Envelope Trajectory of Water Jet Issuing From a Thin Weir Obtained by Photogrammetry

Today, to have a good command of the energy dissipation of a jet issuing from a weir we need to improve our knowledge of the location of the impact. This laboratory experiment applied photogrammetry to determine the envelope trajectory of a water jet coming from a thin wall weir. The fall was about 9 meters, the weir was 1 meter wide and the flow was up to 500 l/s. The trajectory of the jet was reconstituted in the three spatial dimensions using the PhotoScan software package developed by Agisoft. The exposure time for each picture was enough to make white water. Envelope trajectory was compared to classical expressions such as those of Scimeni (1937) or De Marchi (1928

Quantification of infliximab and adalimumab in human plasma by a liquid chromatography tandem mass spectrometry kit and comparison with two ELISA methods

International audienceBackground: This study compared the performance of plasma infliximab and adalimumab quantification using a commercially available kit (mAbXmise kit) and mass spectrometry readout to that of two ELISA methods in patients treated for inflammatory bowel disease. Methods and results: The mAbXmise method based on liquid chromatography tandem mass spectrometry (LC-MS/MS) was linear from 2 to 100 mu g/ml. It was validated according to international guidelines. Regarding cross-validation for infliximab (n = 70), the mean bias with LC-MS/MS assay was approximately threefold higher with the commercial ELISA assay compared with the in-house ELISA (-6.1 vs -1.8 mu g/ml, respectively). The mean bias between the LC-MS/MS assay and in-house ELISA was -1.2 mu g/ml for adalimumab (n = 35). Conclusion: The LC-MS/MS method is a powerful alternative to immunoassays to monitor concentrations of infliximab and adalimumab

Tools for integrating soil and sub-soil in sustainable urban planning

12 p.This work aims at developing the bases necessary for taking into account in an integrated manner the soil and sub-soil issues in urban development. The diversity of actors and their concerns lead us to develop different tools, with dedicated uses: 1) a multi-actor debate-aid tool based on multi-criteria analysis, that makes more readable the diversity of challenges and viewpoints of actors; 2) a technical aid-tool with a database devoted to stakeholders, that makes an inventory of main issues that may be encountered during typical urban development projects and that enables to agglomerate the information from basic data in order to make it usable in the multi-actor public consultation; 3) a quantitative decision-making aid tool for enlightening the economic value of indispensable investigations. A conceptual framework is proposed, based on the expertise of the project partners in data gathering, in operational urban development or in project management. It is validated and tested on real test cases, corresponding to specific urban projects

Simultaneous quantification of infliximab and adalimumab in human plasma by liquid chromatography-tandem mass spectrometry using ready-to-use kit and comparison with two ELISA methods

International audienceMeeting Abstract PS-03

Simultaneous quantification of infliximab and adalimumab in human plasma by liquid chromatography-tandem mass spectrometry using ready-to-use kit and comparison with two ELISA methods

International audienceMeeting Abstract PS-03

Activité d'<em>Ixodes ricinus</em> en lien avec la météorologie dans le cadre du changement climatique

National audienc

Long-term health-related quality of life of critically ill patients with haematological malignancies: a prospective observational multicenter study

Background: Although outcomes of critically ill patients with haematological malignancies (HMs) have been fully investigated in terms of organ failure and mortality, data are scarce on health-related quality of life (HRQOL) in this population. We aim to assess post-intensive care unit (ICU) burden and HRQOL of critically ill patients with HMs and to identify risk factors for quality-of-life (QOL) impairment. Results: In total, 1011 patients with HMs who required ICU admission in 17 ICUs in France and Belgium were included in the study; 278 and 117 patients were evaluated for QOL at 3 months and 1 year, respectively, after ICU discharge. HRQOL was determined by applying the interview form of the Short Form 36 (SF-36) questionnaire. Psychological distress symptoms were evaluated using the Hospital Anxiety Depression Score (HADS) and the Impact of Event Scale (IES). In-hospital mortality rates at 3 months and 1 year were, respectively, 39.1, 50.7 and 57.2%, respectively. At 3 months, median [IQR] physical and mental component summary scores (PCS and MCS) (SF-36) were 37 [28–46] and 51 [45–58], respectively. PCS was lower in ICU patients with HMs when compared to general ICU septic patients (52 [5–13], p = 0.00001). The median combined HAD score was 8 [5–13], and the median IES score was 8 [3–16]. However, recovery during the first year after ICU discharge was not consistent in all dimensions of HRQOL. Three months after ICU discharge, the maximum daily Sequential Organ Failure Assessment score and status of the underlying malignancy at ICU admission were significantly associated with MCS impairment (− 0.54 points [95% CI − 0.99; − 0.1], p = 0.018 and − 4.83 points [95% CI − 8.44; − 1.22], p = 0.009, respectively). Conclusion: HRQOL is strongly impaired in critically ill patients with HMs at 3 months and 1 year after ICU discharge. Organ failure and disease status are strongly associated with QOL. The kinetic evaluation of QOL at 3 months and 1 year offers the opportunity to focus on QOL aspects that may be improved by therapeutic interventions during the first year after ICU discharge.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Microbes and the environment

The production of traditional fermented meat or dairy products is a complex biological phenomenon affected by the action of indigenous microbes. These traditional manufacturing practices lead to a great variability in the quality and flavor of the products. Understanding the metabolic activities, diversity and behavior of microorganisms during food fermentations is a very interesting and challenging task. This will help the producers to reach high quality of their products in terms of safety, shelf life and organoleptic characteristics, as the most promising strains for starter cultures are those which are isolated from the indigenous microbiota of traditional products. The current chapter describes the microbial diversity of naturally fermented dairy and meat products in relation to processing environment and equipment as well as the impact on quality characteristics including authentication of origin and traditional making practices