Exhumation history of eastern Ladakh revealed by Ar-40/Ar-39 and fission-track ages: the Indus River-Tso Morari transect, NW Himalaya

Fission-track and Ar-40/Ar-39 ages place time constraints on the exhumation of the North Himalayan nappe stack, the Indus Suture Zone and Molasse, and the Transhimalayan Batholith in eastern Ladakh (NW India). Results from this and previous studies on a north-south transect passing near Tso Morari Lake suggest that the SW-directed North Himalayan nappe stack (comprising the Mata, Tetraogal and Tso Morari nappes) was emplaced and metamorphosed by c. 50-45 Ma, and exhumed to moderately shallow depths (c. 10 km) by c. 45-40 Ma. From the mid-Eocene to the present, exhumation continued at a steady and slow rate except for the root zone of the Tso Morari nappe, which cooled faster than the rest of the nappe stack. Rapid cooling occurred at c. 20 Ma and is linked to brittle deformation along the normal Ribil-Zildat Fault concomitant with extrusion of the Crystalline nappe in the south. Data from the Indus Molasse suggest that sediments were still being deposited during the Miocene

Miocene paleoaltimetry of the Mt. Everest region

Abstract HKT-ISTP 2013 A

Cerro Quema (Azuero Peninsula, Panama): geology, alteration, mineralization and geochronology of a volcanic dome-hosted high sulfidation Au-Cu deposit.

Cerro Quema (Azuero Peninsula, SW Panama) is a high sulfidation epithermal Au-Cu deposit hosted by a dacite dome complex of the Río Quema Formation (Late Campanian to Maastrichtian), a fore-arc basin sequence. Mineral resource estimate (Indicated + Inferred) are 30.86 Mt @ 0.73 g/t Au, containing 728,000 Oz Au (including 76.900 Oz AuEq of Cu ore). Hydrothermal alteration and mineralization are controlled by an E trending regional fault system. Hydrothermal alteration consists of an inner zone of vuggy quartz with locally developed advanced argillic alteration, enclosed by a well-developed zone of argillic alteration, grading to an external halo of propylitic alteration. Mineralization produced dissemination and microveinlets of pyrite and minor chalcopyrite, enargite and tennantite, with traces of sphalerite, crosscut by late stage base metal veins. New 40Ar/39Ar data of igneous rocks combined with biostratigraphic ages of the volcanic sequence indicate a maximum age of Lower Eocene (~55-49 Ma) for the Cerro Quema deposit. It was probably triggered by the emplacement of an underlying porphyry-like intrusion associated with the Valle Rico batholith. The geologic model suggests that in the Azuero Peninsula high sulfidation epithermal mineralization occur in the Cretaceous-Paleogene fore-arc. This consideration should be taken into account when exploring for this deposit type in similar geologic terranes

Miocene to Holocene exhumation of metamorphic crustal wedges in the NW Himalaya: evidence for tectonic extrusion coupled to fluvial erosion

[1] The Himalayan crystalline core zone exposed along the Sutlej Valley (India) is composed of two high‐grade metamorphic gneiss sheets that were successively underthrusted and tectonically extruded, as a consequence of the foreland‐directed propagation of crustal deformation in the Indian plate margin. The High Himalayan Crystalline Sequence (HHCS) is composed of amphibolite facies to migmatitic paragneisses, metamorphosed at temperatures up to 750°C at 30 km depth between Eocene and early Miocene. During early Miocene, combined thrusting along the Main Central Thrust (MCT) and extension along the Sangla Detachment induced the rapid exhumation and cooling of the HHCS, whereas exhumation was mainly controlled by erosion since middle Miocene. The Lesser Himalayan Crystalline Sequence (LHCS) is composed of amphibolite facies para‐ and orthogneisses, metamorphosed at temperatures up to 700°C during underthrusting down to 30 km depth beneath the MCT. The LHCS cooled very rapidly since late Miocene, as a consequence of exhumation controlled by thrusting along the Munsiari Thrust and extension in the MCT hanging wall. This renewed phase of tectonic extrusion at the Himalayan front is still active, as indicated by the present‐day regional seismicity, and by hydrothermal circulation linked to elevated near‐surface geothermal gradients in the LHCS. As recently evidenced in the Himalayan syntaxes, active exhumation of deep crustal rocks along the Sutlej Valley is spatially correlated with the high erosional potential of this major trans‐Himalayan river. This correlation supports the emerging view of a positive feedback during continental collision between crustal‐scale tectono‐thermal reworking and efficient erosion along major river systems

Efficacy and safety of blonanserin transdermal patch in patients with schizophrenia: A 6-week randomized, double-blind, placebo-controlled, multicenter study

© 2019 The Authors Background: Blonanserin is a second-generation antipsychotic used for the treatment of schizophrenia. This study determined the efficacy, safety and pharmacokinetics of a blonanserin transdermal patch in patients with acutely exacerbated schizophrenia. Methods: This double-blind, multicenter, phase 3 study consisted of a 1-week observation period during which patients were treated with two patches of placebo, followed by a 6-week double-blind period where patients were randomized (1:1:1) to receive once-daily blonanserin 40 mg, blonanserin 80 mg, or placebo patches. The primary endpoint was the change from baseline in the total Positive and Negative Symptom Scale (PANSS) score. Safety assessments included treatment-emergent adverse events (TEAEs). Results: Between December 2014 and October 2018, patients were recruited and randomly assigned to blonanserin 40 mg (n = 196), blonanserin 80 mg (n = 194), or placebo (n = 190); of these, 77.2% completed the study. Compared with placebo, blonanserin significantly improved PANSS total scores at 6 weeks (least square mean [LSM] difference vs placebo: −5.6 with blonanserin 40 mg; 95% confidence interval [CI] −9.6, −1.6; adjusted p = 0.007, and − 10.4 with blonanserin 80 mg; 95% CI −14.4, −6.4; adjusted p \u3c 0.001). Blonanserin was well tolerated; the most common TEAEs reported were application-site erythema and pruritus, akathisia, tremor, and insomnia. Conclusions: Blonanserin transdermal patch improved the symptoms of acute schizophrenia with acceptable tolerability

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

A multi-decade record of high quality fCO2 data in version 3 of the Surface Ocean CO2 Atlas (SOCAT)

The Surface Ocean CO2 Atlas (SOCAT) is a synthesis of quality-controlled fCO2 (fugacity of carbon dioxide) values for the global surface oceans and coastal seas with regular updates. Version 3 of SOCAT has 14.7 million fCO2 values from 3646 data sets covering the years 1957 to 2014. This latest version has an additional 4.6 million fCO2 values relative to version 2 and extends the record from 2011 to 2014. Version 3 also significantly increases the data availability for 2005 to 2013. SOCAT has an average of approximately 1.2 million surface water fCO2 values per year for the years 2006 to 2012. Quality and documentation of the data has improved. A new feature is the data set quality control (QC) flag of E for data from alternative sensors and platforms. The accuracy of surface water fCO2 has been defined for all data set QC flags. Automated range checking has been carried out for all data sets during their upload into SOCAT. The upgrade of the interactive Data Set Viewer (previously known as the Cruise Data Viewer) allows better interrogation of the SOCAT data collection and rapid creation of high-quality figures for scientific presentations. Automated data upload has been launched for version 4 and will enable more frequent SOCAT releases in the future. High-profile scientific applications of SOCAT include quantification of the ocean sink for atmospheric carbon dioxide and its long-term variation, detection of ocean acidification, as well as evaluation of coupled-climate and ocean-only biogeochemical models. Users of SOCAT data products are urged to acknowledge the contribution of data providers, as stated in the SOCAT Fair Data Use Statement. This ESSD (Earth System Science Data) “living data” publication documents the methods and data sets used for the assembly of this new version of the SOCAT data collection and compares these with those used for earlier versions of the data collection (Pfeil et al., 2013; Sabine et al., 2013; Bakker et al., 2014). Individual data set files, included in the synthesis product, can be downloaded here: doi:10.1594/PANGAEA.849770. The gridded products are available here: doi:10.3334/CDIAC/OTG.SOCAT_V3_GRID

Age of Izu-Bonin-Mariana arc basement

Documenting the early tectonic and magmatic evolution of the Izu–Bonin–Mariana (IBM) arc system in the Western Pacific is critical for understanding the process and cause of subduction initiation along the current convergent margin between the Pacific and Philippine Sea plates. Forearc igneous sections provide firm evidence for seafloor spreading at the time of subduction initiation (52 Ma) and production of “forearc basalt”. Ocean floor drilling (International Ocean Discovery Program Expedition 351) recovered basement-forming, low-Ti tholeiitic basalt crust formed shortly after subduction initiation but distal from the convergent margin (nominally reararc) of the future IBM arc (Amami Sankaku Basin: ASB). Radiometric dating of this basement gives an age range (49.3–46.8 Ma with a weighted average of 48.7 Ma) that overlaps that of basalt in the present-day IBM forearc, but up to 3.3 m.y. younger than the onset of forearc basalt activity. Similarity in age range and geochemical character between the reararc and forearc basalts implies that the ocean crust newly formed by seafloor spreading during subduction initiation extends from fore- to reararc of the present-day IBM arc. Given the age difference between the oldest forearc basalt and the ASB crust, asymmetric spreading caused by ridge migration might have taken place. This scenario for the formation of the ASB implies that the Mesozoic remnant arc terrane of the Daito Ridges comprised the overriding plate at subduction initiation. The juxtaposition of a relatively buoyant remnant arc terrane adjacent to an oceanic plate was more favourable for subduction initiation than would have been the case if both downgoing and overriding plates had been oceanic