13 research outputs found
Multiple positive solutions for a fourth-order integral boundary value problem on time scales
Local Resistance in Early Medieval Chinese Historiography and the Problem of Religious Overinterpretation
Official Chinese historiography is a treasure trove of information on local resistance to the centralised empire in early medieval China (third to sixth century). Sinologists specialised in the study of Chinese religions commonly reconstruct the religious history of the era by interpreting some of these data. In the process, however, the primary purpose of the historiography of local resistance is often overlooked, and historical interpretation easily becomes âoverinterpretationââthat is, âfabricating false intensityâ and âseeing intensity everywhereâ, as French historian Paul Veyne proposed to define the term. Focusing on a cluster of historical anecdotes collected in the standard histories of the four centuries under consideration, this study discusses the supposedly âreligiousâ nature of some of the data they contain
Clinical practice guidelines for the diagnosis and treatment of inflammatory breast cancer: Chinese Society of Breast Surgery (CSBrS) Practice Guidelines 2022
Seasonal variation influences flavonoid biosynthesis path and content, and antioxidant activity of metabolites in Tetrastigma hemsleyanum Diels & Gilg.
Environmental conditions contribute to plant growth and metabolism. This study aimed to determine a suitable environment and climate for large-scale artificial cultivation of an endangered plant, Tetrastigma hemsleyanum, by investigating the seasonal variations influencing the flavonoid biosynthetic selectivity and antioxidant activity of its major metabolites. Under conditions of precipitation (2.0~6.6 mm), temperature (17.5~24.1°C), humidity (67.3~80.2%), and sunshine duration (3.4~5.8 h) from April to May, the total flavonoid content in T. hemsleyanum reached higher levels between 281.3 and 392.8 Όg/g. In the second half of April, the production selectivity (PS) of isoorientin (IsoO), orientin (Or), rutin (Rut), isoquercitin (IsoQ), kaempferol-3-O-rutinoside (Km3rut), astragalin (Ast), quercetin (Qu), apigenin (Ap), and kaempferol (Km) were 0.30, 0.06, 0.07, 0.07, 0.00, 0.04, 0.38, 0.05, and 0.03, respectively. Naringenin was dehydrogenated or hydroxylated to initiate two parallel reaction pathways for flavonoid biosynthesis in T. hemsleyanum: path I subsequently generated flavone derivatives including apigenin, luteolin, orientin, and isoorientin, and path II subsequently generated flavonol derivatives including Km, Qu, IsoQ, Rut, Ast, and Km3rut. The reaction selectivity of path II (RPSII) from January 1 to September 30 was considerably higher than that of path I (RPSI), except for March 16-31. In addition, either the content or antioxidant activity of three major metabolites in T. hemsleyanum followed the order of phenolic compounds > polysaccharides > sterols, and exhibited dynamic correlations with environmental factors. Naringenin favored hydroxylation and derived six flavonol compounds from January to September, and favored dehydrogenation and derived three flavone compounds from October to December. In most months of a year, Km preferentially favored hydroxylation rather than glucosylation
Environmental background of evolution from the paleolithic to neolithic culture in Nihewan Basin, North China
Long-term outcomes of COVID-19 convalescents: An 18.5-month longitudinal study in Wuhan
Objectives: This study aimed to describe the full scope of long-term outcomes and the ongoing pathophysiological alterations among COVID-19 survivors. Methods: We established a longitudinal cohort of 208 COVID-19 convalescents and followed them at 3.3 (interquartile range [IQR]: 1.3, 4.4, visit 1), 9.2 (IQR: 9.0, 9.6, visit 2), and 18.5 (IQR: 18.2, 19.1, visit 3) months after infection, respectively. Serial changes in multiple physical and psychological outcomes were comprehensively characterized. We, in addition, explored the potential risk factors of SARS-CoV-2 antibody response and sequelae symptoms. Results: We observed continuous improvement of sequelae symptoms, lung function, chest computed tomography (CT), 6-minute walk test, and the Borg dyspnea scale, whereas sequelae symptoms (at least one) and abnormal chest CT patterns still existed in 45.2% and about 30% of participants at 18.5 months, respectively. Anxiety and depression disorders were alleviated for the convalescents, although depression status was sustained for a longer duration. Conclusions: Most COVID-19 convalescents had an overall improved physical and psychological health status, whereas sequelae symptoms, residual lesions on lung function, exercise impairment, and mental health disorders were still observed in a small proportion of participants at 18.5 months after infection. Implementing appropriate preventive and management strategies for the ever-growing COVID-19 population is warranted