QTL for microstructural and biophysical muscle properties and body composition in pigs

BACKGROUND: The proportion of muscle fibre types and their size affect muscularity as well as functional properties of the musculature and meat quality. We aimed to identify QTL for microstructural muscle properties including muscle fibre size, their numbers and fibre type proportions as well as biophysical parameters of meat quality and traits related to body composition, i.e. pH, conductivity, area of M. longissimus dorsi and lean meat content. A QTL scan was conducted in a porcine experimental population that is based on Duroc and Berlin Miniature Pig. RESULTS: Least square regression interval mapping revealed five significant and 42 suggestive QTL for traits related to muscle fibre composition under the line-cross model as well as eight significant and 40 suggestive QTL under the half-sib model. For traits related to body composition and biophysical parameters of meat quality five and twelve significant plus nine and 22 suggestive QTL were found under the line-cross and half-sib model, respectively. Regions with either significant QTL for muscle fibre traits or significant QTL for meat quality and muscularity or both were detected on SSC1, 2, 3, 4, 5, 13, 14, 15, and 16. QTL for microstructural properties explained a larger proportion of variance than did QTL for meat quality and body composition. CONCLUSION: Microstructural properties of pig muscle and meat quality are governed by genetic variation at many loci distributed throughout the genome. QTL analysis under both, the line-cross and half-sib model, allows detecting QTL in case of fixation or segregation of the QTL alleles among the founder populations and thus provide comprehensive insight into the genetic variation of the traits under investigation. Genomic regions affecting complex traits of muscularity and meat quality as well as microstructural properties might point to QTL that in first instance affect muscle fibre traits and by this in second instance meat quality. Disentangling complex traits in their constituent phenotypes might facilitate the identification of QTL and the elucidation of the pleiotropic nature of QTL effects

O tratamento contábil do capital intelectual em empresas com valor de mercado superior ao valor contábil

Este artigo tem por objetivo sintetizar o resultado da pesquisa sobre o tratamento contábil que é aplicado ao capital intelectual, sob a ótica do processo de gestão, representado pelos conceitos e técnicas que são utilizados e que dão suporte à ação da administração, em empresas com valor de mercado superior ao valor contábil. Para atingir este propósito, o artigo consubstancia-se em uma pesquisa realizada em duas empresas de capital aberto, de Santa Catarina, que apresentam valor de mercado, considerado o valor das ações superior ao seu valor contábil. Observou-se que, embora as empresas pesquisadas possuam todas as características das organizações voltadas ao conhecimento e domínio tecnológico, o tratamento contábil do capital intelectual é algo ainda muito incipiente, e que, os critérios utilizados para mensurar, registrar e evidenciar as informações referentes ao capital humano, capital estrutural e capital de clientes, com vistas ao processo de gestão, é algo que ainda carece de uma sistematização, para que se possa refletir, por meio das demonstrações contábeis, alguma posição nesse sentido. Concluiu-se que as empresas pesquisadas, mesmo não possuindo as informações sistematizadas sobre as iniciativas de mensuração do capital intelectual, têm consciência da sua importância. No entanto, para que os gestores desses empreendimentos possam, efetivamente, utilizá-las como um diferencial competitivo no processo de gestão, as informações sistematizadas sobre o capital intelectual devem fazer parte dos relatórios gerados para a tomada de decisões.The objective of this article si to summarize the result of the research about the accounting treatment which is applied to the intellectual capital, through the management viewpoint, in companies with a market value superior than the accounting value. In order to reach this intention, the article is substantiated on a research carried out in two open capital companies, in SC, which have a market value, considered the action value superior than its accounting value. It was observed that, although the researched companies have all the characteristics of the organizations that aim to the technological knowledge and domain, the accounting treatment of the intellectual capital is still something too incipient and that the criteria used to measure, register and show up the human capital, structural capital and customer capital referred information with view to the management process, is something that still needs a systematization, so that it is possible to reflect, throughout the accounting demonstrations, some position on this sense. It was concluded that the researched companies, even without the systematized information about the initiative of the intelectual capital mensuration, are conscious about this importance. However, the intellectual capital systematized information must be part of the generated reports for the decion takings, so that the managers of these undertakings can effectively use them as a competitive differential in the management process

Herschel Exploitation of Local Galaxy Andromeda (HELGA) III: The Star Formation Law in M31

We present a detailed study of how the Star Formation Rate (SFR) relates to the interstellar medium (ISM) of M31 at ~140pc scales. The SFR is calculated using the far-ultraviolet and 24um emission, corrected for the old stellar population in M31. We find a global value for the SFR of 0.25+/-0.05Msun/yr and compare this with the SFR found using the total far-infrared (FIR) luminosity. There is general agreement in regions where young stars dominate the dust heating. Atomic hydrogen (HI) and molecular gas (traced by carbon monoxide, CO) or the dust mass is used to trace the total gas in the ISM. We show that the global surface densities of SFR and gas mass place M31 amongst a set of low-SFR galaxies in the plot of Kennicutt (1998b). The relationship between SFR and gas surface density is tested in six radial annuli across M31, assuming a power law relationship with index, N. The star formation law using total gas traced by HI and CO gives a global index of N=2.03+/-0.04, with a significant variation with radius; the highest values are observed in the 10kpc ring. We suggest that this slope is due to HI turning molecular at ~10Msun/pc2. When looking at H2 regions, we measure a higher mean SFR suggesting a better spatial correlation between H2 and SF. We find N~0.6 with consistent results throughout the disk - this is at the low end of values found in previous work and argues against a superlinear SF law on small scales.Comment: 12 pages, 10 figure

Moderators of Exercise Effects on Cancer-related Fatigue:A Meta-analysis of Individual Patient Data

PURPOSE: Fatigue is a common and potentially disabling symptom in patients with cancer. It can often be effectively reduced by exercise. Yet, effects of exercise interventions might differ across subgroups. We conducted a meta-analysis using individual patient data of randomized controlled trials (RCT) to investigate moderators of exercise intervention effects on cancer-related fatigue. METHODS: We used individual patient data from 31 exercise RCT worldwide, representing 4366 patients, of whom 3846 had complete fatigue data. We performed a one-step individual patient data meta-analysis, using linear mixed-effect models to analyze the effects of exercise interventions on fatigue (z score) and to identify demographic, clinical, intervention- and exercise-related moderators. Models were adjusted for baseline fatigue and included a random intercept on study level to account for clustering of patients within studies. We identified potential moderators by testing their interaction with group allocation, using a likelihood ratio test. RESULTS: Exercise interventions had statistically significant beneficial effects on fatigue (β = -0.17; 95% confidence interval [CI], -0.22 to -0.12). There was no evidence of moderation by demographic or clinical characteristics. Supervised exercise interventions had significantly larger effects on fatigue than unsupervised exercise interventions (βdifference = -0.18; 95% CI -0.28 to -0.08). Supervised interventions with a duration ≤12 wk showed larger effects on fatigue (β = -0.29; 95% CI, -0.39 to -0.20) than supervised interventions with a longer duration. CONCLUSIONS: In this individual patient data meta-analysis, we found statistically significant beneficial effects of exercise interventions on fatigue, irrespective of demographic and clinical characteristics. These findings support a role for exercise, preferably supervised exercise interventions, in clinical practice. Reasons for differential effects in duration require further exploration

Targeting exercise interventions to patients with cancer in need:An individual patient data meta-analysis

Background: Exercise effects in cancer patients often appear modest, possibly because interventions rarely target patients most in need. This study investigated the moderator effects of baseline values on the exercise outcomes of fatigue, aerobic fitness, muscle strength, quality of life (QoL), and self-reported physical function (PF) in cancer patients during and post-treatment. Methods: Individual patient data from 34 randomized exercise trials (n = 4519) were pooled. Linear mixed-effect models were used to study moderator effects of baseline values on exercise intervention outcomes and to determine whether these moderator effects differed by intervention timing (during vs post-treatment). All statistical tests were two-sided. Results: Moderator effects of baseline fatigue and PF were consistent across intervention timing, with greater effects in patients with worse fatigue (Pinteraction = .05) and worse PF (Pinteraction = .003). Moderator effects of baseline aerobic fitness, muscle strength, and QoL differed by intervention timing. During treatment, effects on aerobic fitness were greater for patients with better baseline aerobic fitness (Pinteraction = .002). Post-treatment, effects on upper (Pinteraction < .001) and lower (Pinteraction = .01) body muscle strength and QoL (Pinteraction < .001) were greater in patients with worse baseline values. Conclusion: Although exercise should be encouraged for most cancer patients during and post-treatments, targeting specific subgroups may be especially beneficial and cost effective. For fatigue and PF, interventions during and post-treatment should target patients with high fatigue and low PF. During treatment, patients experience benefit for muscle strength and QoL regardless of baseline values; however, only patients with low baseline values benefit post-treatment. For aerobic fitness, patients with low baseline values do not appear to benefit from exercise during treatment

First M87 Event Horizon Telescope Results. IV. Imaging the Central Supermassive Black Hole

We present the first Event Horizon Telescope (EHT) images of M87, using observations from April 2017 at 1.3 mm wavelength. These images show a prominent ring with a diameter of similar to 40 mu as, consistent with the size and shape of the lensed photon orbit encircling the "shadow" of a supermassive black hole. The ring is persistent across four observing nights and shows enhanced brightness in the south. To assess the reliability of these results, we implemented a two-stage imaging procedure. In the first stage, four teams, each blind to the others' work, produced images of M87 using both an established method (CLEAN) and a newer technique (regularized maximum likelihood). This stage allowed us to avoid shared human bias and to assess common features among independent reconstructions. In the second stage, we reconstructed synthetic data from a large survey of imaging parameters and then compared the results with the corresponding ground truth images. This stage allowed us to select parameters objectively to use when reconstructing images of M87. Across all tests in both stages, the ring diameter and asymmetry remained stable, insensitive to the choice of imaging technique. We describe the EHT imaging procedures, the primary image features in M87, and the dependence of these features on imaging assumptions

Monitoring the Morphology of M87* in 2009–2017 with the Event Horizon Telescope

The Event Horizon Telescope (EHT) has recently delivered the first resolved images of M87*, the supermassive black hole in the center of the M87 galaxy. These images were produced using 230 GHz observations performed in 2017 April. Additional observations are required to investigate the persistence of the primary image feature—a ring with azimuthal brightness asymmetry—and to quantify the image variability on event horizon scales. To address this need, we analyze M87* data collected with prototype EHT arrays in 2009, 2011, 2012, and 2013. While these observations do not contain enough information to produce images, they are sufficient to constrain simple geometric models. We develop a modeling approach based on the framework utilized for the 2017 EHT data analysis and validate our procedures using synthetic data. Applying the same approach to the observational data sets, we find the M87* morphology in 2009–2017 to be consistent with a persistent asymmetric ring of ~40 μas diameter. The position angle of the peak intensity varies in time. In particular, we find a significant difference between the position angle measured in 2013 and 2017. These variations are in broad agreement with predictions of a subset of general relativistic magnetohydrodynamic simulations. We show that quantifying the variability across multiple observational epochs has the potential to constrain the physical properties of the source, such as the accretion state or the black hole spin

First M87 Event Horizon Telescope Results. VI. The Shadow and Mass of the Central Black Hole

We present measurements of the properties of the central radio source in M87 using Event Horizon Telescope data obtained during the 2017 campaign. We develop and fit geometric crescent models (asymmetric rings with interior brightness depressions) using two independent sampling algorithms that consider distinct representations of the visibility data. We show that the crescent family of models is statistically preferred over other comparably complex geometric models that we explore. We calibrate the geometric model parameters using general relativistic magnetohydrodynamic (GRMHD) models of the emission region and estimate physical properties of the source. We further fit images generated from GRMHD models directly to the data. We compare the derived emission region and black hole parameters from these analyses with those recovered from reconstructed images. There is a remarkable consistency among all methods and data sets. We find that >50% of the total flux at arcsecond scales comes from near the horizon, and that the emission is dramatically suppressed interior to this region by a factor >10, providing direct evidence of the predicted shadow of a black hole. Across all methods, we measure a crescent diameter of 42 +/- 3 mu as and constrain its fractional width to b