143 research outputs found
Nutrition Education: The Older Adult With Diabetes
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68337/2/10.1177_014572179101700505.pd
Revised North Star Ambulatory Assessment for Young Boys with Duchenne Muscular Dystrophy
The advent of therapeutic approaches for Duchenne muscular dystrophy (DMD) has highlighted the need to identify reliable outcome measures for young boys with DMD. The aim of this study was to develop a revised version of the North Star Ambulatory Assessment (NSAA) suitable for boys between the age of 3 and 5 years by identifying age appropriate items and revising the scoring system accordingly. Using the scale in 171 controls between the age of 2.9 and 4.8 years, we identified items that were appropriate at different age points. An item was defined as age appropriate if it was completed, achieving a full score, by at least 85% of the typically developing boys at that age. At 3 years (±3months) there were only 8 items that were age appropriate, at 3 years and 6 months there were 13 items while by the age of 4 years all 17 items were appropriate. A revised version of the scale was developed with items ordered according to the age when they could be reliably performed. The application of the revised version of the scale to data collected in young DMD boys showed that very few of the DMD boys were able to complete with a full score all the age appropriate items. In conclusion, our study suggests that a revised version of the NSAA can be used in boys from the age of 3 years to obtain information on how young DMD boys acquire new abilities and how this correlates with their peers
Antiphospholipid Antibodies Bind ATP: A putative Mechanism for the Pathogenesis of Neuronal Dysfunction
Antiphospholipid antibodies (aPL) generated in experimental animals
cross-react with ATP. We therefore examined the possibility that aPL IgG from
human subjects bind to ATP by affinity column and an enzyme linked
immunosorbent assay (ELISA). Sera with high levels of aPL IgG were collected
from 12 patients with the antiphospholipid syndrome (APS). IgG fractions from
10 of 12 APS patients contained aPL that could be affinity-bound to an ATP
column and completely eluted with NaCl 0.5 M. A significant (>50%) inhibition
of aPL IgG binding by ATP 5 mM was found in the majority. Similar inhibition
was obtained with ADP but not with AMP or cAMP. All the affinity purified
anti-ATP antibodies also bound β2-glycoprotein-I (β2-GPI, also known as
apolipoprotein H) suggesting that, similar to most pathogenic aPL, their binding
depends on this serum cofactor. We further investigated this possibility and found
that the binding of β2-GPI to the ATP column was similar to that of aPL IgG in
that most was reversed by NaCl 0.5 M. Furthermore, addition of β2-GPI to aPL
IgG significantly increased the amount of aPL binding to an ATP column. We
conclude that aPL IgG bind ATP, probably through β2-GPI. This binding could
interfere
with the normal extracellular function of ATP and similar neurotransmitters
Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic
Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p<0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p<0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p<0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer
Measurement of associated production of vector bosons and top quark-antiquark pairs in pp collisions at √s=7 TeV
PubMed ID: 23679709The first measurement of vector-boson production associated with a top quark-antiquark pair in proton-proton collisions at s √ =7 TeV is presented. The results are based on a data set corresponding to an integrated luminosity of 5.0 fb^−1 , recorded by the CMS detector at the LHC in 2011. The measurement is performed in two independent channels through a trilepton analysis of tt ¯ Z events and a same-sign dilepton analysis of tt ¯ V (V=W or Z ) events. In the trilepton channel a direct measurement of the tt ¯ Z cross section σ tt ¯ Z =0.28 [+0.14 −0.11] (stat) [+0.06 −0.03] (syst) pb is obtained. In the dilepton channel a measurement of the tt ¯ V cross section yields σtt¯V=0.43 [+0.17 −0.15] (stat) [+0.09 −0.07] (syst) pb . These measurements have a significance, respectively, of 3.3 and 3.0 standard deviations from the background hypotheses and are compatible, within uncertainties, with the corresponding next-to-leading order predictions of 0.137[+0.012 −0.016] and 0.306 [+0.031 −0.053] pb
Context, cognition and communication in language
Questions pertaining to the unique structure and organisation of language have a
long history in the field of linguistics. In recent years, researchers have explored
cultural evolutionary explanations, showing how language structure emerges from
weak biases amplified over repeated patterns of learning and use. One outstanding
issue in these frameworks is accounting for the role of context. In particular,
many linguistic phenomena are said to to be context-dependent; interpretation
does not take place in a void, and requires enrichment from the current state
of the conversation, the physical situation, and common knowledge about the
world. Modelling the relationship between language structure and context is
therefore crucial for developing a cultural evolutionary approach to language.
One approach is to use statistical analyses to investigate large-scale, cross-cultural
datasets. However, due to the inherent limitations of statistical analyses, especially
with regards to the inadequacy of these methods to test hypotheses about
causal relationships, I argue that experiments are better suited to address questions
pertaining to language structure and context. From here, I present a series
of artificial language experiments, with the central aim being to test how
manipulations to context influence the structure and organisation of language.
Experiment 1 builds upon previous work in iterated learning and communication
games through demonstrating that the emergence of optimal communication systems
is contingent on the contexts in which languages are learned and used. The
results show that language systems gradually evolve to only encode information
that is informative for conveying the intended meaning of the speaker - resulting
in markedly different systems of communication. Whereas Experiment 1 focused
on how context influences the emergence of structure, Experiments 2 and 3 investigate
under what circumstances do manipulations to context result in the loss
of structure. While the results are inconclusive across these two experiments,
there is tentative evidence that manipulations to context can disrupt structure,
but only when interacting with other factors. Lastly, Experiment 4 investigates
whether the degree of signal autonomy (the capacity for a signal to be interpreted without recourse to contextual information) is shaped by manipulations
to contextual predictability: the extent to which a speaker can estimate and exploit
contextual information a hearer uses in interpreting an utterance. When
the context is predictable, speakers organise languages to be less autonomous
(more context-dependent) through combining linguistic signals with contextual
information to reduce effort in production and minimise uncertainty in comprehension.
By decreasing contextual predictability, speakers increasingly rely on
strategies that promote more autonomous signals, as these signals depend less on
contextual information to discriminate between possible meanings. Overall, these
experiments provide proof-of-concept for investigating the relationship between
language structure and context, showing that the organisational principles underpinning
language are the result of competing pressures from context, cognition,
and communication
- …