A influência da diferenciação das relações líder-membro no comprometimento com a unidade de trabalho: o papel mediador do clima de apoio

We investigated whether the influence of LMX differentiation (the extent to which the quality of the leader-member relationships within a work unit varies) on work unit commitment is mediated by support climate. We tested this mediated relationship in a sample composed of 30 health care units. The results obtained showed that LMX differentiation measured at Time 1 was negatively related to work unit support climate measured one year later (Time 2), which in turn was positively related to work unit commitment measured at Time 2. The negative indirect effect of LMX differentiation on work unit commitment through support climate was statistically significant. Our study contributes to having a better understanding of the role of LMX differentiation in work unit functioning.Investigámos se a influência da diferenciação de LMX (o quanto a qualidade das relações de líder-membro dentro de uma unidade de trabalho varia) no comprometimento com a unidade de trabalho é mediada pelo clima de apoio. Testámos essa relação mediada em uma amostra composta por 30 unidades de saúde. Os resultados obtidos mostraram que a diferenciação da LMX medida no Tempo 1 foi negativamente relacionada ao clima de suporte da unidade de trabalho medido um ano depois (Tempo 2), que por sua vez foi positivamente relacionado ao comprometimento com a unidade de trabalho medido no Tempo 2. O efeito indireto negativo da diferenciação da LMX no comprometimento com a unidade de trabalho por meio do clima de apoio foi estatisticamente significativo. O nosso estudo contribui para uma melhor compreensão do papel da diferenciação do LMX no funcionamento da unidade de trabalho

Optimizing radial basis functions by D.C. programming and its use in direct search for global derivative-free optimization

In this paper we address the global optimization of functions subject to bound and linear constraints without using derivatives of the objective function. We investigate the use of derivative-free models based on radial basis functions (RBFs) in the search step of direct-search methods of directional type. We also study the application of algorithms based on difference of convex (d.c.) functions programming to solve the resulting subproblems which consist of the minimization of the RBF models subject to simple bounds on the variables. Extensive numerical results are reported with a test set of bound and linearly constrained problems

A cell-based smoothed finite element method for kinematic limit analysis

This paper presents a new numerical procedure for kinematic limit analysis problems, which incorporates the cell-based smoothed finite element method with second-order cone programming. The application of a strain smoothing technique to the standard displacement finite element both rules out volumetric locking and also results in an efficient method that can provide accurate solutions with minimal computational effort. The non-smooth optimization problem is formulated as a problem of minimizing a sum of Euclidean norms, ensuring that the resulting optimization problem can be solved by an efficient second-order cone programming algorithm. Plane stress and plane strain problems governed by the von Mises criterion are considered, but extensions to problems with other yield criteria having a similar conic quadratic form or 3D problems can be envisaged

Statistics of galaxy warps in the HDF North and South

We present a statistical study of the presence of galaxy warps in the Hubble deep fields. Among a complete sample of 45 edge-on galaxies above a diameter of 1.''3, we find 5 galaxies to be certainly warped and 6 galaxies as good candidates. In addition, 4 galaxies reveal a characteristic U-warp. Compared to statistical studies of local warps, and taking into account the strong bias against observing the outer parts of galaxies at high redshift, these numbers point towards a very high frequency of warps at z \sim 1: almost all galaxy discs might be warped. Furthermore, the amplitude of warps are stronger than for local warps. This is easily interpreted in terms of higher galaxy interactions and matter accretion in the past. This result supports these two mechanisms as the best candidates for the origin of early warps. The mean observed axis ratio of our sample of edge-on galaxies is significantly larger in the high-z sample than is found for samples of local spiral galaxies. This might be due to disk thickening due to more frequent galaxy interactions.Comment: 9 pages, 7 figures, accepted in A and

Warm H2 in the Galactic center region

We present ISO observations of several H2 pure-rotational lines (from S(0) to S(5)) towards a sample of 16 molecular clouds distributed along the central ~ 500 pc of the Galaxy. We also present C18O and 13CO J=1->0 and J=2->1 observations of these sources made with the IRAM-30m telescope. With the CO data we derive H2 densities of 10e(3.5-4.0) cm-3 and H2 column densities of a few 10e22 cm-2. We have corrected the H2 data for ~ 30 magnitudes of visual extinction using a self-consistent method. In every source, we find that the H2 emission exhibits a large temperature gradient. The S(0) and S(1) lines trace temperatures (T) of ~150 K while the S(4) and S(5) lines indicate temperatures of ~ 600K. The warm H2 column density is typically ~1-2 x 10e22 cm-2, and is predominantly gas with T=150 K. This is the first direct estimate of the total column density of the warm molecular gas in the Galactic center region. These warm H2 column densities represent a fraction of ~ 30 % of the gas traced by the CO isotopes emission. The cooling by H2 in the warm component is comparable to that by CO. Comparing our H2 and CO data with available ammonia NH3 observations from literature one obtains relatively high NH3 abundances of a few 10e(-7) in both the warm and the cold gas. A single shock or Photo-Dissociation Region (PDR) cannot explain all the observed H2 lines. Alternatives for the heating mechanisms are discussed.Comment: 14 pages including figures, to be published in A&

Advances in long-acting slow effective release antiretroviral therapies for treatment and prevention of HIV infection

Adherence to daily oral antiretroviral therapy (ART) is a barrier to both treatment and prevention of human immunodeficiency virus (HIV) infection. To overcome limitations of life-long daily regimen adherence, longacting (LA) injectable antiretroviral (ARV) drugs, nanoformulations, implants, vaginal rings, microarray patches, and ultra-long-acting (ULA) prodrugs are now available or in development. These medicines enable persons who are or at risk for HIV infection to be treated with simplified ART regimens. First-generation LA cabotegravir, rilpivirine, and lenacapavir injectables and a dapivirine vaginal ring are now in use. However, each remains limited by existing dosing intervals, ease of administration, or difficulties in finding drug partners. ULA ART regimens provide an answer, but to date, such next-generation formulations remain in development. Establishing the niche will require affirmation of extended dosing, improved access, reduced injection volumes, improved pharmacokinetic profiles, selections of combination treatments, and synchronization of healthcare support. Based on such needs, this review highlights recent pharmacological advances and a future treatment perspective. While first-generation LA ARTs are available for HIV care, they remain far from ideal in meeting patient needs. ULA medicines, now in advanced preclinical development, may close gaps toward broader usage and treatment options

Complete Genome Sequence of the Plant-Pathogenic Fungus Colletotrichum lupini

Colletotrichum is a fungal genus (Ascomycota, Sordariomycetes, Glomerellaceae) that includes many economically important plant pathogens that cause devastating diseases of a wide range of plants. In this work, using a combination of long- and short-read sequencing technologies, we sequenced the genome of Colletotrichum lupini RB221, isolated from white lupin (Lupinus albus) in France during a survey in 2014. The genome was assembled into 11 nuclear chromosomes and a mitochondrial genome with a total assembly size of 63.41 Mb and 36.55 kb, respectively. In total, 18,324 protein-encoding genes have been predicted, of which only 39 are specific to C. lupini. This resource will provide insight into pathogenicity factors and will help provide a better understanding of the evolution and genome structure of this important plant pathogen

La influencia del fenómeno ENSO sobre la fenología primaveral en los bosques boreales de Siberia central

Ponencia presentada en: V Congreso Internacional de la Asociación Española de Climatología celebrado en Zaragoza del 18 al 21 de septiembre de 2006.[ES]Se analiza la influencia de El Niño-Southern Oscillation (ENSO) sobre la variabilidad interanual de las fechas de aparición de las hojas e inicio de la actividad vegetal primaveral en los bosques boreales del hemisferio norte entre 1982 y 2004. Los resultados muestran negativas y significativas correlaciones entre el fenómeno ENSO, cuantificado mediante el Southern Oscillation Index (SOI), y la fecha de aparición de las hojas en Siberia central, con un retraso en dicha influencia de hasta 9 meses. La correlación entre la fecha de aparición de las hojas y la temperatura de superficie oceánica a escala global muestran un patrón espacial que asemeja al fenómeno ENSO, con correlaciones positivas y significativas en el Este del Pacífico y negativas en el Oeste. Esta influencia se explica por el papel del fenómeno ENSO sobre la presión en superficie, el geopotencial a 500hPa, la dirección e intensidad de los flujos de viento y la temperatura de superficie durante los meses en los que aparecen las hojas (abrilmayo) en las zonas boreales de Siberia central.[EN]This paper analyses the role of the El Niño-Southern Oscillation (ENSO) on the interannual variability of the leaf appearance dates of boreal forests in the Northern hemisphere (1982- 2004). We find significant negative correlations between the ENSO, quantified by means of the Southern Oscillation Index (SOI), and the leaf appearance dates in central Siberia with up to 9 months lag. The correlations between leaf appearance dates and summer Sea Surface Temperatures (SST) show a pattern that resembles the ENSO phenomena with positive and significant correlations in the East pacific and negative in the West. These findings are explained by the role of SOI on Sea Level Pressures, 500 hPa Geopotential and the wind flow direction and intensity during the months of leaf appearance (April and May) and on average temperatures, which determine noticeably the date of leaf appearance.Este trabajo se ha realizado gracias a la financiación del proyecto Siberia II (5º Programa Marco de la Comisión Europea)

Pleiotrophin overexpression regulates amphetamine-induced reward and striatal dopaminergic denervation without changing the expression of dopamine D1 and D2 receptors: Implications for neuroinflammation.

It was previously shown that mice with genetic deletion of the neurotrophic factor pleiotrophin (PTN-/-) show enhanced amphetamine neurotoxicity and impair extinction of amphetamine conditioned place preference (CPP), suggesting a modulatory role of PTN in amphetamine neurotoxicity and reward. We have now studied the effects of amphetamine (10mg/kg, 4 times, every 2h) in the striatum of mice with transgenic PTN overexpression (PTN-Tg) in the brain and in wild type (WT) mice. Amphetamine caused an enhanced loss of striatal dopaminergic terminals, together with a highly significant aggravation of amphetamine-induced increase in the number of GFAP-positive astrocytes, in the striatum of PTN-Tg mice compared to WT mice. Given the known contribution of D1 and D2 dopamine receptors to the neurotoxic effects of amphetamine, we also performed quantitative receptor autoradiography of both receptors in the brains of PTN-Tg and WT mice. D1 and D2 receptors binding in the striatum and other regions of interest was not altered by genotype or treatment. Finally, we found that amphetamine CPP was significantly reduced in PTN-Tg mice. The data demonstrate that PTN overexpression in the brain blocks the conditioning effects of amphetamine and enhances the characteristic striatal dopaminergic denervation caused by this drug. These results indicate for the first time deleterious effects of PTN in vivo by mechanisms that are probably independent of changes in the expression of D1 and D2 dopamine receptors. The data also suggest that PTN-induced neuroinflammation could be involved in the enhanced neurotoxic effects of amphetamine in the striatum of PTN-Tg mice