Real-Time Detection and Filtering of Radio Frequency Interference On-board a Spaceborne Microwave Radiometer: The CubeRRT Mission

The Cubesat Radiometer Radio frequency interference Technology validation mission (CubeRRT) was developed to demonstrate real-time on-board detection and filtering of radio frequency interference (RFI) for wide bandwidth microwave radiometers. CubeRRT’s key technology is its radiometer digital backend (RDB) that is capable of measuring an instantaneous bandwidth of 1 GHz and of filtering the input signal into an estimated total power with and without RFI contributions. CubeRRT’s on-board RFI processing capability dramatically reduces the volume of data that must be downlinked to the ground and eliminates the need for ground-based RFI processing. RFI detection is performed by resolving the input bandwidth into 128 frequency sub-channels, with the kurtosis of each sub-channel and the variations in power across frequency used to detect non-thermal contributions. RFI filtering is performed by removing corrupted frequency sub-channels prior to the computation of the total channel power. The 1 GHz bandwidth input signals processed by the RDB are obtained from the payload’s antenna (ANT) and radiometer front end (RFE) subsystems that are capable of tuning across RF center frequencies from 6 to 40 GHz. The CubeRRT payload was installed into a 6U spacecraft bus provided by Blue Canyon Technologies that provides spacecraft power, communications, data management, and navigation functions. The design, development, integration and test, and on-orbit operations of CubeRRT are described in this paper. The spacecraft was delivered on March 22nd, 2018 for launch to the International Space Station (ISS) on May 21st, 2018. Since its deployment from the ISS on July 13th, 2018, the CubeRRT RDB has completed more than 5000 hours of operation successfully, validating its robustness as an RFI processor. Although CubeRRT’s RFE subsystem ceased operating on September 8th, 2018, causing the RDB input thereafter to consist only of internally generated noise, CubeRRT’s key RDB technology continues to operate without issue and has demonstrated its capabilities as a valuable subsystem for future radiometry missions

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Deep brain stimulation for neuropathic pain

Objectives:?To determine whether deep brain stimulation is an effective treatment for neuropathic pain of varied etiology. Material and Methods.?Thirty-four patients with intractable neuropathic pain were prospectively studied using visual analog scores, McGill Pain Questionnaire, and Quality of Life Questionnaires (EUROQOL EQ-5D VAS, and SF-36 v-2). Patients had either deep brain stimulation of either the periventricular gray or ventroposterolateral nucleus of the thalamus, or both. Results.?Seventy-six percent of patients underwent permanent implantation. Overall reduction of pain intensity was 54%. The burning component of pain improved by 77%. Health-related quality of life improved by 38%. Conclusions.?Deep brain stimulation is an effective treatment for neuropathic pain. The factors that influence outcome, including etiology and site of stimulation, are discussed

Testing and Operation Planning of the Cubesat Radiometer Radio Frequency Interference Technology Validation (Cuberrt) System

The CubeSat Radiometer Radio Frequency Interference Technology Validation (CubeRRT) mission is developing a 6U CubeSat system to demonstrate radio frequency interference (RFI) detection and filtering technologies for future microwave radiometer remote sensing missions. CubeRRT will perform observations of Earth brightness temperatures from 6–40 GHz using a 1 GHz bandwidth tuned channel and will demonstrate on-board real-time RFI processing. The system is currently under development, with an expected launch date in mid-2018 followed by a one year period of on-orbit operations. CubeRRT spacecraft and radiometer instrument testing as well as the mission concept of operations are described in this paper

Testing and Operation Planning of the Cubesat Radiometer Radio Frequency Interference Technology Validation (Cuberrt) System

The CubeSat Radiometer Radio Frequency Interference Technology Validation (CubeRRT) mission is developing a 6U CubeSat system to demonstrate radio frequency interference (RFI) detection and filtering technologies for future microwave radiometer remote sensing missions. CubeRRT will perform observations of Earth brightness temperatures from 6–40 GHz using a 1 GHz bandwidth tuned channel and will demonstrate on-board real-time RFI processing. The system is currently under development, with an expected launch date in mid-2018 followed by a one year period of on-orbit operations. CubeRRT spacecraft and radiometer instrument testing as well as the mission concept of operations are described in this paper

CubeSat Radiometer Radio Frequency Interference Technology (CubeRRT) Validation Mission: Enabling Future Resource-Constrained Science Missions

In this paper we discuss the necessary technology required to enable the future of spectrum resource constrained missions. We discuss the CubeSat Radiometer Radio Frequency Interference Technology (CubeRRT) validation mission and the development of its digital backend, necessary for performing on-board RFI detection and filtering for wideband high frequency radiometry. The CubeRRT mission will validate the on-board RFI filtering technology solving technological challenges such as bandwidth, data downlink volume, and RFI types. We present a few initial results of the backend spectrometer leading to full-system integration and test