Detection of Two Massive CO Systems in 4C 41.17 at z = 3.8

We have detected CO(4-3) in the z=3.8 radio galaxy 4C 41.17 with the IRAM Interferometer. The CO is in two massive (M_dyn ~ 6 x 10^10 M_Sun) systems separated by 1.8" (13 kpc), and by 400 km/s in velocity, which coincide with two different dark lanes in a deep Ly-alpha image. One CO component coincides with the cm-radio core of the radio galaxy, and its redshift is close to that of the HeII AGN line. The second CO component is near the base of a cone-shaped region southwest of the nucleus, which resembles the emission-line cones seen in nearby AGN and starburst galaxies. The characteristics of the CO sources and their mm/submm dust continuum are similar to those found in ultraluminous IR galaxies and in some high-z radio galaxies and quasars. The fact that 4C 41.17 contains two CO systems is further evidence for the role of mergers in the evolution of galaxies at high redshift.Comment: 5 Pages, including 4 PostScript figures. Accepted for publication in Astronomy & Astrophysics Letter

Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge

Activation of NF-E2-related factor 2 (Nrf2) is a potential therapeutic intervention against endothelial cell oxidative stress and associated vascular disease. We hypothesized that treatment with the phytochemicals in the patented dietary supplement Protandim would induce Nrf2 nuclear localization and phase II antioxidant enzyme protein in human coronary artery endothelial cells (HCAECs), protecting against an oxidant challenge in an Nrf2- dependent manner. Protandim treatment induced Nrf2 nuclear localization, and HO-1 (778% of control ± 82.25 P < 0.01), SOD1 (125.9% of control ± 6.05 P < 0.01), NQO1 (126% of control ± 6.5 P < 0.01), and GR (119.5% of control ± 7.00 P < 0.05) protein expression in HCAEC. Treatment of HCAEC with H2O2 induced apoptosis in 34% of cells while pretreatment with Protandim resulted in only 6% apoptotic cells (P < 0.01). Nrf2 silencing significantly decreased the Protandim-induced increase in HO-1 protein (P < 0.01). Nrf2 silencing also significantly decreased the protection afforded by Protandim against H2O2- induced apoptosis (P < 0.01 compared to no RNA, and P < 0.05 compared to control RNA). These results show that Protandim induces Nrf2 nuclear localization and antioxidant enzyme expression, and protection of HCAEC from an oxidative challenge is Nrf2 dependent

Effectiveness of current policing-related mental health interventions in England and Wales and Crisis Intervention Teams as a future potential model: a systematic review

Background Experiencing mental ill health adds a layer of complexity for individuals in touch with the justice system and for those responsible for working in the justice service with these individuals, such as frontline police officers. In England and Wales, there are three commonly used but not necessarily commonly designed or operated, mental health interventions associated with policing, Liaison and Diversion, Street Triage and specialist staff embedded in Police Contact Control Rooms. A fourth US designed model, Crisis Intervention Teams (CITs), is now attracting some interest in England and Wales, and these four are to be considered in this review. A fifth intervention, Mental Health Courts, was trialed but has now been abandoned in England and Wales and so has been excluded, but remains in use elsewhere. In recent years, there has been an increase in the level of investment related to these intervention options. This has largely been without an evidence base being available to aid design, structure, and consistency of approach. The review will address this gap and provide a systematic review of each of these options. This will provide a baseline of research evidence for those who commission and provide services for individuals experiencing mental ill health and who are in contact with the justice system. Methods Twenty-nine relevant databases and sources have been selected which will be systematically searched to locate relevant studies. These studies have to meet the set inclusion criteria which require them to report an objective outcome measure(s) in respect of offending or mental health outcomes and to have an experimental or quasi-experimental design including a comparator group(s) or a pre/post comparison. The review will exclude PhD theses, papers in non-English languages and papers published prior to 1980. Keywords have been collected through canvassing experts’ opinion, literature review, controlled vocabulary and reviewing the results of a primary scoping review carried out to aid the development of the PICO, composed of Population/Participants, Intervention/Indicator, Comparator/Control, and Outcomes. For the proposed review, the key elements of the PICO are the following: persons with mental health problems, symptoms or diagnoses who come into contact with the police; interventions involving partnership working between police and mental health nurses and related professionals to divert those with mental health problems away from criminal justice processes; comparisons with control groups or areas where such interventions have not been introduced; and outcomes concerning criminal justice and health outcomes. The results of the searches will be screened using the set criteria and the selected papers reviewed and analysed to allow findings regarding these interventions to be reported. Discussion The objectives of the review are firstly to identify and report research on the relevant interventions, nationally and internationally and then secondly to consider, when possible, which interventions or aspects of those interventions are effective. This is judged with regard to changes in mental health status or service use and future offending behaviour. The approaches to be considered have gained a good deal of support and funding over recent years, and this review will provide a systematic review of the underpinning research evidence to inform future commissioning, service design and investment decisions

The Discovery of a Large Lyman-alpha+HeII Nebula at z~1.67: A Candidate Low Metallicity Region?

We have discovered a ~45 kpc Lya nebula (or Lya ``blob'') at z~1.67 which exhibits strong, spatially-extended HeII emission and very weak CIV and CIII] emission. This is the first spatially-extended Lya+HeII emitter observed and the lowest redshift Lya blob yet found. Strong Lya and HeII-1640 emission in the absence of metal lines has been proposed as a unique observational signature of primordial galaxy formation (e.g., from gravitational cooling radiation or Population III star formation), but no convincing examples of spatially-extended Lya+HeII emitters have surfaced either in Lya-emitting galaxy surveys at high redshifts (z > 4) or in studies of Lya nebulae at lower redshifts. From comparisons with photoionization models, we find that the observed line ratios in this nebula are consistent with low metallicity gas (Z < 10^-2 - 10^-3 Z_sun), but that this conclusion depends on the unknown ionization parameter of the system. The large HeII equivalent width (~37+/-10A) and the large HeII/Lya ratio (0.12+/-0.04) suggest that the cloud is being illuminated by a hard ionizing continuum, either an AGN or very low metallicity stars, or perhaps powered by gravitational cooling radiation. Thus far there is no obvious sign of a powerful AGN in or near the system, so in order to power the nebula while remaining hidden from view even in the mid-infrared, the AGN would need to be heavily obscured. Despite the strong Lya+HeII emission, it is not yet clear what is the dominant power source for this nebula. The system therefore serves as an instructive example of how the complexities of true astrophysical sources will complicate matters when attempting to use a strong Lya+HeII signature as a unique tracer of primordial galaxy formation.Comment: Accepted for publication in ApJ; emulateapj format, 17 pages, 7 figures, 3 tables; updated coordinate

Ly-alpha excess in high redshift radio galaxies: a signature of star formation

About 54% of radio galaxies at z>3 and 8% of radio galaxies at 2<z<3 show unusually strong Ly-alpha emission, compared with the general population of high redshift (z>2) radio galaxies. These Ly-alpha excess objects (LAEs) show Ly-alpha/HeII values consistent with or above standard photoionization model predictions. We show that the most successful explanation is the presence of a young stellar population which provides the extra supply of ionizing photons required to explain the Ly-alpha excess in at least the most extreme LAEs (probably in all of them). The measurement of unusually high Ly-alpha ratios in the extended gas of some high redshift radio galaxies suggests that star formation activity occurs in spatial scales of tens of kpc. We argue that, although the fraction of LAEs may be incompletely determined, both at 23, the much larger fraction of LAEs found at z>3 is a genuine redshift evolution and not due to selection effects. Therefore, our results suggest that the radio galaxy phenomenon is more often associated with a massive starburst at z>3 than at z<3.Comment: 14 pages, 5 figures, accepted for publication in MNRA

The relationship between the optical Halpha filaments and the X-ray emission in the core of the Perseus cluster

NGC 1275 in the centre of the Perseus cluster of galaxies, Abell 426, is surrounded by a spectacular filamentary Halpha nebula. Deep Chandra X-ray imaging has revealed that the brighter outer filaments are also detected in soft X-rays. This can be due to conduction and mixing of the cold gas in the filaments with the hot, dense intracluster medium. We show the correspondence of the filaments in both wavebands and draw attention to the relationship of two prominent curved NW filaments to an outer, buoyant radio bubble seen as a hole in the X-ray image. There is a strong resemblance in the shape of the hole and the disposition of the filaments to the behaviour of a large air bubble rising in water. If this is a correct analogy, then the flow is laminar and the intracluster gas around this radio source is not turbulent. We obtain a limit on the viscosity of this gas.Comment: Accepted for publication in MNRA

Black hole growth and stellar assembly at high-z

Context. Observations indicate a strong link between star formation and black hole (BH) growth, but some questions remain unanswered: whether both activities are coeval or whether one precedes the other, what their characteristic timescales are, and what kinds of physical processes are responsible for this interplay. Aims. We examine stellar and BH masses (M_star and M_BH) in z~2 active systems at the peak of their AGN or star formation activity to investigate how they are linked and whether AGN radiative or else radio power provides a feedback mechanism that regulates the stellar growth in these systems. Methods. We analyze the infrared (IR) spectral energy distributions of radio, sub-millimeter and mid-IR selected AGNs at z~1-3 and constrain their stellar and AGN luminosities using AGN and host-galaxy templates. Results. We find evidence of increasing stellar light, thereby decreasing the AGN mid-IR power going from mid-IR selected AGNs, to radio galaxies, and to sub-millimeter AGNs. This trend can be explained by either decreasing Eddington ratios or increasing offsets from the local M_BH-M_star relation. All systems are characterized by high star formation rates regardless of their different AGN powers, thus neither AGN radiative power nor AGN-driven radio activity seems to influence the star formation rate in the selected AGNs. We discuss two possible evolutionary scenarios that might link these three AGN classes.Comment: A&A Letters accepte

Why Wait Until Our Community Gets Cancer?: Exploring CRC Screening Barriers and Facilitators in the Spanish-Speaking Community in North Carolina

Colorectal cancer (CRC) is a leading cause of death among Hispanics in the United States. Despite the benefits of CRC screening, many Hispanics are not being screened. Using a combined methodology of focus groups and discrete choice experiment (DCE) surveys, the objectives for this research were as follows: (1) to improve understanding of preferences regarding potential CRC screening program characteristics, and (2) to improve understanding of the barriers and facilitators around CRC screening with the Hispanic, immigrant community in North Carolina. Four gender-stratified focus groups were conducted and DCE surveys were administered to 38 Spanish-speaking individuals across four counties in North Carolina. In-depth content analysis was used to examine the focus group data; descriptive analyses and mean attribute importance scores for cost of screening and follow-up care, travel time, and test options were calculated from DCE data. Data analyses showed that this population has a strong interest in CRC screening but experience barrier such as lack of access to resources, cost uncertainty, and stigma. Some of these barriers are unique to their cultural experiences in the United States, such as an expressed lack of tailored CRC information. Based on the DCE, cost variables were more important than testing options or travel time. This study suggests that Hispanics may have a general awareness of and interest in CRC screening, but multiple barriers prevent them from getting screened. Special attention should be given to designing culturally and linguistically appropriate programs to improve access to healthcare resources, insurance, and associated costs among Hispanics