838 research outputs found
Observable Effects of Scalar Fields and Varying Constants
We show by using the method of matched asymptotic expansions that a
sufficient condition can be derived which determines when a local experiment
will detect the cosmological variation of a scalar field which is driving the
spacetime variation of a supposed constant of Nature. We extend our earlier
analyses of this problem by including the possibility that the local region is
undergoing collapse inside a virialised structure, like a galaxy or galaxy
cluster. We show by direct calculation that the sufficient condition is met to
high precision in our own local region and we can therefore legitimately use
local observations to place constraints upon the variation of "constants" of
Nature on cosmological scales.Comment: Invited Festscrift Articl
A Prediction Model to Diabetes using Artificial Metaplasticity
Diabetes is the most common disease nowadays in all populations and in all age groups. Different techniques of artificial intelligence has been applied to diabetes problem. This research proposed the artificial metaplasticity on multilayer perceptron (AMMLP) as prediction model for prediction of diabetes. The Pima Indians diabetes was used to test the proposed model AMMLP. The results obtained by AMMLP were compared with other algorithms, recently proposed by other researchers, that were applied to the same database. The best result obtained so far with the AMMLP algorithm is 89.93
Data arising from drilling investigations in the Loch Borralan intrusion, Sutherland, Scotland
Systematic Study of Fermion Masses and Mixing Angles in Horizontal SU(2) Gauge Theory
Despite its great success in explaining the basic interactions of nature, the
standard model suffers from an inability to explain the observed masses of the
fundamental particles and the weak mixing angles between them. We shall survey
a set of possible extensions to the standard model, employing an SU(2)
``horizontal'' gauge symmetry between the particle generations, to see what
light they can shed on this problem.Comment: 43 pages, 4 figures (available by postal mail on request), OZ-92/0
Solar System planetary tests of \dot c/c
Analytical and numerical calculations show that a putative temporal variation
of the speed of light c, with the meaning of space-time structure constant
c_ST, assumed to be linear over timescales of about one century, would induce a
secular precession of the longitude of the pericenter \varpi of a test particle
orbiting a spherically symmetric body. By comparing such a predicted effect to
the corrections \Delta\dot\varpi to the usual Newtonian/Einsteinian perihelion
precessions of the inner planets of the Solar System, recently estimated by
E.V. Pitjeva by fitting about one century of modern astronomical observations
with the standard dynamical force models of the EPM epehemerides, we obtained
\dot c/c =(0.5 +/- 2)\times 10^-7 yr^-1. Moreover, the possibility that \dot
c/c\neq 0 over the last century is ruled out at 3-12\sigma level by taking the
ratios of the perihelia for different pairs of planets. Our results are
independent of any measurement of the variations of other fundamental constants
which may be explained by a variation of itself (with the meaning of
electromagnetic constant c_EM). It will be important to repeat such tests if
and when other teams of astronomers will estimate their own corrections to the
standard Newtonian/Einsteinian planetary perihelion precessions.Comment: Latex, 12 pages, 1 figure, 3 tables, 23 references. Minor changes. To
appear in General Relativity and Gravitation (GRG
Evaluating synergy between marbofloxacin and gentamicin in Pseudomonas aeruginosa strains isolated from dogs with otitis externa
The aim of this study was to determine antimicrobial susceptibility of Pseudomonas aeruginosa strains to marbofloxacin and gentamicin, and investigate the possible synergistic, additive, indifferent or antagonistic effects between the two agents. P. aeruginosa strains can develop resistance quickly against certain antibiotics if used alone, thus the need emerges to find synergistic combinations. A total of 68 P. aeruginosa strains isolated from dogs were examined. In order to describe interactions between marbofloxacin and gentamicin the checkerboard microdilution method was utilized. The MICs (minimum inhibitory concentrations) for marbofloxacin and gentamicin were in the range 0.25–64 mg/L and 0.25–32 mg/L, respectively. The combination of marbofloxacin and gentamicin was more effective with a MIC range of 0.031–8 mg/L and a MIC90 of 1 mg/L, compared to 16 mg/L for marbofloxacin alone and 8 mg/L for gentamicin alone. The FIC (fractional inhibitory concentration) indices ranged from 0.0945 (pronounced synergy) to 1.0625 (indifference). Synergy between marbofloxacin and gentamicin was found in 33 isolates. The mean FIC index is 0.546, which represents a partial synergistic/additive effect close to the full synergy threshold. In vitro results indicate that marbofloxacin and gentamicin as partially synergistic agents may prove clinically useful in combination therapy against P. aeruginosa infections. Although marbofloxacin is not used in the human practice, the interactions between fluoroquinolones and aminoglycosides may have importance outside the veterinary field
In-vitro evaluation of certain Egyptian traditional medicinal plants against Propionibacterium acnes
Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans
Coronavirus (CoV) cause considerable morbidity and mortality in humans and other mammals, as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in 2003, Middle East Respiratory CoV (MERS-CoV) in 2012, and SARS-CoV-2 in 2019. Although poorly characterized, natural genetic variation in human and other mammals modulate virus pathogenesis, as reflected by the spectrum of clinical outcomes ranging from asymptomatic infections to lethal disease. Using multiple human epidemic and zoonotic Sarbecoviruses, coupled with murine Collaborative Cross genetic reference populations, we identify several dozen quantitative trait loci that regulate SARS-like group-2B CoV pathogenesis and replication. Under a Chr4 QTL, we deleted a candidate interferon stimulated gene, Trim14 which resulted in enhanced SARS-CoV titers and clinical disease, suggesting an antiviral role during infection. Importantly, about 60 % of the murine QTL encode susceptibility genes identified as priority candidates from human genome-wide association studies (GWAS) studies after SARS-CoV-2 infection, suggesting that similar selective forces have targeted analogous genes and pathways to regulate Sarbecovirus disease across diverse mammalian hosts. These studies provide an experimental platform in rodents to investigate the molecular-genetic mechanisms by which potential cross mammalian susceptibility loci and genes regulate type-specific and cross-SARS-like group 2B CoV replication, immunity, and pathogenesis in rodent models. Our study also provides a paradigm for identifying susceptibility loci for other highly heterogeneous and virulent viruses that sporadically emerge from zoonotic reservoirs to plague human and animal populations
Formation of dense partonic matter in relativistic nucleus-nucleus collisions at RHIC: Experimental evaluation by the PHENIX collaboration
Extensive experimental data from high-energy nucleus-nucleus collisions were
recorded using the PHENIX detector at the Relativistic Heavy Ion Collider
(RHIC). The comprehensive set of measurements from the first three years of
RHIC operation includes charged particle multiplicities, transverse energy,
yield ratios and spectra of identified hadrons in a wide range of transverse
momenta (p_T), elliptic flow, two-particle correlations, non-statistical
fluctuations, and suppression of particle production at high p_T. The results
are examined with an emphasis on implications for the formation of a new state
of dense matter. We find that the state of matter created at RHIC cannot be
described in terms of ordinary color neutral hadrons.Comment: 510 authors, 127 pages text, 56 figures, 1 tables, LaTeX. Submitted
to Nuclear Physics A as a regular article; v3 has minor changes in response
to referee comments. Plain text data tables for the points plotted in figures
for this and previous PHENIX publications are (or will be) publicly available
at http://www.phenix.bnl.gov/papers.htm
Spectral and Timing Analysis of NuSTAR and Swift/XRT Observations of the X-Ray Transient MAXI J0637-430
We present results for the first observed outburst from the transient X-ray binary source MAXI J0637-430. This study is based on eight observations from the Nuclear Spectroscopic Telescope Array (NuSTAR) and six observations from the Neil Gehrels Swift Observatory X-Ray Telescope (Swift/XRT) collected from 2019 November 19 to 2020 April 26 as the 3-79 keV source flux declined from 8.2 × 10-10 to 1.4 × 10-12 erg cm-2 s-1. We see the source transition from a soft state with a strong disk-blackbody component to a hard state dominated by a power-law or thermal Comptonization component. NuSTAR provides the first reported coverage of MAXI J0637-430 above 10 keV, and these broadband spectra show that a two-component model does not provide an adequate description of the soft-state spectrum. As such, we test whether blackbody emission from the plunging region could explain the excess emission. As an alternative, we test a reflection model that includes a physical Comptonization continuum. Finally, we also test a spectral component based on reflection of a blackbody illumination spectrum, which can be interpreted as a simple approximation to the reflection produced by returning disk radiation due to the bending of light by the strong gravity of the black hole. We discuss the physical implications of each scenario and demonstrate the value of constraining the source distance
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