[18F]-Fluorodeoxyglucose-positron emission tomography in rats with prolonged cocaine self-administration suggests potential brain biomarkers for addictive behavior

The DSM5-based dimensional diagnostic approach defines substance use disorders on a continuum from recreational drug use to habitual and ultimately addicted behavior. Biomarkers that are indicative of recreational drug use and addicted behavior are lacking. We performed a translational [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) study in the multi-dimensional 0/3crit model of cocaine addiction. Addict-like (3crit) and non-addict-like (0crit) rats, which shared identical life conditions and levels of cocaine self-administration, were acquired for FDG-PET under baseline conditions and following cocaine and yohimbine challenges. Compared to cocaine-naïve control rats, 0crit animals showed higher glucose uptake in the caudate putamen (CPu) and medial prefrontal cortex (mPFC) respect to naïve controls. 3crit animals did not show this adaptive higher glucose utilization, but had lower uptake in several cortical areas. Both cocaine and yohimbine challenges affected glucose uptake in control rats in several brain sites, but not in 0crit and 3crit rats, indicating that impaired glucose mobilization in response to these challenges is not specifically associated with addictive behavior. Compared to 0crit, 3crit rats showed higher reinstatement responses, which were negatively associated with glucose uptake in the ventral tegmental area. Data indicate that cocaine non-addict- and addict-like phenotypes are associated with several potential biomarkers. Specifically, we propose that increased glucose uptake in the CPu and mPFC is a function of controlled drug use, whereas a loss of striatal and prefrontal metabolic activity and reduced uptake in cortical areas are indicative of addictive behavior

Histoquímica de la fase progámica en Capsicum Pubescens

Capsicum pubescens Ruiz & Pav. (Solanaceae), conocido como ‘ají rocoto’, en Argentina se cultiva principalmente en el NO del territorio. En esta especie existe un amplio rango de variación en el nivel de compatibilidad, pero se desconocen los mecanismos que la regulan.Fil: Bo, M. L. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Bo, M. L. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Cosa, M. T. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Carrizo García, C. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Carrizo García, C. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Cosa, M. T. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Ciencias de las Plantas, Botánic

Caracteres histológicos de frutos definen sinapomorfías y plesiomorfías en la familia Solanaceae

Fil: Machado, A.S. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Cosa, M. T. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Barboza, G. E. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Solananceae es una familia cosmopolita con especies de importancia económica y medicinal. Los frutos representan la unidad de dispersión de las semillas y están sometidos a presiones selectivas; por lo que son altamente homoplásicos (Knapp, 2002).Fil: Machado, A.S. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Cosa, M. T. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Barboza, G. E. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Ciencias de las Plantas, Botánic

Característica de la epidermis foliar y mesofilo de siete especes de deprea (solanaceae)

Fil: Deanna, R. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Deanna, R. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Cosa, M. T. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Barboza, G. E. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Barboza, G. E. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Stiefkens, L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Deprea Raf. es un género numeroso (49 spp.) que habita el centro y norte de los Andes. Recientemente, se realizaron estudios taxonómicos, filogenéticos y cromosómicos, que condujeron a cambios en su circunscripción y posición taxonómica.Fil: Deanna, R. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Deanna, R. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Cosa, M. T. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Barboza, G. E. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Barboza, G. E. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Stiefkens, L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Ciencias de las Plantas, Botánic

Anatomía vegetativa e histoquímica en Cynanchum bonariense (Apocynaceae)

Fil: Bravi, V. S. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Morfología Vegetal; Argentina.Fil: Cosa, M. T. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Morfología Vegetal; Argentina.Fil: Pacciaroni, A. del V. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Pacciaroni, A. del V. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Wiemer, A. P. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Morfología Vegetal; Argentina.Cynanchum bonariense (Decne.) T. Mey es una enredaderanativa que habita en los bordes de caminos, sobre arbustos, árboles bajos y está ampliamente distribuida en la zona centro y norte de Argentina. Presenta abundante látex de color blanco.El objetivo del presente trabajo fue realizarun análisis anatómico comparativo de los órganos vegetativos con especial atención en los laticíferos.Fil: Bravi, V. S. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Morfología Vegetal; Argentina.Fil: Cosa, M. T. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Morfología Vegetal; Argentina.Fil: Pacciaroni, A. del V. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Pacciaroni, A. del V. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Wiemer, A. P. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Morfología Vegetal; Argentina.Ciencias de las Plantas, Botánic

Measurement of diffraction dissociation cross sections in pp collisions at s\sqrt{s} = 7 TeV

Measurements of diffractive dissociation cross sections in pp collisions at s√=7  TeV are presented in kinematic regions defined by the masses MX and MY of the two final-state hadronic systems separated by the largest rapidity gap in the event. Differential cross sections are measured as a function of ξX=M2X/s in the region −5.53, log10MX>1.1, and log10MY>1.1, a region dominated by DD. The cross sections integrated over these regions are found to be, respectively, 2.99±0.02(stat)+0.32−0.29(syst)  mb, 1.18±0.02(stat)±0.13(syst)  mb, and 0.58±0.01(stat)+0.13−0.11(syst)  mb, and are used to extract extrapolated total SD and DD cross sections. In addition, the inclusive differential cross section, dσ/dΔηF, for events with a pseudorapidity gap adjacent to the edge of the detector, is measured over ΔηF=8.4 units of pseudorapidity. The results are compared to those of other experiments and to theoretical predictions and found compatible with slowly rising diffractive cross sections as a function of center-of-mass energy

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE

Search for anomalous t t-bar production in the highly-boosted all-hadronic final state

A search is presented for a massive particle, generically referred to as a Z', decaying into a t t-bar pair. The search focuses on Z' resonances that are sufficiently massive to produce highly Lorentz-boosted top quarks, which yield collimated decay products that are partially or fully merged into single jets. The analysis uses new methods to analyze jet substructure, providing suppression of the non-top multijet backgrounds. The analysis is based on a data sample of proton-proton collisions at a center-of-mass energy of 7 TeV, corresponding to an integrated luminosity of 5 inverse femtobarns. Upper limits in the range of 1 pb are set on the product of the production cross section and branching fraction for a topcolor Z' modeled for several widths, as well as for a Randall--Sundrum Kaluza--Klein gluon. In addition, the results constrain any enhancement in t t-bar production beyond expectations of the standard model for t t-bar invariant masses larger than 1 TeV.Comment: Submitted to the Journal of High Energy Physics; this version includes a minor typo correction that will be submitted as an erratu

Combined search for the quarks of a sequential fourth generation

Results are presented from a search for a fourth generation of quarks produced singly or in pairs in a data set corresponding to an integrated luminosity of 5 inverse femtobarns recorded by the CMS experiment at the LHC in 2011. A novel strategy has been developed for a combined search for quarks of the up and down type in decay channels with at least one isolated muon or electron. Limits on the mass of the fourth-generation quarks and the relevant Cabibbo-Kobayashi-Maskawa matrix elements are derived in the context of a simple extension of the standard model with a sequential fourth generation of fermions. The existence of mass-degenerate fourth-generation quarks with masses below 685 GeV is excluded at 95% confidence level for minimal off-diagonal mixing between the third- and the fourth-generation quarks. With a mass difference of 25 GeV between the quark masses, the obtained limit on the masses of the fourth-generation quarks shifts by about +/- 20 GeV. These results significantly reduce the allowed parameter space for a fourth generation of fermions.Comment: Replaced with published version. Added journal reference and DO

Measurement of the t t-bar production cross section in the dilepton channel in pp collisions at sqrt(s) = 7 TeV

The t t-bar production cross section (sigma[t t-bar]) is measured in proton-proton collisions at sqrt(s) = 7 TeV in data collected by the CMS experiment, corresponding to an integrated luminosity of 2.3 inverse femtobarns. The measurement is performed in events with two leptons (electrons or muons) in the final state, at least two jets identified as jets originating from b quarks, and the presence of an imbalance in transverse momentum. The measured value of sigma[t t-bar] for a top-quark mass of 172.5 GeV is 161.9 +/- 2.5 (stat.) +5.1/-5.0 (syst.) +/- 3.6(lumi.) pb, consistent with the prediction of the standard model.Comment: Replaced with published version. Included journal reference and DO