Information Support for the Implementation of Patriotic Education: Challenges of our Time

В статье анализируется необходимость информационного сопровождения для организации деятельности в сфере патриотического воспитания и применения всего комплекса инструментария по продвижению в социальных сетях и Интернет.The article analyzes the need for information support for the organization of activities in the field of patriotic education and the use of the entire range of tools for promotion in social networks and the Internet

Priority Areas of Activity of the Russian Cossacks

В статье анализируются актуальные нормативно-правовые акты в отношении российского казачества и формирования государственной политики по дальнейшему развитию войсковых казачьих обществ, оценивается потенциал российского казачества для дальнейшего применения на укре+пление обороны, государственной и общественной безопасности Российской Федерации.The article analyzes the current regulatory legal acts in relation to the Russian Cossacks and the formation of state policy for the further development of military Cossack societies, assesses the potential of the Russian Cossacks for further application to strengthen the defense, state and public security of the Russian Federation

International symposium: "Evolution of permian marine biota," and problems concerning permian sections in the type region

The main results of the International Symposium "Evolution of Permian Marine Biota," are presented. The Artinskian to Ufimian part of the section at the Kozhim River (Polar Urals) is briefly described including its paleontological characteristics. Potentials for further study of Permian deposits in the Urals and possibilities of using the Uralian stages as international standards are discussed. Copyright © 1997 by MAHK Hayka/Interperiodica Publishing

Neural network parametrization of the lepton energy spectrum in semileptonic B meson decays

We construct a parametrization of the lepton energy spectrum in inclusive semileptonic decays of B mesons, based on the available experimental information: moments of the spectrum with cuts, their errors and their correlations, together with kinematical constraints. The result is obtained in the form of a Monte Carlo sample of neural networks trained on replicas of the experimental data, which represents the probability density in the space of lepton energy spectra. This parametrization is then used to extract the b quark mass m_b^{1S} in a way that theoretical uncertainties are minimized, for which the value m_b^{1S}=4.84 \pm 0.14^{exp}\pm 0.05^{th} GeV is obtained.Comment: 32 pages, 22 figures, JHEP3 class. v4 version accepted for publication in JHE

STUDENT ACTIVITY АNALYSIS IN THE AREA OF PATRIOTIC EDUCATION OF YOUTH BY ROSPATRIOTCENTER’S CONCEPT “10 FACETS OF PATRIOTISM”

The article discusses the student activity specifics in patriotic associations of educational institutions of higher education in the Sverdlovsk region. Projects are described of the civil and patriotic education of students' personality

Experience in genetic testing of hypertrophic cardiomyopathy using nanopore DNA sequencing

Aim. To investigate the application of the Oxford Nanopore Technologies’ third generation sequencing for the genetic testing of hypertrophic cardiomyopathy.Material and methods. The study involved 12 patients with hypertrophic cardiomyopathy aged 18 to 67 years (women, 9; men, 3). Using the PCR barcoding amplicons (SQK-LSK109) protocol, DNA libraries were created which contained long-range PCR fragments of the MYH7, MYBPC3, TNNT2, TNNI3 and TPM1 genes. The sequencing was performed using the MinION system by Oxford Nanopore Technologies (UK). Bioinformatic algorithms for data analysis included Guppy v.5.0.7, Nanopolish and Clairvoyante. The identified genetic variants were confirmed by Sanger sequencing.Results. Data on the complete sequence of the five major sarcomeric genes for hypertrophic cardiomyopathy were obtained. We found eight potentially disease-causing sequence variants in MYH7, MYBPC3 and TNNT2 genes by monomolecular sequencing. However, only three mutations p.Arg243Cys, p.Tyr609Asn, p.Arg870His in the MYH7 gene, and one mutation p.Lys985Asn in the MYBPC3 were confirmed by Sanger sequencing. Cascade screening of pathogenic variant p.Arg870His in the MYH7 gene was performed. We found one asymptomatic carrier.Conclusion. It appears that monomolecular sequencing technology is a feasible approach to identify mutations in patients with hypertrophic cardiomyopathy. Although improvement in accuracy of DNA sequencing, as well as optimization and simplification of bioinformatic algorithms for identification of the genetic variants are needed

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.Peer reviewe