Using a Preoperative Scan Digital Impression and a Digital Index to Build Immediate Interim Full-Arch Implant-Supported Prosthesis. A Case Report and Proof of Concept

The transfer of information such esthetics and occlusion from the preoperative to the postoperative digital impression could reduce the time needed to build an immediately loaded full-arch not-guided rehabilitation and improve the quality of the immediate interim restoration. Based on the digital technology advances of the last years, the purpose of the present clinical report is to describe a novel digital workflow based on computer-aided design and computer-aided manufacturing aimed at fabricating an interim fixed full-arch restoration. The protocol entails recording preoperative information such as esthetics, the occlusal plane and the intermaxillary relationship in implant-supported complete rehabilitations before the surgical insertion of the fixtures. Then, the information is transferred to the postoperative impression using a digital index in the lower jaw and the palatal rugae in the upper jaw. Within the inherent limitations of a case report, the workflow was accurate, predictable, without errors from conventional protocols and was apparently characterized by low biological costs

The BLAST Survey of the Vela Molecular Cloud: Dynamical Properties of the Dense Cores in Vela-D

The Vela-D region, according to the nomenclature given by Murphy & May (1991), of the star forming complex known as the Vela Molecular Ridge (VMR), has been recently analyzed in details by Olmi et al. (2009), who studied the physical properties of 141 pre- and proto-stellar cold dust cores, detected by the ``Balloon-borne Large-Aperture Submillimeter Telescope'' (BLAST) during a much larger (55 sq. degree) Galactic Plane survey encompassing the whole VMR. This survey's primary goal was to identify the coldest, dense dust cores possibly associated with the earliest phases of star formation. In this work, the dynamical state of the Vela-D cores is analyzed. Comparison to dynamical masses of a sub-sample of the Vela-D cores estimated from the 13CO survey of Elia et al. (2007), is complicated by the fact that the 13CO linewidths are likely to trace the lower density intercore material, in addition to the dense gas associated with the compact cores observed by BLAST. In fact, the total internal pressure of these cores, if estimated using the 13CO linewidths, appears to be higher than the cloud ambient pressure. If this were the case, then self-gravity and surface pressure would be insufficient to bind these cores and an additional source of external confinement (e.g., magnetic field pressure) would be required. However, if one attempts to scale down the 13CO linewidths, according to the observations of high-density tracers in a small sample of sources, then most proto-stellar cores would result effectively gravitationally bound.Comment: This paper has 12 pages and 6 figures. Accepted for publication by the Astrophysical Journal on July 19, 201

Effects of two different probiotics on microflora, morphology, and morphometry of gut in organic laying hens

ABSTRACT The current study investigated the effects of Lactobacillus acidophilus and Bacillus subtilis, used as probiotics, on the microflora, morphology, and morphometry of the gut in organic laying hens. The birds (180 Hy-Line laying hens) were divided into 3 homogenous groups and received a pre-deposition diet from 16 to 20 wk of age and a deposition diet for the remaining 7 months of the experiment. The control group (CTR) was fed a corn-soybean cake-based diet, the second group (L) received the same diet supplemented with 0.1% of L. acidophilus while in the third group (B) the basal diet was supplemented with 0.05% of B. subtilis. At 18 wk of age (T1) and at 5 (T2) and 7 months (T3) from the beginning of deposition, 9 subjects per group were humanely killed for microbiological, morphological and morphometric analyses of the intestinal tract. The 2 probiotic-supplemented diets increased Lactobacillus spp. and Bifidobacterium spp. counts compared with the CTR diet. The lowest viable counts of E. coli, coliforms and staphylococci were observed in the L group (

Metabarcoding analysis of the bacterial and fungal communities during the maturation of preparation 500, used in biodynamic agriculture, suggests a rational link between horn and manure

Horn manure (Preparation 500) is a product used in the practice of biodynamic agriculture. It is obtained by an underground fermentation of cow fecal material incubated in cow horns for several months. The product is used as spray treatment meant to increase soil fertility. In the present report, we analyzed the successional changes in bacterial and fungal communities throughout the process of horn manure maturation by high throughput sequencing of ribosomal 16S (bacterial) and ITS (fungal) gene markers. Marked shifts in the microbial community were seen involving a general decrease from a Firmicutes dominated material to a product transiently enriched in Proteobacteria and later in Actinobacteria, mostly within the Nocardioidaceae family. In the fungal community evolution, the most abundant taxon in the starting fecal material resulted a member of the Onygenales order, known to specifically degrade keratin. Its abundance in the intestine is explained by the fact that keratin, which is also the structural component of hairs and horns, is found in all epithelial layers, including gut mucosae. This occurrence suggests a link of enzymatic/catabolic nature between manure and horn

The BLAST Survey of the Vela Molecular Cloud: Physical Properties of the Dense Cores in Vela-D

The Balloon-borne Large-Aperture Submillimeter Telescope (BLAST) carried out a 250, 350 and 500 micron survey of the galactic plane encompassing the Vela Molecular Ridge, with the primary goal of identifying the coldest dense cores possibly associated with the earliest stages of star formation. Here we present the results from observations of the Vela-D region, covering about 4 square degrees, in which we find 141 BLAST cores. We exploit existing data taken with the Spitzer MIPS, IRAC and SEST-SIMBA instruments to constrain their (single-temperature) spectral energy distributions, assuming a dust emissivity index beta = 2.0. This combination of data allows us to determine the temperature, luminosity and mass of each BLAST core, and also enables us to separate starless from proto-stellar sources. We also analyze the effects that the uncertainties on the derived physical parameters of the individual sources have on the overall physical properties of starless and proto-stellar cores, and we find that there appear to be a smooth transition from the pre- to the proto-stellar phase. In particular, for proto-stellar cores we find a correlation between the MIPS24 flux, associated with the central protostar, and the temperature of the dust envelope. We also find that the core mass function of the Vela-D cores has a slope consistent with other similar (sub)millimeter surveys.Comment: Accepted for publication in the Astrophysical Journal. Data and maps are available at http://blastexperiment.info

Non-HDL cholesterol predicts coronary heart disease in primary prevention: findings from an Italian a 40-69 year-old cohort in general practice

Scopo. La frazione lipoproteica denominata “colesterolo non-HDL” viene raccomandata come un indice di rischio coronarico (RC) associata alla dislipidemia combinata ed è stata trovata un utile fattore predittivo del rischio coronarico nei pazienti diabetici. Abbiamo studiato l’associazione tra i fattori di RC noti, incluso la colesterolo non-HDL ed una “condizione di RC elevato”, cioè un “RC a 5-anni >15%” in medicina generale. Metodi. Abbiamo studiato 4085 individui di età 40-69 anni, 489 diabetici e 3596 non-diabetici, appartenenti ad una coorte opportunistica. Sono state utilizzate le statistiche descrittive, e la regressione logistica multivariata aggiustata per età e sesso per i confronti tra i 2 gruppi. Risultati. Circa il 12% dei participanti era diabetico. I confronti aggiustati per età e sesso hanno mostrato che tutte le variabili erano significativamente peggiori nei diabetici rispetto ai non-diabetici (eccetto fumo, colesterolo totale e rapporto colesterolo totale/HDL). I diabetici avevano un “RC medio a 5-anni” più alto dei non-diabetici (18.8±11.9% vs 7.5±6.9%, P15%” (55.4% vs 11.1%, P<0.01). Nei diabetici, le variabili associate ad una “condizione di RC elevato” sono: fumo, pressione arteriosa sistolica (PAS) e colesterolemia non-HDL; nei non-diabetici: fumo, PAS, colesterolemia non-HDL e HDL (inversamente). Conclusioni. Il colesterolo non-HDL – oltre a fumo e PAS – è un forte predittore di una “condizione di RC elevato” sia negli individui diabetici che non-diabetici

Diagnostic Yield and Miss Rate of EndoRings in an Organized Colorectal Cancer Screening Program: the SMART (Study Methodology for ADR-Related Technology) Trial

Background and aims The add-on EndoRings has been claimed to improve adenoma detection at colonoscopy, but available data are inconsistent. When testing a new technology, parallel and crossover methodologies measure different outcomes, leaving uncertainty on their correspondence. Aims of this study were to compare the diagnostic yield and miss rate of the EndoRings for colorectal neoplasia. Methods Consecutive subjects undergoing colonoscopy after a positive fecal immunochemical test (FIT) within organized screening program in 7 Italian centers, were randomized between a parallel (EndoRings or Standard) or a crossover (EndoRings/Standard or Standard/EndoRings) methodology. Outcomes measures were the detection rates of (advanced) adenomas (A-)ADR in the parallel arms and miss rate of adenomas in the crossover arms. Results Of 958 eligible subjects, 927 (317 EndoRings; 317 Standard; 142 EndoRings/Standard; 151 Standard/Endorings) were included in the final analysis. In the parallel arms (mean ADR: 51.3%; mean AADR: 25.4%), no difference between Standard and EndoRings was found for both ADR (RR, 1.10; 95% CI, 0.95-1.28) and A-ADR (RR, 1.16; 95% CI, 0.88-1.51), as well as for the mean number of adenomas and advanced adenomas per patient (EndoRings: 1.9±1.3 and 1.0±1.2; Standard 2.1±1.5 and 1.0±1.2; p=NS for both comparisons). In the crossover arms, no difference in miss rate for adenomas between EndoRings and Standard was found at per-polyp (RR, 1.43; 95% CI, 0.97-2.10), as well as at per-patient analysis (24% vs 26%; p=0.76). Conclusions No statistically significant difference in diagnostic yield and miss rate between EndoRings and Standard colonoscopy was detected in FIT+ patients. A clinically relevant correspondence between miss and detection rates was shown, supporting a cause-effect relationship

A Spitzer Space Telescope far-infrared spectral atlas of compact sources in the Magellanic Clouds. I. The Large Magellanic Cloud

[abridged] We present 52-93 micron spectra obtained with Spitzer in the MIPS-SED mode, of a representative sample of luminous compact far-IR sources in the LMC. These include carbon stars, OH/IR AGB stars, post-AGB objects and PNe, RCrB-type star HV2671, OH/IR red supergiants WOHG064 and IRAS05280-6910, B[e] stars IRAS04530-6916, R66 and R126, Wolf-Rayet star Brey3a, Luminous Blue Variable R71, supernova remnant N49, a large number of young stellar objects, compact HII regions and molecular cores, and a background galaxy (z~0.175). We use the spectra to constrain the presence and temperature of cold dust and the excitation conditions and shocks within the neutral and ionized gas, in the circumstellar environments and interfaces with the surrounding ISM. Evolved stars, including LBV R71, lack cold dust except in some cases where we argue that this is swept-up ISM. This leads to an estimate of the duration of the prolific dust-producing phase ("superwind") of several thousand years for both RSGs and massive AGB stars, with a similar fractional mass loss experienced despite the different masses. We tentatively detect line emission from neutral oxygen in the extreme RSG WOHG064, with implications for the wind driving. In N49, the shock between the supernova ejecta and ISM is revealed by its strong [OI] 63-micron emission and possibly water vapour; we estimate that 0.2 Msun of ISM dust was swept up. Some of the compact HII regions display pronounced [OIII] 88-micron emission. The efficiency of photo-electric heating in the interfaces of ionized gas and molecular clouds is estimated at 0.1-0.3%. We confirm earlier indications of a low nitrogen content in the LMC. Evidence for solid state emission features is found in both young and evolved object; some of the YSOs are found to contain crystalline water ice.Comment: Accepted for publication in The Astronomical Journal. This paper accompanies the Summer 2009 SAGE-Spec release of 48 MIPS-SED spectra, but uses improved spectrum extraction. (Fig. 2 reduced resolution because of arXiv limit.

Consensus based recommendations for diagnosis and medical management of Poland syndrome (sequence)

Background Poland syndrome (OMIM: 173800) is a disorder in which affected individuals are born with missing or underdeveloped muscles on one side of the body, resulting in abnormalities that can affect the chest, breast, shoulder, arm, and hand. The extent and severity of the abnormalities vary among affected individuals. Main body The aim of this work is to provide recommendations for the diagnosis and management of people affected by Poland syndrome based on evidence from literature and experience of health professionals from different medical backgrounds who have followed for several years affected subjects. The literature search was performed in the second half of 2019. Original papers, meta-analyses, reviews, books and guidelines were reviewed and final recommendations were reached by consensus. Conclusion Being Poland syndrome a rare syndrome most recommendations here presented are good clinical practice based on the consensus of the participant experts

Comparison Between Titanium Tetrabutoxide and a New Commercial Titanium Dioxide Based Catalyst Used for the Synthesis of Poly(Ethylene Terephthalate)

Titanium-based catalysts for poly(alkylene terephthalate) synthesis have been known for many years. Up to now, organotitanate compounds are used as catalysts on an industrial scale only for the synthesis of poly(butylenes terephthalate) (PBT), poly(trimethylene terephthalate) (PTT), and related copolyesters; for poly(ethylene terephthalate) (PET), synthesis antimony-based catalysts are preferred. In fact, in this case, titanium is known to cause undesirable discoloration. In this article, a study of PET synthesis using different concentrations of a new titanium dioxide based catalyst (C-94), commercially available from Acordis Industrial Fibers GmbH, is carried out and compared with the results obtained with titanium tetrabutoxide (TBT) catalyst in the same experimental conditions. The solid-state properties and composition of C-94 was investigated by thermogravimetric analysis (TGA) coupled with mass spectroscopy and by X-ray powder diffraction (XRD). A characterization of the polymers prepared with C-94 and TBT is also described. The results have shown that the use of C-94 leads to more hydrolytically stable polymers, whereas no evidence of difference in the catalytic activity, carboxyl end-groups concentration, diethylene glycol content, and thermal properties were revealed