Multifrequency nature of the 0.75 mHz feature in the X-ray light curves of the nova V4743 Sgr

We present timing analyses of eight X-ray light curves and one optical/UV light curve of the nova V4743 Sgr (2002) taken by CHANDRA and XMM on days after outburst: 50 (early hard emission phase), 180, 196, 302, 371, 526 (super soft source, SSS, phase), and 742 and 1286 (quiescent emission phase). We have studied the multifrequency nature and time evolution of the dominant peak at ~0.75 mHz using the standard Lomb-Scargle method and a 2-D sine fitting method. We found a double structure of the peak and its overtone for days 180 and 196. The two frequencies were closer together on day 196, suggesting that the difference between the two peaks is gradually decreasing. For the later observations, only a single frequency can be detected, which is likely due to the exposure times being shorter than the beat period between the two peaks, especially if they are moving closer together. The observations on days 742 and 1286 are long enough to detect two frequencies with the difference found for day 196, but we confidently find only a single frequency. We found significant changes in the oscillation frequency and amplitude. We have derived blackbody temperatures from the SSS spectra, and the evolution of changes in frequency and blackbody temperature suggests that the 0.75-mHz peak was modulated by pulsations. Later, after nuclear burning had ceased, the signal stabilised at a single frequency, although the X-ray frequency differs from the optical/UV frequency obtained consistently from the OM onboard XMM and from ground-based observations. We believe that the late frequency is the white dwarf rotation and that the ratio of spin/orbit period strongly supports that the system is an intermediate polar.Comment: 17 pages, 22 figures, 7 tables, accepted for publication in MNRA

Variability and multi-periodic oscillations in the X-ray light curve of the classical nova V4743 Sgr

The classical nova V4743 Sgr was observed with XMM-Newton for about 10 hours on April 4 2003, 6.5 months after optical maximum. At this time, this nova had become the brightest supersoft X-ray source ever observed. We present the results of a time series analysis performed on the X-ray light curve obtained in this observation, and in a previous shorter observation done with Chandra 16 days earlier. Intense variability, with amplitude as large as 40% of the total flux, was observed both times. Similarities can be found between the two observations in the structure of the variations. Most of the variability is well represented as a combination of oscillations at a set of discrete frequencies lower than 1.7 mHz. At least five frequencies are constant over the 16 day time interval between the two observations. We suggest that a periods in the power spectrum of both light curves at the frequency of 0.75 mHz and its first harmonic are related to the spin period of the white dwarf in the system, and that other observed frequencies are signatures of nonradial white dwarf pulsations. A possible signal with a 24000 sec period is also found in the XMM-Newton light curve: a cycle and a half are clearly identified. This period is consistent with the 24278 s periodicity discovered in the optical light curve of the source and thought to be the orbital period of the nova binary system.Comment: In press in Monthly Notices of the Royal Astronomical Societ

Formation of a disk-structure and jets in the symbiotic prototype Z And during its 2006-2010 active phase

We present an analysis of spectrophotometric observations of the latest cycle of activity of the symbiotic binary Z And from 2006 to 2010. We estimate the temperature of the hot component of Z And to be \approx 150000 - 170000 K at minimum brightness, decreasing to \approx 90000 K at the brightness maximum. Our estimate of the electron density in the gaseous nebula is N_{e}=10^{10}-10^{12} cm^{-3} in the region of formation of lines of neutral helium and 10^6-10^7 cm^{-3} in the region of formation of the [OIII] and [NeIII] nebular lines. A trend for the gas density derived from helium lines to increase and the gas density derived from [OIII] and [NeIII] lines to simultaneously decrease with increasing brightness of the system was observed. Our estimates show that the ratios of the theoretical and observed fluxes in the [OIII] and [NeIII] lines agree best when the O/Ne ratio is similar to its value for planetary nebulae. The model spectral energy distribution showed that, in addition to a cool component and gaseous nebula, a relatively cool pseudophotosphere (5250-11 500 K) is present in the system. The simultaneous presence of a relatively cool pseudophotosphere and high-ionization spectral lines is probably related to a disk-like structure of the pseudophotosphere. The pseudophotosphere formed very rapidly, over several weeks, during a period of increasing brightness of Z And. We infer that in 2009, as in 2006, the activity of the system was accompanied by a collimated bipolar ejection of matter. In contrast to the situation in 2006, the jets were detected even before the system reached its maximum brightness. Moreover, components with velocities close to 1200 km/s disappeared at the maximum, while those with velocities close to 1800 km/s appeared.Comment: 18 pages, 19 figures, Accepted for publication in Astronomy Report

Automated analysis of digital fundus autofluorescence images of geographic atrophy in advanced age-related macular degeneration using confocal scanning laser ophthalmoscopy (cSLO)

BACKGROUND: Fundus autofluorescence (AF) imaging using confocal scanning laser ophthalmoscopy (cSLO) provides an accurate delineation of areas of geographic atrophy (GA). Automated computer-assisted methods for detecting and removing interfering vessels are needed to support the GA quantification process in longitudinal studies and in reading centres. METHODS: A test tool was implemented that uses region-growing techniques to segment GA areas. An algorithm for illuminating shadows can be used to process low-quality images. Agreement between observers and between three different methods was evaluated by two independent readers in a pilot study. Agreement and objectivity were assessed using the Bland-Altman approach. RESULTS: The new method (C) identifies vascular structures that interfere with the delineation of GA. Results are comparable to those of two commonly used procedures (A, B), with a mean difference between C and A of -0.67 mm(2 )(95% CI [-0.99, -0.36]), between B and A of -0.81 mm(2), (95% CI [-1.08, -0.53]), and between C and B of 0.15 mm(2 )(95% CI [-0.12, 0.41]). Objectivity of a method is quantified by the mean difference between observers: A 0.30 mm(2 )(95% CI [0.02, 0.57]), B -0.11 mm(2 )(95% CI [-0.28, 0.10]), and C 0.12 mm(2 )(95% CI [0.02, 0.22]). CONCLUSION: The novel procedure is comparable with regard to objectivity and inter-reader agreement to established methods of quantifying GA. It considerably speeds up the lengthy measurement process in AF with well defined GA zones

Mean ergodicity and spectrum of the Cesàro operator on weighted c0 spaces

[EN] A detailed investigation is made of the continuity, the compactness and the spectrum of the Cesàro operator C acting on the weighted Banach sequence space c0(w) for a bounded, strictly positive weight w. New features arise in the weighted setting (e.g. existence of eigenvalues, compactness, mean ergodicity) which are not present in the classical setting of c0.The research of the first two authors was partially supported by the Projects MTM2013-43540-P, GVA Prometeo II/2013/013 and ACOMP/2015/186 (Spain).Albanese, AA.; Bonet Solves, JA.; Ricker, WJ. (2016). Mean ergodicity and spectrum of the Cesàro operator on weighted c0 spaces. Positivity. 20:761-803. https://doi.org/10.1007/s11117-015-0385-xS76180320Akhmedov, A.M., Başar, F.: On the fine spectrum of the Cesàro operator in $$c_0$$ c 0 . Math. J. Ibaraki Univ. 36, 25–32 (2004)Akhmedov, A.M., Başar, F.: The fine spectrum of the Cesàro operator $$C_1$$ C 1 over the sequence space $$bv_p, (1 \le p < \infty )$$ b v p , ( 1 ≤ p < ∞ ) . Math. J. Okayama Univ. 50, 135–147 (2008)Albanese, A.A., Bonet, J., Ricker, W.J.: Convergence of arithmetic means of operators in Fréchet spaces. J. Math. Anal. Appl. 401, 160–173 (2013)Albanese, A.A., Bonet, J., Ricker, W.J.: Spectrum and compactness of the Cesàro operator on weighted $$\ell _p$$ ℓ p spaces. J. Aust. Math. Soc. 99, 287–314 (2015)Albanese, A.A., Bonet, J., Ricker, W.J.: The Cesàro operator in the Fréchet spaces $$\ell ^{p+}$$ ℓ p + and $$L ^{p-}$$ L p - . Glasg. Math. J (to appear)Ansari, S.I., Bourdon, P.S.: Some properties of cyclic operators. Acta Sci. Math. Szeged 63, 195–207 (1997)Brown, A., Halmos, P.R., Shields, A.L.: Cesàro operators. Acta Sci. Math. Szeged 26, 125–137 (1965)Curbera, G.P., Ricker, W.J.: Spectrum of the Cesàro operator in $$\ell ^p$$ ℓ p . Arch. Math. 100, 267–271 (2013)Curbera, G.P., Ricker, W.J.: Solid extensions of the Cesàro operator on $$\ell ^p$$ ℓ p and $$c_0$$ c 0 . Integr. Equ. Oper. Theory 80, 61–77 (2014)Curbera, G.P., Ricker, W.J.: The Cesàro operator and unconditional Taylor series in Hardy spaces. Integr. Equ. Oper. Theory 83, 179–195 (2015)Diestel, J.: Sequences and Series in Banach Spaces. Springer, New York (1984)Dowson, H.R.: Spectral Theory of Linear Operators. Academic Press, London (1978)Dunford, N., Schwartz, J.T.: Linear Operators I: General Theory, 2nd Printing. Wiley Interscience Publ, New York (1964)Emilion, R.: Mean-bounded operators and mean ergodic theorems. J. Funct. Anal. 61, 1–14 (1985)Goldberg, S.: Unbounded Linear Operators: Theory and Applications. Dover Publ, New York (1985)Hille, E.: Remarks on ergodic theorems. Trans. Am. Math. Soc. 57, 246–269 (1945)Jarchow, H.: Locally Convex Spaces. Teubner, Stuttgart (1981)Krengel, U.: Ergodic Theorems. de Gruyter, Berlin (1985)Leibowitz, G.: Spectra of discrete Cesàro operators. Tamkang J. Math. 3, 123–132 (1972)Lin, M.: On the uniform ergodic theorem. Proc. Am. Math. Soc. 43, 337–340 (1974)Megginson, R.E.: An Introduction to Banach Space Theory. Springer, New York (1998)Mureşan, M.: A Concrete Approach to Classical Analysis. Springer, Berlin (2008)Okutoyi, J.I.: On the spectrum of $$C_1$$ C 1 as an operator on $$bv_0$$ b v 0 . J. Aust. Math. Soc. Ser. A 48, 79–86 (1990)Radjavi, H., Tam, P.-W., Tan, K.-K.: Mean ergodicity for compact operators. Studia Math. 158, 207–217 (2003)Reade, J.B.: On the spectrum of the Cesàro operator. Bull. Lond. Math. Soc. 17, 263–267 (1985)Rhoades, B.E., Yildirim, M.: The spectra and fine spectra of factorable matrices on $$c_0$$ c 0 . Math. Commun. 16, 265–270 (2011)Taylor, A.E.: Introduction to Functional Analysis. Wiley, New York (1958

What do cyclists need to see to avoid single-bicycle crashes?

The number of single-bicycle crash victims is substantial in countries with high levels of cycling. To study the role of visual characteristics of the infrastructure, such as pavement markings, in single-bicycle crashes, a study in two steps was conducted. In Study 1, a questionnaire study was conducted among bicycle crash victims (n = 734). Logistic regression was used to study the relationship between the crashes and age, light condition, alcohol use, gaze direction and familiarity with the crash scene. In Study 2, the image degrading and edge detection method (IDED-method) was used to investigate the visual characteristics of 21 of the crash scenes. The results of the studies indicate that crashes, in which the cyclist collided with a bollard or road narrowing or rode off the road, were related to the visual characteristics of bicycle facilities. Edge markings, especially in curves of bicycle tracks, and improved conspicuity of bollards are recommended. Statement of Relevance: Elevated single-bicycle crash numbers are common in countries with high levels of cycling. No research has been conducted on what cyclists need to see to avoid this type of crash. The IDED-method to investigate crash scenes is new and proves to be a powerful tool to quantify 'visual accessibility'. © 2011 Taylor & Francis

Environmental factors in early childhood are associated with multiple sclerosis: a case-control study

<p>Abstract</p> <p>Background</p> <p>Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) with increasing incidence mainly in high-income countries. One explanation of this phenomenon may be a higher prevalence of allergic and autoimmune diseases in industrialized countries as a consequence of otherwise beneficial advances in sanitation (hygiene hypothesis). We investigated environmental factors in early childhood associated with MS.</p> <p>Methods</p> <p>A case-control study was performed of 245 MS patients and 296 population-based controls in Berlin. The study participants completed a standardized questionnaire on environmental factors in childhood and youth, including aspects of personal and community hygiene. Multivariable logistic regression analysis was performed to investigate factors in childhood and youth associated with the occurrence of MS.</p> <p>Results</p> <p>Mean age was 46 years (range, 20-80) in the MS group and 42 years (range 18-80) in the control group, of which 73.9% in the MS and 61.5% in the control group were female. The multivariable analysis showed that having at least two older siblings (OR 0.54; p = 0.05, for individuals with two older siblings compared to individuals without older siblings), attending a day-care center (OR 0.5; p = 0.004) and growing up in an urban center with more than 100, 000 inhabitants (OR 0.43; p = 0.009) were factors independently associated with a lower chance for MS.</p> <p>Conclusions</p> <p>The hygiene hypothesis may play a role in the occurrence of MS and could explain disease distribution and increasing incidence.</p

The Insulin-Mediated Modulation of Visually Evoked Magnetic Fields Is Reduced in Obese Subjects

BACKGROUND: Insulin is an anorexigenic hormone that contributes to the termination of food intake in the postprandial state. An alteration in insulin action in the brain, named "cerebral insulin resistance", is responsible for overeating and the development of obesity. METHODOLOGY/PRINCIPAL FINDINGS: To analyze the direct effect of insulin on food-related neuronal activity we tested 10 lean and 10 obese subjects. We conducted a magnetencephalography study during a visual working memory task in both the basal state and after applying insulin or placebo spray intranasally to bypass the blood brain barrier. Food and non-food pictures were presented and subjects had to determine whether or not two consecutive pictures belonged to the same category. Intranasal insulin displayed no effect on blood glucose, insulin or C-peptide concentrations in the periphery; however, it led to an increase in the components of evoked fields related to identification and categorization of pictures (at around 170 ms post stimuli in the visual ventral stream) in lean subjects when food pictures were presented. In contrast, insulin did not modulate food-related brain activity in obese subjects. CONCLUSIONS/SIGNIFICANCE: We demonstrated that intranasal insulin increases the cerebral processing of food pictures in lean whereas this was absent in obese subjects. This study further substantiates the presence of a "cerebral insulin resistance" in obese subjects and might be relevant in the pathogenesis of obesity

Multiwavelength observations of V407 Lupi (ASASSN-16kt) --- a very fast nova erupting in an intermediate polar

We present a detailed study of the 2016 eruption of nova V407 Lupi (ASASSN-16kt), including optical, near-infrared, X-ray, and ultraviolet data from SALT, SMARTS, SOAR, Chandra, Swift, and XMM-Newton. Timing analysis of the multiwavelength light-curves shows that, from 168 days post-eruption and for the duration of the X-ray supersoft source phase, two periods at 565 s and 3.57 h are detected. We suggest that these are the rotational period of the white dwarf and the orbital period of the binary, respectively, and that the system is likely to be an intermediate polar. The optical light-curve decline was very fast ($t_2 \leq$ 2.9 d), suggesting that the white dwarf is likely massive ($\gtrsim 1.25$ M$_{\odot}$). The optical spectra obtained during the X-ray supersoft source phase exhibit narrow, complex, and moving emission lines of He II, also characteristics of magnetic cataclysmic variables. The optical and X-ray data show evidence for accretion resumption while the X-ray supersoft source is still on, possibly extending its duration

Pdx1 Is Post-Translationally Modified In vivo and Serine 61 Is the Principal Site of Phosphorylation

Maintaining sufficient levels of Pdx1 activity is a prerequisite for proper regulation of blood glucose homeostasis and beta cell function. Mice that are haploinsufficient for Pdx1 display impaired glucose tolerance and lack the ability to increase beta cell mass in response to decreased insulin signaling. Several studies have shown that post-translational modifications are regulating Pdx1 activity through intracellular localization and binding to co-factors. Understanding the signaling cues converging on Pdx1 and modulating its activity is therefore an attractive approach in diabetes treatment. We employed a novel technique called Nanofluidic Proteomic Immunoassay to characterize the post-translational profile of Pdx1. Following isoelectric focusing in nano-capillaries, this technology relies on a pan specific antibody for detection and it therefore allows the relative abundance of differently charged protein species to be examined simultaneously. In all eukaryotic cells tested we find that the Pdx1 protein separates into four distinct peaks whereas Pdx1 protein from bacteria only produces one peak. Of the four peaks in eukaryotic cells we correlate one of them to a phosphorylation Using alanine scanning and mass spectrometry we map this phosphorylation to serine 61 in both Min6 cells and in exogenous Pdx1 over-expressed in HEK293 cells. A single phosphorylation is also present in cultured islets but it remains unaffected by changes in glucose levels. It is present during embryogenesis but is not required for pancreas development