Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells

The mammalian target of rapamycin (mTOR) kinase is a critical regulator of the differentiation of helper and regulatory CD4+ T cells, as well as memory CD8+ T cells. In this study, we investigated the role of the ERK signaling pathway in regulating mTOR activation in T cells. We showed that activation of ERK following TCR engagement is required for sustained mTOR complex 1 (mTORC1) activation. Absence of kinase suppressor of Ras 1 (KSR1), a scaffold protein of the ERK signaling pathway, or inhibition of ERK resulted in decreased mTORC1 activity following T cell activation. However, KSR1-deficient mice displayed normal regulatory CD4+ T cell development, as well as normal memory CD8+ T cell responses to LCMV and Listeria monocytogenes infection. These data indicate that despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR-dependent T cell differentiation

Ultraviolet to infrared emission of z>1 galaxies: Can we derive reliable star formation rates and stellar masses?

We seek to derive star formation rates (SFR) and stellar masses (M_star) in distant galaxies and to quantify the main uncertainties affecting their measurement. We explore the impact of the assumptions made in their derivation with standard calibrations or through a fitting process, as well as the impact of the available data, focusing on the role of IR emission originating from dust. We build a sample of galaxies with z>1, all observed from the UV to the IR (rest frame). The data are fitted with the code CIGALE, which is also used to build and analyse a catalogue of mock galaxies. Models with different SFHs are introduced. We define different set of data, with or without a good sampling of the UV range, NIR, and thermal IR data. The impact of these different cases on the determination of M_star and SFR are analysed. Exponentially decreasing models with a redshift formation of the stellar population z ~8 cannot fit the data correctly. The other models fit the data correctly at the price of unrealistically young ages when the age of the single stellar population is taken to be a free parameter. The best fits are obtained with two stellar populations. As long as one measurement of the dust emission continuum is available, SFR are robustly estimated whatever the chosen model is, including standard recipes. M_star measurement is more subject to uncertainty, depending on the chosen model and the presence of NIR data, with an impact on the SFR-M_star scatter plot. Conversely, when thermal IR data from dust emission are missing, the uncertainty on SFR measurements largely exceeds that of stellar mass. Among all physical properties investigated here, the stellar ages are found to be the most difficult to constrain and this uncertainty acts as a second parameter in SFR measurements and as the most important parameter for M_star measurements.Comment: 14 pages, 14 figures, accepted for publication A&

New light on gamma-ray burst host galaxies with Herschel

Until recently, dust emission has been detected in very few host galaxies of gamma-ray bursts (GRBHs). With Herschel, we have now observed 17 GRBHs up to redshift z~3 and detected seven of them at infrared (IR) wavelengths. This relatively high detection rate (41%) may be due to the composition of our sample which at a median redshift of 1.1 is dominated by the hosts of dark GRBs. Although the numbers are small, statistics suggest that dark GRBs are more likely to be detected in the IR than their optically-bright counterparts. Combining our IR data with optical, near-infrared, and radio data from our own datasets and from the literature, we have constructed spectral energy distributions (SEDs) which span up to 6 orders of magnitude in wavelength. By fitting the SEDs, we have obtained stellar masses, dust masses, star-formation rate (SFR), and extinctions for our sample galaxies. We find that GRBHs are galaxies that tend to have a high specfic SFR (sSFR), and like other star-forming galaxies, their ratios of dust-to-stellar mass are well correlated with sSFR. We incorporate our Herschel sample into a larger compilation of GRBHs, and compare this combined sample to SFR-weighted median stellar masses of the widest, deepest galaxy survey to date. This is done in order to establish whether or not GRBs can be used as an unbiased tracer of cosmic comoving SFR density (SFRD) in the universe. In contrast with previous results, this comparison shows that GRBHs are medium-sized galaxies with relatively high sSFRs; stellar masses and sSFRs of GRBHs as a function of redshift are similar to what is expected for star-forming galaxy populations at similar redshifts. We conclude that there is no strong evidence that GRBs are biased tracers of SFRD; thus they should be able to reliably probe the SFRD to early epochs.Comment: 18 pages, 9 figures, accepted for publication in A&A. Revised to include Fig. 6, mistakenly omitted in origina

Differential stellar population models: how to reliably measure [Fe/H] and [alpha/Fe] in galaxies

We present differential stellar population models, which allow improved determinations of the ages, iron and alpha-element abundances of old stellar populations from spectral fitting. These new models are calibrated at solar abundances using the predictions from classical, semi-empirical stellar population models. We then use the predictive power of fully synthetic models to compute predictions for different [Fe/H] and [alpha/Fe]. We show that these new differential models provide remarkably accurate fits to the integrated optical spectra of the bulge globular clusters NGC6528 and NGC6553, and that the inferred [Fe/H] and [alpha/Fe] agree with values derived elsewhere from stellar photometry and spectroscopy. The analysis of a small sample of SDSS early-type galaxies further confirms that our alpha-enhanced models provide a better fit to the spectra of massive ellipticals than the solar-scaled ones. Our approach opens new opportunities for precision measurements of abundance ratios in galaxies.Comment: 5 pages, 5 figures, MNRAS in pres

Active-distributed temperature sensing to continuously quantify vertical flow in boreholes

We show how a distributed borehole flowmeter can be created from armored Fiber Optic cables with the Active-Distributed Temperature Sensing (A-DTS) method. The principle is that in a flowing fluid, the difference in temperature between a heated and unheated cable is a function of the fluid velocity. We outline the physical basis of the methodology and report on the deployment of a prototype A-DTS flowmeter in a fractured rock aquifer. With this design, an increase in flow velocity from 0.01 to 0.3 m s−1 elicited a 2.5°C cooling effect. It is envisaged that with further development this method will have applications where point measurements of borehole vertical flow do not fully capture combined spatiotemporal dynamics

Galaxy merger histories and the role of merging in driving star formation at z>1

This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society. © 2015 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society.We use Horizon-AGN, a hydrodynamical cosmological simulation, to explore the role of mergers in the evolution of massive (M > 10^10 MSun) galaxies around the epoch of peak cosmic star formation (1zR(4:1 3 are 'blue' (i.e. have significant associated star formation), the proportion of 'red' mergers increases rapidly at ztodays stellar mass was formed.Peer reviewe

Properties of high-z galaxies as seen through lensing clusters

We discuss the first results obtained on the study of a sample of high-z galaxies (2 < z < 7), using the gravitational amplification effect in the core of lensing clusters. Sources are located close to the critical lines in clusters with well constrained mass distributions, and selected through photometric redshifts, computed on a large wavelength domain, and lens inversion techniques.Comment: 5 pages, 3 figures, Conference Proceedings of the "Clustering at High Redshift" Conference, June 29 to July 2, 1999, Marseille (France

Thermal-Plume fibre Optic Tracking (T-POT) test for flow velocity measurement in groundwater boreholes

International audienceWe develop an approach for measuring in-well fluid velocities using point electrical heating combined with spatially and temporally continuous temperature monitoring using Distributed Temperature Sensing (DTS). The method uses a point heater to warm a discrete volume of water. The rate of advection of this plume, once the heating is stopped, equates to the average flow velocity in the well. We conducted Thermal-Plume fibre Optic Tracking (T-POT) tests in a borehole in a fractured rock aquifer with the heater at the same depth and multiple pumping rates. Tracking of the thermal plume peak allowed the spatially varying velocity to be estimated up to 50 m downstream from the heating point, depending on the pumping rate. The T-POT technique can be used to estimate the velocity throughout long intervals provided that thermal dilution due to inflows, dispersion, or cooling by conduction do not render the thermal pulse unresolvable with DTS. A complete flow log may be obtained by deploying the heater at multiple depths, or with multiple point heaters

The all-sky GEOS RR Lyr survey with the TAROT telescopes. Analysis of the Blazhko effect

We used the GEOS database to study the Blazhko effect of galactic RRab stars. The database is continuously enriched by maxima supplied by amateur astronomers and by a dedicated survey by means of the two TAROT robotic telescopes. The same value of the Blazhko period is observed at different values of the pulsation periods and different values of the Blazhko periods are observed at the same value of the pulsation period. There are clues suggesting that the Blazhko effect is changing from one cycle to the next. The secular changes in the pulsation and Blazhko periods of Z CVn are anticorrelated. The diagrams of magnitudes against phases of the maxima clearly show that the light curves of Blazhko variables can be explained as modulated signals, both in amplitude and in frequency. The closed curves describing the Blazhko cycles in such diagrams have different shapes, reflecting the phase shifts between the epochs of the brightest maximum and the maximum O-C. Our sample shows that both clockwise and anticlockwise directions are possible for similar shapes. The improved observational knowledge of the Blazhko effect, in addition to some peculiarities of the light curves, have still to be explained by a satisfactory physical mechanism.Comment: 13 pages, 12 figures, accepted for publication in Astronomical Journa