The blood labyrinthine barrier in the human normal and Meniere's disease macula utricle.

The ultrastructural organization of the blood labyrinthine barrier (BLB) was investigated in the human vestibular endorgan, the utricular macula, using postmortem specimens from individuals with documented normal auditory and vestibular function and surgical specimens from patients with intractable Meniere's disease. Transmission electron microscopic analysis of capillaries located in the normal human utricular stroma showed vascular endothelial cells with few pinocytotic vesicles, covered by a smooth and uniform basement membrane surrounded by pericyte processes. Meniere's disease specimens revealed differential ultrastructural pathological changes in the cellular elements of the microvasculature. With moderate degeneration of the BLB, there were numerous vesicles within the vascular endothelial cells (VECs), with increased numbers at the abluminal face, pericyte process detachment and disruption of the perivascular basement membrane surrounding the VECs. With severe degeneration of the BLB, there was severe vacuolization or frank apparent necrosis of VECs and loss of subcellular organelles. A higher severity of BLB degenerative changes was associated with a higher degree of basement membrane thickening and edematous changes within the vestibular stroma. This study presents the first ultrastructural analysis of the capillaries constituting the BLB in the human vestibular macula utricle from normal and Meniere's disease

Changing Notions of Environmental Justice in the Decision to Host a Nuclear Fuel Storage Facility on the Skull Valley Goshute Reservation

This paper examines the conflict surrounding the Skull Valley Band of Goshute Indians' decision to host an interim storage facility for high-level radioactive waste on their reservation in Utah. This paper challenges the predominant tradition of environmental justice scholarship and activism that focus on the inequitable distribution of hazards in low-income minority communities. We examine the underlying historical, political, and geographical contexts of the emerging nuclear landscape of the American West and focus on how the political and environmental dynamics of siting a nuclear facility intersect with issues of community self-determination and identity formation. Specifically, we examine notions of tribal sovereignty and contemporary tribal identity politics and how these complicate and hinder tribal involvement in a full range of decisions about development. Environmental justice activism and literature tend to restrictively define the authentic indigenous response to development and natural resource management, particularly when projects are controversial and technologically complex. The restrictive definition expects that tribes will refuse to grapple with technology, calling it an anti-spiritual manifestation of the non-tribal world. In labeling the tribal response, there is no distinction made between the variety of indigenous players and distinct communities represented, the differing scopes of governing authority, and heterogeneous responses to projects tagged as environmentally unjust. Rarely is there discussion of the range of values placed on specific sites by specific tribes and how these values should inform development decisions. Finally, this view of "authentic," legitimate tribal involvement undermines the capacity building necessary for tribes to achieve a level of sovereignty and justice where they are educated and proactive in a full range of development and resource management decisions

Environmental effect on the subhalo abundance -- a solution to the missing dwarf problem

Recent high-resolution simulations of the formation of dark-matter halos have shown that the distribution of subhalos is scale-free, in the sense that if scaled by the velocity dispersion of the parent halo, the velocity distribution function of galaxy-sized and cluster-sized halos are identical. For cluster-sized halos, simulation results agreed well with observations. Simulations, however, predicted far too many subhalos for galaxy-sized halos. Our galaxy has several tens of known dwarf galaxies. On the other hands, simulated dark-matter halos contain thousands of subhalos. We have performed simulation of a single large volume and measured the abundance of subhalos in all massive halos. We found that the variation of the subhalo abundance is very large, and those with largest number of subhalos correspond to simulated halos in previous studies. The subhalo abundance depends strongly on the local density of the background. Halos in high-density regions contain large number of subhalos. Our galaxy is in the low-density region. For our simulated halos in low-density regions, the number of subhalos is within a factor of three to that of our galaxy. We argue that the ``missing dwarf problem'' is not a real problem but caused by the biased selection of the initial conditions in previous studies, which were not appropriate for field galaxies.Comment: 8 pages, 5 figures, higher resolution run added, accepted by PAS

4.45 Pflops Astrophysical N-Body Simulation on K computer -- The Gravitational Trillion-Body Problem

As an entry for the 2012 Gordon-Bell performance prize, we report performance results of astrophysical N-body simulations of one trillion particles performed on the full system of K computer. This is the first gravitational trillion-body simulation in the world. We describe the scientific motivation, the numerical algorithm, the parallelization strategy, and the performance analysis. Unlike many previous Gordon-Bell prize winners that used the tree algorithm for astrophysical N-body simulations, we used the hybrid TreePM method, for similar level of accuracy in which the short-range force is calculated by the tree algorithm, and the long-range force is solved by the particle-mesh algorithm. We developed a highly-tuned gravity kernel for short-range forces, and a novel communication algorithm for long-range forces. The average performance on 24576 and 82944 nodes of K computer are 1.53 and 4.45 Pflops, which correspond to 49% and 42% of the peak speed.Comment: 10 pages, 6 figures, Proceedings of Supercomputing 2012 (http://sc12.supercomputing.org/), Gordon Bell Prize Winner. Additional information is http://www.ccs.tsukuba.ac.jp/CCS/eng/gbp201