Acting out our dam future: science-based role-play simulations as mechanisms for learning and natural resource planning

Science often does not make its way into decisions, leading to a problematic gap between scientific and societal progress. To tackle this issue, our research tests a novel science-based negotiation simulation that integrates a role-play simulation (RPS) with a system dynamics model (SDM). In RPSs, stakeholders engage in a mock decision-making process (reflecting real-life institutional arrangements and scientific knowledge) for a set period. System dynamics models (SDMs) are visual tools used to simulate the interactions and feedback within a complex system. We test the integration of the two approaches with stakeholders in New England via a series of two consecutive workshops across two states. The workshops engage stakeholders from diverse groups to foster dialogue, learning, and creativity. Participants discuss a hypothetical (yet realistic) decision scenario to consider scientific information and explore dam management options that meet one another\u27s interests. In the first workshop, participants contributed to the design of the fictionalized dam decision scenario and the SDM. In the second workshop, participants assumed another representative\u27s role and discussed dam management options for the fictionalized scenario. This presentation will briefly report on the practical design of this science-based role-play, and particularly emphasize preliminary results of workshop outcomes, which were evaluated using debriefing sessions, surveys, concept mapping exercises, and interviews. Results will determine the extent to which this new knowledge production process leads to learning, use of science, and more collaborative decision-making about dams in New England and beyond

Star formation rate and metallicity of damped Lyman-alpha absorbers in cosmological SPH simulations

We study the distribution of the star formation rate and metallicity of damped Lyman-alpha absorbers using cosmological SPH simulations of the Lambda cold dark matter model in the redshift range z=0-4.5. Our approach includes a phenomenological model of galactic wind. We find that there is a positive correlation between the projected stellar mass density and the neutral hydrogen column density (NHI) of DLAs for high NHI systems, and that there is a good correspondence in the spatial distribution of stars and DLAs in the simulations. The evolution of typical star-to-gas mass ratios in DLAs can be characterised by an increase from about 2 at z=4.5 to 3 at z=3, to 10 at z=1, and finally to 20 at z=0. We also find that the projected SFR density in DLAs follows the Kennicutt law well at all redshifts, and the simulated values are consistent with the recent observational estimates of this quantity by Wolfe et al. (2003a,b). The rate of evolution in the mean metallicity of simulated DLAs as a function of redshift is mild, and is consistent with the rate estimated from observations. The predicted metallicity of DLAs is generally sub-solar in our simulations, and there is a significant scatter in the distribution of DLA metallicity for a given NHI. However, we find that the median metallicity of simulated DLAs is close to that of Lyman-break galaxies, which is higher than the values typically observed for DLAs by nearly an order of magnitude. This discrepancy with observations could be due to an inadequate treatment of SN feedback in our current simulations, perhaps indicating that metals are not expelled efficiently enough from DLAs by outflows. Alternatively, the current observations might be missing the majority of the high metallicity DLAs due to selection effects. (abridged)Comment: 18 pages, 15 figures. Accepted to MNRAS. More visual presentations and the version with high resolution figures are available at http://cfa-www.harvard.edu/~knagamine/DLA-pics

Cosmic Variance and Its Effect on the Luminosity Function Determination in Deep High z Surveys

We study cosmic variance in deep high redshift surveys and its influence on the determination of the luminosity function for high redshift galaxies. For several survey geometries relevant for HST and JWST instruments, we characterize the distribution of the galaxy number counts. This is obtained by means of analytic estimates via the two point correlation function in extended Press-Schechter theory as well as by using synthetic catalogs extracted from N-body cosmological simulations of structure formation. We adopt a simple luminosity - dark halo mass relation to investigate the environment effects on the fitting of the luminosity function. We show that in addition to variations of the normalization of the luminosity function, a steepening of its slope is also expected in underdense fields, similarly to what is observed within voids in the local universe. Therefore, to avoid introducing artificial biases, caution must be taken when attempting to correct for field underdensity, such as in the case of HST UDF i-dropout sample, which exhibits a deficit of bright counts with respect to the average counts in GOODS. A public version of the cosmic variance calculator based on the two point correlation function integration is made available on the web.Comment: ApJ, 676, 767; Public cosmic variance calculator relocated at https://www.ph.unimelb.edu.au/~mtrenti/cvc/CosmicVariance.htm

Internal properties and environments of dark matter halos

We use seven high-resolution $N$-body simulations to study the correlations among different halo properties (assembly time, spin, shape and substructure), and how these halo properties are correlated with the large-scale environment in which halos reside. The large-scale tidal field estimated from halos above a mass threshold is used as our primary quantity to characterize the large-scale environment, while other parameters, such as the local overdensity and the morphology of large-scale structure, are used for comparison. For halos at a fixed mass, all the halo properties depend significantly on environment, particularly the tidal field. The environmental dependence of halo assembly time is primarily driven by local tidal field. The mass of the unbound fraction in substructure is boosted in strong tidal force region, while the bound fraction is suppressed. Halos have a tendency to spin faster in stronger tidal field and the trend is stronger for more massive halos. The spin vectors show significant alignment with the intermediate axis of the tidal field, as expected from the tidal torque theory. Both the major and minor axes of halos are strongly aligned with the corresponding principal axes of the tidal field. In general, a halo that can accrete more material after the formation of its main halo on average is younger, is more elongated, spins faster, and contains a larger amount of substructure. Higher density environments not only provide more material for halo to accrete, but also are places of stronger tidal field that tends to suppress halo accretion. The environmental dependencies are the results of these two competing effects. The tidal field based on halos can be estimated from observation, and we discuss the implications of our results for the environmental dependence of galaxy properties.Comment: Accepted for publication in MNRA

Structure of the Shroom-Rho Kinase Complex Reveals a Binding Interface with Monomeric Shroom That Regulates Cell Morphology and Stimulates Kinase Activity

Shroom-mediated remodeling of the actomyosin cytoskeleton is a critical driver of cellular shape and tissue morphology that underlies the development of many tissues including the neural tube, eye, intestines, and vasculature. Shroom uses a conserved SD2 domain to direct the subcellular localization of Rho-associated kinase (Rock), which in turn drives changes in the cytoskeleton and cellular morphology through its ability to phosphorylate and activate non-muscle myosin II. Here, we present the structure of the human Shroom-Rock binding module, revealing an unexpected stoichiometry for Shroom in which two Shroom SD2 domains bind independent surfaces on Rock. Mutation of interfacial residues impaired Shroom-Rock binding in vitro and resulted in altered remodeling of the cytoskeleton and loss of Shroom-mediated changes in cellular morphology. Additionally, we provide the first direct evidence that Shroom can function as a Rock activator. These data provide molecular insight into the Shroom-Rock interface and demonstrate that Shroom directly participates in regulating cytoskeletal dynamics, adding to its known role in Rock localization

The Evolution of the Dark Halo Spin Parameters lambda and lambda' in a LCDM Universe: The Role of Minor and Major Mergers

The evolution of the spin parameter of dark halos and the dependence on the halo merging history in a set of dissipationless cosmological LCDM simulations is investigated. Special focus is placed on the differences of the two commonly used versions of the spin parameter, namely lambda=J*E^1/2/(G*M^5/2) (Peebles 80) and lambda'=J/(sqrt(2)*M_vir*R_vir*V_vir) (Bullock et al. 01). Though the distribution of the spin transfer rate defined as the ratio of the spin parameters after and prior to a merger is similar to a high degree for both, lambda and lambda', we find considerable differences in the time evolution: while lambda' is roughly independent of redshift, lambda turns out to increase significantly with decreasing redshift. This distinct behaviour arises from small differences in the spin transfer during accretion events. The evolution of the spin parameter is strongly coupled with the virial ratio eta:=2*E_kin/|E_pot| of dark halos. Major mergers disturb halos and increase both their virial ratio and spin parameter for 1-2 Gyrs. At high redshifts (z=2-3) many halos are disturbed with an average virial ratio of eta = 1.3 which approaches unity until z=0. We find that the redshift evolution of the spin parameters is dominated by the huge number of minor mergers rather than the rare major merger events.Comment: 10 pages, 11 figures, submitted to MNRA

Galaxy Clustering Evolution in the UH8K Weak Lensing Fields

We present measurements of the two-point galaxy angular correlation function as a function of apparent magnitude, color, and morphology. We present new galaxy number counts to limiting magnitudes of I=24.0 and V=25.0. We find $\omega(\theta)$ to be well described by a power-law of slope -0.8. We find the amplitude of the correlation function to decrease monotonically with increasingly faint apparent magnitude. We compare with predictions utilizing redshift distributions based on deep spectroscopic observations. We conclude that simple redshift-dependent models which characterize evolution by means of the epsilon parameter inadequately describe the observations. We find a strong clustering dependence on V-I color because galaxies of extreme color lie at similar redshifts and the angular correlation functions for these samples are minimally diluted by chance projections. We then present the first attempt to investigate the redshift evolution of clustering, utilizing a population of galaxies of the same morphological type and absolute luminosity. We study the dependence of $\omega(\theta)$ on redshift for Lstar early-type galaxies in the redshift range 0.2<z<0.9. Although uncertainties are large, we find the evolution in the clustering of these galaxies to be consistent with stable clustering [epsilon=0]. We find Lstar early-type galaxies to cluster slightly more strongly (rnought = 5.25\pm0.28 \hMpc assuming epsilon=0) than the local full field population. This is in good agreement with the 2dFGRS value for Lstar early-type galaxies in the local universe (abridged).Comment: 41 pages, including 12 figs, 10 tables, to appear in Ap

Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting.

In resource-limited settings, many patients, with no prior protease inhibitor (PI) treatment on a second-line, high genetic barrier, ritonavir-boosted PI-containing regimen have virologic failure

The Impact of Cooling and Feedback on Disc Galaxies

We present detailed, analytical models for the formation of disc galaxies to investigate the impact that cooling and feedback have on their structural properties. In particular, we investigate which observables extracted directly from the models are best suited as virial mass estimators, and to what extent they allow the recovery of the model input parameters regarding the feedback and cooling efficiencies. Contrary to naive expectations, the luminosities and circular velocities of disc galaxies are extremely poor indicators of total virial mass. Instead, we show that the product of disc scale length and rotation velocity squared yields a much more robust estimate. We show that feedback can cause a narrow correlation between galaxy mass fraction and halo spin parameter, similar to that found recently by van den Bosch, Burkert and Swaters from an analysis of dwarf galaxy rotation curves. Finally we investigate the impact that cooling and feedback have on the colors, metallicities, star formation histories and Tully-Fisher relation of disc galaxies.Comment: 20 pages, 12 figures. To be published in MNRA

HI as a Probe of the Large Scale Structure in the Post-Reionization Universe

We model the distribution of neutral Hydrogen (HI hereafter) in the post-reionization universe. This model uses gravity only N-Body simulations and an ansatz to assign HI to dark matter haloes that is consistent with observational constraints and theoretical models. We resolve the smallest haloes that are likely to host HI in the simulations, care is also taken to ensure that any errors due to the finite size of the simulation box are small. We then compute the smoothed one point probability distribution function and the power spectrum of fluctuations in HI. This is compared with other predictions that have been made using different techniques. We highlight the significantly high bias for the HI distribution at small scales. This aspect has not been discussed before. We then discuss the prospects for detection with the MWA, GMRT and the hypothetical MWA5000. The MWA5000 can detect visibility correlations at large angular scales at all redshifts in the post-reionization era. The GMRT can detect visibility correlations at lower redshifts, specifically there is a strong case for a survey at z=1.3. We also discuss prospects for direct detection of rare peaks in the HI distribution using the GMRT. We show that direct detection should be possible with an integration time that is comparable to, or even less than, the time required for a statistical detection. Specifically, it is possible to make a statistical detection of the HI distribution by measuring the visibility correlation, and, direct detection of rare peaks in the HI distribution at z = 1.3 with the GMRT in less than 1000 hours of observations.Comment: 15 pages, 11 figures. Accepted for publication in the MNRAS. This is a merged manuscript also containing material covered in 0908.385