Nonlinear dynamics of soft fermion excitations in hot QCD plasma II: Soft-quark - hard-particle scattering and energy losses

In general line with our first work [Yu.A. Markov, M.A. Markova, Nucl. Phys. A 770 (2006) 162] within the framework of semiclassical approximation a general theory for the scattering processes of soft (anti)quark excitations off hard thermal particles in hot QCD-medium is thoroughly considered. The dynamical equations describing evolution for the usual classical color charge $Q^a(t)$ and Grassmann color charges $\theta^i(t), \theta^{\dagger i}(t)$ of hard particle taking into account the soft fermion degree of freedom of the system are suggested. On the basis of these equations and the Blaizot-Iancu equations iterative procedure of calculation of effective currents and sources generating the scattering processes under consideration is defined and their form up to third order in powers of free soft quark field, soft gluon one, and initial values of the color charges of hard particle is explicitly calculated. With use of the generalized Tsytovich principle a connection between matrix elements of the scattering processes and the effective currents and sources is established. In the context of the effective theory suggested for soft and hard fermion excitations new mechanisms of energy losses of high-energy parton propagating through QCD-medium are considered.Comment: 85 pages, 15 figures, added new appendix A, section 10 is removed, mistakes, and typing errors are corrected. Version to appear in Nucl. Phys.

The turmeric protective properties at ethanol-induced behavioral disorders.

The aim of the study was to determine the effect of mechanically modified turmeric extract on the parameters of orienting-exploratory behavior in mice with chronic ethanol consumption. Material and methods. Mice behavior was assessed in the "open field" test. In the both control groups the animals received water or 10% ethanol solution; in the test group — turmeric extract in 10% ethanol solution. Amount of blood mononuclear cells, thymocytes, and splenocytes were estimated. Results. Analysis of the behavioral parameters in animals after chronic exposure to ethanol showed suppression of motor and exploratory components of the behavior. In mice that received both ethanol and turmeric extract recorded behavior parameters were significantly higher than in the group of animals who received ethanol only. It was shown that the turmeric extract enhances the amount of blood immune cells. Conclusion. Mechanically modified turmeric extract possesses protective properties against ethanol-induced behavioral disorders.</p

Nonlinear dynamics of soft boson excitations in hot QCD plasma I: plasmon-plasmon scattering

On the basis of pure gauge sector of Blaizot-Iancu equation, we derive kinetic equation of Boltzmann type, taking into account 2n+2-colorless plasmon decay processes, n=1,2,.... Using so-called Tsytovich correspondence principle, a direct connection between matrix elements of the plasmon decay processes and certain effective current, generating these processes, is established. The procedure of calculation of matrix element for simplest four-plasmon decay is considered comprehensively. The limiting value of the plasmon occupation number (~ 1/g^2, where g is a strong coupling) wherein all plasmon decays with n >= 1, contribute to the right-hand side of the Boltzmann equation, is defined. The iterative method of calculation of matrix elements for higher decay processes (n > 1), is proposed, and a problem of their gauge-invariance is discussed. Proceed from the general reasons the problem of extension of suggested approach to the case of color plasmons, is considered. The explicit form of linearized Boltzmann equation for color plasmons is written out, and it is shown that this equation covariantly conserves the color current, resulting from color-plasmon number density.Comment: 41 pages, LaTeX, 2 figures in P

Nonlinear dynamics of soft fermion excitations in hot QCD plasma I: soft-quark - soft-gluon scattering

Within the framework of the hard thermal loop effective theory we derive a system of Boltzmann-like kinetic equations taking into account the simplest processes of nonlinear interaction of soft fermionic and bosonic QCD plasma excitations: elastic scattering of soft-(anti)quark excitations off soft-gluon and soft-quark excitations, pair production of soft quark-antiquark excitations, annihilation into two soft-gluon excitations. The matrix elements of these processes to leading order in the coupling constant $g$ are obtained. The iterative method of calculation of the matrix elements for the higher processes of soft-mode interactions is proposed. The most general expression for the emitted radiant power induced by the effective currents and effective sources in a quark-gluon plasma (QGP) taking into account an existence of fermion sector of plasma excitations is defined. The explicit form of the linearized Boltzmann equation accounting for scattering of color(less) plasminos off color(less) plasmons is written out.Comment: 54 pages, 5 EPS figures, some important changes in sections 2,5,7,8. Introduction and conclusion are expanded. The version accepted for the publication in Nucl. Phys.

Взаимосвязь полиморфных локусов, расположенных в промоторных областях генов VEGF (rs699947 и rs2010963), ICAM1 (rs281437) и ET-1 (rs1800541), с уровнем соответствующих белковых продуктов в сыворотке крови и риском развития алкогольного цирроза печени

Background: Uncontrolled use of alcohol can lead to the development of cirrhosis of the liver, which is manifested by fibrosis with the formation of regenerative nodes, an increase in pressure in the portal vein system and impaired liver function. Hepatic endothelium dysfunction during the formation of portal hypertension is accompanied by an increase in the level of protein molecules involved in the functioning of the endothelium: vascular endothelial growth factor A (VEGF-A), a soluble form of the intercellular adhesion molecule (s-ICAM-1) and endothelin-1 (ET -one). It is assumed that elevated levels of VEGF-A, s-ICAM-1 and ET-1 in alcoholic liver cirrhosis (AHC) may be interconnected with the structure of polymorphic loci, the promoter regions of the respective genes, which in turn may be a genetic risk factor for developing cirrhosis.Aims: Investigate the relationship of carriage of variant forms of polymorphic loci located in the promoter regions of VEGF-A, ICAM-1 and ET-1 with the level of the corresponding proteins in the blood serum and the risk of AHC.Materials and methods: The main group consisted of patients with pathological dependence on alcohol, aggravated by cirrhosis of the liver (AHC, n=60). The control group consisted of persons suffering from alcohol abuse, without liver pathology (AA, n=24). The observation period was the period of hospitalization. The serum levels of VEGF-A, s-ICAM-1 and ET-1 were evaluated by enzyme immunoassay. The distribution of variant forms of polymorphic loci located in the promoter regions of the VEGF-A genes (rs699947 and rs2010963), ICAM1 (rs281437) and ET-1 (rs1800541) in the studied sample was performed by real-time PCR.Results: The development of alcoholic cirrhosis was accompanied by a significant increase in the concentration of VEGF-A, s-ICAM-1 and ET-1 in serum. At the same time, direct correlations between the concentrations of VEGF-A, s-ICAM-1 and ET-1 in serum and the diameter of the portal vein in persons with liver cirrhosis were revealed. Patients with AHC are often carriers of the G allele of rs1800541 locus, located in the promoter of the ET-1 gene, compared with individuals suffering from control without liver pathology, which is associated with an increased risk of developing cirrhosis in alcohol dependence. The carriage of the C allele rs699947, as well as the C allele rs2010963 located in the promoter of the VEGF gene was associated with an increased level of VEGF-A in the AHC compared to carriers of this allele in the AA group. In addition, in the group of patients with AHC, carriers of allele C, homozygous CC genotype and heterozygous GC genotype of rs2010963 locus compared with carriers of G allele or homozygous GG genotype, respectively, were characterized by elevated serum VEGF-A levels.Conclusion: Carrier allele G of the rs1800541 locus (ET-1) is a risk factor for liver cirrhosis with alcohol abuse. The carriage of the C allele rs699947, as well as the C allele rs2010963 located in the promoter of the VEGF gene, can determine the elevated serum VEGF-A level in the AHC.Обоснование. Неконтролируемое употребление алкоголя может обусловливать развитие цирроза печени, который проявляется фиброзом с образованием узлов-регенератов, повышением давления в системе воротной вены и нарушением функции печени. Дисфункция печеночного эндотелия при формировании портальной гипертензии сопровождается повышением уровня молекул белковой природы, участвующих в функционировании эндотелия, ― васкулоэндотелиального фактора роста А (VEGF-A), растворимой формы молекулы межклеточной адгезии (s-ICAM-1) и эндотелина-1 (ET-1). Предполагается, что повышенный уровень VEGF-A, s-ICAM-1 и ET-1 при алкогольном циррозе печени (АЦП) может быть взаимосвязан со строением полиморфных локусов промоторных областей соответствующих генов, что в свою очередь может являться генетическим фактором риска развития цирроза печени.Цель ― исследовать взаимосвязь носительства вариантных форм полиморфных локусов, расположенных в промоторных областях VEGF-A, ICAM-1 и ET-1, с уровнем соответствующих белков в сыворотке крови и риском развития АЦП.Методы. Основную группу составили пациенты с патологической зависимостью от алкоголя, отягощенной циррозом печени (АЦП, n=60). Группу контроля составили лица, страдающие алкогольной зависимостью, без патологии печени (АЗ, n=24). Период наблюдения равнялся периоду госпитализации. Содержание VEGF-A, s-ICAM-1 и ET-1 в сыворотке крови оценивали посредством иммуноферментного анализа. Распределение вариантных форм полиморфных локусов, расположенных в промоторных областях генов VEGF-A (rs699947 и rs2010963), ICAM1 (rs281437) и ET-1 (rs1800541), в исследуемой выборке проводили с помощью полимеразной цепной реакции в режиме реального времени.Результаты. Развитие алкогольного цирроза печени сопровождалось значительным повышением концентрации VEGF-A, s-ICAM-1 и ET-1 в сыворотке крови. При этом были выявлены прямые корреляционные отношения между значениями концентрации VEGF-A, s-ICAM-1 и ET-1 в сыворотке крови и диаметром портальной вены у лиц с циррозом печени. Пациенты с АЦП чаще являются носителями аллеля G локуса rs1800541, расположенного в промоторе гена ET-1, по сравнению с лицами, страдающими АЗ без патологии печени, что сопряжено с повышенным риском развития цирроза при алкогольной зависимости. Носительство аллеля С локуса rs699947, а также аллеля С локуса rs2010963, расположенных в промоторе гена VEGF, было связано с повышенным уровнем VEGF-A при АЦП по сравнению носителями данного аллеля в группе АЗ. Кроме того, в группе пациентов с АЦП носители аллеля С, гомозиготного генотипа СС и гетерозиготного генотипа GC локуса rs2010963 по сравнению с носителями аллеля G или гомозиготного генотипа GG соответственно характеризовались повышенным уровнем VEGF-A в сыворотке крови.Заключение. Носительство аллеля G локуса rs1800541 (ET-1) является фактором риска развития цирроза печени при злоупотреблении алкоголем. Носительство аллеля С локуса rs699947, а также аллеля С локуса rs2010963, расположенных в промоторе гена VEGF, может определять повышенный уровень VEGF-А в сыворотке крови при АЦП

Nonlinear dynamics of soft boson collective excitations in hot QCD plasma III: bremsstrahlung and energy losses

Within of the framework of semiclassical approximation a general formalism for deriving an effective current generating bremsstrahlung of arbitrary number of soft gluons (longitudinal or transverse ones) in scattering of higher-energy parton off thermal parton in hot quark-gluon plasma with subsequent extension to two and more scatterers, is obtained. For the case of static color centers an expression for energy loss induced by usual bremsstrahlung of lowest-order with allowance for an effective temperature-induced gluon mass and finite mass of the projectile (heavy quark), is derived. The detailed analysis of contribution to radiation energy loss associated with existence of effective three-gluon vertex induced by hot QCD medium, is performed. It is shown that in general, the bremsstrahlung associated with this vertex have no sharp direction (as in the case of usual bremsstrahlung) and therefore here, we can expect an absence of suppression effect due to multiple scattering. For the case of two color static scattering centers it was shown that the problem of calculation of bremsstrahlung induced by four-gluon hard thermal loop (HTL) vertex correction can be reduced to the problem of the calculation of bremsstrahlung induced by three-gluon HTL correction. It was shown that for limiting value of soft gluon occupation number $N_{\bf k}\sim 1/\alpha_s$ all higher processes of bremsstrahlung of arbitrary number of soft gluons become of the same order in coupling, and the problem of resummation of all relevant contributions to radiation energy loss of fast parton, arises. An explicit expression for matrix element of two soft gluon bremsstrahlung in small angles approximation is obtained.Comment: 68 pages, 9 EPS figures; added new sections 8, 10 and reference

Fragmentation processes of ionized 5-fluorouracil in the gas phase and within clusters

We have measured mass spectra for positive ions produced from neutral 5-fluorouracil by electron impact at energies from 0 to 100 eV. Fragment ion appearance energies of this (radio-)chemotherapy agent have been determined for the first time and we have identified several new fragment ions of low abundance. The main fragmentations are similar to uracil, involving HNCO loss and subsequent HCN loss, CO loss, or FCCO loss. The features adjacent to these prominent peaks in the mass spectra are attributed to tautomerization preceding the fragmentation and/or the loss of one or two additional hydrogen atoms. A few fragmentions are distinct for 5-fluorouracil compared to uracil, most notably the production of the reactive moiety CF+. Finally, multiphoton ionization mass spectra are compared for 5-fluorouracil from a laser thermal desorption source and from a supersonic expansion source. The detection of a new fragment ion at 114 u in the supersonic expansion experiments provides the first evidence for a clustering effect on the radiation response of 5-fluorouracil. By analogy with previous experiments and calculations on protonated uracil, this is assigned to NH3 loss from protonated 5-fluorouracil

Clinical value of complex ambulatory monitoring of blood pressure and arterial rigidity in elderly patients

Aim. To study the clinical and diagnostic role of pulse wave time (PWT) in 24-hour blood pressure monitoring (BPM) and its link to elasticity of larger arteries and aorta (carotid-femoral pulse wave velocity, PWVcf, cardioankle vascular index, CAVI) in patients aged over 75 years. Material and methods. The study included 52 patients (20 men) aged over 75 years (mean age 79,1 3,5 years) with arterial hypertension (AH). Fifteen participants had cardiovascular events (CVE) in anamnesis: myocardial infarction, MI (n=11) or stroke (n=4). Sixteen patients had Functional Class II-III angina (n=16), and 32 received antihypertensive therapy. 24-hour BM P and PWT parameters were measured. Corrected PWT 100-60 was calculated for systolic BP (SBP) 100 mm Hg and heart rate (HR) 60 bpm. PWVcf and CAVI were assessed with a screening device VS 1000 VaSera, Fukuda Denshi, Japan. Results. In all participants, clinical BP level was 147,5 +/- 6,9/76,5 +/- 5,1 nim Hg; 24-hour BPM BP level - 139,6 +/- 6,7/70,7 +/- 4,6 mm Hg; PWT 100-60 - 161,7 +/- 6,2 ms; PVWcf - 17,3 +/- 4,6 m/s, and CAVI - 10,6 +/- 3,1. A significant negative correlation between PWT 100-60 and 24-hour BPM SBP (r=-0,36, p<0,05), 24-hour BPM PBP (r=-0,43, p<0,01), PWcf (r=-0,54, p<0,01) and CAVI (r=-0,34, p<0,05) was observed. Patients with and without CVE were comparable by age. CVE-free participants were characterised by lower frequency of antihypertensive therapy, higher levels of clinical BP (153,5 +/- 6,9/82,5 +/- 6,3 vs. 136,5 +/- 3,4/71,1 +/- 3,9 mm Hg), higher 24-hour BPM BP (144,0 +/- 6,9/73,2 +/- 5,3 vs. 132,6 +/- 4,2/69,3 +/- 3,8 mm Hg), lower PVWcf (15,8 +/- 4 vs. 18,7 +/- 4,4 m/s), lower CAVI (9,7 +/- 2,4 vs. 11,5 +/- 3,8), and higher PWT 100-60 (167 +/- 5,4 vs. 156,2 +/- 6,9 ms; p<0,05). Conclusion. In AH patients aged over 75 years, PWT 100-60 correlated with traditional indices of arterial rigidity. Lower PWT 100-60 and higher PWV were observed among individuals with CVE in anamnesis

The development of portal hypertension and liver failure on the background of long-term intake of vitamin A in a young woman. Case report [Развитие портальной гипертензии и печеночной недостаточности у молодой женщины на фоне длительного приема витамина А. Клиническое наблюдение]

The use of over-the-Counter (OTC) pharmaceuticals is a common phenomenon in today's society. We present a case of liver injury associated with long-term OTC use of vitamin A. The young patient took daily up to 15 capsules of a combined preparation for 2 years containing retinol palmitate 55 mg (100,000 IU) + Alpha-Tocopherol acetate 100 mg, the content of vitamin A in which significantly exceeded the recommended daily dose. Gradually, the patient noted the appearance of arthralgia, skin itching, hyperemia of the palms and feet, exfoliation of the skin on the soles, profuse hair loss, cracks in the corners of the mouth and in the area of the earlobes. Patient's condition worsened with the development of signs of liver cirrhosis in the form of portal hypertension (ascites, splenomegaly) and a decrease in the protein-synthetic function of the organ. Chronic viral hepatitis, autoimmune hepatitis, primary biliary cirrhosis, hemochromatosis, Wilson's disease, alcoholic liver disease were exclude. Liver biopsy showed characteristic signs of hypervitaminosis A without fibrosis. A complete regression of symptoms was observe within 8 months after discontinuation of the drug. A toxicity can lead to serious liver injury and should be considere in the differential diagnosis of chronic liver disease. Vitamin A should only be prescribe for medical reasons, for a limited period of time, and under close medical supervision. © 2022 Consilium Medikum. All rights reserved