Corals not serpulids: mineralized colonial fossils in the Lower Jurassic marginal facies of South Wales

Poorly preserved colonial corals occur near the base of the Lower Jurassic marginal facies at Southerndown, South Wales. Previously they have been interpreted as serpulid colonies, despite a dissimilarity to any serpulids known from elsewhere in the Lias or the few known extant colonial serpulids. However, local preservation of fine detail reveals evidence, in the form of corallites, septa and tabulae, that they are scleractinian corals of the Suborder Faviina, Family Stylophyllidae. These coral specimens occur in close association with barite–galena veins in the underlying Carboniferous Limestone and adjacent Lias marginal facies. Their widespread misindentification as ‘serpulid reefs’ is a consequence of coarse replacive mineralization by barite, which has largely obscured the diagnostic characters

Late Holocene relative sea levels near Palmer Station, northern Antarctic Peninsula, strongly controlled by late Holocene ice-mass changes

Many studies of Holocene relative sea-level (RSL) changes across Antarctica assume that their reconstructions record uplift from glacial isostatic adjustment caused by the demise of the Last Glacial Maximum (LGM) ice sheets. However, recent analysis of GPS observations suggests that mantle viscosity beneath the Antarctic Peninsula is weaker than previously thought, which would imply that solid Earth motion is not controlled by post-LGM ice-sheet retreat but instead by late Holocene ice-mass changes. If this hypothesis is correct, one might expect to find Holocene RSL records that do not reflect a monotonic decrease in the rate of RSL fall but show variations in the rate of RSL change through the Holocene. We present a new record of late Holocene RSL change from Torgersen Island near Palmer Station in the western Antarctic Peninsula that shows an increase in the rate of relative sea-level fall from 3.0 ± 1.2 mm/yr to 5.1 ± 1.8 mm/yr during the late Holocene. Independent studies of the glacial history of the region provide evidence of ice-sheet changes over similar time scales that may be driving this change. When our RSL records are corrected for sea-surface height changes associated with glacial isostatic adjustment (GIA), the rate of post-0.79 ka land uplift at Torgersen Island, 5.3 ± 1.8 mm/yr, is much higher than the rate of uplift recorded at a nearby GPS site at Palmer Station prior to the Larsen B breakup in 2002 AD (1998-2002 AD; <0.1 mm/yr), but similar to the rates observed after 2002 AD (2002-2013 AD; 6–9 mm/yr). This substantial variation in uplift rates further supports the hypothesis that Holocene RSL rates of change are recording responses to late Holocene and recent changes in local ice loading rather than a post-LGM signal across portions of the Antarctic Peninsula. Thus middle-to-late Holocene RSL data may not be an effective tool for constraining the size of the LGM ice sheet across portions of the Antarctic Peninsula underlain by weaker mantle. In addition, current global-scale GIA models are unable to predict our observed changes in late Holocene RSL. Complexities in Earth structure and neoglacial history need to be taken into consideration in GIA models used for correcting modern satellite-based observations of ice-mass loss

Comparison of multiple and logistic regression analyses of relativistic electron flux enhancement at geosynchronous orbit following storms.

Many factors influence relativistic outer radiation belt electron fluxes, such as waves in the ultra low frequency (ULF) Pc5, very low frequency (VLF), and electromagnetic ion cyclotron (EMIC) frequency bands, seed electron flux, Dst disturbance levels, substorm occurrence, and solar wind inputs. In this work we compared relativistic electron flux post storm vs. pre‐storm using three methods of analysis: 1) multiple regression to predict flux values following storms, 2) multiple regression to predict the size and direction of the change in electron flux, and 3) multiple logistic regression to predict only the probability of the flux rising or falling. We determined which is the most predictive model, and which factors are most influential. We found that a linear regression predicting the difference in pre‐storm and post storm flux (Model 2) results in the highest validation correlations. The logistic regression used in Model 3 had slightly weaker predictive abilities than the other two models, but had most value in providing a prediction of the probability of the electron flux increasing after a storm. Of the variables used (ULF Pc5 and VLF waves, seed electrons, substorm activity, and EMIC waves), the most influential in the final model were ULF Pc5 waves and the seed electrons. IMF Bz, Dst, and solar wind number density, velocity, and pressure did not improve any of the models, and were deemed unnecessary for effective predictions

Palaeoenvironmental control on distribution of crinoids in the Bathonian (Middle Jurassic) of England and France

Bulk sampling of a number of different marine and marginal marine lithofacies in the British Bathonian has allowed us to assess the palaeoenvironmental distribution of crinoids for the first time. Although remains are largely fragmentary, many species have been identified by comparison with articulated specimens from elsewhere, whilst the large and unbiased sample sizes allowed assessment of relative proportions of different taxa. Results indicate that distribution of crinoids well corresponds to particular facies. Ossicles of Chariocrinus and Balanocrinus dominate in deeper-water and lower-energy facies,with the former extending further into shallower-water facies than the latter. Isocrinus dominates in shallower water carbonate facies, accompanied by rarer comatulids, and was also present in the more marine parts of lagoons. Pentacrinites remains are abundant in very high-energy oolite shoal lithofacies. The presence of millericrinids within one, partly allochthonous lithofacies suggests the presence of an otherwise unknown hard substrate from which they have been transported. These results are compared to crinoid assemblages from other Mesozoic localities, and it is evident that the same morphological ad-aptations are present within crinoids from similar lithofacies throughout the Jurassic and Early Cretaceous

A community-based geological reconstruction of Antarctic Ice Sheet deglaciation since the Last Glacial Maximum

A robust understanding of Antarctic Ice Sheet deglacial history since the Last Glacial Maximum is important in order to constrain ice sheet and glacial-isostatic adjustment models, and to explore the forcing mechanisms responsible for ice sheet retreat. Such understanding can be derived from a broad range of geological and glaciological datasets and recent decades have seen an upsurge in such data gathering around the continent and Sub-Antarctic islands. Here, we report a new synthesis of those datasets, based on an accompanying series of reviews of the geological data, organised by sector. We present a series of timeslice maps for 20 ka, 15 ka, 10 ka and 5 ka, including grounding line position and ice sheet thickness changes, along with a clear assessment of levels of confidence. The reconstruction shows that the Antarctic Ice sheet did not everywhere reach the continental shelf edge at its maximum, that initial retreat was asynchronous, and that the spatial pattern of deglaciation was highly variable, particularly on the inner shelf. The deglacial reconstruction is consistent with a moderate overall excess ice volume and with a relatively small Antarctic contribution to meltwater pulse 1a. We discuss key areas of uncertainty both around the continent and by time interval, and we highlight potential priorities for future work. The synthesis is intended to be a resource for the modelling and glacial geological community

Impact of Chlamydia trachomatis in the reproductive setting: British Fertility Society Guidelines for practice

Chlamydia trachomatis infection of the genital tract is the most common sexually transmitted infection and has a world-wide distribution. The consequences of infection have an adverse effect on the reproductive health of women and are a common cause of infertility. Recent evidence also suggests an adverse effect on male reproduction. There is a need to standardise the approach in managing the impact of C. trachomatis infection on reproductive health. We have surveyed current UK practice towards screening and management of Chlamydia infections in the fertility setting. We found that at least 90% of clinicians surveyed offered screening. The literature on this topic was examined and revealed a paucity of solid evidence for estimating the risks of long-term reproductive sequelae following lower genital tract infection with C. trachomatis. The mechanism for the damage that occurs after Chlamydial infections is uncertain. However, instrumentation of the uterus in women with C. trachomatis infection is associated with a high risk of pelvic inflammatory disease, which can be prevented by appropriate antibiotic treatment and may prevent infected women from being at increased risk of the adverse sequelae, such as ectopic pregnancy and tubal factor infertility. Recommendations for practice have been proposed and the need for further studies is identified

Psychosocial Treatment of Children in Foster Care: A Review

A substantial number of children in foster care exhibit psychiatric difficulties. Recent epidemiologi-cal and historical trends in foster care, clinical findings about the adjustment of children in foster care, and adult outcomes are reviewed, followed by a description of current approaches to treatment and extant empirical support. Available interventions for these children can be categorized as either symptom-focused or systemic, with empirical support for specific methods ranging from scant to substantial. Even with treatment, behavioral and emotional problems often persist into adulthood, resulting in poor functional outcomes. We suggest that self-regulation may be an important mediat-ing factor in the appearance of emotional and behavioral disturbance in these children

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes.

GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by ∼9720 regulatory modules, of which ∼3000 operate in multiple tissues and ∼970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules. Based on these analyses, we resequence 45 of the corresponding 100 candidate genes in 6600 Crohn disease (CD) cases and 5500 controls, and show with burden tests that they include likely causative genes. Our analyses indicate that ≥10-fold larger sample sizes will be required to demonstrate the causality of individual genes using this approach

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease