76 research outputs found
Association of childhood trauma with cognitive function in healthy adults: a pilot study
- Author
- A Avital
- A Sahgal
- AE Yasik
- AJ Beauchamp
- AJ Sameroff
- AM Owen
- B Aisa
- BJ Sahakian
- C Heim
- C Heim
- C Heim
- C Heim
- C Heim
- CD Spielberger
- DP Bernstein
- EJ Ozer
- EJ Thomas
- GA Bonanno
- GS Wilkinson
- J Hardt
- JD Bremner
- Jin-Mann S Lin
- JP Capitanio
- KL Brunson
- L Robbins
- LJ Martin
- LR Squire
- Lucile Capuron
- M Vythilingam
- Matthias Majer
- MJ Meaney
- MJ Meaney
- MS Oitzl
- MW Gilbertson
- O Agid
- PA Saigh
- PR Amato
- RE Culp
- RF Anda
- RL Huot
- RT Ammerman
- SJ Lupien
- TW Robbins
- Urs M Nater
- WC Reeves
- William C Reeves
- WWK Zung
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
BACKGROUND: Animal and human studies suggest that stress experienced early in life has detrimental consequences on brain development, including brain regions involved in cognitive function. Cognitive changes are cardinal features of depression and posttraumatic stress disorder. Early-life trauma is a major risk factor for these disorders. Only few studies have measured the long-term consequences of childhood trauma on cognitive function in healthy adults. METHODS: In this pilot study, we investigated the relationship between childhood trauma exposure and cognitive function in 47 healthy adults, who were identified as part of a larger study from the general population in Wichita, KS. We used the Cambridge Neuropsychological Test Automated Battery (CANTAB) and the Wide-Range-Achievement-Test (WRAT-3) to examine cognitive function and individual achievement. Type and severity of childhood trauma was assessed by the Childhood Trauma Questionnaire (CTQ). Data were analyzed using multiple linear regression on CANTAB measures with primary predictors (CTQ scales) and potential confounders (age, sex, education, income). RESULTS: Specific CTQ scales were significantly associated with measures of cognitive function. Emotional abuse was associated with impaired spatial working memory performance. Physical neglect correlated with impaired spatial working memory and pattern recognition memory. Sexual abuse and physical neglect were negatively associated with WRAT-3 scores. However, the association did not reach the significance level of p < 0.01. CONCLUSIONS: Our results suggest that physical neglect and emotional abuse might be associated with memory deficits in adulthood, which in turn might pose a risk factor for the development of psychopathology
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
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- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
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- Andelin D
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- Anghel IM
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- Anisimov A
- Antillon E
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- Antunes JR
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- Xella S.
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- Zachariadou A
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- Ziebarth EB
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- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Multi-antigen print immunoassay (MAPIA)-based evaluation of novel recombinant Leishmania infantum antigens for the serodiagnosis of canine visceral leishmaniasis
- Author
- A Boarino
- A Falqueto
- Alexandre Barbosa Reis
- BM Buddle
- C Dye
- CM Souza de
- DA Ashford
- Deborah Bittencourt MothĂŠ Fraga
- ED Moreira Jr
- Edmilson Domingos da Silva
- G Grimaldi Jr
- G Lombardo
- Gabriel Grimaldi
- GG Oliveira
- Isaac Queiroz de Oliveira
- J Alvar
- J Alvar
- KP Lyashchenko
- KP Lyashchenko
- KP Lyashchenko
- KP Lyashchenko
- L Solano-Gallego
- M Mettler
- MC Teixeira
- Michel Vergne Sucupira
- MJ Aisa
- MM Costa
- PatrĂcia Sampaio Tavares Veras
- R Reithinger
- RJ Quinnell
- RJ Quinnell
- Rodrigo Araujo Silva
- RT Costa da
- S Passos
- S Rosati
- S Solca Mda
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Identification and Validation of Novel Cerebrospinal Fluid Biomarkers for Staging Early Alzheimer's Disease
- Author
- A Alban
- A Biroccio
- A Bredemeyer
- A D'Aniello
- A Fagan
- A Fagan
- A Guiotto
- A Hye
- A Katzav
- A Konecna
- A Levi
- A Ludwig
- A Simonsen
- A Takanohashi
- A Vitiello
- A Woronowicz
- A Woronowicz
- Aarti R. Shah
- AC Paula-Lima
- AC Puche
- AH Simonsen
- AH Simonsen
- AI Fogel
- AL Perrier
- Alan E. Davis
- AM Fagan
- AM Fagan
- Anne M. Fagan
- AR Hipkiss
- AR Massaro
- B Aisa
- B Hu
- B Mollenhauer
- B Perarnau
- B Sun
- BE Hakala
- BF Murphy
- BJ Snider
- C Abraham
- C Ostergaard
- C Schrick
- C Supnet
- CA Colton
- Catherine M. Roe
- Christopher M. Clark
- CM Balion
- CR Abraham
- CR Capo
- D Antequera
- D Bonneh-Barkay
- D Harold
- D Liang
- D Owen
- DA Eberhard
- DA Loeffler
- DA Loeffler
- DAM Choe L
- David M. Holtzman
- DB Zimmer
- DF Steiner
- DL Kolson
- DM Kovacs
- Douglas R. Galasko
- E Castano
- E Jansen Steur
- E Kapaki
- EA Slee
- ED Levin
- EJ Finehout
- EJ Finehout
- Elaine R. Peskind
- ES Lein
- ES Roberts
- F Abdi
- F Benfenati
- G Hintsch
- G Li
- G McKhann
- Ge Li
- GL Chupp
- GN Shah
- GN Yin
- GN Yin
- H Akiyama
- H Bian
- H Braak
- H Houlden
- H Kessler
- H Lassmann
- H Ling
- H Liu
- H Vollbach
- H Wati
- H Zanjani
- HE Lob
- HM Nielsen
- I Berggard
- I Kalus
- I Ray
- IH Pang
- IN Zelko
- J Alder
- J Gao
- J Kim
- J King
- J Morris
- J Price
- J Schweden
- J Sikora
- J Vukovic
- J Zhang
- JA Wood
- James P. Malone
- JC Lambert
- JC Morris
- Jeffrey A. Kaye
- JJ Park
- JM Schmidbaur
- JN Buxbaum
- JN Buxbaum
- John C. Morris
- Joseph F. Quinn
- JS O'Brien
- K Blennow
- K French
- K Kaneko
- K Kubota
- K Uemura
- L Bergamaschini
- L Ji
- L Li
- L Todaro
- L Vogt
- L Zhong
- LH Lim
- LL Barnes
- M Hosaka
- M Hosaka
- M Hosaka
- M Narita
- M Okada
- M Perretti
- M Puchades
- M Riemenschneider
- M Storandt
- M Takahashi
- M Teufel
- MA Lovell
- Mark P. Mattson
- MC Gasser
- MH Nissen
- MJ Gunzburg
- MJ Storan
- ML Selenica
- MM Bilak
- MY Kaynar
- N Hosokawa
- N Junker
- N Okii
- N Suzuki
- N Svichar
- N Svichar
- N Tolboom
- NH Choi-Miura
- NH Choi-Miura
- NS Latefi
- NT Wright
- NV Bekirov IH
- O Bozdagi
- O Carrette
- O Hansson
- P Arun
- P Davidsson
- P Davidsson
- PA Klenotic
- Petra Gilmore
- PG Kehoe
- PL McGeer
- R Costa
- R Craig-Schapiro
- R Milner
- R Milner
- R Misasi
- R Motter
- R Squitti
- R Squitti
- R. Reid Townsend
- Rebecca Craig-Schapiro
- RH Palmer
- Richard J. Perrin
- RJ Bateman
- RJ Castellani
- RJ Folz
- RL Redondo
- RW Cho
- RW Kuncl
- S DeKosky
- S Kakunaga
- S Koch
- S Kothakota
- S LĂŠtuvĂŠ
- S Nag
- S Paco
- S Pan
- S Ray
- S WĂźrdig
- S Yamagishi
- SA Kaeser
- SD Harr
- SE Stoltzner
- SF Hansson
- SH Choi
- SP Mysore
- SR Hughes
- T Grimmer
- T Kanekiyo
- T Lechner
- T Masaki
- T Ochiai
- T Sanagi
- T Sanagi
- T Sunderland
- T Tapiola
- T Ueyama
- T Wisniewski
- T Yabe
- TH Havlis J
- TJ Montine
- TM Shin
- TR Henion
- U Eder
- U RĂźetschi
- VP Chauhan
- W Markesbery
- W Mi
- WA Kaufmann
- WC Shyu
- WJ Jagust
- WT Hu
- X Liu
- X Zhu
- Y Harigaya
- Y Hu
- Y Hu
- Y Sun
- Y Umezawa
- YN Jang
- Z Ablonczy
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Ideally, disease modifying therapies for Alzheimer disease (AD) will be applied during the 'preclinical' stage (pathology present with cognition intact) before severe neuronal damage occurs, or upon recognizing very mild cognitive impairment. Developing and judiciously administering such therapies will require biomarker panels to identify early AD pathology, classify disease stage, monitor pathological progression, and predict cognitive decline. To discover such biomarkers, we measured AD-associated changes in the cerebrospinal fluid (CSF) proteome.CSF samples from individuals with mild AD (Clinical Dementia Rating [CDR] 1) (nâ=â24) and cognitively normal controls (CDR 0) (nâ=â24) were subjected to two-dimensional difference-in-gel electrophoresis. Within 119 differentially-abundant gel features, mass spectrometry (LC-MS/MS) identified 47 proteins. For validation, eleven proteins were re-evaluated by enzyme-linked immunosorbent assays (ELISA). Six of these assays (NrCAM, YKL-40, chromogranin A, carnosinase I, transthyretin, cystatin C) distinguished CDR 1 and CDR 0 groups and were subsequently applied (with tau, p-tau181 and Aβ42 ELISAs) to a larger independent cohort (nâ=â292) that included individuals with very mild dementia (CDR 0.5). Receiver-operating characteristic curve analyses using stepwise logistic regression yielded optimal biomarker combinations to distinguish CDR 0 from CDR>0 (tau, YKL-40, NrCAM) and CDR 1 from CDR<1 (tau, chromogranin A, carnosinase I) with areas under the curve of 0.90 (0.85-0.94 95% confidence interval [CI]) and 0.88 (0.81-0.94 CI), respectively.Four novel CSF biomarkers for AD (NrCAM, YKL-40, chromogranin A, carnosinase I) can improve the diagnostic accuracy of Aβ42 and tau. Together, these six markers describe six clinicopathological stages from cognitive normalcy to mild dementia, including stages defined by increased risk of cognitive decline. Such a panel might improve clinical trial efficiency by guiding subject enrollment and monitoring disease progression. Further studies will be required to validate this panel and evaluate its potential for distinguishing AD from other dementing conditions
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
- Author
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- Zogheib Eh
- Ăamendys-Silva Sa
- Ănal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS. Trial registration: NCT02010073. Registered on 12 December 2013
Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study
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- Abad RD
- Abe T
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- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
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- Algaba Ă
- Aliaga FA
- Alisasis AU
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- Allue RM
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- Alonso JG
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- Andruszkiewicz P
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- Ăamendys-Silva SA
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- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2019
- Field of study
OBJECTIVES: To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to investigate whether the effects of spontaneous breathing on outcome depend on acute respiratory distress syndrome severity. DESIGN: Planned secondary analysis of a prospective, observational, multicentre cohort study. SETTING: International sample of 459 ICUs from 50 countries. PATIENTS: Patients with acute respiratory distress syndrome and at least 2 days of invasive mechanical ventilation and available data for the mode of mechanical ventilation and respiratory rate for the 2 first days. INTERVENTIONS: Analysis of patients with and without spontaneous breathing, defined by the mode of mechanical ventilation and by actual respiratory rate compared with set respiratory rate during the first 48 hours of mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: Spontaneous breathing was present in 67% of patients with mild acute respiratory distress syndrome, 58% of patients with moderate acute respiratory distress syndrome, and 46% of patients with severe acute respiratory distress syndrome. Patients with spontaneous breathing were older and had lower acute respiratory distress syndrome severity, Sequential Organ Failure Assessment scores, ICU and hospital mortality, and were less likely to be diagnosed with acute respiratory distress syndrome by clinicians. In adjusted analysis, spontaneous breathing during the first 2 days was not associated with an effect on ICU or hospital mortality (33% vs 37%; odds ratio, 1.18 [0.92-1.51]; p = 0.19 and 37% vs 41%; odds ratio, 1.18 [0.93-1.50]; p = 0.196, respectively ). Spontaneous breathing was associated with increased ventilator-free days (13 [0-22] vs 8 [0-20]; p = 0.014) and shorter duration of ICU stay (11 [6-20] vs 12 [7-22]; p = 0.04). CONCLUSIONS: Spontaneous breathing is common in patients with acute respiratory distress syndrome during the first 48 hours of mechanical ventilation. Spontaneous breathing is not associated with worse outcomes and may hasten liberation from the ventilator and from ICU. Although these results support the use of spontaneous breathing in patients with acute respiratory distress syndrome independent of acute respiratory distress syndrome severity, the use of controlled ventilation indicates a bias toward use in patients with higher disease severity. In addition, because the lack of reliable data on inspiratory effort in our study, prospective studies incorporating the magnitude of inspiratory effort and adjusting for all potential severity confounders are required
Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries
- Author
- Abad RD
- Abe T
- Abe T.
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
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- Aisiku I
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- Albaiceta GM
- Albarrak MM
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- Zogheib EH
- Ăamendys-Silva SA
- Ănal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteristics, management and outcomes of patients that received tracheostomy, in the cohort of patients that developed ARDS on day 1-2 of acute hypoxemic respiratory failure, and in a subsequent propensity-matched cohort. Results: Of the 2377 patients with ARDS that fulfilled the inclusion criteria, 309 (13.0%) underwent tracheostomy during their ICU stay. Patients from high-income European countries (n = 198/1263) more frequently underwent tracheostomy compared to patients from non-European high-income countries (n = 63/649) or patients from middle-income countries (n = 48/465). Only 86/309 (27.8%) underwent tracheostomy on or before day 7, while the median timing of tracheostomy was 14 (Q1-Q3, 7-21) days after onset of ARDS. In the subsample matched by propensity score, ICU and hospital stay were longer in patients with tracheostomy. While patients with tracheostomy had the highest survival probability, there was no difference in 60-day or 90-day mortality in either the patient subgroup that survived for at least 5 days in ICU, or in the propensity-matched subsample. Conclusions: Most patients that receive tracheostomy do so after the first week of critical illness. Tracheostomy may prolong patient survival but does not reduce 60-day or 90-day mortality. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
CMS Data Processing Workflows during an Extended Cosmic Ray Run
- Author
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- Abbaneo D
- Abbiendi G
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- Vorobyev A
- Voutilainen M
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- Zachariadou A
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- Zeidler C
- Zeinali M
- Zeise M
- Zelepoukine S
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang L
- Zhang Y
- Zhang Z
- Zheng Y
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- Zhokin A
- Zhu B
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- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Zielinski M
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- Zumerle G
- Zuranski A
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
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- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
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- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
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- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
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- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anh T. Vu
- Anisimov A
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- Anttila E
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- Asghar MI
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- Askew A
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- Atramentov O
- Auffray E
- Aurisano A
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- Publication venue
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Commissioning of the CMS high-level trigger with cosmic rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
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- Publication venue
- 'IOP Publishing'
- Publication date
- 26/11/2009
- Field of study
This is the Pre-print version of the Article. The official published version of the paper can be accessed from the link below - Copyright @ 2010 IOPThe CMS High-Level Trigger (HLT) is responsible for ensuring that data samples with potentially interesting events are recorded with high efficiency and good quality. This paper gives an overview of the HLT and focuses on its commissioning using cosmic rays. The selection of triggers that were deployed is presented and the online grouping of triggered events into streams and primary datasets is discussed. Tools for online and offline data quality monitoring for the HLT are described, and the operational performance of the muon HLT algorithms is reviewed. The average time taken for the HLT selection and its dependence on detector and operating conditions are presented. The HLT performed reliably and helped provide a large dataset. This dataset has proven to be invaluable for understanding the performance of the trigger and the CMS experiment as a whole.This work is supported by FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ,
and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS
(Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia);
Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR
(Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTDS (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)
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