831 research outputs found

    Facing the Crises of Higher Education: Reflections on a State University’s Experiment with TILT

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    Facing the Crises of Higher Education: Reflections on a State University’s Experiment with TIL

    Multi-Agent Search for a Moving and Camouflaging Target

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    In multi-agent search planning for a randomly moving and camouflaging target, we examine heterogeneous searchers that differ in terms of their endurance level, travel speed, and detection ability. This leads to a convex mixed-integer nonlinear program, which we reformulate using three linearization techniques. We develop preprocessing steps, outer approximations via lazy constraints, and bundle-based cutting plane methods to address large-scale instances. Further specializations emerge when the target moves according to a Markov chain. We carry out an extensive numerical study to show the computational efficiency of our methods and to derive insights regarding which approach should be favored for which type of problem instance

    The CORALIE survey for southern extra-solar planets XV. Discovery of two eccentric planets orbiting HD4113 and HD156846

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    We report the detection of two very eccentric planets orbiting HD4113 and HD156846 with the CORALIE Echelle spectrograph mounted on the 1.2-m Euler Swiss telescope at La Silla. The first planet, HD4113b, has minimum mass of msini=1.6±0.2MJupm\sin{i}=1.6\pm0.2 M_{\rm Jup}, a period of P=526.59±0.21P=526.59\pm0.21 days and an eccentricity of e=0.903±0.02e=0.903\pm0.02. It orbits a metal rich G5V star at a=1.28a=1.28 AU which displays an additional radial velocity drift of 28 m s1^{-1}/yr observed during 8 years. The combination of the radial-velocity data and the non-detection of any main sequence stellar companion in our high contrast images taken at the VLT with NACO/SDI, characterizes the companion as a probable brown dwarf or as a faint white dwarf. The second planet, \object{HD 156846 b}, has minimum mass of msini=10.45±0.05m\sin{i}=10.45\pm0.05 MJup_{\rm Jup}, a period of P=359.51±0.09P=359.51\pm0.09 days, an eccentricity of e=0.847±0.002e=0.847\pm0.002 and is located at a=1.0a=1.0 AU from its parent star. HD156846 is a metal rich G0 dwarf and is also the primary of a wide binary system (a>250a>250 AU, P>4000P>4000 years). Its stellar companion, \object{IDS 17147-1914 B}, is a M4 dwarf. The very high eccentricities of both planets can be explained by Kozai oscillations induced by the presence of a third object.Comment: 4 pages, 5 figures, A&A Letter accepte

    Dealing with paralogy in RADseq data: in silico detection and single nucleotide polymorphism validation in Robinia pseudoacacia L.

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    peer reviewedThe RADseq technology allows researchers to efficiently develop thousands of polymorphic loci across multiple individuals with little or no prior information on the genome. However, many questions remain about the biases inherent to this technology. Notably, sequence misalignments arising from paralogy may affect the development of single nucleotide polymorphism (SNP) markers and the estimation of genetic diversity. We evaluated the impact of putative paralog loci on genetic diversity estimation during the development of SNPs from a RADseq dataset for the nonmodel tree species Robinia pseudoacacia L. We sequenced nine genotypes and analyzed the frequency of putative paralogous RAD loci as a function of both the depth of coverage and the mismatch threshold allowed between loci. Putative paralogy was detected in a very variable number of loci, from 1% to more than 20%, with the depth of coverage having a major influence on the result. Putative paralogy artificially increased the observed degree of polymorphism and resulting estimates of diversity. The choice of the depth of coverage also affected diversity estimation and SNP validation: A low threshold decreased the chances of detecting minor alleles while a high threshold increased allelic dropout. SNP validation was better for the low threshold (4×) than for the high threshold (18×) we tested. Using the strategy developed here, we were able to validate more than 80% of the SNPs tested by means of individual genotyping, resulting in a readily usable set of 330 SNPs, suitable for use in population genetics applications

    Association of plasma Aβ40/Aβ42 ratio and brain Aβ accumulation: testing a whole-brain PLS-VIP in individuals at risk of Alzheimer's disease

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    Molecular and brain regional/network-wise pathophysiological changes at preclinical stages of Alzheimer's disease (AD) have primarily been found through knowledge-based studies conducted in late-stage mild cognitive impairment/dementia populations. However, such an approach may compromise the objective of identifying the earliest spatial-temporal pathophysiological processes. We investigated 261 individuals with subjective memory complaints, a condition at increased risk of AD, to test a whole-brain, non-a-priori method based on partial least squares, in unraveling the association between plasma Aβ42/Aβ40 ratio and an extensive set of brain regions characterized through molecular imaging of Aβ accumulation and cortical metabolism. Significant associations were mapped onto large-scale networks, identified through an atlas and by knowledge, to elaborate on the reliability of the results. Plasma Aβ42/40 ratio was associated with Aβ-PET uptake (but not FDG-PET) in regions generally investigated in preclinical AD such as those belonging to the default mode network, but also in regions/networks normally not accounted - including the central executive and salience networks - which likely have a selective vulnerability to incipient Aβ accumulation. The present whole-brain approach is promising to investigate early pathophysiological changes of AD to fully capture the complexity of the disease, which is essential to develop timely screening, detection, diagnostic, and therapeutic interventions

    The Nucleon Spectral Function at Finite Temperature and the Onset of Superfluidity in Nuclear Matter

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    Nucleon selfenergies and spectral functions are calculated at the saturation density of symmetric nuclear matter at finite temperatures. In particular, the behaviour of these quantities at temperatures above and close to the critical temperature for the superfluid phase transition in nuclear matter is discussed. It is shown how the singularity in the thermodynamic T-matrix at the critical temperature for superfluidity (Thouless criterion) reflects in the selfenergy and correspondingly in the spectral function. The real part of the on-shell selfenergy (optical potential) shows an anomalous behaviour for momenta near the Fermi momentum and temperatures close to the critical temperature related to the pairing singularity in the imaginary part. For comparison the selfenergy derived from the K-matrix of Brueckner theory is also calculated. It is found, that there is no pairing singularity in the imaginary part of the selfenergy in this case, which is due to the neglect of hole-hole scattering in the K-matrix. From the selfenergy the spectral function and the occupation numbers for finite temperatures are calculated.Comment: LaTex, 23 pages, 21 PostScript figures included (uuencoded), uses prc.sty, aps.sty, revtex.sty, psfig.sty (last included

    Testing intermediate-age stellar evolution models with VLT photometry of LMC clusters. I. The data

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    This is the first of a series of three papers devoted to the calibration of a few parameters of crucial importance in the modeling of the evolution of intermediate-mass stars, with special attention to the amount of convective core overshoot. To this end we acquired deep V and R photometry for three globular clusters of the Large Magellanic Cloud (LMC), namely NGC 2173, SL 556 and NGC 2155, in the age interval 1-3 Gyr. In this first paper, we describe the aim of the project, the VLT observations and data reduction, and we make preliminary comparisons of the color-magnitude diagrams with both Padova and Yonsei-Yale isochrones. Two following papers in this series present the results of a detailed analysis of these data, independently carried out by members of the Yale and Padova stellar evolution groups. This allows us to compare both sets of models and discuss their main differences, as well as the systematic effects that they would have to the determination of the ages and metallicities of intermediate-age single stellar populations.Comment: 27 pages with 10 figures. Accepted by the Astronomical Journa

    The COSMOS-WIRCam near-infrared imaging survey: I: BzK selected passive and star forming galaxy candidates at z>1.4

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    (abridged) We present a new near-infrared survey covering the 2 deg sq COSMOS field. Combining our survey with Subaru B and z images we construct a deep, wide-field optical-infrared catalogue. At Ks<23 (AB magnitudes) our survey completeness is greater than 90% and 70% for stars and galaxies respectively and contains 143,466 galaxies and 13,254 stars. At z~2 our catalogues contain 3931 quiescent and 25,757 star-forming BzK-selected galaxies representing the largest and most secure sample of these objects to date. Our counts of quiescent galaxies turns over at Ks~22 an effect which we demonstrate cannot be due to sample incompleteness. In our survey both the number of faint and bright quiescent objects exceeds the predictions of a semi-analytic galaxy formation model, indicating potentially the need for further refinements in the amount of merging and AGN feedback at z~2 in these models. We measure the angular correlation function for each sample and find that at small scales the correlation function for passive BzK galaxies exceeds the clustering of dark matter. We use 30-band photometric redshifts to derive the spatial correlation length and the redshift distributions for each object class. At Ks<22 we find r_0^{\gamma/1.8}=7.0 +/-0.5h^{-1} Mpc for the passive BzK candidates and 4.7+/-0.8h^{-1} Mpc for the star-forming BzK galaxies. Our pBzK galaxies have an average photometric redshift of z_p~1.4, in approximate agreement with the limited spectroscopic information currently available. The stacked Ks image will be made publicly available from IRSA.Comment: Accepted for publication in Astrophysical Journal. 17 pages, 17 figures, minor revisions to match published version available at http://adsabs.harvard.edu/abs/2010ApJ...708..202

    VLT/SPHERE deep insight of NGC 3603's core: Segregation or confusion?

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    We present new near-infrared photometric measurements of the core of the young massive cluster NGC 3603 obtained with extreme adaptive optics. The data were obtained with the SPHERE instrument mounted on ESO Very Large Telescope, and cover three fields in the core of this cluster. We applied a correction for the effect of extinction to our data obtained in the J and K broadband filters and estimated the mass of detected sources inside the field of view of SPHERE/IRDIS, which is 13.5"x13.5". We derived the mass function (MF) slope for each spectral band and field. The MF slope in the core is unusual compared to previous results based on Hubble space telescope (HST) and very large telescope (VLT) observations. The average slope in the core is estimated as -1.06^{+0.26}_{-0.26} for the main sequence stars with 3.5 Msun < M < 120 Msun.Thanks to the SPHERE extreme adaptive optics, 814 low-mass stars were detected to estimate the MF slope for the pre-main sequence stars with 0.6 Msun< M < 3.5 Msun , Gamma = -0.54^{+0.11}_{-0.11} in the K-band images in two fields in the core of the cluster. For the first time, we derive the mass function of the very core of the NGC 3603 young cluster for masses in the range 0.6 - 120 Msun. Previous studies were either limited by crowding, lack of dynamic range, or a combination of both
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