term employment and marriage biographies that then intensified existing health disparities in mid-life. The analysis also shows that this accumulation of disadvantage was more prominent in the US than in Britain

Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62

Atypical protein kinase C (aPKC) enzymes signal on protein scaffolds, yet how they are maintained in an active conformation on scaffolds is unclear. A myristoylated peptide based on the autoinhibitory pseudosubstrate fragment of the atypical PKCζ, zeta inhibitory peptide (ZIP), has been extensively used to inhibit aPKC activity; however, we have previously shown that ZIP does not inhibit the catalytic activity of aPKC isozymes in cells (Wu-Zhang, A. X., Schramm, C. L., Nabavi, S., Malinow, R., and Newton, A. C. (2012) J. Biol. Chem. 287, 12879–12885). Here we sought to identify a bona fide target of ZIP and, in so doing, unveiled a novel mechanism by which aPKCs are maintained in an active conformation on a protein scaffold. Specifically, we used protein-protein interaction network analysis, structural modeling, and protein-protein docking to predict that ZIP binds an acidic surface on the Phox and Bem1 (PB1) domain of p62, an interaction validated by peptide array analysis. Using a genetically encoded reporter for PKC activity fused to the p62 scaffold, we show that ZIP inhibits the activity of wild-type aPKC, but not a construct lacking the pseudosubstrate. These data support a model in which the pseudosubstrate of aPKCs is tethered to the acidic surface on p62, locking aPKC in an open, signaling-competent conformation. ZIP competes for binding to the acidic surface, resulting in displacement of the pseudosubstrate of aPKC and re-engagement in the substrate-binding cavity. This study not only identifies a cellular target for ZIP, but also unveils a novel mechanism by which scaffolded aPKC is maintained in an active conformation