Perfil lipídico y su relación con síndrome metabólico en personal del Hospital Sagrado Corazón de Jesús periodo 2022

Cardiovascular health is essential for overall well-being, especially in the hospital setting, where staff face physical and emotional challenges. The lipid profile, which includes cholesterol and triglyceride levels, plays a crucial role in cardiovascular health. This study focuses on the evaluation of the cardiovascular and metabolic health of the staff of the Sagrado Corazón de Jesús Hospital through the analysis of lipid levels, the prevalence of metabolic syndrome and the association between the lipid profile and the presence of said syndrome. Data collected through laboratory testing and statistical analysis were used to obtain meaningful results. A majority was observed with high levels of HDL cholesterol, which is positive for cardiovascular health, and a predominance of normal levels of LDL cholesterol, indicating a low risk. Lipid profiles in the staff of the Sacred Heart of Jesus Hospital show variations by gender, with 58% of women and 43% of men within the desirable range of total cholesterol. Although the prevalence of metabolic syndrome is 16.07%, lipid profiles do not show a significant association with this condition. In conclusion, the data reveal gender differences in the lipid profiles of the staff at the Sacred Heart of Jesus Hospital, with a higher percentage of women within the desirable range of total cholesterol. In summary, while there are gender differences in lipid profiles, their relationship with metabolic syndrome is weak.  La salud cardiovascular es fundamental para el bienestar general, especialmente en el ámbito hospitalario, donde el personal enfrenta desafíos físicos y emocionales. El perfil lipídico, que comprende niveles de colesterol y triglicéridos, desempeña un papel crucial en la salud cardiovascular. Este estudio se centra en la evaluación de la salud cardiovascular y metabólica del personal del Hospital Sagrado Corazón de Jesús a través del análisis de los niveles de lípidos, la prevalencia del síndrome metabólico y la asociación entre el perfil lipídico y la presencia de dicho síndrome. Se utilizaron datos recopilados mediante pruebas de laboratorio y análisis estadísticos para obtener resultados significativos. Se observó una mayoría con niveles altos de colesterol HDL, lo cual es positivo para la salud cardiovascular, y una predominancia de niveles normales de colesterol LDL, indicando un riesgo bajo. Los perfiles lipídicos en el personal del Hospital Sagrado Corazón de Jesús muestran variaciones según el género, con el 58% de las mujeres y el 43% de los hombres dentro del rango deseable de colesterol total. Aunque la prevalencia del síndrome metabólico es del 16.07%, los perfiles lipídicos no muestran una asociación significativa con esta condición. En conclusión, los datos revelan diferencias de género en los perfiles lipídicos del personal del Hospital Sagrado Corazón de Jesús, con un porcentaje mayor de mujeres dentro del rango deseable de colesterol total. En resumen, mientras existen diferencias de género en los perfiles lipídicos, su relación con el síndrome metabólico es débil

Controlled three-dimensional manipulation of vanadium oxide nanotubes with optical tweezers

We present a direct nanotube-microsphere tagging technique for the controlled three-dimensional 3D manipulation and transportation of vanadium oxide nanotubes VOx-NTs with optical tweezers. The high scattering and absorptive nature of the VOx-NTs preclude the 3D optical trapping of such nanostructures. VOx-NTs are adhered to 3-aminopropyl-triethoxysilane functionalized silica microspheres, which act as handles for indirectly manipulating and transporting the nanotubes in three dimensions with optical tweezers. The optical tweezers can also operate as optical scissors that can remove the dielectric handles and trim these nanotubes. This technique may be extended to the optical manipulation of nanotubes of any material.Hernández-Pozos acknowledges the support from the Academia Mexicana de Ciencias and the Royal Society U.K.. K.D. is a Royal Society-Wolfson Merit Award holder. We thank the EPSRC for funding

Plan de negocios para la instalaci?n de un resto-bar de cerveza artesanal en la ciudad de M?ncora - Piura - Per?

El presente trabajo es un plan de negocios para la instalaci?n de un resto-bar de cerveza artesanal en el Balneario de M?ncora. La idea se origina luego de identificar que el consumo de cerveza artesanal se encuentra en crecimiento dada la aceptaci?n de este producto en el mercado lime?o, asimismo dado que Lima posee una numerosa oferta de locales que ofrecen comida y bebida se opt? por seleccionar una provincia con actividad tur?stica

A communal catalogue reveals Earth's multiscale microbial diversity

Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth's microbial diversity.Peer reviewe

A communal catalogue reveals Earth’s multiscale microbial diversity

Our growing awareness of the microbial world’s importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth’s microbial diversity

Flexible Electroactive Nanomaterials Biotemplated with Versatile M13 Phage Platforms

International audienceno abstrac

Dielectric enhanced nanoparticles for three-dimensional optical manipulation

Engineering semiconductor nanostructures has immense potential for applications pertaining to nanophotonics especially due to their optical properties. Nanostructures can come in various forms i.e. tubes, rods and dots. Each presents themselves as a possible candidate for creating larger photonics structures. In this paper, we describe the optical trapping characteristic of dielectric enhanced nanoparticles. Two techniques of dielectric enhancements are employed: silica coating and microsphere tagging, for the efficient manipulation of nanoparticles

Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

BackgroundEstimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period.Methods22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution.FindingsGlobal all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98–5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50–6·01) in 2019. An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8–24·8), from 49·0 years (46·7–51·3) to 71·7 years (70·9–72·5). Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67–8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4–52·7]) and south Asia (26·3% [9·0–44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations.InterpretationGlobal adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic