115 research outputs found
Levamisole adulterated cocaine and pulmonary vasculitis: Presentation of two lethal cases and brief literature review
Linearized hydrodynamics from probe-sources in the gauge-string duality
We study the response of an infinite, asymptotically static N=4 plasma to a
generic localized source in the probe approximation. At large distances, the
energy momentum tensor of the plasma includes a term which satisfies the
constitutive relations of linearized hydrodynamics, but it can also include a
non-hydrodynamical term which contributes at the same order as viscous
corrections, or even at leading order in some cases. The conditions for the
appearance of a laminar wake far behind the source and its relevance for
phenomenological models used to explain di-hadron correlations are discussed.
We also consider the energy momentum tensor near the source, where the
hydrodynamical approximation can be expected to break down. Our analysis
encompasses a wide range of sources which are localized in the bulk of AdS,
including trailing strings, mesonic and baryonic configurations of strings, and
point particles.Comment: 43 pages, 3 appendice
Momentum fluctuations of heavy quarks in the gauge-string duality
Using the gauge-string duality, I compute two-point functions of the force
acting on an external quark moving through a finite temperature bath of N=4
super-Yang-Mills theory. I comment on the possible relevance of the string
theory calculations to heavy quarks propagating through a quark-gluon plasma.Comment: 37 pages, 2 figures. v2: small improvements, ref added. v3:
substantial revisions. v4: fixed a few typo
Non-conformal examples of AdS/CFT
Asymptotically anti-de Sitter spacetimes with Poincare invariance along the
boundary can describe, via the AdS/CFT correspondence, either relevant
deformations of a conformal field theory or non-conformal vacuum states. I
consider examples of both types constructed in the framework of
five-dimensional gauged supergravity. I explain the proof and motivation of a
gravitational ``c-theorem'' which is independent of dimension. I show how one
class of examples can be elevated to ten-dimensional geometries involving
distributions of parallel D3-branes. For these cases some peculiar properties
of two-point functions emerge, and I close with speculations on their physical
origin.Comment: 16 pages, two figures, latex. Strings '99 tal
Cerebrospinal fluid total prion protein in the spectrum of prion diseases
Cerebrospinal fluid (CSF) total prion protein (t-PrP) is decreased in sporadic Creutzfeldt-Jakob disease (sCJD). However, data on the comparative signatures of t-PrP across the spectrum of prion diseases, longitudinal changes during disease progression, and levels in pre-clinical cases are scarce. T-PrP was quantified in neurological diseases (ND, n = 147) and in prion diseases from different aetiologies including sporadic (sCJD, n = 193), iatrogenic (iCJD, n = 12) and genetic (n = 209) forms. T-PrP was also measured in serial lumbar punctures obtained from sCJD cases at different symptomatic disease stages, and in asymptomatic prion protein gene (PRNP) mutation carriers. Compared to ND, t-PrP concentrations were significantly decreased in sCJD, iCJD and in genetic prion diseases associated with the three most common mutations E200K, V210I (associated with genetic CJD) and D178N-129M (associated with fatal familial insomnia). In contrast, t-PrP concentrations in P102L mutants (associated with the Gerstmann-Sträussler-Scheinker syndrome) remained unaltered. In serial lumbar punctures obtained at different disease stages of sCJD patients, t-PrP concentrations inversely correlated with disease progression. Decreased mean t-PrP values were detected in asymptomatic D178-129M mutant carriers, but not in E200K and P102L carriers. The presence of low CSF t-PrP is common to all types of prion diseases regardless of their aetiology albeit with mutation-specific exceptions in a minority of genetic cases. In some genetic prion disease, decreased levels are already detected at pre-clinical stages and diminish in parallel with disease progression. Our data indicate that CSF t-PrP concentrations may have a role as a pre-clinical or early symptomatic diagnostic biomarker in prion diseases as well as in the evaluation of therapeutic interventions
Functional magnetic resonance imaging of a parametric working memory task in schizophrenia: relationship with performance and effects of antipsychotic treatment
Fine Mapping of Genetic Variants in BIN1, CLU, CR1 and PICALM for Association with Cerebrospinal Fluid Biomarkers for Alzheimer's Disease
Recent genome-wide association studies of Alzheimer's disease (AD) have identified variants in BIN1, CLU, CR1 and PICALM that show replicable association with risk for disease. We have thoroughly sampled common variation in these genes, genotyping 355 variants in over 600 individuals for whom measurements of two AD biomarkers, cerebrospinal fluid (CSF) 42 amino acid amyloid beta fragments (Aβ42) and tau phosphorylated at threonine 181 (ptau181), have been obtained. Association analyses were performed to determine whether variants in BIN1, CLU, CR1 or PICALM are associated with changes in the CSF levels of these biomarkers. Despite adequate power to detect effects as small as a 1.05 fold difference, we have failed to detect evidence for association between SNPs in these genes and CSF Aβ42 or ptau181 levels in our sample. Our results suggest that these variants do not affect risk via a mechanism that results in a strong additive effect on CSF levels of Aβ42 or ptau181
Discrepant comorbidity between minority and white suicides: a national multiple cause-of-death analysis
Abstract
Background
Clinician training deficits and a low and declining autopsy rate adversely impact the quality of death certificates in the United States. Self-report and records data for the general population indicate that proximate mental and physical health of minority suicides was at least as poor as that of white suicides.
Methods
This cross-sectional mortality study uses data from Multiple Cause-of-Death (MCOD) public use files for 1999–2003 to describe and evaluate comorbidity among black, Hispanic, and white suicides. Unintentional injury decedents are the referent for multivariate analyses.
Results
One or more mentions of comorbid psychopathology are documented on the death certificates of 8% of white male suicides compared to 4% and 3% of black and Hispanic counterparts, respectively. Corresponding female figures are 10%, 8%, and 6%. Racial-ethnic discrepancies in the prevalence of comorbid physical disease are more attenuated. Cross-validation with National Violent Death Reporting System data reveals high relative underenumeration of comorbid depression/mood disorders and high relative overenumeration of schizophrenia on the death certificates of both minorities. In all three racial-ethnic groups, suicide is positively associated with depression/mood disorders [whites: adjusted odds ratio (AOR) = 31.9, 95% CI = 29.80–34.13; blacks: AOR = 60.9, 95% CI = 42.80–86.63; Hispanics: AOR = 34.7, 95% CI = 23.36–51.62] and schizophrenia [whites: AOR = 2.4, 95% CI = 2.07–2.86; blacks: AOR = 4.2, 95% CI = 2.73–6.37; Hispanics: AOR = 4.1, 95% CI = 2.01–8.22]. Suicide is positively associated with cancer in whites [AOR = 1.8, 95% CI = 1.69–1.93] and blacks [AOR = 1.8, 95% CI = 1.36–2.48], but not with HIV or alcohol and other substance use disorders in any group under review.
Conclusion
The multivariate analyses indicate high consistency in predicting suicide-associated comorbidities across racial-ethnic groups using MCOD data. However, low prevalence of documented comorbid psychopathology in suicides, and concomitant racial-ethnic discrepancies underscore the need for training in death certification, and routinization and standardization of timely psychological autopsies in all cases of suicide, suspected suicide, and other traumatic deaths of equivocal cause
Venice Chart International Consensus Document on Atrial Fibrillation Ablation: 2011 Update
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/93647/1/j.1540-8167.2012.02381.x.pd
- …