909 research outputs found
Parametric macromodeling of integrated inductors for RF circuit design
Nowadays, parametric macromodeling techniques are widely used to describe electromagnetic structures. In this contribution, the application of such parametric macromodeling techniques to the design of integrated inductors and radio-frequency circuit design is investigated. In order to allow such different operations, a new modeling methodology is proposed, which improves the modeling accuracy when compared to former techniques. The new methodology is tailored to the unique characteristics of the devices under study. The obtained parametric macromodel is then used in a synthesis methodology and in the design of a voltage controlled oscillator in a 0.35-ÎŒm CMOS technologyMinisterio de EconomĂa y Competitividad TEC2013-45638-C3- 3-RJunta de AndalucĂa P12-TIC-148
Los mirmeleĂłnidos (hormigas-leĂłn) de la PenĂnsula IbĂ©rica e Islas Baleares (Insecta, Neuropterida, Neuroptera, Myrmeleontidae)
Multi-site, multi-year monitoring of the oscillating Algol-type eclipsing binary CT Her
We present the results of a multi-site photometric campaign carried out in
2004-2008 for the Algol-type eclipsing binary system CT Her, the primary
component of which shows Delta Scuti-type oscillations. Our data consist of
differential light curves collected in the filters B and V which have been
analysed using the method of Wilson-Devinney (PHOEBE). After identification of
an adequate binary model and removal of the best-matching light curve solution,
we performed a Fourier analysis of the residual B and V light curves to
investigate the pulsational behaviour. We confirm the presence of rapid
pulsations with a main period of 27.2 min. Up to eight significant frequencies
with semi-amplitudes in the range 3 to 1 mmag were detected, all of which
surprisingly lie in the frequency range 43.5-53.5 c\d. This result is
independent from the choice of the primary's effective temperature (8200 or
8700 K) since the light curve models for the binary are very similar in both
cases. This is yet another case of a complex frequency spectrum observed for an
accreting Delta Scuti-type star (after Y Cam). In addition, we demonstrate that
the amplitudes of several of these pulsation frequencies show evidence of
variability on time scales as short as 1-2 years, perhaps even less. Moreover,
our analysis takes into account some recently acquired spectra, from which we
obtained the corresponding radial velocities for the years 2007-2009.
Investigation of the O-C diagram shows that further monitoring of the epochs of
eclipse minima of CT Her will cast a new light on the evolution of its orbital
period.Comment: 13 pages, 13 encapsulated Postscript figures. Tables~3, 4, 9 and 12
will be available in electronic form only. Astronomy and Astrophysics, in
process (2011). Replaced the abstract with its final versio
Recommended from our members
Demonstration of the event identification capabilities of the NEXT-White detector
In experiments searching for neutrinoless double-beta decay, the possibility of identifying the two emitted electrons is a powerful tool in rejecting background events and therefore improving the overall sensitivity of the experiment. In this paper we present the first measurement of the efficiency of a cut based on the different event signatures of double and single electron tracks, using the data of the NEXT-White detector, the first detector of the NEXT experiment operating underground. Using a 228Th calibration source to produce signal-like and background-like events with energies near 1.6 MeV, a signal efficiency of 71.6 ± 1.5 stat± 0.3 sys% for a background acceptance of 20.6 ± 0.4 stat± 0.3 sys% is found, in good agreement with Monte Carlo simulations. An extrapolation to the energy region of the neutrinoless double beta decay by means of Monte Carlo simulations is also carried out, and the results obtained show an improvement in background rejection over those obtained at lower energies. [Figure not available: see fulltext.
Nuevos datos sobre algunas especies de crisĂłpidos de la PenĂnsula IbĂ©rica, islas Baleares e islas Canarias (Insecta, Neuroptera, Chrysopidae)
Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.
The epidemic of obesity imposes unprecedented challenges on human adipose tissue (WAT) storage capacity that may benefit from adaptive mechanisms to maintain adipocyte functionality. Here, we demonstrate that changes in the regulatory feedback set point control of Insig1/SREBP1 represent an adaptive response that preserves WAT lipid homeostasis in obese and insulin-resistant states. In our experiments, we show that Insig1 mRNA expression decreases in WAT from mice with obesity-associated insulin resistance and from morbidly obese humans and in in vitro models of adipocyte insulin resistance. Insig1 downregulation is part of an adaptive response that promotes the maintenance of SREBP1 maturation and facilitates lipogenesis and availability of appropriate levels of fatty acid unsaturation, partially compensating the antilipogenic effect associated with insulin resistance. We describe for the first time the existence of this adaptive mechanism in WAT, which involves Insig1/SREBP1 and preserves the degree of lipid unsaturation under conditions of obesity-induced insulin resistance. These adaptive mechanisms contribute to maintain lipid desaturation through preferential SCD1 regulation and facilitate fat storage in WAT, despite on-going metabolic stress
Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation
The success of antipsychotic drug treatment in patients with schizophrenia is limited by the propensity of these drugs to induce hyperphagia, weight gain and other metabolic disturbances, particularly evident for olanzapine and clozapine. However, the molecular mechanisms involved in antipsychotic-induced hyperphagia remain unclear. Here, we investigate the effect of olanzapine administration on the regulation of hypothalamic mechanisms controlling food intake, namely neuropeptide expression and AMP-activated protein kinase (AMPK) phosphorylation in rats. Our results show that subchronic exposure to olanzapine upregulates neuropeptide Y (NPY) and agouti related protein (AgRP) and downregulates proopiomelanocortin (POMC) in the arcuate nucleus of the hypothalamus (ARC). This effect was evident both in rats fed ad libitum and in pair-fed rats. Of note, despite weight gain and increased expression of orexigenic neuropeptides, subchronic administration of olanzapine decreased AMPK phosphorylation levels. This reduction in AMPK was not observed after acute administration of either olanzapine or clozapine. Overall, our data suggest that olanzapine-induced hyperphagia is mediated through appropriate changes in hypothalamic neuropeptides, and that this effect does not require concomitant AMPK activation. Our data shed new light on the hypothalamic mechanism underlying antipsychotic-induced hyperphagia and weight gain, and provide the basis for alternative targets to control energy balance
Determination of diquat by flow injection-chemiluminescence
A simple, economic, sensitive and rapid method for the determination of the pesticide diquat was described. This new method was based on the coupling of flow injection analysis methodology and direct chemiluminescent detection; to the authors' knowledge, this approach had not been used up to now with this pesticide. It was based on its oxidation with ferricyanide in alkaline medium; significant improvements in the analytical signal were achieved by using high temperatures and quinine as sensitiser. Its high throughput (144 h(-1)), together with its low limit of detection (2 ng mL(-1)), achieved without need of preconcentration steps, permitted the reliable quantification of diquat over the linear range of (0.01-0.6) mu g mL(-1) in samples from different origins (river, tap, mineral and ground waters), even in the presence of a 40-fold concentration of paraquat, a pesticide commonly present in the commercial formulations of diquat.LĂłpez-Paz, JL.; CatalĂĄ-Icardo, M.; AntĂłn Garrido, B. (2009). Determination of diquat by flow injection-chemiluminescence. Analytical and Bioanalytical Chemistry. 394(4):1073-1079. doi:10.1007/s00216-009-2609-zS107310793944Hayes WJ Jr, Laws ER Jr (1991) Handbook of pesticide toxicology, Academic Press, San DiegoUS Environmental Protection Agency. http://www.epa.gov/06WDW/contaminants/dw_contamfs/diquat.html (accessed in August 2008)Horwitz W (2000) Official methods of analysis of AOAC International 17th edition. AOAC International, Gaithersburg, MD, USAHara S, Sasaki N, Takase D, Shiotsuka S, Ogata K, Futagami K, Tamura K (2007) Anal Sci 23(5):523â531Rial Otero R, Cancho Grande B, PĂ©rez Lamela C, Simal Gandara J, Aria Estevez M (2006) J Chromatogr Sci 44(9):539â542Aramendia MA, Borau V, Lafont F, Marinas JM, Moreno JM, Porras JM, Urbano FJ (2006) Food Chem 97(1):181â188Nuñez O, Moyano E, Galceran MT (2004) Anal Chim Acta 525(2):183â190Martinez Vidal JL, Belmonte Vega A, Sanchez Lopez FJ, Garrido Frenich AJ (2004) Chromatogr A 1050(2):179â184Lee XP, Kumazawa T, Fujishiro M, Hasegawa C, Arinobu T, Seno H, Sato K (2004) J Mass Spectrom 39(10):1147â1152De Almeida RM, Yonamine M (2007) J Chromatogr B 853(1â2):260â264De Souza D, Machado SAS (2006) Electroanalysis 18(9):862â872De Souza D, Da Silva MRC, Machado SAS (2006) Electroanalysis 18(23):2305â2313PicĂł Y, Rodriguez R, Manes J (2003) Trends Anal Chem 22(3):133â151Ishiwata T (2004) Bunseki Kagaku 53(8):863â864Carneiro MC, Puignou L, GalcerĂĄn MT (2000) Anal Chim Acta 408:263Luque M, Rios A, Valcarcel M (1998) Analyst 123(11):2383â2387Perez Ruiz T, MartĂnez Lozano C, Tomas V (1991) Int J Environ Anal Chem 44(4):243â252Perez Ruiz T, MartĂnez Lozano C, Tomas V (1991) Anal Chim Acta 244(1):99â104Townshend A (1990) Analyst 115:495â500LĂłpez Paz JL, CatalĂĄ Icardo M (2008) Anal Chim Acta 625:173â179PawlicovĂĄ Z, Sahuquillo I, CatalĂĄ Icardo M, GarcĂa Mateo JV, MartĂnez Calatayud J (2006) Anal Sci 22:29â34Albert GarcĂa JR, CatalĂĄ Icardo M, MartĂnez Calatayud J (2006) Talanta 69:608â614Tomlin CDS (1997) The pesticide manual, 11th edn.The British Crop Protection CouncilUKCatalĂĄ-Icardo M, MartĂnez-Calatayud J (2008) Crit Rev Anal Chem 38:118â130Ministerio de Medio Ambiente y Medio Rural y Marino. http://www.marm.es/ (accessed in September 2008)US Environmental Protection Agency. http://www.epa.gov/OGWWDW/contaminants (accessed in October 2008
Recommended from our members
Energy calibration of the NEXT-White detector with 1% resolution near Q ÎČÎČ of 136Xe
Excellent energy resolution is one of the primary advantages of electroluminescent high-pressure xenon TPCs. These detectors are promising tools in searching for rare physics events, such as neutrinoless double-beta decay (ÎČÎČ0Îœ), which require precise energy measurements. Using the NEXT-White detector, developed by the NEXT (Neutrino Experiment with a Xenon TPC) collaboration, we show for the first time that an energy resolution of 1% FWHM can be achieved at 2.6 MeV, establishing the present technology as the one with the best energy resolution of all xenon detectors for ÎČÎČ0Îœ searches. [Figure not available: see fulltext.
- âŠ