Influence of the megathrust earthquake cycle on upper-plate deformation in the Cascadia forearc of Washington State, USA

The influence of subduction zone earthquake cycle processes on permanent forearc deformation is poorly understood. In the Cascadia subduction zone forearc of Washington State, USA, deformed and incised fluvial terraces serve as archives of longer-term (103–104 yr) strain manifest as both fluvial incision and slip on upper-plate faults. We focus on comparing these geomorphic records in the Wynoochee River valley in the southern Olympic Mountains with short-term (101 yr) deformation driven by interseismic subduction zone coupling. We use optically stimulated luminescence dating and high-resolution elevation data to characterize strath terrace incision and differential uplift across the Canyon River fault, which cuts Wynoochee River terraces. This analysis demonstrates reverse slip rates of ∼0.1–0.3 mm/yr over the past ∼12–37 k.y., which agree with rates predicted by a GPS-constrained boundary element model of interseismic stress from Cascadia subduction zone coupling. Similarly, model-predicted patterns of interseismic uplift mimic the overall pattern of incision in the lower Wynoochee River valley, as revealed by strath elevations dated at 14.1 ± 1.2 ka. Agreement between modeled short-term and observed long-term records of forearc strain suggests that interseismic stress drives slip on upper-plate faults and fluvial incision in Cascadia. Consistency over multiple time scales may indicate relative stability in spatial patterns of subduction zone coupling over at least ∼104 yr intervals

What to do about Inequality? Support for the European Union and Further European Integration in the Republic of Ireland

This paper investigates individual’s perceptions of inequality and the impact this has on mass public opinion support for the European Union (EU) in the Republic of Ireland. This question is posed in the context of the onset of the economic and financial crisis of 2007/8 as the crisis can be regarded as a critical juncture in Ireland’s relationship with the EU as a result of the economic downturn and the widening of economic disparities individuals have experienced. Ireland is a critical case in examining EU support as since its accession to the EU in 1973 it is often considered an exemplar of what the EU could offer small member states with a strongly pro-integrationist mass public. Using Ordinary Least Squares (OLS) multiple regression analysis on 2009 European Election Study (EES) data, this paper shows that individuals’ concerns about inequality lowers support for the EU as it is currently constituted, but increases support for continued European integration. This suggests that individual-levels of support may be in a precarious state, yet they can be salvaged as individuals in Ireland regard the EU as the institutional-driving force to address market-generated inequality

Measurement of the CMS Magnetic Field

The measurement of the magnetic field in the tracking volume inside the superconducting coil of the Compact Muon Solenoid (CMS) detector under construction at CERN is done with a fieldmapper designed and produced at Fermilab. The fieldmapper uses 10 3-D B-sensors (Hall probes) developed at NIKHEF and calibrated at CERN to precision 0.05% for a nominal 4 T field. The precise fieldmapper measurements are done in 33840 points inside a cylinder of 1.724 m radius and 7 m long at central fields of 2, 3, 3.5, 3.8, and 4 T. Three components of the magnetic flux density at the CMS coil maximum excitation and the remanent fields on the steel-air interface after discharge of the coil are measured in check-points with 95 3-D B-sensors located near the magnetic flux return yoke elements. Voltages induced in 22 flux-loops made of 405-turn installed on selected segments of the yoke are sampled online during the entire fast discharge (190 s time-constant) of the CMS coil and integrated offline to provide a measurement of the initial magnetic flux density in steel at the maximum field to an accuracy of a few percent. The results of the measurements made at 4 T are reported and compared with a three-dimensional model of the CMS magnet system calculated with TOSCA.Comment: 4 pages, 5 figures, 15 reference

The hidden link of exosomes to head and neck cancer

Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Head and neck squamous cell carcinoma (HNSCC) represents an aggressive and heteroge-nous group of cancers whose pathologies remain largely unresolved. Despite recent advances in HNSCC therapeutic strategies, the overall survival of HNSCC patients remains poor and continues to prompt efforts to develop more effective therapies. Exosomes are a subtype of extracellular vesicles secreted by a variety of cells that have begun to spark significant interest in their roles in cancer. As membranous vesicles, spanning from 30–150 nm in diameter, exosomes mediate the transport of various molecules, such as proteins, nucleic acids, and lipids, intercellularly throughout the body. In doing so, exosomes not only act to deliver materials to cancer cells but also as signals that can confer their progression. Accumulating evidence shows the direct correlation between exosomes and the aggressiveness of HNSCC. However, more research is warranted in this field to further our under-standing. In this review, we attempt to highlight the tumor-supporting roles and therapeutic potential of exosomes in HNSCC. We introduce first the biogenesis and component features of exosomes, followed by their involvement in HNSCC proliferation and metastasis. We then move on to discuss HNSCC-derived exosomes’ influence on the tumor microenvironment and their function in tumor drug resistance. Finally, we explore the promising potential of exosomes as HNSCC biomarkers and therapeutic targets and drug carriers for HNSCC treatments.Peer reviewe

Status of the CMS magnet (MT17)

The CMS experiment (Compact Muon Solenoid) is a general-purpose detector designed to run at the highest luminosity at the CERN Large Hadron Collider (LHC). Its distinctive features include a 4 T superconducting solenoid with a free bore of 6 m diameter and 12.5-m length, enclosed inside a 10 000-ton return yoke. The magnet will be assembled and tested in a surface hall at Point 5 of the LHC at the beginning of 2004 before being transferred by heavy lifting means to an experimental hall 90 m below ground level. The design and construction of the magnet is a common project of the CMS Collaboration. The task is organized by a CERN based group with strong technical and contractual participation from CEA Saclay, ETH Zurich, Fermilab, INFN Genova, ITEP Moscow, University of Wisconsin and CERN. The magnet project will be described, with emphasis on the present status of the fabrication. (15 refs)

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE

Search for New Physics with Jets and Missing Transverse Momentum in pp collisions at sqrt(s) = 7 TeV

A search for new physics is presented based on an event signature of at least three jets accompanied by large missing transverse momentum, using a data sample corresponding to an integrated luminosity of 36 inverse picobarns collected in proton--proton collisions at sqrt(s)=7 TeV with the CMS detector at the LHC. No excess of events is observed above the expected standard model backgrounds, which are all estimated from the data. Exclusion limits are presented for the constrained minimal supersymmetric extension of the standard model. Cross section limits are also presented using simplified models with new particles decaying to an undetected particle and one or two jets