Impacts of land use and land cover change on surface runoff, discharge and low flows: evidence from East Africa

Region: East Africa. Focus: A review of catchment studies (n=37) conducted in East Africa evaluating the impacts of Land Use and Land Cover Changes (LULCC) on discharge, surface runoff, and low flows. New hydrological insights: Forest cover loss is accompanied by increased stream discharges and surface runoff. No significant difference in stream discharge is observed between bamboo and pine plantation catchments, and between cultivated and tea plantation catchments. Trend analyses show that despite forest cover loss, 63% of the watersheds show non-significant changes in annual discharges while 31% show increasing trends. Half of the watersheds show non-significant trends in wet season flows and low flows while 35% reveal decreasing trends in low flows. Modeling studies estimate that forest cover loss increases annual discharges and surface runoff by 16 ± 5.5% and 45 ± 14%, respectively. Peak flows increased by a mean of 10 ± 2.8% while low flows decreased by a mean of 7 ± 5.3%. Increased forest cover decreases annual discharges and surface runoff by 13 ± 1.9% and 25 ± 5%, respectively. Weak correlations between forest cover and runoff (r=0.42, p < 0.05), mean discharge (r=0.63, p < 0.05) and peak discharge (r=0.67, p < 0.05) indicate that forest cover alone is not an accurate predictor of hydrological fluxes in East African catchments. The variability in these results supports the need for long-term field monitoring to better understand catchment responses and to improve the calibration of currently used simulation models

Diagnostic and Therapeutic Perspectives Associated to Cobalamin-Dependent Metabolism and Transcobalamins’ Synthesis in Solid Cancers

Cobalamin or vitamin B12 (B12) is a cofactor for methionine synthase and methylmalonyl-CoA mutase, two enzymes implicated in key pathways for cell proliferation: methylation, purine synthesis, succinylation and ATP production. Ensuring these functions in cancer cells therefore requires important cobalamin needs and its uptake through the transcobalamin II receptor (TCII-R). Thus, both the TCII-R and the cobalamin-dependent metabolic pathways constitute promising therapeutic targets to inhibit cancer development. However, the link between cobalamin and solid cancers is not limited to cellular metabolism, as it also involves the circulating transcobalamins I and II (TCI or haptocorrin and TCII) carrier proteins, encoded by TCN1 and TCN2, respectively. In this respect, elevations of B12, TCI and TCII concentrations in plasma are associated with cancer onset and relapse, and with the presence of metastases and worse prognosis. In addition, TCN1 and TCN2 overexpressions are associated with chemoresistance and a proliferative phenotype, respectively. Here we review the involvement of cobalamin and transcobalamins in cancer diagnosis and prognosis, and as potential therapeutic targets. We further detail the relationship between cobalamin-dependent metabolic pathways in cancer cells and the transcobalamins' abundancies in plasma and tumors, to ultimately hypothesize screening and therapeutic strategies linking these aspects

Diagnostic and Therapeutic Perspectives Associated to Cobalamin-Dependent Metabolism and Transcobalamins’ Synthesis in Solid Cancers

Cobalamin or vitamin B12 (B12) is a cofactor for methionine synthase and methylmalonyl-CoA mutase, two enzymes implicated in key pathways for cell proliferation: methylation, purine synthesis, succinylation and ATP production. Ensuring these functions in cancer cells therefore requires important cobalamin needs and its uptake through the transcobalamin II receptor (TCII-R). Thus, both the TCII-R and the cobalamin-dependent metabolic pathways constitute promising therapeutic targets to inhibit cancer development. However, the link between cobalamin and solid cancers is not limited to cellular metabolism, as it also involves the circulating transcobalamins I and II (TCI or haptocorrin and TCII) carrier proteins, encoded by TCN1 and TCN2, respectively. In this respect, elevations of B12, TCI and TCII concentrations in plasma are associated with cancer onset and relapse, and with the presence of metastases and worse prognosis. In addition, TCN1 and TCN2 overexpressions are associated with chemoresistance and a proliferative phenotype, respectively. Here we review the involvement of cobalamin and transcobalamins in cancer diagnosis and prognosis, and as potential therapeutic targets. We further detail the relationship between cobalamin-dependent metabolic pathways in cancer cells and the transcobalamins’ abundancies in plasma and tumors, to ultimately hypothesize screening and therapeutic strategies linking these aspects

Impact of land-use change on the hydrology of North Lao PDR watersheds

We investigated the impact of land-use change on the hydrology of different major Lao tributary watersheds of Mekong River. The region is the North of Laos centred on Luang Prabang and the watersheds are the Nam Khan, Nam Ou, Nam Suong, Nam Lik and Nam Ngum. An additional small agricultural catchment called Houay Pano close to the Nam Khan, is also considered. We used the lumped rainfall–runoff conceptual models GR4J and GR2M, developed by Irstea in France, the Mekong River Commission hydro-meteorological database and the Japanese Aphrodite meteorological database. The objective was to detect in the hydrological regime of the watersheds an impact of de(re)forestation, processes known to have occurred since the 1980s, but at a degree which has not been quantified. For this purpose we adopted the cross simulation methodology developed by Irstea which has proved to be efficient to detect trends in long term watershed hydrology. The results did not show any significant hydrological change since 1960. On the other hand the application of the same methodology to the small catchment Houay Pano surveyed since 2001 proved to be convincing. We saw evidence of the impact of slash and burn practice, followed by a long fallow period, on a catchment’s hydrology over a seven year period

The relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome

BackgroundPost-COVID-19 syndrome (PCS) shares many features with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). PCS represents a major health issue worldwide because it severely impacts patients' work activities and their quality of life. In the absence of treatment for both conditions and given the beneficial effect of pacing strategies in ME/CFS, we conducted this study to assess the effectiveness of pacing in PCS patients.MethodsWe retrospectively included patients meeting the World Health Organization definition of PCS who attended the Internal Medicine Department of Angers University Hospital, France between June 2020 and June 2022, and were followed up until December 2022. Pacing strategies were systematically proposed for all patients. Their medical records were reviewed and data related to baseline and follow-up assessments were collected. This included epidemiological characteristics, COVID-19 symptoms and associated conditions, fatigue features, perceived health status, employment activity, and the degree of pacing adherence assessed by the engagement in pacing subscale (EPS). Recovery was defined as the ability to return to work, and improvement was regarded as the reduction of the number and severity of symptoms.ResultsA total of 86 patients were included and followed-up for a median time of 10 [6-13] months. Recovery and improvement rates were 33.7% and 23.3%, respectively. The EPS score was the only variable significantly associated with recovery on multivariate analysis (OR 40.43 [95% CI 6.22-262.6], p &lt; 0.001). Patients who better adhered to pacing (high EPS scores) experienced significantly higher recovery and improvement rates (60-33.3% respectively) than those with low (5.5-5.5% respectively), or moderate (4.3-17.4% respectively) scores.ConclusionOur findings demonstrated that pacing is effective in the management of patients with PCS, and that high levels of adherence to pacing are associated with better outcomes

Impact of land-use change on the hydrology of North Lao PDR watersheds

International audienceWe investigated the impact of land-use change on the hydrology of different major Lao tributary watersheds of Mekong River. The region is the North of Laos centred on Luang Prabang and the watersheds are the Nam Khan, Nam Ou, Nam Suong, Nam Lik and Nam Ngum. An additional small agricultural catchment called Houay Pano close to the Nam Khan, is also considered. We used the lumped rainfall–-runoff conceptual models GR4J and GR2M, developed by Irstea in France, the Mekong River Commission hydro-meteorological database and the Japanese Aphrodite meteorological database. The objective was to detect in the hydrological regime of the watersheds an impact of de(re)forestation, processes known to have occurred since the 1980s, but at a degree which has not been quantified. For this purpose we adopted the cross simulation methodology developed by Irstea which has proved to be efficient to detect trends in long term watershed hydrology. The results did not show any significant hydrological change since 1960. On the other hand the application of the same methodology to the small catchment Houay Pano surveyed since 2001 proved to be convincing. We saw evidence of the impact of slash and burn practice, followed by a long fallow period, on a catchment's hydrology over a seven year period

Distinction between clonal and paraclonal cutaneous involvements in VEXAS syndrome

VEXAS (vacuoles, E1 enzyme, X-linked, auto-inflammatory, somatic) syndrome is an inflammatory disorder with hematological and systemic features. A recent study demonstrated that the dermal infiltrate in neutrophilic dermatosis from VEXAS patients is derived from the pathological UBA1-mutated myeloid clone. Neutrophilic dermatosis is, however, only one of the various skin involvements observed in VEXAS syndrome. We analyzed 10 formalin-fixed paraffin-embedded skin biopsies from genetically confirmed VEXAS syndrome. UBA1 mutation was found in the biopsies related to neutrophilic dermatitis but in none of the other histological patterns (leukocytoclastic vasculitis and septal panniculitis). This could lead to a distinction between clonal and paraclonal cutaneous involvements in VEXAS syndrome, which could in turn improve therapeutic outcomes