Performance Study of a Torsional Wave Sensor and Cervical Tissue Characterization

A novel torsional wave sensor designed to characterize mechanical properties of soft tissues is presented in this work. Elastography is a widely used technique since the 1990s to map tissue stiffness. Moreover, quantitative elastography uses the velocity of shear waves to achieve the shear stiffness. This technique exhibits significant limitations caused by the difficulty of the separation between longitudinal and shear waves and the pressure applied while measuring. To overcome these drawbacks, the proposed torsional wave sensor can isolate a pure shear wave, avoiding the possibility of multiple wave interference. It comprises a rotational actuator disk and a piezoceramic receiver ring circumferentially aligned. Both allow the transmission of shear waves that interact with the tissue before being received. Experimental tests are performed using tissue mimicking phantoms and cervical tissues. One contribution is a sensor sensitivity study that has been conducted to evaluate the robustness of the new proposed torsional wave elastography (TWE) technique. The variables object of the study are both the applied pressure and the angle of incidence sensor–phantom. The other contribution consists of a cervical tissue characterization. To this end, three rheological models have fit the experimental data and a static independent testing method has been performed. The proposed methodology permits the reconstruction of the mechanical constants from the propagated shear wave, providing a proof of principle and warranting further studies to confirm the validity of the results.This research was supported by the Ministry of Education DPI2014-51870-R, DPI2010-17065 and UNGR15-CE-3664, Ministry of Health DTS15/00093 and PI16/00339, and Junta de Andalucía P11-CTS-8089 projects. Modesto T. López-López acknowledges financial support by the project FIS2013-41821-R (Ministry of Economy and Competitiveness, co-funded by the ERDF, European Union). We acknowledge the collaboration of the members of the Anatomical Pathology Unit of the University Hospital Complex of Granada. Finally, Antonio Callejas is grateful to the University of Granada for the award of an PhD fellowship

Does abscisic acid affect strigolactone biosynthesis?

Strigolactones are considered a novel class of plant hormones that, in addition to their endogenous signalling function, are exuded into the rhizosphere acting as a signal to stimulate hyphal branching of arbuscular mycorrhizal (AM) fungi and germination of root parasitic plant seeds. Considering the importance of the strigolactones and their biosynthetic origin (from carotenoids), we investigated the relationship with the plant hormone abscisic acid (ABA). Strigolactone production and ABA content in the presence of specific inhibitors of oxidative carotenoid cleavage enzymes and in several tomato ABA-deficient mutants were analysed by LC-MS/MS. In addition, the expression of two genes involved in strigolactone biosynthesis was studied. * • The carotenoid cleavage dioxygenase (CCD) inhibitor D2 reduced strigolactone but not ABA content of roots. However, in abamineSG-treated plants, an inhibitor of 9-cis-epoxycarotenoid dioxygenase (NCED), and the ABA mutants notabilis, sitiens and flacca, ABA and strigolactones were greatly reduced. The reduction in strigolactone production correlated with the downregulation of LeCCD7 and LeCCD8 genes in all three mutants. * • The results show a correlation between ABA levels and strigolactone production, and suggest a role for ABA in the regulation of strigolactone biosynthesis

El grado actual de armonización contable entre las legislaciones de España y Canadá: un caso basado en el análisis de los estados financieros de una pyme del sector vitivinícola

The purpose of this paper is to analyze the international accounting level of harmonization through the comparative simulation of the accounting cycle and the financial statements of a company, under national regulations of Spain and Canada. Starting with the same assets and performing the same transactions, the national regulations are applied in both countries in order to compare, at the end of an accounting cycle, the resulting financial statements. The chosen company for this comparison is a medium-sized winery, based on real company, from Castilla-La Mancha, called Bodegasmasquevinos. After the analysis of the outcomes of this comparison, the conclusion is that both regulations, belonging to very different economic environments and following a very different evolution, offer a high degree of accounting harmonization. This circumstance is due to the influence of international accounting standards, considered in both countries.El objetivo de este trabajo es analizar el grado de armonización contable internacional, a través de la comparación simulada del ciclo contable y el balance final de una misma empresa sometida a las regulaciones nacionales de España y Canadá. Partiendo de los mismos elementos patrimoniales y realizando las mismas operaciones, se aplican las regulaciones nacionales de ambos países para comparar, al final de un ciclo contable, el balance resultante. La compañía sometida a esta comparación es una bodega de tamaño medio, basada en la empresa real Bodegasmasquevinos, dedicada a la producción de vinos en Castilla-La Mancha. Una vez analizados los resultados de esta comparación, se concluye que ambas regulaciones, aun perteneciendo a entornos económicos muy diferentes y partiendo de regulaciones propias dispares, presentan en la actualidad un alto grado de armonización contable. Esta circunstancia es debida a la influencia de la normativa IFRS internacional, incorporada parcialmente en ambos países

Percepción de profesores universitarios mexicanos sobre el buen formador de profesores de Educación Física

In the last decade, research on Physical Education (PE) teacher trainers (TT) has increased. In Mexico, however, this production is scarce and many relevant questions remain unanswered. It is necessary to develop a more complete understanding of this professional group, as it is an integral part of the PE profession. This study was developed using the theory of occupational socialization. The objective was to describe and interpret perceptions on the PE concept of good TT of PE by university professors (who are also teacher trainers) from public universities in Mexico. 202 TT participated, who were specifically asked to answer the following question: describe what a good teacher of Higher Education, teacher trainer, is to you. Content analysis was used for the processing of information in the first instance; descriptive statistics were subsequently used, namely frequencies and percentages. The results reveal that, for TT, a good trainer is characterized mainly by his personality traits, followed by scientific and pedagogical competences.En la última década se ha incrementado la investigación sobre los formadores de profesores (FP) de Educación Física (EF). En México, sin embargo, esta producción es escasa y muchas preguntas relevantes siguen sin respuesta. Es necesario desarrollar una comprensión más completa de este grupo profesional, ya que es parte integral para la profesión de la EF. El presente estudio se desarrolló usando la teoría de la socialización ocupacional. El objetivo fue describir e interpretar las percepciones sobre el concepto de buen FP de EF que poseen profesores universitarios (quienes son también formadores de profesores) de universidades públicas en México. Participaron 202 FP, a quienes se les pidió específicamente responder la siguiente cuestión: describa lo que es para usted un buen profesor de Educación Superior, formador de profesores. Para el tratamiento de la información, en primera instancia se utilizó el análisis de contenido; posteriormente, se usó la estadística descriptiva, concretamente, las frecuencias y los porcentajes. Los resultados revelan que, para los FP, un buen formador se caracteriza principalmente por sus rasgos de personalidad, seguido de las competencias científicas y pedagógicas.seguido de las competencias científicas y pedagógicas

Recent reforms in Spanish housing markets: an evaluation using a DSGE model

After a long academic debate, Spain finally repealed in 2012 the deduction for home purchase. The abrogation took effect in 2013. In parallel, the VAT for the purchase of new housing was increased after a short period in which it had a reduced rate. The aim of this paper is to assess the macroeconomic effects of these two relevant housing market reforms. In order to do that, we use a dynamic stochastic general equilibrium (DSGE) model calibrated to capture the key ratios of the Spanish economy. The model includes a housing market, covering both the rental market side and the property market side and credit-constrained agents. We find that these measures drive down housing prices and have a negative impact on output and employment in the construction sector. However, in the long run, this last effect is offset by the benefits of a reduction in distortionary taxes

Health-Related Factors in Rural and Urban Mexican Adolescents from the State of Jalisco: The HELENA-MEX Study

Mexico shows a high prevalence of obesity in children and adolescents. Geographical location and cultural environment could play a role in the promotion of healthy lifestyles in terms of physical activity (PA), sedentary behavior (SB) and nutrition. The purpose of this study was to assess rural and urban differences in body composition (BC), physical fitness (PF), PA and nutritional status of adolescents from the state of Jalisco (Mexico). The study involved 469 students aged 13–17 years (55.0% girls) from eight high schools. BC was analyzed by bioimpedance and PF by standardized field tests. Objective measurements of PA and SB were taken in a subsample (n = 240). Energy intake (EI) was calculated from two 24h recalls. Rural residents presented a higher prevalence of overweight, waist circumference, trunk fat mass, regional fat free mass and muscle handgrip strength (all p < 0.05, η2p < 0.06). Cardiorespiratory fitness was similar among participants, whereas urban adolescents showed higher muscle power, speed-agility and flexibility scores (all p < 0.05, η2p < 0.07). Overall lifestyle behavior in urban adolescents was more sedentary (p < 0.05, η2p = 0.11). EI was similar in both locations. In conclusion, rural Mexican adolescents presented a generally lower sedentary behavior and a lower fitness and fatness profile than their urban peers

Simplifying the detection of MUTYH mutations by high resolution melting analysis

<p>Abstract</p> <p>Background</p> <p><it>MUTYH</it>-associated polyposis (MAP) is a disorder caused by bi-allelic germline <it>MUTYH </it>mutation, characterized by multiple colorectal adenomas. In order to identify mutations in <it>MUTYH </it>gene we applied High Resolution Melting (HRM) genotyping. HRM analysis is extensively employed as a scanning method for the detection of heterozygous mutations. Therefore, we applied HRM to show effectiveness in detecting homozygous mutations for these clinically important and frequent patients.</p> <p>Methods</p> <p>In this study, we analyzed phenotype and genotype data from 82 patients, with multiple (>= 10) synchronous (19/82) or metachronous (63/82) adenomas and negative <it>APC </it>study (except one case). Analysis was performed by HRM-PCR and direct sequencing, in order to identify mutations in <it>MUTYH </it>exons 7, 12 and 13, where the most prevalent mutations are located. In monoallelic mutation carriers, we evaluated entire <it>MUTYH </it>gene in search of another possible alteration. HRM-PCR was performed with strict conditions in several rounds: the first one to discriminate the heteroduplex patterns and homoduplex patterns and the next ones, in order to refine and confirm parameters. The genotypes obtained were correlated to phenotypic features (number of adenomas (synchronous or metachronous), colorectal cancer (CRC) and family history).</p> <p>Results</p> <p><it>MUTYH </it>germline mutations were found in 15.8% (13/82) of patients. The hot spots, Y179C (exon 7) and G396D (exon 13), were readily identified and other mutations were also detected. Each mutation had a reproducible melting profile by HRM, both heterozygous mutations and homozygous mutations. In our study of 82 patients, biallelic mutation is associated with being a carrier of ≥10 synchronous polyps (p = 0.05) and there is no association between biallelic mutation and CRC (p = 0.39) nor family history (p = 0.63). G338H non-pathogenic polymorphism (exon 12) was found in 23.1% (19/82) of patients. In all cases there was concordance between HRM (first and subsequent rounds) and sequencing data.</p> <p>Conclusions</p> <p>Here, we describe a screening method, HRM, for the detection of both heterozygous and homozygous mutations in the gene encoding <it>MUTYH </it>in selected samples of patients with phenotype of MAP. We refine the capabilities of HRM-PCR and apply it to a gene not yet analyzed by this tool. As clinical decisions will increasingly rely on molecular medicine, the power of identifying germline mutations must be continuously evaluated and improved.</p

Dissecting quasars with the J-PAS narrow-band photometric survey

Nuclear Activity in Galaxies Across Cosmic Time, Proceedings of the conference held 7-11 October 2019 in Addis Ababa, Ethiopia. Edited by Mirjana Pović et al. Proceedings of the International Astronomical Union, Volume 356, pp. 12-16The J-PAS survey will soon start observing thousands of square degrees of the Northern Sky with its unique set of 56 narrow band filters covering the entire optical wavelength range, providing, effectively, a low resolution spectra for every object detected. Active galaxies and quasars, thanks to their strong emission lines, can be easily identified and characterized with J-PAS data. A variety of studies can be performed, from IFU-like analysis of local AGN, to clustering of high-z quasars. We also expect to be able to extract intrinsic physical quasar properties from the J-PAS pseudo-spectra, including continuum slope and emission line luminosities. Here we show the first attempts of using the QSFit software package to derive the properties for 22 quasars at 0.8 < z < 2 observed by the miniJPAS survey, the first deg2 of J-PAS data obtained with an interim camera. Results are compared with the ones obtained by applying the same software to SDSS quasar spectra.Financial support from the State Agency for Research of the Spanish MCIU through the "Center of Excellence Severo Ochoa" award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709

The feasibility of an augment reality system to study the psychophysiological correlates of fear-related responses

Previous studies have successfully used augmented reality (AR) as an aid to exposure-based treatments for anxiety disorders. However, to the best of our knowledge, none of these studies have measured the physiological correlates of the fear response, relying solely on self-reports and behavioral avoidance tests.publishe

The role of analytical chemistry in exposure science: Focus on the aquatic environment

Exposure science, in its broadest sense, studies the interactions between stressors (chemical, biological, and physical agents) and receptors (e.g. humans and other living organisms, and non-living items like buildings), together with the associated pathways and processes potentially leading to negative effects on human health and the environment. The aquatic environment may contain thousands of compounds, many of them still unknown, that can pose a risk to ecosystems and human health. Due to the unquestionable importance of the aquatic environment, one of the main challenges in the field of exposure science is the comprehensive characterization and evaluation of complex environmental mixtures beyond the classical/priority contaminants to new emerging contaminants. The role of advanced analytical chemistry to identify and quantify potential chemical risks, that might cause adverse effects to the aquatic environment, is essential. In this paper, we present the strategies and tools that analytical chemistry has nowadays, focused on chromatography hyphenated to (high-resolution) mass spectrometry because of its relevance in this field. Key issues, such as the application of effect direct analysis to reduce the complexity of the sample, the investigation of the huge number of transformation/degradation products that may be present in the aquatic environment, the analysis of urban wastewater as a source of valuable information on our lifestyle and substances we consumed and/or are exposed to, or the monitoring of drinking water, are discussed in this article. The trends and perspectives for the next few years are also highlighted, when it is expected that new developments and tools will allow a better knowledge of chemical composition in the aquatic environment. This will help regulatory authorities to protect water bodies and to advance towards improved regulations that enable practical and efficient abatements for environmental and public health protection