Postbuckling failure of composite plates with central holes

The postbuckling failure of square composite plates with central holes is analyzed numerically and experimentally. The particular plates studies have stacking sequences of: (+ and - 45/0/90)(sub 2S); (+ and - 45/0(sub 2))(sub 2S); (+ and - 45/0(sub 6))(sub S); and (+ and - 45)(sub 4S). A simple plate geometry, one with a hole diameter to plate width ratio of 0.3 is compared. Failure load, failure mode, and failure location are predicted numerically by using the finite element method. Predictions are compared with experimental results. In numerical failure analysis the interlaminar shear stresses, as well as the inplane stresses are taken into account. An issue addressed in this study is the possible mode shape change of the plate during loading. It is predicted that the first three laminates fail due to excessive stresses in the fiber direction, and more importantly, that the load level is independent of whether the laminate is deformed in a one-half or two-half wave configuration. It is predicted that the fourth laminate fails due to excessive inplane shear stress. Interlaminar shear failure is not predicted for any laminates. For the first two laminates the experimental observations correlated well with the predictions. Experimentally, the third laminate failed along the side support due to interlaminar shear strength S(sub 23). The fourth experimental laminate failed due to inplane shear in the location predicted, however material softening resulted in a different failure load from predictions

Innovative design of composite structures: The use of curvilinear fiber format to improve buckling resistance of composite plates with central circular holes

The gains in buckling performance are explored that can be achieved by deviating from the conventional straightline fiber format and considering the situation whereby the fiber orientation in a layer, or a group of layers, can vary from point to point. The particular situation studied is a simply supported square plate with a centrally located hole loaded in compression. By using both a sensitivity analysis and a gradient-search technique, fiber orientation in a number of regions of the plate are selected so as to increase the buckling load relative to baseline straightline designs. The sensitivity analysis is used to determine which regions of the plate have the most influence on buckling load, and the gradient search is used to find the design that is believed to represent the absolute maximum buckling load for the conditions prescribed. Convergence studies and sensitivity of the final design are discussed. By examining the stress resultant contours, it is shown how the curvilinear fibers move the load away from the unsupported hole region of the plate to the supported edges, thus increasing the buckling capacity. The tensile capacity of the improved buckling design is investigated, and it is shown that both tensile capacity and buckling capacity can be improved with the curvilinear fiber concept

3D FEA modelling of laminated composites in bending and their failure mechanisms

keywords: 3D keywords: 3D keywords: 3D keywords: 3D keywords: 3DAbstract This paper developed three-dimensional (3D) Finite Element Analysis (FEA) to investigate the effect of fibre lay-up on the initiation of failure of laminated composites in bending. Tsai-Hill failure criterion was applied to identify the critical areas of failure in composite laminates. In accordance with the 3D FEA, unidirectional ([0]16), cross-ply ([0/90]4s) and angle-ply ([±45]4s) laminates made up of pre-preg Carbon Fibre Reinforced Plastics (CFRP) composites were manufactured and tested under three-point bending. The basic principles of Classical Laminate Theory (CLT) were extended to three-dimension, and the analytical solution was critically compared with the FEA results. The 3D FEA results revealed significant transverse normal stresses in the cross-ply laminate and in-plane shear stress in the angle-ply laminate near free edge regions which are overlooked by conventional laminate model. The microscopic images showed that these free edge effects were the main reason for stiffness reduction observed in the bending tests. The study illustrated the significant effects of fibre lay-up on the flexural failure mechanisms in composite laminates which lead to some suggestions to improve the design of composite laminates

Factors influencing employee perceptions in lean transformations

The purpose of the study was to investigate employee perceptions during a lean transformation1. The combination of case study and survey methodologies was used to define elements influencing the perceived lean success of shop floor employees. According to our findings, belief, commitment, work method and communication all have a considerable direct impact on workers’ perceptions of lean success. However, their effects are very different based on the scope and focus of changes that is influenced by process characteristics. Perceptions regarding successful lean transformation during a moderate reorganisation of the company’s welding plant, where mainly males work, are affected only by commitment and work method, whereas the deep reorganisation of the sewing plant (populated by female employees) is only influenced by belief and communication

Effects of insulin-like growth factor-1 on retinal endothelial cell glucose transport and proliferation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65813/1/j.1471-4159.2001.00325.x.pd

3D printing of twisting and rotational bistable structures with tuning elements

Three-dimensional (3D) printing is ideal for the fabrication of various customized 3D components with fine details and material-design complexities. However, most components fabricated so far have been static structures with fixed shapes and functions. Here we introduce bistability to 3D printing to realize highly-controlled, reconfigurable structures. Particularly, we demonstrate 3D printing of twisting and rotational bistable structures. To this end, we have introduced special joints to construct twisting and rotational structures without post-assembly. Bistability produces a well-defined energy diagram, which is important for precise motion control and reconfigurable structures. Therefore, these bistable structures can be useful for simplified motion control in actuators or for mechanical switches. Moreover, we demonstrate tunable bistable components exploiting shape memory polymers. We can readjust the bistability-energy diagram (barrier height, slope, displacement, symmetry) after printing and achieve tunable bistability. This tunability can significantly increase the use of bistable structures in various 3D-printed components

A systematic review of the concept and clinical applications of Bone Marrow Aspirate Concentrate in Orthopaedics

INTRODUCTION: Mesenchymal stem cells (MSC's) are believed to have multipotent plasticity with the capability to differentiate along multiple cell lineages such as cartilage, bone, tendon, muscle, and nerve. Such multipotency has the potential to play an important role in the repair and reconstruction of multiple tissues across a number of orthopaedic specialties. Bone marrow and fat are the most abundant and accessible source of MSC's with bone marrow aspirate the most commonly being reported to stimulate healing. METHODS: This review examines the current reported 20 Q2 clinical applications of bone marrow aspirate concentrate and its effectiveness. RESULTS: The published studies reported techniques of collection and preparation of BMAC in addition to its applications in a number of orthopaedic sub-specialities. Studies could be sub-categorised into: techniques of extraction, processing and microscopic examination of BMAC (31), reconstruction of osseous defects/non-union (20), treatment of avascular necrosis (9), repair of cartilage defects (8), treatment of sports injuries and tendon injury/repair (9), injection in regenerative therapy (4), treatment of spine conditions (4) including enhancing postoperative fusion and degenerative disc pathology and orthopaedic oncology (4). A few published studies combined the use of platelet-rich plasma (PRP) with BMAC (4) or compared them in different applications (5). CONCLUSIONS: BMAC has been used in bone, cartilage and tendon injuries with encouraging results

A systematic review of the concept and clinical applications of bone marrow aspirate concentrate in tendon pathology

Tendon pathologies are a group of musculoskeletal conditions frequently seen in clinical practice. They can be broadly classified into traumatic, degenerative and overuse-related tendinopathies. Rotator cuff tears, Achilles tendinopathy and tennis elbow are common examples of these conditions. Conventional treatments have shown inconsistent outcomes and might fail to provide satisfactory clinical improvement. With the growing trend towards the use of mesenchymal stem cells (MSCs) in other branches of medicine, there is an increasing interest in treating tendon pathologies using the bone marrow MSC. In this article, we provide a systematic literature review documenting the current status of the use of bone marrow aspirate concentrate (BMAC) for the treatment of tendon pathologies. We also asked the question on the safety of BMAC and whether there are potential complications associated with BMAC therapy. Our hypothesis is that the use of BMAC provides safe clinical benefit when used for the treatment of tendinopathy or as a biological augmentation of tendon repair. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist while preparing this systematic review. A literature search was carried out including the online databases of PubMed, EMBASE, ClinicalTrial.gov and the Cochrane Library from 1960 to the end of May 2015. Relevant studies were selected and critically appraised. Data from eligible studies were extracted and classified per type of tendon pathology. We included 37 articles discussing the application and use of BMAC for the treatment of tendon pathologies. The Critical Appraisal Skills Program (CASP) appraisal confirmed a satisfactory standard of 37 studies. Studies were sub-categorised into: techniques of extraction, processing and microscopic examination of BMAC (n = 18), where five studies looked at the evaluation of aspiration techniques (n = 5), augmentation of rotator cuff tears (n = 5), augmentation of tendo-achilles tendon (n = 1), treatment of gluteal tendon injuries (n = 1), management of elbow epicondylitis (n = 2), management of patellar tendinopathy (n = 1) and complications related to BMAC (n = 5). Multiple experimental studies investigated the use of BMAC for tendon repair; nonetheless, there are only limited clinical studies available in this field. Unfortunately, due to the scarcity of studies, which were mainly case series, the current level of evidence is weak. We strongly recommend further future randomised controlled studies in this field to allow scientists and clinicians make evidence-based conclusions

Coordinated Morphogenetic Mechanisms Shape the Vertebrate Eye.

The molecular bases of vertebrate eye formation have been extensively investigated during the past 20 years. This has resulted in the definition of the backbone of the gene regulatory networks controlling the different steps of eye development and has further highlighted a substantial conservation of these networks among vertebrates. Yet, the precise morphogenetic events allowing the formation of the optic cup from a small group of cells within the anterior neural plate are still poorly understood. It is also unclear if the morphogenetic events leading to eyes of very similar shape are indeed comparable among all vertebrates or if there are any species-specific peculiarities. Improved imaging techniques have enabled to follow how the eye forms in living embryos of a few vertebrate models, whereas the development of organoid cultures has provided fascinating tools to recapitulate tissue morphogenesis of other less accessible species. Here, we will discuss what these advances have taught us about eye morphogenesis, underscoring possible similarities and differences among vertebrates. We will also discuss the contribution of cell shape changes to this process and how morphogenetic and patterning mechanisms integrate to assemble the final architecture of the eye