Nuclear tau and its potential role in Alzheimer’s disease

Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD). For nearly four decades, research efforts have focused more on tau’s role in physiology and pathology in the context of the microtubules, even though, for over three decades, tau has been localised in the nucleus and the nucleolus. Its nuclear and nucleolar localisation had stimulated many questions regarding its role in these compartments. Data from cell culture, mouse brain, and the human brain suggests that nuclear tau could be essential for genome defense against cellular distress. However, its nature of translocation to the nucleus, its nuclear conformation and interaction with the DNA and other nuclear proteins highly suggest it could play multiple roles in the nucleus. To find efficient tau-based therapies, there is a need to understand more about the functional relevance of the varied cellular distribution of tau, identify whether specific tau transcripts or isoforms could predict tau’s localisation and function and how they are altered in diseases like AD. Here, we explore the cellular distribution of tau, its nuclear localisation and function and its possible involvement in neurodegeneration

Contextual Emotion Expression: Profiles of African American Report in the Family and on Campus

Background: African American culture has long been known for its emphasis on emotion expression (Boykin, 1986). However, African Americans have learned to restrict emotion publicly due to pervasive stereotypes (Consedine & Magai, 2002). It’s likely that such behavior is learned in the family, in which parents alert children to racial discrimination that is typically associated with context (Dunbar et al., 2017). Thus, African Americans are likely to vary emotion expression according to context. The current study explored emotion expression in the family and public context. Methods: 188 African American/Black college students from 3 different types of college campuses. The sample was 62.4% female, 35.4% male, and 2.2. genderqueer/gender non- conforming. Data were collected via an online survey with all self-report measures. Contextual differences in emotion expression were explored via latent profile analysis (LPA). Results: Five profiles emerged: More Positive and Negative Submissive Expression (n = 49; 26%), More Family Expression (n = 8; 5%), Low Family and Campus Expression (n = 24; 13%), More Campus Positive and Negative Dominant Expression (n = 45; 24%), and More Positive and Less Negative Dominant Expression (n = 63; 33%). Racial discrimination significantly predicted profile membership for the More Campus Positive and Negative Dominant Expression profile in particular. Conclusions: African American youth express emotion differently in the family context compared to campus, particularly in the face of racial discrimination. The patterns of emotion expression revealed here are helpful in terms of evaluating outcomes of African American’s emotion-related behavior as taught in the family.https://scholarscompass.vcu.edu/gradposters/1080/thumbnail.jp

Stable dose cannabinoid medicine (Sativex®, THC+CBD) can provide sustained efficacy in the treatment of refractory painful diabetic neuropathy or other peripheral neuropathic pain associated with allodynia [poster]

No abstract available

Prevention of headache after lumbar puncture: questionnaire survey of neurologists and neurosurgeons in United Kingdom

No abstract available

CLEARER: a new tool for the analysis of X-ray fibre diffraction patterns and diffraction simulation from atomic structural models

Fibre diffraction can provide structural information about polymers and biopolymers that is unobtainable using other methods. This method has been used to elucidate the structures of many polymers, biopolymers and protein assemblies. Extracting structural information from fibre diffraction patterns is a major challenge. A computer program called CLEARER has been developed that aids the detailed analysis of polycrystalline fibre diffraction patterns. It offers an easy-to-use interface that enables diffraction data processing, analysis and simulation of diffraction patterns. It is likely to be applicable to structural determination for a wide range of polymeric fibrous materials. CLEARER simplifies and speeds up the data analysis process and helps to utilize all of the structural information present in the analysed X-ray and electron diffraction patterns

Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study

<b>Objective</b>: To compare the analgesic efficacy and side effects of the synthetic cannabinoid nabilone with those of the weak opioid dihydrocodeine for chronic neuropathic pain. <b>Design</b>: Randomised, double blind, crossover trial of 14 weeks’ duration comparing dihydrocodeine and nabilone. <b>Setting</b>: Outpatient units of three hospitals in the United Kingdom. <b>Participants</b>: 96 patients with chronic neuropathic pain, aged 23-84 years. <b>Main outcome measures</b>: The primary outcome was difference between nabilone and dihydrocodeine in pain, as measured by the mean visual analogue score computed over the last 2 weeks of each treatment period. Secondary outcomes were changes in mood, quality of life, sleep, and psychometric function. Side effects were measured by a questionnaire. <b>Intervention</b>: Patients received a maximum daily dose of 240 mg dihydrocodeine or 2 mg nabilone at the end of each escalating treatment period of 6 weeks. Treatment periods were separated by a 2 week washout period. <b>Results</b>: Mean baseline visual analogue score was 69.6 mm (range 29.4-95.2) on a 0-100 mm scale. 73 patients were included in the available case analysis and 64 patients in the per protocol analysis. The mean score was 6.0 mm longer for nabilone than for dihydrocodeine (95% confidence interval 1.4 to 10.5) in the available case analysis and 5.6 mm (10.3 to 0.8) in the per protocol analysis. Side effects were more frequent with nabilone. <b>Conclusion</b>: Dihydrocodeine provided better pain relief than the synthetic cannabinoid nabilone and had slightly fewer side effects, although no major adverse events occurred for either drug

Growing Awareness of Cultural Aspects of Psychology as a Resource for Managing Progressive Social Change

I suggest that CCP’s early preoccupation with direct comparison between culturally-contrastive groups has been overtaken in importance by a number of trends in developmental and applied psychology. Some Western theorists now acknowledge reflexively that their interpretation of psychological variables is itself informed by a particular cultural system of meanings. A growing number of non-Western theorists have proposed alternative cultural psychologies. Mainstream developmental psychology has incorporated culture as an essential dimension of the field, leading to increasingly systemic theories. Cultural sensitivity is widely perceived as essential for the design and interpretation of psychological assessment. The IACCP has contributed to these trends by fostering inter-cultural communication among psychologists working in many different cultural contexts around the world. Collectively, they are in a position to impress on the next generation of planners and policy-makers the importance of culture in the formulation of strategies for managing progressive social change

Incorporating data quality improvement into supply–use table balancing

© 2017 The International Input–Output Association. This paper investigates the benefits of using a boundary tightening algorithm to improve the quality of the data used in supply and use table (SUT) balancing, building on similarities with certain approaches to statistical disclosure control. Boundary tightening was shown to significantly improve the quality of the finally balanced SUTs well beyond that of existing techniques. Most notably, improvements occurred when boundary tightening was applied prior to the balancing process–showing that it can be used as a valuable preliminary to other approaches. It also multiplied the improvement in SUTs quality when more accurate updated information was added to the SUTs. The findings of this paper strongly suggest that this boundary tightening algorithm will improve the quality of the output of the balancing process and it is equally likely to be useful when applied to other processes that handle uncertain data

Double-blind, randomised, placebo controlled, parallel group study of sativex® in the treatment of patients with peripheral neuropathic pain, associated with allodynia [poster]

No abstract available