Diseño de los procesos comerciales y su influencia en la productividad en ventas de la empresa Lagencia S. A. C. – Trujillo 2018

La investigación tuvo por objetivo determinar la influencia del diseño de los procesos comerciales en la productividad en ventas de la empresa LAGENCIA S.A.C., empresa dedicada a brindar servicios de marketing y publicidad en la ciudad de Trujillo. Por medio de la aplicación de encuestas a 13 clientes de la empresa, entrevistas con el gerente general de la misma y la revisión documental se identificó la inexistencia de los procesos comerciales definidos lo cual provocaba un déficit en la productividad de las ventas. Se analizó la realidad problemática, se identificaron los aspectos a replantear, se definieron los procesos y se elaboró un plan de mejora continua. Luego de diseñar los procesos comerciales, se estimó el impacto económico, el cual arrojó un aumento en las utilidades del periodo Julio 2017 con S/ 4 142.00 y terminando con S/ 7 842.00 a finales del periodo Diciembre 2017, reflejo de la productividad en las ventas. Se tuvo como resultado la viabilidad del proyecto tras el análisis económico y el plan diseñado con mejoras en las mediciones realizadas. Llegando a la conclusión que el diseño de los procesos comerciales influye positivamente en la productividad en ventas de la empresa LAGENCIA S.A.C.The objective of the research was to determine the influence of the design of commercial processes on the sales productivity of the company LAGENCIA S.A.C., a company dedicated to providing marketing and advertising services in the city of Trujillo. Through the application of surveys to 13 clients of the company, interviews with the company's general manager and the documentary review, the lack of defined business processes was identified, which caused a deficit in sales productivity. The problematic reality was analyzed, the aspects to be reframed were identified, the processes were defined and a continuous improvement plan was elaborated. After designing the commercial processes, the economic impact was estimated, which showed an increase in the profits of the period July 2017 with S / 4 142.00 and ending with S / 7 842.00 at the end of the period December 2017, reflecting the productivity in the sales The feasibility of the project was achieved after the economic analysis and the plan designed with improvements in the measurements made. Reaching the conclusion that the design of the commercial processes positively influences the sales productivity of the company LAGENCIA S.A.C

The angiotensin-(1-7)/Mas receptor a xis protects from endothelial cell senescence via klotho and Nrf2 activation

Endothelial cell senescence is a hallmark of va scular aging that pre disposes to vascular disease. We aimed to explore the capacity of the renin-angiotensin system (RAS) heptapeptide angiotensin (Ang)-(1-7) to counteract human endothelial cell senescence and to identify intracellular pathways mediati ng its potential protective action. In human umbilical vein endothelial cell (HUVEC) cult ures, Ang II promoted cell senescence, as revealed by the enhancement in se nescence-associated galactosidase (SA- -gal+) positive staining, total and telomeric DNA damage, adhesion molecules expression and human mononuclear adhesion to HUVEC monolaye rs. By activating the G-coupled receptor Mas, Ang-(1-7) inhibit ed the pro-senescence action of Ang II, but also of a non- RAS stressor such as the cytokine IL-1 . Moreover, Ang-(1-7) enhanced endothelial klotho levels, while klotho silencing resulted in th e loss of the anti-senescence action of the heptapeptide. Indeed, both Ang-(1-7) and recombinant klotho activated the cytoprotective Nrf2/heme-oxygenase-1 (HO)-1 pathway. The HO-1 inhibitor tin protoporphyrin IX prevented the anti-senescence action evoked by Ang-(1-7) or recombinant klotho. Overall, the present study ide ntifies Ang-(1-7) as an anti-senescence peptide displaying its protectiv e action beyond the RAS by consecutively activating klotho and Nrf2/HO-1. Ang-(1-7) mimetic dru gs may thus prove useful to prevent endothelial cell senescence and its re lated vascular complications

Research Network PalmerNET. Unity makes strength

PalmerNET es una Red de Investigación (RED2022-134285-T), financiada por la Agencia Española de Investigación, para combatir Amaranthus palmeri (A. palmeri)S. Wats., especie invasora establecida en Lleida, Huesca y Extremadura, con capacidad de generar resistencias a herbicidas. Bajo la dirección del investigador Joel Torra, la Fundación Centro de Investigación en Agrotecnología (Agrotecnio) y la Universitat de Lleida (UdL) han puesto en marcha PalmerNET, donde participan, además, otras tres universidades: la Universidad Pública de Navarra, la Universidad de Vigo y la Universitat Politècnica de València, y otros tres centros de investigación: el Centro de Investigación y Tecnología Agraria de Aragón (CITA), el Instituto Nacional de Investigaciones Agrarias de Madrid (INIA-CSIC) y el Centro de Investigaciones Científicas y Tecnológicas de Extremadura (CICYTEX). Un total de 25 personas, entre investigadores, profesores y estudiantes predoctorales, integran PalmerNET. La red promoverá la colaboración e investigación entre los grupos participantes para comprender y poder contener la expansión de la mala hierba y divulgar el concimiento disponible sobre este grave problema fitosanitario. Durante la vigencia de la red PalmerNET (de 2023 a 2025), se realizarán Jornadas Técnicas de divulgación, se actualizará la información mediante reuniones de los miembros y la creación de una página web. La red potenciará la cooperación entre los investigadores participantes para alcanzar una visión global del problema, uniendo esfuerzos de investigación y de actuación.PalmerNET is a Research Network (RED2022-134285-T), financed by the Agencia Española de Investigación, to fight against Amaranthus palmeri (A. palmeri)S. Wats., an invasive weed species established in Lleida, Huesca and Extremadura, with the ability to evolve herbicide resistance. Under the leadership of researcher Joel Torra, the Agrotechnology Research CERCA Centre (Agrotecnio) and the Universitat de Lleida (UdL) have started PalmerNET, where three other universities participate, namely the Universidad Pública de Navarra, the Universidad de Vigo and the Universitat Politècnica de València, and three other research institutes namely the Centro de Investigación y Tecnología Agraria de Aragón (CITA), the Instituto Nacional de Investigaciones Agrarias of Madrid (INIA-CSIC) and the Centro de Investigaciones Científicas y Tecnológicas de Extremadura (CICYTEX). A total of 25 people, including researchers, professors and PhD students, integrate PalmerNET. The net will promote the collaboration and research between these research groups to understand and contribute to containing the spread of this invasive weed and disseminate the available knowledge regarding this worrying crop protection problem. During the period of the network PalmerNET (from 2023 to 2025), several activities will be undertaken, like technical seminars with the sector, periodic meetings of the net members, and the creation of a web page. This network will foster cooperation between the participating members to reach a global view of the problem and join research and action effortsPalmerNET es una Red de Investigación (RED2022-134285-T), financiada por la Agencia Española de Investigación.Figura 2 - Logo de la Red de Investigación PalmerNET.Palmer amaranthinvasive weeddisseminationcooperationAmaranthus palmeriPublishe

La educación en psicología a través de la virtualidad

La educación en psicología a través de la virtualidad es la presentación de las investigaciones que se han realizado en Politécnico Grancolombiano sobre cómo educar (y mejorar el proceso educativo), desde la disciplina encargada de velar por la salud mental de las personas. A lo largo de estos capítulos se describen las mejores estrategias para mantener la educación virtual con los más altos estándares de calidad, para finalmente entender cómo proyectarnos en medio de los retos de ejercer una profesión que tradicionalmente se ha contextualizado en la presencialidad

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Annual Conference on Formative Research on EFL. Practices thar inspire change.

The conference papers of the Annual Conference on Formative Research on EFL. Practices thar inspire change collect pedagogical experiences, research reports, and reflections about social issues, language teaching, teaching training, interculturality under the panorama of the Covid-19 pandemic. Each paper invites the reader to implement changes in their teaching practice through disruptive pedagogies, reflect on the social and emotional consequences of the lockdown, new paths for teacher training and different approaches for teaching interculturality. We expect to inspire new ways to train pre-service teachers and teach languages in this changing times

Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.

Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics

IMPACTO DE VARIÁVEIS CONGNITIVAS E CONTEXTUAIS SOBRE O SUCESSO ACADÊMICO E O BEM ESTAR NA UNIVERSIDADE – QUE FAZER? QUE DEIXAR DE FAZER?

Este estudo parte de uma investigação longitudinal (2019-2022) mais ampla, vinculada ao Grupo Multidisciplinar de Pesquisa em Educação, Psicopedagogia e Psicologia Escolar, UFAM/CNPq, PROCAD/AMAZÔNIA-PPGEUFAM/UFPA/UFMT, Processo CAPES 8881.314288/2019-0, articula-se metodológica e teoricamente com interfaces entre a psicologia escolar, psicologia educacional, pedagogia do ensino superior e educação escolar. Atua no sentido de entender os efeitos de variáveis cognitivas e contextuais sobre o sucesso acadêmico e o bem estar na universidade. A metodologia para coleta de dados é a aplicação de caderno de instrumentos próprios com apoio do Googleodocs, a amostra atual é de n=1112 estudantes de diferentes países (Brasil, México, República Dominicana, Bolívia, Moçambique, Angola, Venezuela, Colômbia, Espanha e Portugal), do sexo masculino e feminino, idade entre 18 e 54 anos e de 51 universidades públicas e privadas que colaboram com a iniciativa. Os dados são analisados com auxílio do Excel e SPSS, de acordo com os interesses dos pesquisadores e objetivos da investigação. Os resultados atuais demonstram a importância da pesquisa sobre os temas abordados pela iniciativa considerando o impacto das variáveis estudadas sobre o rendimento acadêmico e bom estar tanto de estudantes como de docentes e técnicos no ensino superior. Foram identificadas diferenças de países, renda, etnia, gênero e renda. No caso dos docentes e técnicos verificamos evidências da exaustão feminina. Os resultados podem apoiar a administração geral e coordenação educativa e psicopedagógica universitária em sentido amplo, visando a melhoria dos indicadores de sucesso acadêmico e bem estar, por meio da proposição de novas políticas e gestão da educação superior. Palavras-chave: Pesquisa em educação, Ensino superior, Rendimento acadêmico, Bem estar. Políticas de gestão da educação superior. Educação comparada.   IMPACT OF COGNITIVE AND CONTEXTUAL VARIABLES ABOUT ACADEMIC PERFORMANCE AND  WELLBEING IN THE UNIVERSITY. Whato to do? Qhato not to do?   Abstract: This study, part of a further longitudinal investigation (2019-2022), attached to a multidisciplinary group of Educational Research  Scholar Psychotherapy and Psychology, UFAM/CNPq, PROCAD/AMAZONIA-PPGEUFAM/UFPA/UFMT, CAPES process 8881.314288/2019-0, it is articulated methodological and theoretically with interfaces between the scholar and educational psychology, upper and scholar education pedagogy. It acts in the direction of understanding 5he effects og cognitive and contextual variables about the academic achievement and wellness in the university. The methodology to data collection is the application of own instrument cards with the support of Googledocs, the actual sample is quantity of n=1112 students from 51 private and public universities of different countries (Brazil, Mexico, Dominican Republic, Bolivia, Mozambique, Angola, Venezuela, Colombia, Spain and Portugal), from both male and female genders, aging between 18 and 54 years-old. The data were analyzed with the support of software Excel and SPSS, according to the interests of researchers and investigation focus. The actual results show the importance of the research about the themes cited in the initiative considering the impacts of the studied variables over the academic performance and wellness of the students as the teachers and technicians from upper education. There were found differences between countries, income, ethnic and gender. In the cases of the teachers and technicians it was found evidences of female exhaustion. The results could support the general administration, educative and psychopedagogy coordination and in a wide range, looking forward the better successful academic indicators and wellness, through the proposition of new policies and management of upper education. Keywords: Educational Reserch, upper educatión, academic performance, wellness, upper educaciton mangement policies, compared education. &nbsp