A street view of groundwater policymaking and management in Azraq, Jordan

Groundwater management is a complex task that includes a multitude of actors. It is even more complicated in water scarce countries with less well-established formal water governance structures. In these settings, local government officers have been recognised for their essential role in groundwater management. Often, their role is described as problematic, with officers being under-resourced, under-motivated and, at times, corrupt. In this paper we zoom in on these street-level bureaucrats in Azraq, one of the most depleted groundwater basins in Jordan. Based on inputs from officers, farmers, and sector experts, we collate and analyse information on how the settings in which local officers work influence their day-to-day implementation of policies. We observe that officers in Azraq are heavily influenced by the context in which they operate. This context is characterised by the physical scarcity of groundwater, the formal policy setting, and the presence of the shadow state. The context shapes local officers’ relationships with farmers, their own personal beliefs and subjectivities, and their capacity and resources. As a result, their divergent actions arguably become the groundwater management policy. Based on these findings, we argue that a deeper understanding is needed of the underlying factors and drivers that shape local groundwater management if we are to arrive at better groundwater policy for a more sustainable futur

On Capturing Human Agency and Methodological Interdisciplinarity in socio-hydrology Research

Socio-hydrology has expanded and been effective in exposing the hydrological community to ideas and approaches from other scientific disciplines, and social sciences in particular. Yet it still has much to explore regarding how to capture human agency and how to combine different methods and disciplinary views from both the hydrological and the social sciences to develop knowledge. A useful starting ground is noting that the complexity of human–water relations is due to interactions not only across spatial and temporal scales but also across different organizational levels of social systems. This calls for consideration of another analytical scale, the human organizational scale, and interdisciplinarity in study methods. Based on the papers published in this journal’s Special Issue Advancing Socio-hydrology over 2019–2022, this paper illuminates how the understanding of coupled human–water systems can be strengthened by capturing the multi-level nature of human decision making and by applying an interdisciplinary multi-method approach

Non-pharmacological interventions for adults with intellectual disabilities and depression

Background: Although high rates of depression symptoms are reported in adults with intellectual disabilities (IDs), there is a lack of knowledge about non-pharmacological treatment options for depression in this population. The first research question of this paper is: Which non-pharmacological interventions have been studied in adults with ID and depression? The second research question is: What were the results of these non-pharmacological interventions?. Method: Systematic review of the literature with an electronic search in six databases has been completed with hand searches. Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines have been followed. Selected studies met predefined inclusion criteria. Results: Literature search resulted in 4267 papers of which 15 met the inclusion criteria. Five different types of non-pharmacological interventions have been studied: cognitive behavioural therapy, behavioural therapy, exercise intervention, social problem-solving skills programme and bright light therapy. Conclusion: There are only a few studies of good quality evaluating non-pharmacological interventions for adults with ID and depression. Some of these studies, especially studies on cognitive behavioural therapy, show good results in decreasing depressive symptoms. High-quality randomised controlled trials evaluating non-pharmacological

Cytoreductive surgery followed by chemotherapy versus chemotherapy alone for recurrent platinum- sensitive epithelial ovarian cancer (SOCceR trial):a multicenter randomised controlled study

BACKGROUND: Improvement in treatment for patients with recurrent ovarian cancer is needed. Standard therapy in patients with platinum-sensitive recurrent ovarian cancer consists of platinum-based chemotherapy. Median overall survival is reported between 18 and 35 months. Currently, the role of surgery in recurrent ovarian cancer is not clear. In selective patients a survival benefit up to 62 months is reported for patients undergoing complete secondary cytoreductive surgery. Whether cytoreductive surgery in recurrent platinum-sensitive ovarian cancer is beneficial remains questionable due to the lack of level I-II evidence. METHODS/DESIGN: Multicentre randomized controlled trial, including all nine gynecologic oncologic centres in the Netherlands and their affiliated hospitals. Eligible patients are women, with first recurrence of FIGO stage Ic-IV platinum-sensitive epithelial ovarian cancer, primary peritoneal cancer or fallopian tube cancer, who meet the inclusion criteria. Participants are randomized between the standard treatment consisting of at least six cycles of intravenous platinum based chemotherapy and the experimental treatment which consists of secondary cytoreductive surgery followed by at least six cycles of intravenous platinum based chemotherapy. Primary outcome measure is progression free survival. In total 230 patients will be randomized. Data will be analysed according to intention to treat. DISCUSSION: Where the role of cytoreductive surgery is widely accepted in the initial treatment of ovarian cancer, its value in recurrent platinum-sensitive epithelial ovarian cancer has not been established so far. A better understanding of the benefits and patients selection criteria for secondary cytoreductive surgery has to be obtained. Therefore the 4(th) ovarian cancer consensus conference in 2010 stated that randomized controlled phase 3 trials evaluating the role of surgery in platinum-sensitive recurrent epithelial ovarian cancer are urgently needed. We present a recently started multicentre randomized controlled trial that will investigate the role of secondary cytoreductive surgery followed by chemotherapy will improve progression free survival in selected patients with first recurrence of platinum-sensitive epithelial ovarian cancer. TRIAL REGISTRATION: Netherlands Trial Register number: NTR3337

Adaptation of water resources systems to changing society and environment: a statement by the International Association of Hydrological Sciences

Hydrol. Sci. J.-J. Sci. Hydrol.ISI Document Delivery No.: EB2CDTimes Cited: 0Cited Reference Count: 153Ceola, Serena Montanari, Alberto Krueger, Tobias Dyer, Fiona Kreibich, Heidi Westerberg, Ida Carr, Gemma Cudennec, Christophe Elshorbagy, Amin Savenije, Hubert Van der Zaag, Pieter Rosbjerg, Dan Aksoy, Hafzullah Viola, Francesco Petrucci, Guido MacLeod, Kit Croke, Barry Ganora, Daniele Hermans, Leon Polo, Maria J. Xu, Zongxue Borga, Marco Helmschrot, Jorg Toth, Elena Ranzi, Roberto Castellarin, Attilio Hurford, Anthony Brilly, Mitija Viglione, Alberto Bloeschl, Guenter Sivapalan, Murugesu Domeneghetti, Alessio Marinelli, Alberto Di Baldassarre, GiulianoPeople Programme (Marie Curie Actions) of the European Union [329762]; IRI THESys; German Excellence Initiative; EU [603587]IW acknowledges the support of the People Programme (Marie Curie Actions) of the European Union's 7th Framework Programme FP7/2007-2013/(grant agreement no. 329762). TK is funded, through IRI THESys, by the German Excellence Initiative. SC, AM, AC, and ET acknowledge financial support from the EU funded project SWITCHON (603587).Taylor & francis ltdAbingdonWe explore how to address the challenges of adaptation of water resources systems under changing conditions by supporting flexible, resilient and low-regret solutions, coupled with on-going monitoring and evaluation. This will require improved understanding of the linkages between biophysical and social aspects in order to better anticipate the possible future co-evolution of water systems and society. We also present a call to enhance the dialogue and foster the actions of governments, the international scientific community, research funding agencies and additional stakeholders in order to develop effective solutions to support water resources systems adaptation. Finally, we call the scientific community to a renewed and unified effort to deliver an innovative message to stakeholders. Water science is essential to resolve the water crisis, but the effectiveness of solutions depends, inter alia, on the capability of scientists to deliver a new, coherent and technical vision for the future development of water systems

Does transient increase in axial length during accommodation attenuate with age?

Background: The aim was to profile transient accommodative axial length (AXL) changes from early adulthood to advanced presbyopia and to determine whether any differences exist between the responses of myopic and emmetropic individuals. Methods: Ocular biometry was measured by the LenStar biometer (Haag-Streit, Switzerland) in response to 0.00, 3.00 and 4.50 D accommodative stimuli in 35 emmetropes and 37 myopes, aged 18 to 60 years. All results were corrected to reduce errors arising from the increase in crystalline lens thickness with accommodation. Accommodative responses were measured sequentially by the WAM 5500 Auto Ref/Keratometer (Grand Seiko, Japan). Results: AXL increased significantly with accommodation (p<0.001), with a mean corrected AXL elongation of 2 ± 18 µm and 8 ± 16 µm observed at 3.00 D and 4.50 D, respectively. The magnitude of accommodative AXL change was not dependent on refractive error classification (p=0.959), however a significant reduction in the magnitude and variance of AXL change was evident after 43-44 years of age (p<0.002). Conclusion: The negative association between transient AXL elongation and age, in combination with reduced variance of data after age 43-44 years, is consistent with a significant increase in posterior ocular rigidity, which may be influential in the development of presbyopia

In Vitro Neutralisation of Rotavirus Infection by Two Broadly Specific Recombinant Monovalent Llama-Derived Antibody Fragments

Rotavirus is the main cause of viral gastroenteritis in young children. Therefore, the development of inexpensive antiviral products for the prevention and/or treatment of rotavirus disease remains a priority. Previously we have shown that a recombinant monovalent antibody fragment (referred to as Anti-Rotavirus Proteins or ARP1) derived from a heavy chain antibody of a llama immunised with rotavirus was able to neutralise rotavirus infection in a mouse model system. In the present work we investigated the specificity and neutralising activity of two llama antibody fragments, ARP1 and ARP3, against 13 cell culture adapted rotavirus strains of diverse genotypes. In addition, immunocapture electron microscopy (IEM) was performed to determine binding of ARP1 to clinical isolates and cell culture adapted strains. ARP1 and ARP3 were able to neutralise a broad variety of rotavirus serotypes/genotypes in vitro, and in addition, IEM showed specific binding to a variety of cell adapted strains as well as strains from clinical specimens. These results indicated that these molecules could potentially be used as immunoprophylactic and/or immunotherapeutic products for the prevention and/or treatment of infection of a broad range of clinically relevant rotavirus strains

Unexpected differential metabolic responses of Campylobacter jejuni to the abundant presence of glutamate and fucose

Introduction: Campylobacter jejuni is the leading cause of foodborne bacterial enteritis in humans, and yet little is known in regard to how genetic diversity and metabolic capabilities among isolates affect their metabolic phenotype and pathogenicity. Objectives: For instance, the C. jejuni 11168 strain can utilize both l-fucose and l-glutamate as a carbon source, which provides the strain with a competitive advantage in some environments and in this study we set out to assess the metabolic response of C. jejuni 11168 to the presence of l-fucose and l-glutamate in the growth medium. Methods: To achieve this, untargeted hydrophilic liquid chromatography coupled to mass spectrometry was used to obtain metabolite profiles of supernatant extracts obtained at three different time points up to 24 h. Results: This study identified both the depletion and the production and subsequent release of a multitude of expected and unexpected metabolites during the growth of C. jejuni 11168 under three different conditions. A large set of standards allowed identification of a number of metabolites. Further mass spectrometry fragmentation analysis allowed the additional annotation of substrate-specific metabolites. The results show that C. jejuni 11168 upon l-fucose addition indeed produces degradation products of the fucose pathway. Furthermore, methionine was faster depleted from the medium, consistent with previously-observed methionine auxotrophy. Conclusions: Moreover, a multitude of not previously annotated metabolites in C. jejuni were found to be increased specifically upon l-fucose addition. These metabolites may well play a role in the pathogenicity of this C. jejuni strain.</p