Effects of nanodispersed iron on the morphofunctional parameters of the blood system

The effects of nanodispersed iron forms on the morphology and function of the blood system were studied. Maghemite and lepidocrocite caused a leukocytic shift towards segmented neutrophil forms, reduction of lymphocyte rigidity, and stimulated their compactization. In addition, the counts of small hyperchromatic erythrocytes with high rigidity increased in the blood flow. The results indicated that a single dose of nanodispersed iron-containing drugs improved the blood respiratory function and its microrheolog

Adaptive correction of thermal distortions of multichannel laser radiation

Results of the simulation of multichannel radiation propagation under conditions of thermal blooming are presented. The correction of nonlinear thermal distortion by means of the beam phase and amplitudephase control is considered. The results show the dependence of the correction effectiveness on the number of channels and on the precision of the reference beam phase retrieval. An additional increase in the effectiveness is possible by means of adjustment of amplification in the channels of the optical system, i.e., with the use of amplitude-phase control over the beam wavefront

Dog filariosis in the Lazio region (Central Italy): first report on the presence of Dirofilaria repens

BACKGROUND: Epidemiological investigations were carried out in the Lazio Region to assess the status of canine filariosis and to evaluate the actual risk for veterinary and medical public health. METHODS: Since August 2001 to June 2003, a total of 972 canine blood samples, collected in public kennels and from private owners animals of the 5 Provinces of the Region, were tested. The presence of filarial parasites was evaluated by microscopy and bio-molecular techniques; the species identification was performed by means of the same diagnostic tools. RESULTS: A total of 17/972 (1.75%; 95%CI 1.06%–2.85%) blood samples were parasitized by D. repens,13 out them drawn by dogs resident in the Province of Roma, and 4 in the other provinces. Multivariate analysis was performed in order to evaluate the association between filariosis and risk factors. The origin from coastal territories seems to be a significant risk factor to acquire the infection. CONCLUSION: This is the first report of canine filariosis in the Lazio Region, where D. repens was before reported only in foxes. The risk of human zoonotic infection is stressed, and the absence of other filarial species is discusse

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.Peer reviewe

Chétotaxie cercarienne d’

Le cycle biologique d’Echinostoma revolutum et E. echinatum est réalisé en partant de Mollusques naturellement infestés émettant des cercaires. Une Lymnaea auricularia est à l’origine de la souche d’Echinostoma revolutum, une Lymnaea truncatula et un Planorbis planorbis sont à l’origine d’E. echinatum, un Planorbarius corneus à l’origine d’un Echinostome qui pourrait être soit E. echinatum, soit une autre espèce : E. sp. — Les stades métacercaires et adultes sont obtenus en laboratoire sur des hôtes expérimentaux. Les adultes de ces Échinostomes ne présentent aucune différence morphologique précise : leurs stades larvaires respectifs montrent, par contre, des différences utilisées pour la diagnose de l’espèce. — La chétotaxie cercarienne est décrite pour chacun de ces lots et comparée à celle des espèces décrites sous le nom de E. audyi, E. lindoense et E. caproni. Les différences constatées son discutées

Chétotaxie de la cercaire de

La chétotaxie de la cercaire de Philophthalmus posaviniensis est décrite en détail et comparée à celle des métacercaires d’autres espèces du genre et à celle des autres cercaires d’Echinostomatoidea. La chétotaxie corporelle de la cercaire de P. posaviniensis est très proche de celle des métacercaires de P. megalurus et P. hegeneri. La cercaire possède des papilles CIV I comme les Petasigeridae et les Echinostomatidae qui admettent comme Mollusques vecteurs des Pulmonés et comme les Psilostomidae qui évoluent chez des Prosobranches, de même que les Philophthalmidae. En outre, la cercaire présente des caractères très particuliers : nombre élevé de papilles acétabulaires (15 à 19) et 2 papilles caudales seulement. Philophthalmus serait donc, si l’on tient compte de l’hypothèse de Richard (1971), un genre hyperspécialisé qui tirerait son origine d’un ancêtre proche des Psilostomidae

Chétotaxie cercarienne de trois espèces de trématodes Notocotylidae

La chétotaxie cercarienne de trois espèces de Notocotyles est décrite : Notocotylus attenuatus, N. ephemera et N. zduni. L’origine des souches est la suivante :