Agricultural Best Management Practices and Treatment Wetlands in the Gabilan Watershed: Project Asessment and Evaluation Plan

Several local groups have come together for this project to addresses water quality concerns in the Gabilan Watershed – also known as the Reclamation Ditch Watershed (Fig. 1.1). These are Moss Landing Marine Laboratories (MLML), the Resource Conservation District of Monterey County (RCDMC), Central Coast Watershed Studies (CCoWS), Return of the Natives (RON), Community Alliance with Family Farmers (CAFF), and Coastal Conservation and Research (CC&R). The primary goal is to reduce non-point source pollution – particularly suspended sediment, nutrients, and pesticides – and thereby improve near-shore coastal waters of Moss Landing Harbor and the Monterey Bay. (Document contains 33 pages

A tuple space for data sharing in robot swarms

In this paper, we present a system to allow a swarm of robots to agree on a set of (key,value) pairs. This system enables a form of information sharing that has the potential to be an asset for coordination in complex environments, such as globally optimized task allocation. Taking inspiration from the environment-mediated communication of social insects, we call the system virtual stigmergy. Experimental evaluation indicates that virtual stigmergy can work in a wide variety of running conditions including heavy packet loss, and can cope with random motion trajectories

State and trait characteristics of anterior insula time-varying functional connectivity.

The human anterior insula (aINS) is a topographically organized brain region, in which ventral portions contribute to socio-emotional function through limbic and autonomic connections, whereas the dorsal aINS contributes to cognitive processes through frontal and parietal connections. Open questions remain, however, regarding how aINS connectivity varies over time. We implemented a novel approach combining seed-to-whole-brain sliding-window functional connectivity MRI and k-means clustering to assess time-varying functional connectivity of aINS subregions. We studied three independent large samples of healthy participants and longitudinal datasets to assess inter- and intra-subject stability, and related aINS time-varying functional connectivity profiles to dispositional empathy. We identified four robust aINS time-varying functional connectivity modes that displayed both "state" and "trait" characteristics: while modes featuring connectivity to sensory regions were modulated by eye closure, modes featuring connectivity to higher cognitive and emotional processing regions were stable over time and related to empathy measures

Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene

G protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH β-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH(2)-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH β-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH(2)-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH β-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression

Evidence in support of the call to ban the tackle and harmful contact in school rugby: a response to World Rugby

In a paper published in BJSM (June 2016), World Rugby employees Ross Tucker and Martin Raftery and a third coauthor Evert Verhagen took issue with the recent call to ban tackling in school rugby in the UK and Ireland. That call (to ban tackling) was supported by a systematic review published in BJSM. Tucker et al claim that: (1) the mechanisms and risk factors for injury along with the incidence and severity of injury in youth rugby union have not been thoroughly identified or understood; (2) rugby players are at no greater risk of injury than other sports people, (3) this is particularly the case for children under 15 years and (4) removing the opportunity to learn the tackle from school pupils might increase rates of injuries. They conclude that a ban ‘may be unnecessary and may also lead to unintended consequences such as an increase in the risk of injury later in participation.’ Here we aim to rebut the case by Tucker et al. We share new research that extends the findings of our original systematic review and meta-analysis. A cautionary approach requires the removal of the tackle from school rugby as the quickest and most effective method of reducing high injury rates in youth rugby, a public health priority

Disk Loss and Disk Renewal Phases in Classical Be Stars I: Analysis of Long-Term Spectropolarimetric Data

(Abridged) Classical Be stars occasionally transition from having a gaseous circumstellar disk (''Be phase'') to a state in which all observational evidence for the presence of these disks disappears (''normal B-star phase''). We present one of the most comprehensive spectropolarimetric views to date of such a transition for two Be stars, pi Aquarii and 60 Cygni. 60 Cyg's disk loss episode was characterized by a monotonic decrease in emission strength over a time-scale of 1000 days, consistent with the viscous time-scale of the disk, assuming alpha is 0.14. pi Aqr's disk loss was episodic in nature and occurred over a time-scale of 2440 days. An observed time lag between the behavior of the polarization and H-alpha in both stars indicates the disk clearing proceeded in an ''inside-out'' manner. We determine the position angle of the intrinsic polarization to be 166.7 +/- 0.1 degrees for pi Aqr and 107.7 +/- 0.4 degrees for 60 Cyg, and model the observed polarization during the quiescent diskless phase of each star to determine the interstellar polarization along the line of sight. Minor outbursts observed during the quiescent phase of each star shared similar lifetimes as those previously reported for mu Cen, suggesting that the outbursts represent the injection and subsequent viscous dissipation of individual blobs of material into the inner circumstellar environments of these stars. We also observe deviations from the mean intrinsic polarization position angle during polarization outbursts in each star, indicating deviations from axisymmetry. We propose that these deviations might be indicative of the injection (and subsequent circularization) of new blobs into the inner disk, either in the plane of the bulk of the disk material or in a slightly inclined (non-coplanar) orbit.Comment: 30 pages, 14 figures; accepted in Ap

Galaxy clustering in the NEWFIRM Medium Band Survey: the relationship between stellar mass and dark matter halo mass at 1 < z < 2

We present an analysis of the clustering of galaxies as a function of their stellar mass at 1 < z < 2 using data from the NEWFIRM Medium Band Survey (NMBS). The precise photometric redshifts and stellar masses that the NMBS produces allows us to define a series of mass limited samples of galaxies more massive than 0.7, 1 and 3x10^10 Msun in redshift intervals centered on z = 1.1, 1.5 and 1.9 respectively. In each redshift interval we show that there exists a strong dependence of clustering strength on the stellar mass limit of the sample, with more massive galaxies showing a higher clustering amplitude on all scales. We further interpret our clustering measurements in the LCDM cosmological context using the halo model of galaxy clustering. We show that the typical halo mass of central and satellite galaxies increases with stellar mass, whereas the satellite fraction decreases with stellar mass, qualitatively the same as is seen at z < 1. We see little evidence of any redshift dependence in the stellar mass-to-halo mass relationship over our narrow redshift range. However, when we compare with similar measurements at z~0, we see clear evidence for a change in this relation. If we assume a universal baryon fraction, the ratio of stellar mass to halo mass reveals the fraction of baryons that have been converted to stars. We see that the peak in this star formation efficiency for central galaxies shifts to higher halo masses at higher redshift, moving from ~7x10^11 Msun at z~0 to ~3x10^12 Msun at z~1.5, revealing evidence of `halo downsizing'. Finally we show that for highly biased galaxy populations at z > 1 there may be a discrepancy between the measured space density and clustering and that predicted by the halo model. This could imply that there is a problem with one or more ingredients of the halo model at these redshifts, for instance the halo bias relation or the halo profile.Comment: Accepted for publication in ApJ. Correction made to typo in halo masses in conclusion

Synthesis of the originally proposed structures of elatenyne and an enyne from Laurencia majuscula

A bidirectional synthesis of the originally proposed structures for the natural products elatenyne and a chloroenyne from Laurencia majuscula is described along with a reassessment of the structures of the halogenated enynes based upon a C-13 NMR chemical shift/structure correlation