Effects of bariatric surgery on adipokine-induced inflammation and insulin resistance

Over a third of the US population is obese and at high risk for developing type 2 diabetes, insulin resistance, and other metabolic disorders. Obesity is considered a chronic lowgrade inflammatory condition that is primarily attributed to expansion and inflammation of adipose tissues. Indeed, adipocytes produce and secrete numerous proinflammatory and anti-inflammatory cytokines known as adipokines.When the balance of these adipokines is shifted toward higher production of proinflammatory factors, local inflammation within adipose tissues and subsequently systemic inflammation occur. These adipokines including leptin, visfatin, resistin, apelin, vaspin, and retinol binding protein-4 can regulate inflammatory responses and contribute to the pathogenesis of diabetes.These effects are mediated by key inflammatory signaling molecules including activated serine kinases such as c-Jun N-terminal kinase and serine kinases inhibitor κB kinase and insulin signaling molecules including insulin receptor substrates, protein kinase B (PKB, also known as Akt), and nuclear factor kappa B. Bariatric surgery can decrease body weight and improve insulin resistance in morbidly obese subjects. However, despite reports suggesting reduced inflammation and weight-independent effects of bariatric surgery on glucose metabolism, mechanisms behind such improvements are not yet well understood. This review article focuses on some of these novel adipokines and discusses their changes after bariatric surgery and their relationship to insulin resistance, fat mass, inflammation, and glucose homeostasis

Dwarfs Gobbling Dwarfs: A Stellar Tidal Stream Around NGC 4449 and Hierarchical Galaxy Formation on Small Scales

A candidate diffuse stellar substructure was previously reported in the halo of the nearby dwarf starburst galaxy NGC 4449 by Karachentsev et al. We map and analyze this feature using a unique combination of deep integrated-light images from the Black Bird 0.5-meter telescope, and high-resolution wide-field images from the 8-meter Subaru telescope, which resolve the nebulosity into a stream of red giant branch stars, and confirm its physical association with NGC 4449. The properties of the stream imply a massive dwarf spheroidal progenitor, which after complete disruption will deposit an amount of stellar mass that is comparable to the existing stellar halo of the main galaxy. The ratio between luminosity or stellar-mass between the two galaxies is ~1:50, while the indirectly measured dynamical mass-ratio, when including dark matter, may be ~1:10-1:5. This system may thus represent a "stealth" merger, where an infalling satellite galaxy is nearly undetectable by conventional means, yet has a substantial dynamical influence on its host galaxy. This singular discovery also suggests that satellite accretion can play a significant role in building up the stellar halos of low-mass galaxies, and possibly in triggering their starbursts.Comment: ApJ Letters, in press. Minor changes. 6 pages, 3 figures. A high resolution version of the paper and Subaru image are available at http://www.cosmotography.com/images/small_ngc4449.htm

An analytical model for the accretion of dark matter subhalos

An analytical model is developed for the mass function of cold dark matter subhalos at the time of accretion and for the distribution of their accretion times. Our model is based on the model of Zhao et al. (2009) for the median assembly histories of dark matter halos, combined with a simple log-normal distribution to describe the scatter in the main-branch mass at a given time for halos of the same final mass. Our model is simple, and can be used to predict the un-evolved subhalo mass function, the mass function of subhalos accreted at a given time, the accretion-time distribution of subhalos of a given initial mass, and the frequency of major mergers as a function of time. We test our model using high-resolution cosmological $N$-body simulations, and find that our model predictions match the simulation results remarkably well. Finally, we discuss the implications of our model for the evolution of subhalos in their hosts and for the construction of a self-consistent model to link galaxies and dark matter halos at different cosmic times.Comment: 14 pages, 10 figures (caption for figure 10 fixed). Accepted for publication in Ap

Large scale bias and the inaccuracy of the peak-background split

The peak-background split argument is commonly used to relate the abundance of dark matter halos to their spatial clustering. Testing this argument requires an accurate determination of the halo mass function. We present a Maximum Likelihood method for fitting parametric functional forms to halo abundances which differs from previous work because it does not require binned counts. Our conclusions do not depend on whether we use our method or more conventional ones. In addition, halo abundances depend on how halos are defined. Our conclusions do not depend on the choice of link length associated with the friends-of-friends halo-finder, nor do they change if we identify halos using a spherical overdensity algorithm instead. The large scale halo bias measured from the matter-halo cross spectrum b_x and the halo autocorrelation function b_xi (on scales k~0.03h/Mpc and r ~50 Mpc/h) can differ by as much as 5% for halos that are significantly more massive than the characteristic mass M*. At these large masses, the peak background split estimate of the linear bias factor b1 is 3-5% smaller than b_xi, which is 5% smaller than b_x. We discuss the origin of these discrepancies: deterministic nonlinear local bias, with parameters determined by the peak-background split argument, is unable to account for the discrepancies we see. A simple linear but nonlocal bias model, motivated by peaks theory, may also be difficult to reconcile with our measurements. More work on such nonlocal bias models may be needed to understand the nature of halo bias at this level of precision.Comment: MNRAS accepted. New section with Spherical Overdensity identified halos included. Appendix enlarge

The impact of environment on the dynamical structure of satellite systems

We examine the effects of environment on the dynamical structure of satellite systems based on the Millennium--II Simulation. Satellite halos are defined as sub--halos within the virial radius of a host halo. The satellite sample is restricted to those sub--halos which showed a maximum circular velocity above 30 km/s at the time of accretion. Host halo masses range from 10^11 to 10^14 Msol/h. We compute the satellites' average accretion redshift, z_acc, velocity dispersion, sigma, and velocity anisotropy parameter, beta, utilising stacked satellite samples of equal mass hosts at similar background densities. The main results are: (1) On average satellites within hosts in high density environments are accreted earlier (Delta z~ 0.1$) compared to their counterparts at low densities. For host masses above 5 times10^13 Msol/h this trend weakens and may reverse for higher host masses; (2) The velocity dispersion of satellites in low density environments follows that of the host, i.e. no velocity bias is observed for host halos at low densities independent of host mass. However, for low mass hosts in high density environments the velocity dispersion of the satellites can be up to ~30% larger than that of the host halo, i.e. the satellites are dynamically hotter than their host halos. (3) The anisotropy parameter depends on host mass and environment. Satellites of massive hosts show more radially biased velocity distributions. Moreover in low density environments satellites have more radially biased velocities (Delta beta > 0.1) compared to their counterparts in high density environments. We believe that our approach allows to predict a similar behaviour for observed satellite galaxy systems.Comment: 7 pages, 4 figures, accepted for publication in MNRA

The nature of assembly bias - I. Clues from a LCDM cosmology

We present a new proxy for the overdensity peak height for which the large-scale clustering of haloes of a given mass does not vary significantly with the assembly history. The peak height, usually taken to be well represented by the virial mass, can instead be approximated by the mass inside spheres of different radii, which in some cases can be larger than the virial radius and therefore include mass outside the individual host halo. The sphere radii are defined as r = $a$ delta_t + $b$ log_10(M_vir/M_nl), where delta_t is the age relative to the typical age of galaxies hosted by haloes with virial mass M_vir, M_nl is the non-linear mass, and $a$=0.2 and $b$=-0.02 are the free parameters adjusted to trace the assembly bias effect. Note that $r$ depends on both halo mass and age. In this new approach, some of the objects which were initially considered low-mass peaks belong to regions with higher overdensities. At large scales, i.e. in the two-halo regime, this model properly recovers the simple prescription where the bias responds to the height of the mass peak alone, in contrast to the usual definition (virial mass) that shows a strong dependence on additional halo properties such as formation time. The dependence on the age in the one-halo term is also remarkably reduced. The population of galaxies whose "peak height" changes with this new definition consists mainly of old stellar populations and are preferentially hosted by low-mass haloes located near more massive objects. The latter is in agreement with recent results which indicate that old, low-mass haloes would suffer truncation of mass accretion by nearby larger haloes or simply due to the high density of their surroundings, thus showing an assembly bias effect. The change in mass is small enough that the Sheth et al. (2001) mass function is still a good fit to the resulting distribution of new masses.Comment: 13 pages, 10 figures, submitted to MNRAS, comments welcom

On the Orbits of Infalling Satellite Halos

The orbital properties of infalling satellite halos set the initial conditions which control the subsequent evolution of subhalos and the galaxies that they host, with implications for mass stripping, star formation quenching, and merging. Using a high-resolution, cosmological N-body simulation, I examine the orbital parameters of satellite halos as they merge with larger host halos, focusing primarily on orbital circularity and pericenter. I explore in detail how these orbital parameters depend on mass and redshift. Satellite orbits become more radial and plunge deeper into their host halo at higher host halo mass, but they do not significantly depend on satellite halo mass. Additionally, satellite orbits become more radial and plunge deeper into their host halos at higher redshift. I also examine satellite velocities, finding that most satellites infall with less specific angular momentum than the host halo virial value, but that satellites are `hotter' than the host virial velocity. I discuss the implications of these results to the processes of galaxy formation and evolution, and I provide fitting formulas to the mass and redshift dependence of satellite orbital circularity and pericenter.Comment: 11 pages, 12 figures, accepted for publication in MNRA

Removal and mixing of the coronal gas from satellites in galaxy groups: cooling the intragoup gas

The existence of an extended hot gaseous corona surrounding clusters, groups and massive galaxies is well established by observational evidence and predicted by current theories of galaxy formation. When a small galaxy collides with a larger one, their coronae are the first to interact, producing disturbances that remove gas from the smaller system and settle it into the corona of the larger one. For a Milky-Way-size galaxy merging into a low-mass group, ram pressure stripping and the Kelvin-Helmholtz instability are the most relevant of these disturbances. We argue that the turbulence generated by the latter mixes the material of both coronae in the wake of the orbiting satellite creating a "warm phase" mixture with a cooling time a factor of several shorter than that of the ambient intragroup gas. We reach this conclusion using analytic estimates, as well as adiabatic and dissipative high resolution numerical simulations of a spherical corona subject to the ablation process of a constant velocity wind with uniform density and temperature. Although this is a preliminary analysis, our results are promising and we speculate that the mixture could potentially trigger in situ star formation and/or be accreted into the central galaxy as a cold gas flow resulting in a new mode of star formation in galaxy groups and clusters.Comment: 15 pages, 5 figures, accepted for publication in MNRA

The specific star formation rate of high redshift galaxies: the case for two modes of star formation

We study the specific star formation rate (SSFR) and its evolution at z\gtsim 4, in models of galaxy formation, where the star formation is driven by cold accretion flows. We show that constant star formation and feedback efficiencies cannot reproduce the observed trend of SSFR with stellar mass and its observed lack of evolution at $z>4$. Model galaxies with \log(M_*) \ltsim 9.5 M$_{\odot}$ show systematically lower specific star formation rates by orders of magnitudes, while massive galaxies with M_* \gtsim 5 \times 10^{10} M$_{\odot}$ have up to an order of magnitude larger SSFRs, compared to recent observations by Stark et al.. To recover these observations we apply an empirical star formation efficiency in galaxies that scales with the host halo velocity dispersion as $\propto 1/\sigma^3$ during galaxy mergers. We find that this modification needs to be of stochastic nature to reproduce the observations, i.e. only applied during mergers and not during accretion driven star formation phases. Our choice of star formation efficiency during mergers allows us to capture both, the boost in star formation at low masses and the quenching at high masses, and at the same time produce a constant SSFR-stellar mass relation at z\gtsim 4 under the assumption that most of the observed galaxies are in a merger triggered star formation phase. Our results suggest that observed high-z low mass galaxies with high SSFRs are likely to be frequently interacting systems, which experienced bursts in their star formation rate and efficiency (mode 1), in contrast to low redshift z \ltsim 3 galaxies which are cold accretion-regulated star forming systems with lower star formation efficiencies (mode 2).Comment: 5 pages, accepted to MNRAS, replaced by version with including referees comment

From dwarf spheroidals to cDs: Simulating the galaxy population in a LCDM cosmology

We apply updated semi-analytic galaxy formation models simultaneously to the stored halo/subhalo merger trees of the Millennium and Millennium-II simulations. These differ by a factor of 125 in mass resolution, allowing explicit testing of resolution effects on predicted galaxy properties. We have revised the treatments of the transition between the rapid infall and cooling flow regimes of gas accretion, of the sizes of bulges and of gaseous and stellar disks, of supernova feedback, of the transition between central and satellite status as galaxies fall into larger systems, and of gas and star stripping once they become satellites. Plausible values of efficiency and scaling parameters yield an excellent fit not only to the observed abundance of low-redshift galaxies over 5 orders of magnitude in stellar mass and 9 magnitudes in luminosity, but also to the observed abundance of Milky Way satellites. This suggests that reionisation effects may not be needed to solve the "missing satellite" problem except, perhaps, for the faintest objects. The same model matches the observed large-scale clustering of galaxies as a function of stellar mass and colour. The fit remains excellent down to ~30kpc for massive galaxies. For M* < 6 x 10^10Msun, however, the model overpredicts clustering at scales below 1 Mpc, suggesting that the sigma_8 adopted in the simulations (0.9) is too high. Galaxy distributions within rich clusters agree between the simulations and match those observed, but only if galaxies without dark matter subhalos (so-called orphans) are included. Our model predicts a larger passive fraction among low-mass galaxies than is observed, as well as an overabundance of ~10^10Msun galaxies beyond z~0.6, reflecting deficiencies in the way star-formation rates are modelled.Comment: Accepted for publication in MNRAS. SQL databases containing the full galaxy data at all redshifts and for both the Millennium and Millennium-II simulations are publicly released at http://www.mpa-garching.mpg.de/millenniu