The XMM-Newton survey of the Small Magellanic Cloud: The X-ray point-source catalogue

Local-Group galaxies provide access to samples of X-ray source populations of whole galaxies. The XMM-Newton survey of the Small Magellanic Cloud (SMC) completely covers the bar and eastern wing with a 5.6 deg^2 area in the (0.2-12.0) keV band. To characterise the X-ray sources in the SMC field, we created a catalogue of point sources and sources with moderate extent. Sources with high extent (>40") have been presented in a companion paper. We searched for point sources in the EPIC images using sliding-box and maximum-likelihood techniques and classified the sources using hardness ratios, X-ray variability, and their multi-wavelength properties. The catalogue comprises 3053 unique X-ray sources with a median position uncertainty of 1.3" down to a flux limit for point sources of ~10^-14 erg cm^-2 s^-1 in the (0.2-4.5) keV band, corresponding to 5x10^33 erg s^-1 for sources in the SMC. We discuss statistical properties, like the spatial distribution, X-ray colour diagrams, luminosity functions, and time variability. We identified 49 SMC high-mass X-ray binaries (HMXB), four super-soft X-ray sources (SSS), 34 foreground stars, and 72 active galactic nuclei (AGN) behind the SMC. In addition, we found candidates for SMC HMXBs (45) and faint SSSs (8) as well as AGN (2092) and galaxy clusters (13). We present the most up-to-date catalogue of the X-ray source population in the SMC field. In particular, the known population of X-ray binaries is greatly increased. We find that the bright-end slope of the luminosity function of Be/X-ray binaries significantly deviates from the expected universal high-mass X-ray binary luminosity function.Comment: 32 pages, 18 figures, accepted for publication in A&A, catalog will be available at CD

Facilitators and challenges in delivering a peer-support physical activity intervention for older adults: a qualitative study with multiple stakeholders

Background:Involving peer volunteers in intervention delivery can provide social support and improve adherence. Whilst such interventions have the potential to reduce physical activity (PA) intervention costs, little is known about the process of delivering them in practice. This qualitative study explored the facilitators and challenges of delivering a peer-support PA intervention for older adults, with a view to making recommendations for the delivery of future interventions.Methods: Data were collected via (7) semi-structured interviews and a focus group with stakeholders involved in a peer-support PA intervention for older adults in a large city in the North-West of England. Participants included local authority staff (n = 3), peer volunteers (n= 2) and service users (n = 7). Audio data were transcribed verbatim and thematically coded to identify perceived facilitators and challenges.Results:Facilitators to delivery included social interaction, community referral pathways, suitable facilities, peer volunteers and high-quality instructors. Challenges surrounded inconsistent practice, staff capacity, safety and accountability, and awareness raising.Conclusions:Peer volunteers can provide an additional support mechanism alongside qualified instructors for increasing social interaction within PA interventions. For optimal intervention delivery, consideration needs to be given to equipment and space, safety and accountability and consistency of practice

Feed-restricted broiler breeders: state-dependent learning as a novel welfare assessment tool to evaluate their hunger state?

This paper reports three experiments that aimed to validate the use of state-dependent learning (SDL) as a novel welfare assessment tool to evaluate the hunger state of feed-restricted broiler breeders.\ud \ud In each experiment, birds alternated every 2 days between two food rations: quantitative feed restriction (QFR) and ad libitum access to the same feed (AL). Each food ration was paired with a different, end of day, coloured food reward. It was predicted that the reward associated with hunger (QFR FR) would be preferred to the food reward associated with AL (AL FR) in a subsequent choice test. The SDL preference testing took place after 4 and 8 days of training. Each bird was tested twice (once per food ration fed on the test day).\ud \ud In experiment 1 (pilot, n = 4), birds preferred the QFR-associated reward during both tests (mean (±S.E.M.) preference: QFR FR: 35.0 (±3.5) g; AL FR: 2 (±1.3) g, but differential food reward intake between hunger states during training confounded the results.\ud \ud In experiment two (n = 12) a smaller food reward was used during training to try and equalise intake. The birds preferred the QFR FR in test 1 only (least significant difference (L.S.D.) = 15.08, P < 0.05). The mean (±S.E.M.) consumption in test 1 was: QFR FR: 31.6 (±4.3) g; AL FR: 9.41 (±2.3) g. However, differential reward intake continued to confound the findings.\ud \ud In experiment three (n = 8), the food reward was made more palatable by feeding moist and food reward intake during training was equalised between hunger states. During testing, birds continued to show a significant preference in test 1 only (L.S.D. = 13.73, P < 0.05).\ud \ud It was concluded that SDL-derived preferences observed do exist but are not a robust phenomenon. Therefore, further research is needed to quantify factors influencing SDL development and maintenance before using SDL as a tool to assess hunger in feed-restricted broiler breeders

Determining the extragalactic extinction law with SALT

We present CCD imaging observations of early-type galaxies with dark lanes obtained with the Southern African Large Telescope (SALT) during its performance-verification phase. We derive the extinction law by the extragalactic dust in the dark lanes in the spectral range 1.11mu m^{-1} < lambda^{-1} < 2.94 mu m^{-1} by fitting model galaxies to the unextinguished parts of the image, and subtracting from these the actual images. We find that the extinction curves run parallel to the Galactic extinction curve, which implies that the properties of dust in the extragalactic enviroment are similar to those of the Milky Way. The ratio of the total V band extinction to the selective extinction between the V and B bands is derived for each galaxy with an average of 2.82+-0.38, compared to a canonical value of 3.1 for the Milky Way. The similar values imply that galaxies with well-defined dark lanes have characteristic dust grain sizes similar to those of Galactic dust.Comment: 20 pages, 15 figures and 4 tables. Accepted for publication in MNRA

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis ( RA) by assessing a panel of T cell, macrophage, and stromal cell related cytokines and chemokines in the synovial fluid of patients with early synovitis. Synovial fluid was aspirated from inflamed joints of patients with inflammatory arthritis of duration 3 months or less, whose outcomes were subsequently determined by follow up. For comparison, synovial fluid was aspirated from patients with acute crystal arthritis, established RA and osteoarthritis. Rheumatoid factor activity was blocked in the synovial fluid samples, and a panel of 23 cytokines and chemokines measured using a multiplex based system. Patients with early inflammatory arthritis who subsequently developed RA had a distinct but transient synovial fluid cytokine profile. The levels of a range of T cell, macrophage and stromal cell related cytokines ( e. g. IL-2, IL-4, IL-13, IL-17, IL-15, basic fibroblast growth factor and epidermal growth factor) were significantly elevated in these patients within 3 months after symptom onset, as compared with early arthritis patients who did not develop RA. In addition, this profile was no longer present in established RA. In contrast, patients with non-rheumatoid persistent synovitis exhibited elevated levels of interferon-gamma at initiation. Early synovitis destined to develop into RA is thus characterized by a distinct and transient synovial fluid cytokine profile. The cytokines present in the early rheumatoid lesion suggest that this response is likely to influence the microenvironment required for persistent RA

The type 2 cannabinoid receptor regulates susceptibility to osteoarthritis in mice

SummaryObjectiveCannabinoid receptors and their ligands have been implicated in the regulation of various physiological processes but their role in osteoarthritis has not been investigated. The aim of this study was to evaluate the role of the type 2 cannabinoid receptor (Cnr2) in regulating susceptibility to osteoarthritis in mice.MethodsWe analysed the severity of knee osteoarthritis as assessed by the Osteoarthritis Research Society International (OARSI) scoring system in mice with targeted deletion of Cnr2 (Cnr2−/−) and wild type (WT) littermates. Studies were conducted in mice subjected to surgical destabilisation of the medial meniscus (DMM) and in those with spontaneous age-related osteoarthritis (OA).ResultsOsteoarthritis was more severe following DMM in the medial compartment of the knee in Cnr2−/− compared with WT mice (mean ± sem score = 4.9 ± 0.5 vs 3.6 ± 0.3; P = 0.017). Treatment of WT mice with the CB2-selective agonist HU308 following DMM reduced the severity of OA in the whole joint (HU308 = 8.4 ± 0.2 vs vehicle = 10.4 ± 0.6; P = 0.007). Spontaneous age related osteoarthritis was also more severe in the medial compartment of the knee in 12-month old Cnr2−/− mice compared with WT (5.6 ± 0.5 vs 3.5 ± 0.3, P = 0.008). Cultured articular chondrocytes from Cnr2−/− mice produced less proteoglycans in vitro than wild type chondrocytes.ConclusionThese studies demonstrate that the Cnr2 pathway plays a role in the pathophysiology of osteoarthritis in mice and shows that pharmacological activation of CB2 has a protective effect. Further studies of the role of cannabinoid receptors in the pathogenesis of osteoarthritis in man are warranted

The masses of the cataclysmic variables AC Cancri and V363 Aurigae

We present time-resolved spectroscopy and photometry of the double-lined eclipsing cataclysmic variables AC Cnc and V363 Aur (= Lanning 10). There is evidence of irradiation on the inner hemisphere of the secondary star in both systems, which we correct for using a model that reproduces the observations remarkably well. We find the radial velocity of the secondary star in AC Cnc to be KR= 176 ± 3 km s−1 and its rotational velocity to be v sin i= 135 ± 3 km s−1. From these parameters we obtain masses of M1= 0.76 ± 0.03 M⊙ for the white-dwarf primary and M2= 0.77 ± 0.05 M⊙ for the K2 ± 1V secondary star, giving a mass ratio of q= 1.02 ± 0.04. We measure the radial and rotational velocities of the G7 ± 2V secondary star in V363 Aur to be KR= 168 ± 5 km s−1 and v sin i= 143 ± 5 km s−1, respectively. The component masses of V363 Aur are M1= 0.90 ± 0.06 M⊙ and M2= 1.06 ± 0.11 M⊙, giving a mass ratio of q= 1.17 ± 0.07. The mass ratios for AC Cnc and V363 Aur fall within the theoretical limits for dynamically and thermally stable mass transfer. Both systems are similar to the SW Sex stars, exhibiting single-peaked emission lines with transient absorption features, high-velocity S-wave components and phase-offsets in their radial-velocity curves. The Balmer lines in V363 Aur show a rapid increase in flux around phase 0 followed by a rapid decrease, which we attribute to the eclipse of an optically thick region at the centre of the disc. This model could also account for the behaviour of other SW Sex stars where the Balmer lines show only a shallow eclipse compared to the continuum

Susceptibility of hamsters to clostridium difficile isolates of differing toxinotype

Clostridium difficile is the most commonly associated cause of antibiotic associated disease (AAD), which caused ~21,000 cases of AAD in 2011 in the U.K. alone. The golden Syrian hamster model of CDI is an acute model displaying many of the clinical features of C. difficile disease. Using this model we characterised three clinical strains of C. difficile, all differing in toxinotype; CD1342 (PaLoc negative), M68 (toxinotype VIII) and BI-7 (toxinotype III). The naturally occurring non-toxic strain colonised all hamsters within 1-day post challenge (d.p.c.) with high-levels of spores being shed in the faeces of animals that appeared well throughout the entire experiment. However, some changes including increased neutrophil influx and unclotted red blood cells were observed at early time points despite the fact that the known C. difficile toxins (TcdA, TcdB and CDT) are absent from the genome. In contrast, hamsters challenged with strain M68 resulted in a 45% mortality rate, with those that survived challenge remaining highly colonised. It is currently unclear why some hamsters survive infection, as bacterial and toxin levels and histology scores were similar to those culled at a similar time-point. Hamsters challenged with strain BI-7 resulted in a rapid fatal infection in 100% of the hamsters approximately 26 hr post challenge. Severe caecal pathology, including transmural neutrophil infiltrates and extensive submucosal damage correlated with high levels of toxin measured in gut filtrates ex vivo. These data describes the infection kinetics and disease outcomes of 3 clinical C. difficile isolates differing in toxin carriage and provides additional insights to the role of each toxin in disease progression

Fuzzy Modeling for Uncertain Nonlinear Systems Using Fuzzy Equations and Z-Numbers

In this paper, the uncertainty property is represented by Z-number as the coefficients and variables of the fuzzy equation. This modification for the fuzzy equation is suitable for nonlinear system modeling with uncertain parameters. Here, we use fuzzy equations as the models for the uncertain nonlinear systems. The modeling of the uncertain nonlinear systems is to find the coefficients of the fuzzy equation. However, it is very difficult to obtain Z-number coefficients of the fuzzy equations. Taking into consideration the modeling case at par with uncertain nonlinear systems, the implementation of neural network technique is contributed in the complex way of dealing the appropriate coefficients of the fuzzy equations. We use the neural network method to approximate Z-number coefficients of the fuzzy equations

A Search for Dark Matter Annihilation with the Whipple 10m Telescope

We present observations of the dwarf galaxies Draco and Ursa Minor, the local group galaxies M32 and M33, and the globular cluster M15 conducted with the Whipple 10m gamma-ray telescope to search for the gamma-ray signature of self-annihilating weakly interacting massive particles (WIMPs) which may constitute astrophysical dark matter (DM). We review the motivations for selecting these sources based on their unique astrophysical environments and report the results of the data analysis which produced upper limits on excess rate of gamma rays for each source. We consider models for the DM distribution in each source based on the available observational constraints and discuss possible scenarios for the enhancement of the gamma-ray luminosity. Limits on the thermally averaged product of the total self-annihilation cross section and velocity of the WIMP, , are derived using conservative estimates for the magnitude of the astrophysical contribution to the gamma-ray flux. Although these limits do not constrain predictions from the currently favored theoretical models of supersymmetry (SUSY), future observations with VERITAS will probe a larger region of the WIMP parameter phase space, and WIMP particle mass (m_\chi).Comment: 33 pages, 12 figures, accepted for publication in the Astrophysical Journa