278 research outputs found
The Supernova Legacy Survey 3-year sample: Type Ia Supernovae photometric distances and cosmological constraints
We present photometric properties and distance measurements of 252 high
redshift Type Ia supernovae (0.15 < z < 1.1) discovered during the first three
years of the Supernova Legacy Survey (SNLS). These events were detected and
their multi-colour light curves measured using the MegaPrime/MegaCam instrument
at the Canada-France-Hawaii Telescope (CFHT), by repeatedly imaging four
one-square degree fields in four bands. Follow-up spectroscopy was performed at
the VLT, Gemini and Keck telescopes to confirm the nature of the supernovae and
to measure their redshifts. Systematic uncertainties arising from light curve
modeling are studied, making use of two techniques to derive the peak
magnitude, shape and colour of the supernovae, and taking advantage of a
precise calibration of the SNLS fields. A flat LambdaCDM cosmological fit to
231 SNLS high redshift Type Ia supernovae alone gives Omega_M = 0.211 +/-
0.034(stat) +/- 0.069(sys). The dominant systematic uncertainty comes from
uncertainties in the photometric calibration. Systematic uncertainties from
light curve fitters come next with a total contribution of +/- 0.026 on
Omega_M. No clear evidence is found for a possible evolution of the slope
(beta) of the colour-luminosity relation with redshift.Comment: (The SNLS Collaboration) 40 pages, 32 figures, Accepted in A&
Constraining dark matter halo properties using lensed SNLS supernovae
This paper exploits the gravitational magnification of SNe Ia to measure
properties of dark matter haloes. The magnification of individual SNe Ia can be
computed using observed properties of foreground galaxies and dark matter halo
models. We model the dark matter haloes of the galaxies as truncated singular
isothermal spheres with velocity dispersion and truncation radius obeying
luminosity dependent scaling laws. A homogeneously selected sample of 175 SNe
Ia from the first 3-years of the Supernova Legacy Survey (SNLS) in the redshift
range 0.2 < z < 1 is used to constrain models of the dark matter haloes
associated with foreground galaxies. The best-fitting velocity dispersion
scaling law agrees well with galaxy-galaxy lensing measurements. We further
find that the normalisation of the velocity dispersion of passive and star
forming galaxies are consistent with empirical Faber-Jackson and Tully-Fisher
relations, respectively. If we make no assumption on the normalisation of these
relations, we find that the data prefer gravitational lensing at the 92 per
cent confidence level. Using recent models of dust extinction we deduce that
the impact of this effect on our results is very small. We also investigate the
brightness scatter of SNe Ia due to gravitational lensing. The gravitational
lensing scatter is approximately proportional to the SN Ia redshift. We find
the constant of proportionality to be B = 0.055 +0.039 -0.041 mag (B < 0.12 mag
at the 95 per cent confidence level). If this model is correct, the
contribution from lensing to the intrinsic brightness scatter of SNe Ia is
small for the SNLS sample.Comment: 11 pages, 7 figures, accepted for publication in MNRA
Supernova Legacy Survey: Using Spectral Signatures To Improve Type Ia Supernovae As Distance Indicators
GMOS optical long-slit spectroscopy at the Gemini-North telescope was used to
classify targets from the Supernova Legacy Survey (SNLS) from July 2005 and May
2006 - May 2008. During this time, 95 objects were observed. Where possible the
objects' redshifts (z) were measured from narrow emission or absorption
features in the host galaxy spectrum, otherwise they were measured from the
broader supernova features. We present spectra of 68 confirmed or probable SNe
Ia from SNLS with redshifts in the range 0.17 \leq z \leq 1.02. In combination
with earlier SNLS Gemini and VLT spectra, we used these new observations to
measure pseudo-equivalent widths (EWs) of three spectral features - CaII H&K,
SiII and MgII - in 144 objects and compared them to the EWs of low-redshift SNe
Ia from a sample drawn from the literature. No signs of changes with z are seen
for the CaII H&K and MgII features. Systematically lower EW SiII is seen at
high redshift, but this can be explained by a change in demographics of the SNe
Ia population within a two-component model combined with an observed
correlation between EW SiII and photometric lightcurve stretch.Comment: 49 pages including 2 online-only appendices, accepted for publication
in MNRA
SNLS3: Constraints on Dark Energy Combining the Supernova Legacy Survey Three Year Data with Other Probes
We present observational constraints on the nature of dark energy using the
Supernova Legacy Survey three year sample (SNLS3) of Guy et al. (2010) and
Conley et al. (2011). We use the 472 SNe Ia in this sample, accounting for
recently discovered correlations between SN Ia luminosity and host galaxy
properties, and include the effects of all identified systematic uncertainties
directly in the cosmological fits. Combining the SNLS3 data with the full WMAP7
power spectrum, the Sloan Digital Sky Survey luminous red galaxy power
spectrum, and a prior on the Hubble constant H0 from SHOES, in a flat universe
we find omega_m=0.269+/-0.015 and w=-1.061+0.069-0.068 -- a 6.5% measure of the
dark energy equation-of-state parameter w. The statistical and systematic
uncertainties are approximately equal, with the systematic uncertainties
dominated by the photometric calibration of the SN Ia fluxes -- without these
calibration effects, systematics contribute only a ~2% error in w. When
relaxing the assumption of flatness, we find omega_m=0.271+/-0.015,
omega_k=-0.002+/-0.006, and w=-1.069+0.091-0.092. Parameterizing the time
evolution of w as w(a)=w_0+w_a(1-a), gives w_0=-0.905+/-0.196,
w_a=-0.984+1.094-1.097 in a flat universe. All of our results are consistent
with a flat, w=-1 universe. The size of the SNLS3 sample allows various tests
to be performed with the SNe segregated according to their light curve and host
galaxy properties. We find that the cosmological constraints derived from these
different sub-samples are consistent. There is evidence that the coefficient,
beta, relating SN Ia luminosity and color, varies with host parameters at
>4sigma significance (in addition to the known SN luminosity--host relation);
however this has only a small effect on the cosmological results and is
currently a sub-dominant systematic.Comment: Accepted for publication in ApJ. Data available from
https://tspace.library.utoronto.ca/snl
Can we <i>S</i>ave the rectum by watchful waiting or <i>T</i>rans<i>A</i>nal microsurgery following (chemo) <i>R</i>adiotherapy versus total mesorectal excision for early <i>RE</i>ctal <i>C</i>ancer (STAR-TREC study)?::protocol for a multicentre, randomised feasibility study
Introduction Total mesorectal excision (TME) is the highly effective standard treatment for rectal cancer but is associated with significant morbidity and may be overtreatment for low-risk cancers. This study is designed to determine the feasibility of international recruitment in a study comparing organ-saving approaches versus standard TME surgery. Methods and analysis STAR-TREC trial is a multicentre international randomised, three-arm parallel, phase II feasibility study in patients with biopsy-proven adenocarcinoma of the rectum. The trial is coordinated from Birmingham, UK with national hubs in Radboudumc (the Netherlands) and Odense University Hospital Svendborg UMC (Denmark). Patients with rectal cancer, staged by CT and MRI as ≤cT3b (up to 5 mm of extramural spread) N0 M0 can be included. Patients will be randomised to either standard TME surgery (control), organ-saving treatment using long-course concurrent chemoradiation or organ-saving treatment using short-course radiotherapy. For patients treated with an organ-saving strategy, clinical response to (chemo)radiotherapy determines the next treatment step. An active surveillance regime will be performed in the case of a complete clinical regression. In the case of incomplete clinical regression, patients will proceed to local excision using an optimised platform such as transanal endoscopic microsurgery or other transanal techniques (eg, transanal endoscopic operation or transanal minimally invasive surgery). The primary endpoint of this phase II study is to demonstrate sufficient international recruitment in order to sustain a phase III study incorporating pelvic failure as the primary endpoint. Success in phase II is defined as randomisation of at least four cases per month internationally in year 1, rising to at least six cases per month internationally during year 2
Age, gender and disability predict future disability in older people: the Rotterdam Study
<p>Abstract</p> <p>Background</p> <p>To develop a prediction model that predicts disability in community-dwelling older people. Insight in the predictors of disability is needed to target preventive strategies for people at increased risk.</p> <p>Methods</p> <p>Data were obtained from the Rotterdam Study, including subjects of 55 years and over. Subjects who had complete data for sociodemographic factors, life style variables, health conditions, disability status at baseline and complete data for disability at follow-up were included in the analysis. Disability was expressed as a Disability Index (DI) measured with the Health Assessment Questionnaire.</p> <p>We used a multivariable polytomous logistic regression to derive a basic prediction model and an extended prediction model. Finally we developed readily applicable score charts for the calculation of outcome probabilities.</p> <p>Results</p> <p>Of the 5027 subjects included, 49% had no disability, 18% had mild disability, 16% had severe disability and 18% had deceased at follow-up after six years. The strongest predictors were age and prior disability. The contribution of other predictors was relatively small. The discriminative ability of the basic model was high; the extended model did not enhance predictive ability.</p> <p>Conclusion</p> <p>As prior disability status predicts future disability status, interventive strategies should be aimed at preventing disability in the first place.</p
Mortality after Hospitalization for Pneumonia among Individuals with HIV, 1995–2008: A Danish Cohort Study
BACKGROUND: HIV-infected persons are at increased risk of pneumonia, even with highly active antiretroviral treatment (HAART). We examined the impact of pneumonia on mortality and identified prognostic factors for death among HIV-infected. METHODOLOGY/PRINCIPAL FINDINGS: In a nationwide, population-based cohort of individuals with HIV, we included persons hospitalized with pneumonia from the Danish National Hospital Registry and obtained mortality data from the Danish Civil Registration System. Comparing individuals with and without pneumonia, we used Poisson regression to estimate relative mortality and logistic regression to examine prognostic factors for death following pneumonia. From January 1, 1995, to July 1, 2008, we observed 699 episodes of first hospitalization for pneumonia among 4,352 HIV patients. Ninety-day mortality after pneumonia decreased from 22.4% (95% confidence interval [CI]: 16.5%-28.9%) in 1995-1996 to 8.4% (95% CI: 6.1%-11.6%) in 2000-2008. Mortality remained elevated for more than a year after hospitalization for pneumonia: adjusted mortality rate ratio 5.38 (95% CI: 4.27-6.78), 1.80 (95% CI: 1.36-2.37), and 1.62 (95% CI: 1.32-2.00) for days 0-90, 91-365, and 366+, respectively. The following variables predicted mortality within 90 days following hospitalization for pneumonia (adjusted Odds Ratios): male sex (3.77, 95% CI: 1.37-10.4), Charlson Comorbidity Index score > or = 2 (3.86, 95% CI: 2.19-6.78); no current HAART (3.58, 95% CI: 1.83-6.99); history of AIDS (2.46, 95% CI: 1.40-4.32); age per 10 year increase (1.43, 95% CI: 1.11-1.85); and CD4+ cell count < or = 200 (2.52, 95% CI: 1.37-4.65). CONCLUSIONS/SIGNIFICANCE: The first hospitalization for pneumonia among HIV-infected individuals was associated with elevated risk of death up to more than a year later. Use of HAART decreased the risk, independent of current CD4+ cell count. Prognosis following pneumonia improved over calendar time
Education and training of healthcare staff in the knowledge, attitudes and skills needed to work effectively with breastfeeding women:a systematic review
BACKGROUND: Current evidence suggests that women need effective support to breastfeed, but many healthcare staff lack the necessary knowledge, attitudes and skills. There is therefore a need for breastfeeding education and training for healthcare staff. The primary aim of this review is to determine whether education and training programs for healthcare staff have an effect on their knowledge and attitudes about supporting breastfeeding women. The secondary aim of this review was to identify whether any differences in type of training or discipline of staff mattered. METHODS: A systematic search of the literature was conducted using the Cochrane Pregnancy and Childbirth Group’s trial register. Randomised controlled trials comparing breastfeeding education and training for healthcare staff with no or usual training and education were included if they measured the impact on staff knowledge, attitudes or compliance with the Baby Friendly Hospital Initiative (BFHI). RESULTS: From the 1192 reports identified, four distinct studies were included. Three studies were two-arm cluster-randomised trials and one was a two-arm individual randomised trial. Of these, three contributed quantitative data from a total of 250 participants. Due to heterogeneity of outcome measures meta-analysis was not possible. Knowledge was included as an outcome in two studies and demonstrated small but significant positive effects. Attitudes towards breastfeeding was included as an outcome in two studies, however, results were inconsistent both in terms of how they were measured and the intervention effects. One study reported a small but significant positive effect on BFHI compliance. Study quality was generally deemed low with the majority of domains being judged as high or unclear risk of bias. CONCLUSIONS: This review identified a lack of good evidence on breastfeeding education and training for healthcare staff. There is therefore a critical need for research to address breastfeeding education and training needs of multidisciplinary healthcare staff in different contexts through large, well-conducted RCTs
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